PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35163314-0 2022 Galangin Reverses H2O2-Induced Dermal Fibroblast Senescence via SIRT1-PGC-1alpha/Nrf2 Signaling. Hydrogen Peroxide 18-22 sirtuin 1 Mus musculus 64-69 34220528-9 2021 The results showed that SIRT1 overexpression promoted ATP production and reactive oxygen species (ROS) activity and reduced the levels of LPO, FFA, and NO in H9C2 cardiomyocytes treated with H2O2 and TMZ. Hydrogen Peroxide 191-195 sirtuin 1 Mus musculus 24-29 34184072-5 2021 In the present study, SFN was shown to significantly inhibit chondrocyte apoptosis while enhancing expression levels of SIRT1 in a H2O2-induced OA mouse model. Hydrogen Peroxide 131-135 sirtuin 1 Mus musculus 120-125 35163314-6 2022 Our results indicated that galangin treatment attenuates H2O2/UVB-induced cell viability reduction, dermal aging, and SIRT1/PGC-1alpha/Nrf2 signaling activation. Hydrogen Peroxide 57-61 sirtuin 1 Mus musculus 118-123 35109721-0 2022 Melatonin alleviates hydrogen peroxide induced oxidative damage in MC3T3-E1 cells and promotes osteogenesis by activating SIRT1. Hydrogen Peroxide 21-38 sirtuin 1 Mus musculus 122-127 32453975-4 2020 Consistently, melatonin treatment during in vitro maturation also attenuated the meiotic defects induced by H2O2 by regulating autophagy and SIRT1, which could be abolished by SIRT1 inhibitor, Ex527 and autophagy inhibitor Bafilomycin A1 (Baf A1). Hydrogen Peroxide 108-112 sirtuin 1 Mus musculus 141-146 33198615-7 2021 Moreover, treatment with PCr suppressed reactive oxygen species (ROS) over-generation and promoted the ATP production as well as increased the PGC-1alpha, FOXO1 and SIRT1 protein expression levels in H2O2-induced MC3T3-E1 cells. Hydrogen Peroxide 200-204 sirtuin 1 Mus musculus 165-170 33205668-5 2022 Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence. Hydrogen Peroxide 192-196 sirtuin 1 Mus musculus 150-155 32453975-4 2020 Consistently, melatonin treatment during in vitro maturation also attenuated the meiotic defects induced by H2O2 by regulating autophagy and SIRT1, which could be abolished by SIRT1 inhibitor, Ex527 and autophagy inhibitor Bafilomycin A1 (Baf A1). Hydrogen Peroxide 108-112 sirtuin 1 Mus musculus 176-181 28237267-8 2017 Expressions of endothelial nitric oxide synthase and silent information regulator protein 1 (SIRT1) were significantly up-regulated but those of P53 and P21 were markedly down-regulated both in aged mice and in hydrogen peroxide-treated MAECs in the absence of the TRPC5 gene. Hydrogen Peroxide 211-228 sirtuin 1 Mus musculus 53-91 29326403-11 2018 Transfection with Nrf2 and SIRT1 siRNA prevented resveratrol-induced anti-oxidative effect in HK2 cells in media treated with H2O2. Hydrogen Peroxide 126-130 sirtuin 1 Mus musculus 27-32 28956094-14 2017 The treatment with SIRT1 inhibitors did not affect osteoclast differentiation but, when supplemented with exogenous hydrogen peroxide, a partial rescue of melatonin-suppressed osteoclastogenesis was observed. Hydrogen Peroxide 116-133 sirtuin 1 Mus musculus 19-24 31182679-5 2019 Hydrogen peroxide (H2O2) treatment induced cellular senescence and down-regulated the expression of MEF2A and PI3K/p-AKT/SIRT1. Hydrogen Peroxide 0-17 sirtuin 1 Mus musculus 121-126 31182679-5 2019 Hydrogen peroxide (H2O2) treatment induced cellular senescence and down-regulated the expression of MEF2A and