PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12386145-5	2002	PDGF and H2O2 time-dependently suppressed VDUP-1 expression (13-fold and 30-fold reduction after 1 hour, respectively; P<0.001), and this was inhibited by the cell-permeable antioxidants N-acetylcysteine and 4,5-dihydroxy-1,3-benzene-disulfonic acid (Tiron).	Hydrogen Peroxide	9-13	thioredoxin interacting protein	Homo sapiens	42-48	
34663173-9	2021	Expressions of TXNIP and NLRP3 in HUVECs were up-regulated by H2O2 but down-regulated by Gen. Overexpressed TXNIP partially reversed the suppressive effect of Gen on H2O2-induced senescence and apoptosis of HUVECs.	Hydrogen Peroxide	62-66	thioredoxin interacting protein	Homo sapiens	108-113	
34663173-9	2021	Expressions of TXNIP and NLRP3 in HUVECs were up-regulated by H2O2 but down-regulated by Gen. Overexpressed TXNIP partially reversed the suppressive effect of Gen on H2O2-induced senescence and apoptosis of HUVECs.	Hydrogen Peroxide	166-170	thioredoxin interacting protein	Homo sapiens	108-113	
34663173-0	2021	Genistein alleviates H2O2-induced senescence of human umbilical vein endothelial cells via regulating the TXNIP/NLRP3 axis.	Hydrogen Peroxide	21-25	thioredoxin interacting protein	Homo sapiens	106-111	
34663173-8	2021	H2O2-induced HUVEC senescence and the expression of TXNIP and NLRP3 in HUVECs were down-regulated by Gen (40 and 80 microg/mL).	Hydrogen Peroxide	0-4	thioredoxin interacting protein	Homo sapiens	52-57	
34663173-10	2021	Expressions of p16, p21, TXNIP, NLRP3, cleaved caspase-3 and cleaved caspase-1 in H2O2-treated HUVECs were inhibited by Gen, while the inhibition as such was partially reversed by overexpressed TXNIP.	Hydrogen Peroxide	82-86	thioredoxin interacting protein	Homo sapiens	25-30	
34663173-9	2021	Expressions of TXNIP and NLRP3 in HUVECs were up-regulated by H2O2 but down-regulated by Gen. Overexpressed TXNIP partially reversed the suppressive effect of Gen on H2O2-induced senescence and apoptosis of HUVECs.	Hydrogen Peroxide	62-66	thioredoxin interacting protein	Homo sapiens	15-20	
34663173-11	2021	DISCUSSION AND CONCLUSIONS: H2O2-induced HUVEC senescence was alleviated by Gen via suppressing the TXNIP/NLRP3 axis, which may offer a potential therapeutic approach for improving HUVEC senescence and provide a new direction for the treatment of cardiovascular disease.	Hydrogen Peroxide	28-32	thioredoxin interacting protein	Homo sapiens	100-105	
34603601-7	2021	Importantly, REDD1 formed a complex with TXNIP to strengthen its own action, and the combination was consolidated under H2O2-induced oxidative stress.	Hydrogen Peroxide	120-124	thioredoxin interacting protein	Homo sapiens	41-46	
34603601-10	2021	Altogether, our results demonstrated that the REDD1/TXNIP complex mediated H2O2-induced human NP cell apoptosis and IVD degeneration through the mitochondrial pathway.	Hydrogen Peroxide	75-79	thioredoxin interacting protein	Homo sapiens	52-57	
35471587-9	2022	H2 O2 -induced ROS production and EGFR phosphorylation decreased in NHEKs with TXNIP knockdown.	Hydrogen Peroxide	0-5	thioredoxin interacting protein	Homo sapiens	79-84	
31922218-8	2020	Thioredoxin interacting protein (TXNIP) was predicted as a target gene for miR-20b and knockdown of TXNIP increased cell viability, inhibited cell senescence, reduced the expression of p16, p21, TXNIP, NLR family pyrin domain containing 3 (NLRP3) and cleaved Caspase-1 and reversed the promoting effects of the miR-20b inhibitor and H2O2 on cell senescence.	Hydrogen Peroxide	333-337	thioredoxin interacting protein	Homo sapiens	0-31	
31922218-8	2020	Thioredoxin interacting protein (TXNIP) was predicted as a target gene for miR-20b and knockdown of TXNIP increased cell viability, inhibited cell senescence, reduced the expression of p16, p21, TXNIP, NLR family pyrin domain containing 3 (NLRP3) and cleaved Caspase-1 and reversed the promoting effects of the miR-20b inhibitor and H2O2 on cell senescence.	Hydrogen Peroxide	333-337	thioredoxin interacting protein	Homo sapiens	33-38	
31922218-8	2020	Thioredoxin interacting protein (TXNIP) was predicted as a target gene for miR-20b and knockdown of TXNIP increased cell viability, inhibited cell senescence, reduced the expression of p16, p21, TXNIP, NLR family pyrin domain containing 3 (NLRP3) and cleaved Caspase-1 and reversed the promoting effects of the miR-20b inhibitor and H2O2 on cell senescence.	Hydrogen Peroxide	333-337	thioredoxin interacting protein	Homo sapiens	100-105	
31922218-8	2020	Thioredoxin interacting protein (TXNIP) was predicted as a target gene for miR-20b and knockdown of TXNIP increased cell viability, inhibited cell senescence, reduced the expression of p16, p21, TXNIP, NLR family pyrin domain containing 3 (NLRP3) and cleaved Caspase-1 and reversed the promoting effects of the miR-20b inhibitor and H2O2 on cell senescence.	Hydrogen Peroxide	333-337	thioredoxin interacting protein	Homo sapiens	100-105	
23519408-2	2013	Various stress stimuli such as high glucose, heat shock, UV, H2O2 and mechanical stress among others robustly induce the expression of TXNIP, resulting in the sequestration and inactivation of thioredoxin, which in turn leads to cellular oxidative stress.	Hydrogen Peroxide	61-65	thioredoxin interacting protein	Homo sapiens	135-140	
28367274-5	2017	Also, H2O2 caused an increase in TXNIP expression.	Hydrogen Peroxide	6-10	thioredoxin interacting protein	Homo sapiens	33-38