PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24577881-7	2014	RESULTS: H2 O2 and ONOO(-) inhibited ERK pathway signaling in T cells by inhibiting the upstream regulator protein kinase Cdelta, decreased DNMT-1 levels, and caused demethylation and overexpression of genes previously shown to be suppressed by DNA methylation in T cells from patients with active lupus.	Hydrogen Peroxide	9-14	DNA methyltransferase 1	Homo sapiens	140-146	
33761969-2	2021	We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by sublethal doses of hydrogen peroxide (H2O2).	Hydrogen Peroxide	107-124	DNA methyltransferase 1	Homo sapiens	30-51	
33761969-2	2021	We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by sublethal doses of hydrogen peroxide (H2O2).	Hydrogen Peroxide	107-124	DNA methyltransferase 1	Homo sapiens	53-57	
33761969-2	2021	We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by sublethal doses of hydrogen peroxide (H2O2).	Hydrogen Peroxide	126-130	DNA methyltransferase 1	Homo sapiens	30-51	
33761969-2	2021	We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by sublethal doses of hydrogen peroxide (H2O2).	Hydrogen Peroxide	126-130	DNA methyltransferase 1	Homo sapiens	53-57	
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Hydrogen Peroxide	44-49	DNA methyltransferase 1	Homo sapiens	96-101	
29131266-13	2017	Finally, both the mRNA level and protein level of DNMT1 increased in H2O2 simulated endometrial cells.	Hydrogen Peroxide	69-73	DNA methyltransferase 1	Homo sapiens	50-55	
26186941-5	2016	Hydrogen peroxide treatment induces the interaction of MSH2-MSH6 with DNMT1, suggesting that the recruitment is through a protein-protein interaction.	Hydrogen Peroxide	0-17	DNA methyltransferase 1	Homo sapiens	70-75	
26165613-7	2015	H2O2 and ONOO(-) decreased Dnmt1 expression in CD4(+) T cells and caused the upregulation of genes known to be suppressed by DNA methylation in patients with lupus and animal models of SLE.	Hydrogen Peroxide	0-4	DNA methyltransferase 1	Homo sapiens	27-32	
30954555-5	2019	Sublethal dosage of H2O2 treatment decrease E-cadherin, increase DNMT1, HDAC1, Snail, Slug and enrich H3K9me3 and H3K27me3 in the CDH1 promoter.	Hydrogen Peroxide	20-24	DNA methyltransferase 1	Homo sapiens	65-70	
30954555-7	2019	DNMT inhibitor, AZA prevented the H2O2 induced promoter-CpG-island methylation of CDH1.	Hydrogen Peroxide	34-38	DNA methyltransferase 1	Homo sapiens	0-4	
23671287-3	2013	Inhibition of the production of H2O2 by the addition of catalase blocked the ability of this group of compounds to inhibit DNA methyltransferase (DNMT) activity.	Hydrogen Peroxide	32-36	DNA methyltransferase 1	Homo sapiens	123-144	
23618814-8	2013	Furthermore, H2O2 treatment resulted in up-regulation of DNA methyltransferase 1 (DNMT1) and histone deacetylase 1 (HDAC1) expression and activity, and enhanced the association between DNMT1 and HDAC1.	Hydrogen Peroxide	13-17	DNA methyltransferase 1	Homo sapiens	57-80	
23618814-8	2013	Furthermore, H2O2 treatment resulted in up-regulation of DNA methyltransferase 1 (DNMT1) and histone deacetylase 1 (HDAC1) expression and activity, and enhanced the association between DNMT1 and HDAC1.	Hydrogen Peroxide	13-17	DNA methyltransferase 1	Homo sapiens	82-87	
23618814-8	2013	Furthermore, H2O2 treatment resulted in up-regulation of DNA methyltransferase 1 (DNMT1) and histone deacetylase 1 (HDAC1) expression and activity, and enhanced the association between DNMT1 and HDAC1.	Hydrogen Peroxide	13-17	DNA methyltransferase 1	Homo sapiens	185-190	
23671287-3	2013	Inhibition of the production of H2O2 by the addition of catalase blocked the ability of this group of compounds to inhibit DNA methyltransferase (DNMT) activity.	Hydrogen Peroxide	32-36	DNA methyltransferase 1	Homo sapiens	146-150	
22094255-2	2011	We demonstrate that inducing cellular oxidative stress by hydrogen peroxide treatment recruits DNA methyltransferase 1 (DNMT1) to damaged chromatin.	Hydrogen Peroxide	58-75	DNA methyltransferase 1	Homo sapiens	95-118	
22094255-2	2011	We demonstrate that inducing cellular oxidative stress by hydrogen peroxide treatment recruits DNA methyltransferase 1 (DNMT1) to damaged chromatin.	Hydrogen Peroxide	58-75	DNA methyltransferase 1	Homo sapiens	120-125