PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20497715-0 2010 Low- and high-dose hydrogen peroxide regulation of transcription factor NF-E2-related factor 2. Hydrogen Peroxide 19-36 NFE2 like bZIP transcription factor 2 Rattus norvegicus 72-94 20681953-3 2010 From the standpoint of NO activation, we tested a possible protective mechanism through the nitrosative Kelch-like ECH-associated protein (Keap1)/NF-E2-related factor 2 (Nrf2)-antioxidant response element pathway in rat retinal ganglion cells (RGC-5 cells) in culture, and in vivo, against hydrogen peroxide and optic nerve injury (ONI), respectively, using a long-acting (1R)-isoPropyloxygenipin (IPRG001). Hydrogen Peroxide 290-307 NFE2 like bZIP transcription factor 2 Rattus norvegicus 170-174 20371185-0 2010 A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation. Hydrogen Peroxide 48-52 NFE2 like bZIP transcription factor 2 Rattus norvegicus 81-85 20497715-6 2010 RESULTS: Low and moderate (0.125 mmol/L, 0.25 mmol/L and 0.5 mmol/L) doses hydrogen peroxide exposure of rat pulmonary microvascular endothelial cells led to the nuclear accumulation of Nrf2, increased activity of transcription regulation and up-regulation of ARE-medicated gene expression. Hydrogen Peroxide 75-92 NFE2 like bZIP transcription factor 2 Rattus norvegicus 186-190 20497715-7 2010 In contrast, high doses of hydrogen peroxide (1 mmol/L, 2 mmol/L) exposure of the cells led to the nuclear exclusion of Nrf2, decreased activity transcription regulation and down-regulation of ARE-mediated gene expression. Hydrogen Peroxide 27-44 NFE2 like bZIP transcription factor 2 Rattus norvegicus 120-124 20497715-8 2010 CONCLUSION: Low and moderate doses of hydrogen peroxide play protective roles by increasing transcription activity of Nrf2, whereas high- dose hydrogen peroxide plays a deleterious role by decreasing transcription activity of Nrf2. Hydrogen Peroxide 38-55 NFE2 like bZIP transcription factor 2 Rattus norvegicus 118-122 20497715-8 2010 CONCLUSION: Low and moderate doses of hydrogen peroxide play protective roles by increasing transcription activity of Nrf2, whereas high- dose hydrogen peroxide plays a deleterious role by decreasing transcription activity of Nrf2. Hydrogen Peroxide 143-160 NFE2 like bZIP transcription factor 2 Rattus norvegicus 226-230 18775681-0 2008 15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2. Hydrogen Peroxide 65-69 NFE2 like bZIP transcription factor 2 Rattus norvegicus 96-100 18775681-6 2008 Treatment of the PC12 cells with 15d-PGJ(2) resulted in increased nuclear translocation, DNA-binding and transcriptional activity of NF-E2-related factor 2 (Nrf2), leading to upregulation of heme oxygenase-1 (HO-1) expression, which provided an adaptive survival response against the H2O2-derived oxidative cytotoxicity. Hydrogen Peroxide 284-288 NFE2 like bZIP transcription factor 2 Rattus norvegicus 133-155 18775681-6 2008 Treatment of the PC12 cells with 15d-PGJ(2) resulted in increased nuclear translocation, DNA-binding and transcriptional activity of NF-E2-related factor 2 (Nrf2), leading to upregulation of heme oxygenase-1 (HO-1) expression, which provided an adaptive survival response against the H2O2-derived oxidative cytotoxicity. Hydrogen Peroxide 284-288 NFE2 like bZIP transcription factor 2 Rattus norvegicus 157-161 17676812-2 2007 tert-Butylhydroquinone ( tBHQ) is a known inducer of Nrf2-mediated transcription, and treatment of cells with tBHQ can confer protection against H 2O 2 and 6-hydroxydopamine (6-OHDA). Hydrogen Peroxide 145-151 NFE2 like bZIP transcription factor 2 Rattus norvegicus 53-57 18355458-0 2008 Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis. Hydrogen Peroxide 37-54 NFE2 like bZIP transcription factor 2 Rattus norvegicus 59-63 17652445-2 2007 We found that H(2)O(2) treatment caused a rapid increase in endogenous Nrf2 protein level in rat cardiomyocytes. Hydrogen Peroxide 14-22 NFE2 like bZIP transcription factor 2 Rattus norvegicus 71-75 17652445-5 2007 Although inhibiting protein synthesis with cycloheximide prevented H(2)O(2) from elevating Nrf2 protein level, RNA synthesis inhibition with actinomycin D failed to do so. Hydrogen Peroxide 67-75 NFE2 like bZIP transcription factor 2 Rattus norvegicus 91-95 17652445-7 2007 Inhibitors of phosphoinositide 3-kinase were able to abolish the induction of Nrf2 protein by H(2)O(2). Hydrogen Peroxide 94-102 NFE2 like bZIP transcription factor 2 