PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22550140-1 2012 RATIONALE: We have previously demonstrated that the importance of endothelium-derived hyperpolarizing factor (EDHF) increases as the vessel size decreases and that endothelium-derived hydrogen peroxide (H(2)O(2)) is an EDHF in animals and humans, for which endothelial nitric oxide synthase (eNOS) is the major source. Hydrogen Peroxide 184-201 nitric oxide synthase 3 Homo sapiens 257-290 20562903-6 2010 RESULTS: Treatment of HUVEC with H(2)O(2) 100 micromol/L for 30 min inhibited the mRNA and protein expression of endothelial nitric oxide synthase (eNOS). Hydrogen Peroxide 33-41 nitric oxide synthase 3 Homo sapiens 113-146 20513234-0 2010 Grape seed extract enhances eNOS expression and NO production through regulating calcium-mediated AKT phosphorylation in H2O2-treated endothelium. Hydrogen Peroxide 121-125 nitric oxide synthase 3 Homo sapiens 28-32 20513234-3 2010 GSE enhanced eNOS expression and NO release in H2O2-treated cells in a dose-dependent manner. Hydrogen Peroxide 47-51 nitric oxide synthase 3 Homo sapiens 13-17 20562903-6 2010 RESULTS: Treatment of HUVEC with H(2)O(2) 100 micromol/L for 30 min inhibited the mRNA and protein expression of endothelial nitric oxide synthase (eNOS). Hydrogen Peroxide 33-41 nitric oxide synthase 3 Homo sapiens 148-152 21188246-2 2010 Tetrahydrobiopterin (BH(4)) is an essential cofactor of endothelial NO synthase (eNOS) to produce NO, whereas dihydrobiopterin (BH(2)) can shift the eNOS product profile from NO to superoxide, which is further converted to hydrogen peroxide (H(2)O(2)) and cause I/R injury. Hydrogen Peroxide 223-240 nitric oxide synthase 3 Homo sapiens 81-85 20184449-0 2010 Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption. Hydrogen Peroxide 101-118 nitric oxide synthase 3 Homo sapiens 49-82 20184449-1 2010 Endothelial nitric oxide synthase (eNOS) is inhibited by hydrogen peroxide (H(2)O(2)), but the mechanism has not been determined. Hydrogen Peroxide 57-74 nitric oxide synthase 3 Homo sapiens 0-33 20184449-1 2010 Endothelial nitric oxide synthase (eNOS) is inhibited by hydrogen peroxide (H(2)O(2)), but the mechanism has not been determined. Hydrogen Peroxide 57-74 nitric oxide synthase 3 Homo sapiens 35-39 20184449-2 2010 Thus, the purpose of this study was to delineate the mechanism by which H(2)O(2) inhibits eNOS activity. Hydrogen Peroxide 72-80 nitric oxide synthase 3 Homo sapiens 90-94 18617528-11 2008 In long term H(2)O(2)-treated cells where Akt was deactivated, significant amounts of Ser(1179)-phosphorylated eNOS remained. Hydrogen Peroxide 13-21 nitric oxide synthase 3 Homo sapiens 111-115 19105596-0 2009 Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity. Hydrogen Peroxide 0-17 nitric oxide synthase 3 Homo sapiens 28-61 19105596-1 2009 We have previously shown that endothelial nitric oxide synthase (eNOS) promoter activity is decreased in endothelial cells in response to the addition of hydrogen peroxide (H(2)O(2)), and this involves, at least in part, the inhibition of AP-1 activity. Hydrogen Peroxide 154-171 nitric oxide synthase 3 Homo sapiens 30-63 19105596-1 2009 We have previously shown that endothelial nitric oxide synthase (eNOS) promoter activity is decreased in endothelial cells in response to the addition of hydrogen peroxide (H(2)O(2)), and this involves, at least in part, the inhibition of AP-1 activity. Hydrogen Peroxide 154-171 nitric oxide synthase 3 Homo sapiens 65-69 19105596-3 2009 Our initial experiments indicated that although H(2)O(2) treatment increased eNOS mRNA levels in ovine pulmonary arterial endothelial cells (OPAECs), there was a significant decrease in the promoter activity of an eNOS promoter construct containing 840 bp of upstream sequence. Hydrogen Peroxide 48-56 nitric oxide synthase 3 Homo sapiens 77-81 18931031-6 2008 H2O2 also induced NO generation that was associated with NOS3 Ser-1177 site phosphorylation and