PI3K/p-AKT/SIRT1. Hydrogen Peroxide 19-23 sirtuin 1 Mus musculus 121-126 31182679-6 2019 MEF2A overexpression inhibited cellular senescence and the down-regulation of PI3K/p-AKT/SIRT1 induced by H2O2. Hydrogen Peroxide 106-110 sirtuin 1 Mus musculus 89-94 30556210-10 2019 The regulatory relationship among MIAT, miR-29b, and SIRT1 was further validated by comparing the differentiated expression of these factors in cells treated with phosphate-buffered saline + H2 O2, a negative control + H2 O2, MIAT + H2 O2 , or H2 O2 + anti-miR-29b. Hydrogen Peroxide 191-196 sirtuin 1 Mus musculus 53-58 29053994-11 2017 Similarly, muscle stem cells isolated from mouse skeletal muscles showed reduced Sirt1 protein abundance with H2O2 treatment, but this could be reversed by resveratrol. Hydrogen Peroxide 110-114 sirtuin 1 Mus musculus 81-86 28237267-8 2017 Expressions of endothelial nitric oxide synthase and silent information regulator protein 1 (SIRT1) were significantly up-regulated but those of P53 and P21 were markedly down-regulated both in aged mice and in hydrogen peroxide-treated MAECs in the absence of the TRPC5 gene. Hydrogen Peroxide 211-228 sirtuin 1 Mus musculus 93-98 26406155-6 2015 In conclusion, Sirt 1 was downregulated during the H2O2-induced apoptosis in MC3T3-E1 cells. Hydrogen Peroxide 51-55 sirtuin 1 Mus musculus 15-21 25424328-9 2015 In vitro, actin cytoskeleton derangement in H2O2-treated podocytes became prominent when the cells were pretreated with SIRT1 inhibitors. Hydrogen Peroxide 44-48 sirtuin 1 Mus musculus 120-125 25424328-10 2015 Conversely, this H2O2-induced derangement was ameliorated by SIRT1 activation. Hydrogen Peroxide 17-21 sirtuin 1 Mus musculus 61-66 26223904-0 2016 Carnosic acid protects normal mouse hepatocytes against H2 O2 -induced cytotoxicity via sirtuin 1-mediated signaling. Hydrogen Peroxide 56-61 sirtuin 1 Mus musculus 88-97 26223904-9 2016 Pretreatment with EX527 or transfection of siRNA-targeting SIRT1 weakened the protective effects of CA against H2 O2 -induced cell death. Hydrogen Peroxide 111-116 sirtuin 1 Mus musculus 59-64 26406155-0 2015 Resveratrol inhibits the hydrogen dioxide-induced apoptosis via Sirt 1 activation in osteoblast cells. Hydrogen Peroxide 25-41 sirtuin 1 Mus musculus 64-70 26406155-4 2015 Results demonstrated that Sirt 1 and Bcl-2 were inhibited, whereas p53 acetylation, Bax, and caspase 9 were promoted by H2O2, as was aggravated by the Sirt 1 inhibitor, EX-527. Hydrogen Peroxide 120-124 sirtuin 1 Mus musculus 151-157 26406155-7 2015 And the chemical activation of Sirt 1 inhibited the H2O2-induced apoptosis via the downregulation of p53 acetylation. Hydrogen Peroxide 52-56 sirtuin 1 Mus musculus 31-37 24894401-6 2014 Role of oxidative stress in the regulation of Sirt1 was evaluated in the cells incubated in H2O2. Hydrogen Peroxide 92-96 sirtuin 1 Mus musculus 46-51 24894401-9 2014 While Sirt1 was decreased by H2O2, MMP-9 was significantly increased. Hydrogen Peroxide 29-33 sirtuin 1 Mus musculus 6-11 23755229-7 2013 APE1/Ref-1 protects endothelial SIRT1 from hydrogen peroxide-induced oxidation of sulfhydryls and from inactivation. Hydrogen Peroxide 43-60 sirtuin 1 Mus musculus 32-37 18753379-10 2008 In organotypic forebrain slice cultures treated with hydrogen peroxide, p53 is accumulated and colocalized with necdin and Sirt1 in cortical neurons. Hydrogen Peroxide 53-70 sirtuin 1 Mus musculus 123-128