PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35471587-9 2022 H2 O2 -induced ROS production and EGFR phosphorylation decreased in NHEKs with TXNIP knockdown. Hydrogen Peroxide 0-5 thioredoxin interacting protein Homo sapiens 79-84 34663173-0 2021 Genistein alleviates H2O2-induced senescence of human umbilical vein endothelial cells via regulating the TXNIP/NLRP3 axis. Hydrogen Peroxide 21-25 thioredoxin interacting protein Homo sapiens 106-111 34663173-8 2021 H2O2-induced HUVEC senescence and the expression of TXNIP and NLRP3 in HUVECs were down-regulated by Gen (40 and 80 microg/mL). Hydrogen Peroxide 0-4 thioredoxin interacting protein Homo sapiens 52-57 34663173-9 2021 Expressions of TXNIP and NLRP3 in HUVECs were up-regulated by H2O2 but down-regulated by Gen. Overexpressed TXNIP partially reversed the suppressive effect of Gen on H2O2-induced senescence and apoptosis of HUVECs. Hydrogen Peroxide 62-66 thioredoxin interacting protein Homo sapiens 15-20 34603601-7 2021 Importantly, REDD1 formed a complex with TXNIP to strengthen its own action, and the combination was consolidated under H2O2-induced oxidative stress. Hydrogen Peroxide 120-124 thioredoxin interacting protein Homo sapiens 41-46 34603601-10 2021 Altogether, our results demonstrated that the REDD1/TXNIP complex mediated H2O2-induced human NP cell apoptosis and IVD degeneration through the mitochondrial pathway. Hydrogen Peroxide 75-79 thioredoxin interacting protein Homo sapiens 52-57 12386145-5 2002 PDGF and H2O2 time-dependently suppressed VDUP-1 expression (13-fold and 30-fold reduction after 1 hour, respectively; P<0.001), and this was inhibited by the cell-permeable antioxidants N-acetylcysteine and 4,5-dihydroxy-1,3-benzene-disulfonic acid (Tiron). Hydrogen Peroxide 9-13 thioredoxin interacting protein Homo sapiens 42-48 34663173-9 2021 Expressions of TXNIP and NLRP3 in HUVECs were up-regulated by H2O2 but down-regulated by Gen. Overexpressed TXNIP partially reversed the suppressive effect of Gen on H2O2-induced senescence and apoptosis of HUVECs. Hydrogen Peroxide 62-66 thioredoxin interacting protein Homo sapiens 108-113 34663173-9 2021 Expressions of TXNIP and NLRP3 in HUVECs were up-regulated by H2O2 but down-regulated by Gen. Overexpressed TXNIP partially reversed the suppressive effect of Gen on H2O2-induced senescence and apoptosis of HUVECs. Hydrogen Peroxide 166-170 thioredoxin interacting protein Homo sapiens 108-113 34663173-10 2021 Expressions of p16, p21, TXNIP, NLRP3, cleaved caspase-3 and cleaved caspase-1 in H2O2-treated HUVECs were inhibited by Gen, while the inhibition as such was partially reversed by overexpressed TXNIP. Hydrogen Peroxide 82-86 thioredoxin interacting protein Homo sapiens 25-30 34663173-11 2021 DISCUSSION AND CONCLUSIONS: H2O2-induced HUVEC senescence was alleviated by Gen via suppressing the TXNIP/NLRP3 axis, which may offer a potential therapeutic approach for improving HUVEC senescence and provide a new direction for the treatment of cardiovascular disease. Hydrogen Peroxide 28-32 thioredoxin interacting protein Homo sapiens 100-105 31922218-8 2020 Thioredoxin interacting protein (TXNIP) was predicted as a target gene for miR-20b and knockdown of TXNIP increased cell viability, inhibited cell senescence, reduced the expression of p16, p21, TXNIP, NLR family pyrin domain containing 3 (NLRP3) and cleaved Caspase-1 and reversed the promoting effects of the miR-20b inhibitor and H2O2 on cell senescence. Hydrogen Peroxide 333-337 thioredoxin interacting protein Homo sapiens 0-31 31922218-8 2020 Thioredoxin interacting protein (TXNIP) was predicted as a target gene for miR-20b and knockdown of TXNIP increased cell viability, inhibited cell senescence, reduced the expression of p16, p21, TXNIP, NLR family pyrin domain containing 3 (NLRP3) and cleaved Caspase-1 and reversed the promoting effects of the miR-20b inhibitor and H2O2 on cell senescence. Hydrogen Peroxide 333-337 thioredoxin interacting protein Homo sapiens 33-38 31922218-8 2020 Thioredoxin interacting protein (TXNIP) was predicted as a target gene for miR-20b and knockdown of TXNIP increased cell viability, inhibited cell senescence, reduced the expression of p16, p21, TXNIP, NLR family pyrin domain containing 3 (NLRP3) and cleaved Caspase-1 and reversed the promoting effects of the miR-20b inhibitor and H2O2 on cell senescence. Hydrogen Peroxide 333-337 thioredoxin interacting protein Homo sapiens 100-105 31922218-8 2020 Thioredoxin interacting protein (TXNIP) was predicted as a target gene for miR-20b and knockdown of TXNIP increased cell viability, inhibited cell senescence, reduced the expression of p16, p21, TXNIP, NLR family pyrin domain containing 3 (NLRP3) and cleaved Caspase-1 and reversed the promoting effects of the miR-20b inhibitor and H2O2 on cell senescence. Hydrogen Peroxide 333-337 thioredoxin interacting protein Homo sapiens 100-105 23519408-2 2013 Various stress stimuli such as high glucose, heat shock, UV, H2O2 and mechanical stress among others robustly induce the expression of TXNIP, resulting in the sequestration and inactivation of thioredoxin, which in turn leads to cellular oxidative stress. Hydrogen Peroxide 61-65 thioredoxin interacting protein Homo sapiens 135-140 28367274-5 2017 Also, H2O2 caused an increase in TXNIP expression. Hydrogen Peroxide 6-10 thioredoxin interacting protein Homo sapiens 33-38