Thr-495 dephosphorylation, with Ser-1177 effects attenuated by LY-294002 and an Akt inhibitor, Akt/PKB signaling inhibitor-2 (API-2). Hydrogen Peroxide 0-4 nitric oxide synthase 3 Homo sapiens 57-61 18617528-0 2008 Bidirectional actions of hydrogen peroxide on endothelial nitric-oxide synthase phosphorylation and function: co-commitment and interplay of Akt and AMPK. Hydrogen Peroxide 25-42 nitric oxide synthase 3 Homo sapiens 46-79 18617528-2 2008 Reactive oxygen species such as H(2)O(2) was reported to activate Akt, leading to increased eNOS Ser(1179) phosphorylation and activity. Hydrogen Peroxide 32-40 nitric oxide synthase 3 Homo sapiens 92-96 18617528-4 2008 Prior studies showing H(2)O(2)-stimulated eNOS phosphorylation were performed on serum-starved cells, and only the short term effect of H(2)O(2) was examined. Hydrogen Peroxide 22-30 nitric oxide synthase 3 Homo sapiens 42-46 18617528-5 2008 Here we found that the effects of H(2)O(2) on eNOS Ser(1179) phosphorylation and function were bidirectional. Hydrogen Peroxide 34-42 nitric oxide synthase 3 Homo sapiens 46-50 18617528-6 2008 With endothelial cells cultured with serum, H(2)O(2) initially raised eNOS Ser(1179) phosphorylation and activity. Hydrogen Peroxide 44-52 nitric oxide synthase 3 Homo sapiens 70-74 18617528-13 2008 Taken together, these studies revealed that Akt and AMPK orchestrated a bidirectional action on eNOS Ser(1179) phosphorylation in H(2)O(2)-treated cells. Hydrogen Peroxide 130-138 nitric oxide synthase 3 Homo sapiens 96-100 18617528-8 2008 Parallel to the alterations of eNOS Ser(1179) phosphorylation, Akt was transiently activated by H(2)O(2) and subsequently became dormant. Hydrogen Peroxide 96-104 nitric oxide synthase 3 Homo sapiens 31-35 15860762-5 2005 Recent studies have shown that H2O2 stimulates reactive oxygen species production via enhanced intracellular iron uptake, mitochondrial damage, and sources of vascular NAD(P)H oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase (eNOS). Hydrogen Peroxide 31-35 nitric oxide synthase 3 Homo sapiens 218-251 18695006-2 2008 We have previously demonstrated in animals and humans that endothelium-derived hydrogen peroxide (H(2)O(2)) is an EDHF that is produced in part by endothelial NO synthase (eNOS). Hydrogen Peroxide 79-96 nitric oxide synthase 3 Homo sapiens 172-176 18556800-1 2008 Previously, we have reported that endothelial nitric oxide synthase (eNOS) promoter activity is decreased in pulmonary arterial endothelial cells (PAECs) in response to hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 169-186 nitric oxide synthase 3 Homo sapiens 34-67 18556800-1 2008 Previously, we have reported that endothelial nitric oxide synthase (eNOS) promoter activity is decreased in pulmonary arterial endothelial cells (PAECs) in response to hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 169-186 nitric oxide synthase 3 Homo sapiens 69-73 17898383-0 2007 Propofol reduces apoptosis and up-regulates endothelial nitric oxide synthase protein expression in hydrogen peroxide-stimulated human umbilical vein endothelial cells. Hydrogen Peroxide 100-117 nitric oxide synthase 3 Homo sapiens 44-77 16337498-7 2006 Coincubation of C (0.5-1.0-2.0 mM), AC (0.1-0.2-0.4 mM) and PC (0.05-0.1-0.2 mM) with H2O2 further increased HO-1 gene expression and not only normalized vs. H2O2 but even increased vs. basal ecNOS mRNA. Hydrogen Peroxide 86-90 nitric oxide synthase 3 Homo sapiens 192-197 15808421-2 2005 Recent reports show that H(2)O(2) induces phosphorylation and activation of endothelial nitric oxide synthase (eNOS) through an Akt-phosphorylation-dependent pathway. Hydrogen Peroxide 25-33 nitric oxide synthase 3 Homo sapiens 76-109 15808421-2 2005 Recent reports show that H(2)O(2) induces phosphorylation and activation of endothelial nitric oxide synthase (eNOS) through an Akt-phosphorylation-dependent pathway. Hydrogen Peroxide 25-33 nitric oxide synthase 3 Homo sapiens 