PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33817783-7 2021 In C2C12 myotubes, direct exposure to H2 O2 or CSE caused myofiber wasting, which was associated with ~50% loss in muscle-derived insulin-like growth factor (IGF)-1 and 2-fold induction of Nox2, independent of cellular inflammation. Hydrogen Peroxide 38-43 insulin-like growth factor 1 Mus musculus 130-170 1648617-0 1991 Transient chondrocyte nonresponsiveness to insulin-like growth factor-1 upon H2O2 exposure is not related to IGF receptor damage. Hydrogen Peroxide 77-81 insulin-like growth factor 1 Mus musculus 43-71 1648617-7 1991 In contrast, cartilage which was longterm exposed to H2O2 in vivo after injection of amidated glucoseoxidase (aGO) showed only a moderate IGF-1 response. Hydrogen Peroxide 53-57 insulin-like growth factor 1 Mus musculus 138-143 1648617-10 1991 Binding of radiolabelled IGF-1 to H2O2 treated chondrocytes was unimpaired. Hydrogen Peroxide 34-38 insulin-like growth factor 1 Mus musculus 25-30 1648617-12 1991 Transient chondrocyte IGF-1 nonresponsiveness found after H2O2 exposure is not related to IGF receptor damage, and contrasts with the complete nonresponsiveness found in arthritic cartilage. Hydrogen Peroxide 58-62 insulin-like growth factor 1 Mus musculus 22-27 26354375-0 2015 Adenoviral vector expressing IGF-1 protects murine chondrogenic ATDC5 cells against hydrogen peroxide-induced mitochondrial dysfunction and apoptosis. Hydrogen Peroxide 84-101 insulin-like growth factor 1 Mus musculus 29-34 34420367-10 2021 Conclusions: Combined insulin and IGF-1 resistance restricted to the endothelium leads to a potentially favourable adaptation in contrast to pure insulin resistance, with increased Nox4-derived H2O2 generation mediating enhanced whole-body insulin sensitivity. Hydrogen Peroxide 194-198 insulin-like growth factor 1 Mus musculus 34-39 33187642-0 2020 Corrigendum to (title of manuscript): IGF-1 resist oxidative damage to HaCaT and depigmentation in mice treated with H2O2. Hydrogen Peroxide 117-121 insulin-like growth factor 1 Mus musculus 38-43 30208515-0 2018 IGF-1 resist oxidative damage to HaCaT and depigmentation in mice treated with H2O2. Hydrogen Peroxide 79-83 insulin-like growth factor 1 Mus musculus 0-5 30208515-6 2018 After 50 days, IGF-1 obviously ameliorated depigmentation of mice skin and reduced hair follicle length, skin thickness and Tyrosinase induced by H2O2. Hydrogen Peroxide 146-150 insulin-like growth factor 1 Mus musculus 15-20 30208515-9 2018 It suggests that IGF-1 inhibits oxidative damage to HaCaT and immunosuppressive effects on CD8+ T cells proliferation and activation to resist depigmentation induced by H2O2. Hydrogen Peroxide 169-173 insulin-like growth factor 1 Mus musculus 17-22 26354375-6 2015 However, the IGF-1 overexpression by adenovirus inhibited the H2O2-induced mitochondrial dysfunction and further inhibited the H2O2-promoted apoptosis in ATDC5 cells. Hydrogen Peroxide 127-131 insulin-like growth factor 1 Mus musculus 13-18 26354375-2 2015 The present study was to investigate the regulatory role of IGF-1 against hydrogen peroxide(H2O2)-induced mitochondrial dysfunction and apoptosis in murine chondrocytic ATDC5 cells. Hydrogen Peroxide 74-91 insulin-like growth factor 1 Mus musculus 60-65 26354375-2 2015 The present study was to investigate the regulatory role of IGF-1 against hydrogen peroxide(H2O2)-induced mitochondrial dysfunction and apoptosis in murine chondrocytic ATDC5 cells. Hydrogen Peroxide 92-96 insulin-like growth factor 1 Mus musculus 60-65 26354375-4 2015 We then constructed an IGF-1-overexpressed adenovirus (IGF-1-Ad) harboring the IGF-1 coding sequence, and investigated the regulatory role of the overexpressed IGF-1 against the H2O2-induced mitochondrial dysfunction and apoptosis in ATDC5 cells. Hydrogen Peroxide 178-182 insulin-like growth factor 1 Mus musculus 23-28 26354375-6 2015 However, the IGF-1 overexpression by adenovirus inhibited the H2O2-induced mitochondrial dysfunction and further inhibited the H2O2-promoted apoptosis in ATDC5 cells. Hydrogen Peroxide 62-66 insulin-like growth factor 1 Mus musculus 13-18 22403243-6 2012 Indeed, IGF-1 significantly inhibited H(2)O(2)-induced miR-34a expression, and miR-34a overexpression abolished the antiapoptotic effect of IGF-1. Hydrogen Peroxide 38-46 insulin-like growth factor 1 Mus musculus 8-13 11145585-8 2001 This is the first evidence that the insulin-like growth factor I/phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway is required for gene regulation by amino acid deprivation and that this pathway is involved in the induction of CHOP by both amino acid deficiency and oxidative stress by hydrogen peroxide. Hydrogen Peroxide 304-321 insulin-like growth factor 1 Mus musculus 36-64 15521713-11 2004 In media containing hydrogen peroxide and one of the four tested factors (IGF1, IGF2, SCF or EGF) the embryos developed faster than in media with hydrogen peroxide alone. Hydrogen Peroxide 20-37 insulin-like growth factor 1 Mus musculus 74-78 15521713-12 2004 IGF1, IGF2 and EGF increased both TB and (or) ICM counts in embryos exposed to hydrogen peroxide. Hydrogen Peroxide 79-96 insulin-like growth factor 1 Mus musculus 0-4 14666155-10 2002 In oxidative stress setting, IGF-I, IGF-II, EGF and ITS minimized the negative influence of H2O2, and embryos developed faster than in control conditions. Hydrogen Peroxide 92-96 insulin-like growth factor 1 Mus musculus 29-34