111-115 15808421-4 2005 Whereas moderate levels of H(2)O(2) (100 microM) activated the Akt/eNOS pathway, higher levels (500 microM) did not, suggesting differential effects by differing levels of oxidative stress. Hydrogen Peroxide 27-35 nitric oxide synthase 3 Homo sapiens 67-71 15808421-7 2005 However, down-regulation of cell membrane surface and intracellular free thiols was associated with the inhibition of phosphorylation, suggesting that oxidation of non-GSH thiols inhibits the H(2)O(2)-induced phosphorylation of eNOS and Akt. Hydrogen Peroxide 192-200 nitric oxide synthase 3 Homo sapiens 228-232 18556800-0 2008 Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity. Hydrogen Peroxide 0-17 nitric oxide synthase 3 Homo sapiens 28-61 18006482-5 2008 In macrovascular endothelial cells derived from aortas, CaM Kinase II mediates redox-sensitive upregulation of endothelial nitric oxide synthase (eNOS) gene expression by hydrogen peroxide (H2O2) and oscillatory shear stress, and a rapid activation of eNOS in response to bradykinin. Hydrogen Peroxide 171-188 nitric oxide synthase 3 Homo sapiens 111-144 18006482-5 2008 In macrovascular endothelial cells derived from aortas, CaM Kinase II mediates redox-sensitive upregulation of endothelial nitric oxide synthase (eNOS) gene expression by hydrogen peroxide (H2O2) and oscillatory shear stress, and a rapid activation of eNOS in response to bradykinin. Hydrogen Peroxide 171-188 nitric oxide synthase 3 Homo sapiens 146-150 18006482-5 2008 In macrovascular endothelial cells derived from aortas, CaM Kinase II mediates redox-sensitive upregulation of endothelial nitric oxide synthase (eNOS) gene expression by hydrogen peroxide (H2O2) and oscillatory shear stress, and a rapid activation of eNOS in response to bradykinin. Hydrogen Peroxide 190-194 nitric oxide synthase 3 Homo sapiens 111-144 18006482-5 2008 In macrovascular endothelial cells derived from aortas, CaM Kinase II mediates redox-sensitive upregulation of endothelial nitric oxide synthase (eNOS) gene expression by hydrogen peroxide (H2O2) and oscillatory shear stress, and a rapid activation of eNOS in response to bradykinin. Hydrogen Peroxide 190-194 nitric oxide synthase 3 Homo sapiens 146-150 17916362-9 2007 Conversely, overexpression of Sirt1 prevented hydrogen peroxide-induced SA-beta-gal activity, morphological changes and deranged expression of PAI-1 and eNOS. Hydrogen Peroxide 46-63 nitric oxide synthase 3 Homo sapiens 153-157 15905462-10 2005 Furthermore, hydrogen peroxide and HMG Co-A reductase inhibitors, other stimuli known to modulate eNOS expression posttranscriptionally, also induced eNOS 3" poly(A) tail lengthening. Hydrogen Peroxide 13-30 nitric oxide synthase 3 Homo sapiens 98-102 15905462-10 2005 Furthermore, hydrogen peroxide and HMG Co-A reductase inhibitors, other stimuli known to modulate eNOS expression posttranscriptionally, also induced eNOS 3" poly(A) tail lengthening. Hydrogen Peroxide 13-30 nitric oxide synthase 3 Homo sapiens 150-154 15705930-1 2005 UNLABELLED: Background- We have recently identified that endothelium-derived hydrogen peroxide (H2O2) is an endothelium-derived hyperpolarizing factor (EDHF) in animals and humans, for which endothelial nitric oxide synthase (eNOS) is an important source. Hydrogen Peroxide 77-94 nitric oxide synthase 3 Homo sapiens 191-224 15705930-1 2005 UNLABELLED: Background- We have recently identified that endothelium-derived hydrogen peroxide (H2O2) is an endothelium-derived hyperpolarizing factor (EDHF) in animals and humans, for which endothelial nitric oxide synthase (eNOS) is an important source. Hydrogen Peroxide 96-100 nitric oxide synthase 3 Homo sapiens 191-224 12707237-10 2003 Furthermore, these data support other studies suggesting a role for hydrogen peroxide in the upregulation of eNOS. Hydrogen Peroxide 68-85 nitric oxide synthase 3 Homo sapiens 109-113 15531748-0 2005 Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide. Hydrogen Peroxide 107-124 nitric oxide synthase 3 Homo sapiens 23-38 15531748-10 2005 In FPAEC in monoculture treated with 0-100 microM H2O2, 12 microM had no effect on eNOS promoter activity, but it increased eNOS protein levels by 50%. Hydrogen Peroxide 50-54 nitric oxide synthase 3 Homo sapiens 124-128 15531748-11 2005 However, at 100 microM, H2O2 decreased eNOS promoter activity and protein levels in FPAEC by 79 and 40%, respectively. Hydrogen Peroxide 24-28 nitric oxide synthase 3 Homo sapiens 39-43 15531748-12 2005 These data suggest a role for smooth muscle cell-derived H2O2 in ET-1-mediated downregulation of eNOS expression in children born with PPHN. Hydrogen Peroxide 57-61 nitric oxide synthase 3 Homo sapiens 97-101 34394836-9 2021 In conclusion, our findings suggested that LEO can ameliorate the oxidative stress damage and insufficient angiogenesis of HUVECs induced by H2O2 through activating the PI3K/Akt-eNOS signaling pathway. Hydrogen Peroxide 141-145 nitric oxide synthase 3 Homo sapiens 178-182 12875691-8 2003 Both H(2)O(2) and LPS significantly increased the eNOS protein expression and the increase was attenuated after pretreatment with propofol. Hydrogen Peroxide 5-13 nitric oxide synthase 3 Homo sapiens 50-54 12162424-5 2002 H2O2 in turn enhanced endothelial nitric oxide synthase (eNOS) transcription in endothelial cells and myocytes. Hydrogen Peroxide 0-4 nitric oxide synthase 3 Homo sapiens 22-55 12162424-5 2002 H2O2 in turn enhanced endothelial nitric oxide synthase (eNOS) transcription in endothelial cells and myocytes. Hydrogen Peroxide 0-4 nitric oxide synthase 3 Homo sapiens 57-61 34380696-2 2021 In this study, we show genetic deletion and viral knockdown of hepatocyte-specific eNOS exacerbated hepatic steatosis and inflammation, decreased hepatic mitochondrial fatty acid oxidation and respiration, increased mitochondrial H2O2 emission, and impaired the hepatic mitophagic (BNIP3 and LC3II) response. Hydrogen Peroxide 230-234 nitric oxide synthase 3 Homo sapiens 83-87 12875691-7 2003 Both H(2)O(2) and LPS significantly increased the eNOS transcript levels and the increases were significantly attenuated after pretreatment with propofol. Hydrogen Peroxide 5-13 nitric oxide synthase 3 Homo sapiens 50-54 12569550-5 2003 Elevation of ROS by treatment of tumor spheroids with either buthionine sulfoximine (BSO) or hydrogen peroxide resulted in upregulation of eNOS, whereas iNOS was downregulated. Hydrogen Peroxide 93-110 nitric oxide synthase 3 Homo sapiens 139-143 12569550-7 2003 Upregulation of eNOS after treatment with hydrogen peroxide was apparently transduced through receptor tyrosine kinase signaling pathways since it was abolished by the protein kinase C (PKC) inhibitor bisindolylmaleimide-1 (BIM-1), the p21(ras) inhibitor S-trans-trans-farnesylthiosalicylic acid (FTS), the c-Raf inhibitor ZM 336372 and PD98059, which inhibits ERK1/2 activation. Hydrogen Peroxide 42-59 nitric oxide synthase 3 Homo sapiens 16-20 11744698-0 2002 Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. Hydrogen Peroxide 0-17 nitric oxide synthase 3 Homo sapiens 28-61 9333325-11 1997 This may lead eNOS to generate peroxynitrite and hydrogen peroxide, potent oxidants implicated in several vascular pathologies. Hydrogen Peroxide 49-66 nitric oxide synthase 3 Homo sapiens 14-18 33539947-5 2021 Exposure of MPO-containing ECs to low micromolar concentrations of H2O2 yielded enhanced rates of H2O2 consumption that correlated with HOCl formation and increased eNOS enzyme activity. Hydrogen Peroxide 67-71 nitric oxide synthase 3 Homo sapiens 165-169 34050207-5 2021 In this study, hypertonic stress, hyperthermia and hydrogen peroxide all increased the expression levels of eNOS O-GlcNAc, whereas hypoxia and high levels of alcohol had no effect. Hydrogen Peroxide 51-68 nitric oxide synthase 3 Homo sapiens 108-112 33621475-7 2021 In both BeWo and explants, the protective effect of NP-Plac1-hIGF1 treatment against H2O2 inducedcell death/lactate dehydrogenase release was prevented by eNOS inhibition (P=0.003 and P<0.0001, respectively). Hydrogen Peroxide 85-89 nitric oxide synthase 3 Homo sapiens 155-159 33539947-7 2021 Activation of eNOS in MPO-containing ECs exposed to H2O2 involved a rapid elevation in cytosolic calcium and increased eNOS phosphorylation at Ser-1179 and de-phosphorylation at Thr-497. Hydrogen Peroxide 52-56 nitric oxide synthase 3 Homo sapiens 14-18 33539947-7 2021 Activation of eNOS in MPO-containing ECs exposed to H2O2 involved a rapid elevation in cytosolic calcium and increased eNOS phosphorylation at Ser-1179 and de-phosphorylation at Thr-497. Hydrogen Peroxide 52-56 nitric oxide synthase 3 Homo sapiens 119-123 32590330-1 2020 Hydrogen peroxide (H2O2) modulates critical phosphorylation pathways in vascular endothelial cells, many of which affect endothelial nitric oxide synthase (eNOS) signal transduction. Hydrogen Peroxide 0-17 nitric oxide synthase 3 Homo sapiens 121-154 32590330-1 2020 Hydrogen peroxide (H2O2) modulates critical phosphorylation pathways in vascular endothelial cells, many of which affect endothelial nitric oxide synthase (eNOS) signal transduction. Hydrogen Peroxide 0-17 nitric oxide synthase 3 Homo sapiens 156-160 32590330-1 2020 Hydrogen peroxide (H2O2) modulates critical phosphorylation pathways in vascular endothelial cells, many of which affect endothelial nitric oxide synthase (eNOS) signal transduction. Hydrogen Peroxide 19-23 nitric oxide synthase 3 Homo sapiens 121-154 32590330-1 2020 Hydrogen peroxide (H2O2) modulates critical phosphorylation pathways in vascular endothelial cells, many of which affect endothelial nitric oxide synthase (eNOS) signal transduction. Hydrogen Peroxide 19-23 nitric oxide synthase 3 Homo sapiens 156-160 32590330-2 2020 Both intracellular and extracellular sources of H2O2 have been implicated in eNOS regulation, yet the specific endothelial pathways remain incompletely understood. Hydrogen Peroxide 48-52 nitric oxide synthase 3 Homo sapiens 77-81 32590330-10 2020 Addition of extracellular H2O2 had only a nominal effect on phosphorylation of eNOS, kinase Akt or AMP-activated protein kinase (AMPK). Hydrogen Peroxide 26-30 nitric oxide synthase 3 Homo sapiens 79-83 32590330-12 2020 We also found that the AMPK inhibitor Compound C completely blocked nuclear H2O2-promoted eNOS phosphorylation. Hydrogen Peroxide 76-80 nitric oxide synthase 3 Homo sapiens 90-94 32590330-14 2020 We conclude that H2O2 generated in the cell nucleus activates AMPK, leading to eNOS phosphorylation; in contrast, AMPK activation by cytosol- or caveolae-derived H2O2 does not promote eNOS phosphorylation via AMPK. Hydrogen Peroxide 17-21 nitric oxide synthase 3 Homo sapiens 79-83 30119249-8 2018 Moreover, we found that H2O2 decreased Akt and eNOS phosphorylation, which perhaps, indirectly reduced nitric oxide (NO) production. Hydrogen Peroxide 24-28 nitric oxide synthase 3 Homo sapiens 47-51 32402583-7 2020 H2O2 downregulated the expression of eNOS and upregulated iNOS, which in turn contribute to an elevated NO generation and protein nitrosylation. Hydrogen Peroxide 0-4 nitric oxide synthase 3 Homo sapiens 37-41 32455928-6 2020 H2O2 treatment significantly increased senescence in endothelial cells and mural cells, human neonatal dermal fibroblasts (hNDFs), as measured by increased p21 levels and reduced NOS3 expression. Hydrogen Peroxide 0-4 nitric oxide synthase 3 Homo sapiens 179-183 31750822-0 2019 [Tanshinone IIA attenuates hydrogen peroxide-induced senescence of human umbilical vein endothelial cells through activating SIRT1/eNOS pathway]. Hydrogen Peroxide 27-44 nitric oxide synthase 3 Homo sapiens 131-135 30119249-12 2018 Furthermore, BEG reduced H2O2-induced endothelial cells injury by the involvement of antioxidation and PI3K/Akt/eNOS/NO signaling pathways. Hydrogen Peroxide 25-29 nitric oxide synthase 3 Homo sapiens 112-116 26660451-4 2017 Thus, the consequences of the interaction (redox crosstalk) of superoxide/hydrogen peroxide produced by mitochondria with other ROS producing enzymes such as NADPH oxidases (Nox) are of outstanding importance and will be discussed including the consequences for endothelial nitric oxide synthase (eNOS) uncoupling as well as the redox regulation of the vascular function/tone in general (soluble guanylyl cyclase, endothelin-1, prostanoid synthesis). Hydrogen Peroxide 74-91 nitric oxide synthase 3 Homo sapiens 262-295 29992759-5 2018 Kallistatin reversed H2 O2 -mediated inhibition of endothelial nitric oxide synthase (eNOS), SIRT1, catalase and superoxide dismutase (SOD)-2 expression, and kallistatin alone stimulated the synthesis of these antioxidant enzymes. Hydrogen Peroxide 21-26 nitric oxide synthase 3 Homo sapiens 86-90 30048241-6 2018 Moreover, HO-1 induction prevented the decrease of eNOS dimer/monomer ratio stimulated by H2O2 via its antioxidant properties. Hydrogen Peroxide 90-94 nitric oxide synthase 3 Homo sapiens 51-55 27184745-4 2016 Endothelial dysfunction is linked to eNOS uncoupling, which consists of a switch from the generation of NO to the generation of superoxide anions and hydrogen peroxide. Hydrogen Peroxide 150-167 nitric oxide synthase 3 Homo sapiens 37-41 25963768-5 2015 Herein, we report for the first time that the hydrogen peroxide (H2O2), a redox signaling molecule, generated by these EHNs activates the endothelial nitric oxide synthase (eNOS) that promotes the nitric oxide (NO) production in a PI3K (phosphoinositide 3-kinase)/Akt dependent manner, eventually triggering angiogenesis. Hydrogen Peroxide 46-63 nitric oxide synthase 3 Homo sapiens 138-171 25963768-5 2015 Herein, we report for the first time that the hydrogen peroxide (H2O2), a redox signaling molecule, generated by these EHNs activates the endothelial nitric oxide synthase (eNOS) that promotes the nitric oxide (NO) production in a PI3K (phosphoinositide 3-kinase)/Akt dependent manner, eventually triggering angiogenesis. Hydrogen Peroxide 65-69 nitric oxide synthase 3 Homo sapiens 138-171 26235577-8 2015 Treatment of HUVECs with H2O2 also down-regulated the phosphorylation of endothelial nitric oxide synthase (eNOS), decreased the level of nitric oxide in the culture medium, and inhibited the protein expression and enzymatic activity of silent information regulator 1 (SIRT1), while pretreatment with curcumin partly reversed these effects (all p<0.05). Hydrogen Peroxide 25-29 nitric oxide synthase 3 Homo sapiens 73-106 24868319-6 2014 The underlying mechanisms involve the inhibition of H2O2-induced activation of endothelial nitric oxide synthase (eNOS), adenosine monophosphate-activated protein kinase (AMPK), and Akt, as well as the redox sensitive transcription factor, NF-kappa B (NF- kappa B). Hydrogen Peroxide 52-56 nitric oxide synthase 3 Homo sapiens 79-112 24008236-0 2013 Endothelial nitric oxide synthase phosphorylation at Threonine 495 and mitochondrial reactive oxygen species formation in response to a high H2O2 concentration. Hydrogen Peroxide 141-145 nitric oxide synthase 3 Homo sapiens 0-33 22861189-7 2013 The supplementation with hydrogen peroxide (H(2)O(2)) increased NOS-3 activity and cell death in 4TO-NOS cells. Hydrogen Peroxide 25-42 nitric oxide synthase 3 Homo sapiens 64-69 22861189-7 2013 The supplementation with hydrogen peroxide (H(2)O(2)) increased NOS-3 activity and cell death in 4TO-NOS cells. Hydrogen Peroxide 44-53 nitric oxide synthase 3 Homo sapiens 64-69 24008236-2 2013 We investigated cellular pathways involved in endothelial nitric oxide synthase (eNOS) phosphorylation at Threonine 495 (Thr(495)) in human umbilical vein endothelial cells (HUVECs) exposed to H2O2. Hydrogen Peroxide 193-197 nitric oxide synthase 3 Homo sapiens 46-79 22902249-0 2012 Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. Hydrogen Peroxide 147-164 nitric oxide synthase 3 Homo sapiens 99-132