Rattus norvegicus 78-82 34216727-12 2021 H2O2 stimulated the activation of Nrf2 and JNK signaling pathways, but TGD increased the extent of Nrf2 antioxidant activation, decreased the activation of JNK, and eventually reversed the H2O2-induced protein expression of p-MKK7, Keap1, HO-1, Cleaved Caspase3 (CL-Casp3), Cleaved Caspase9 (CL-Casp9), Bax, and Bcl-2. Hydrogen Peroxide 0-4 NFE2 like bZIP transcription factor 2 Rattus norvegicus 34-38 34859377-2 2021 The present study aimed to investigate whether the mitochondrial-derived peptide MOTS-c could alleviate H2O2-induced oxidative stress and inflammatory status in H9c2 cells through activation of nuclear factor erythroid 2-related Factor 2 (Nrf2)/antioxidative response element (ARE) and inhibition of the NF-kappaB pathway. Hydrogen Peroxide 104-108 NFE2 like bZIP transcription factor 2 Rattus norvegicus 194-237 34859377-2 2021 The present study aimed to investigate whether the mitochondrial-derived peptide MOTS-c could alleviate H2O2-induced oxidative stress and inflammatory status in H9c2 cells through activation of nuclear factor erythroid 2-related Factor 2 (Nrf2)/antioxidative response element (ARE) and inhibition of the NF-kappaB pathway. Hydrogen Peroxide 104-108 NFE2 like bZIP transcription factor 2 Rattus norvegicus 239-243 34859377-12 2021 The expression levels of Nrf2, HO-1 and NQO-1 were significantly downregulated in the H2O2, while the phosphorylation of NF-kappaBp65 was promoted by H2O2. Hydrogen Peroxide 86-90 NFE2 like bZIP transcription factor 2 Rattus norvegicus 25-29 34859377-12 2021 The expression levels of Nrf2, HO-1 and NQO-1 were significantly downregulated in the H2O2, while the phosphorylation of NF-kappaBp65 was promoted by H2O2. Hydrogen Peroxide 150-154 NFE2 like bZIP transcription factor 2 Rattus norvegicus 25-29 34216727-12 2021 H2O2 stimulated the activation of Nrf2 and JNK signaling pathways, but TGD increased the extent of Nrf2 antioxidant activation, decreased the activation of JNK, and eventually reversed the H2O2-induced protein expression of p-MKK7, Keap1, HO-1, Cleaved Caspase3 (CL-Casp3), Cleaved Caspase9 (CL-Casp9), Bax, and Bcl-2. Hydrogen Peroxide 189-193 NFE2 like bZIP transcription factor 2 Rattus norvegicus 34-38 34067571-4 2021 Compared with H2O2 alone, PCs enhanced antioxidant activities (e.g., GSH-Px, CAT, and SOD), decreased levels of ROS and MDA, and enhanced Nrf2/ antioxidant response element (ARE) activation and raised expression levels of NQO1, HO-1, GCLM, and GCLC. Hydrogen Peroxide 14-18 NFE2 like bZIP transcription factor 2 Rattus norvegicus 138-142 34236028-10 2021 Immunocytochemical staining confirmed that the isolated and cultured cells were AA-FLS; NAC inhibited the proliferation of AA-FLS treated with H2O2 in a concentration-dependent manner, and the mitochondrial ROS content and the protein expressions of Nrf2 and Keap1 decreased. Hydrogen Peroxide 143-147 NFE2 like bZIP transcription factor 2 Rattus norvegicus 250-254 34236028-11 2021 Conclusion NAC can inhibit the proliferation of AA-FLS treated with H2O2, which may be related to blocking Nrf2/Keap1 pathway. Hydrogen Peroxide 68-72 NFE2 like bZIP transcription factor 2 Rattus norvegicus 107-111 34236028-0 2021 (N-acetylcysteine inhibits the proliferation of hydrogen peroxide treated fibroblast-like synoviocytes in rats with adjuvant arthritis (AA) via blocking Nrf2/Keap1 pathway). Hydrogen Peroxide 48-65 NFE2 like bZIP transcription factor 2 Rattus norvegicus 153-157 34236028-8 2021 The effects of NAC (final concentration 0, 3, 10, 30 mumol/L) on Nrf2 and Keap1 protein expressions in AA-FLS treated with H2O2 at low concentration were detected by Western blotting. Hydrogen Peroxide 123-127 NFE2 like bZIP transcription factor 2 Rattus norvegicus 65-69 35487038-0 2022 Lignans from Eucommia ulmoides Oliver leaves exhibit neuroprotective effects via activation of the PI3K/Akt/GSK-3beta/Nrf2 signaling pathways in H2O2-treated PC-12 cells. Hydrogen Peroxide 145-149 NFE2 like bZIP transcription factor 2 Rattus norvegicus 118-122 33288327-9 2021 Correspondingly, compared to H2O2 group, the expressions of Mn-SOD and nuclear Nrf2 (N-Nrf2) was up-regulated in Resveratrol + H2O2 group (p < 0.05). Hydrogen Peroxide 29-33 NFE2 like bZIP transcription factor 2 Rattus norvegicus 79-83 35178104-7 2022 Furthermore, 0.5-50 mug/mL ABLP reversed H2O2-induced imbalance in the mRNA levels of DHPR, RyR2, SCN5A, Keap1, Nrf2, and HO-1 gene in H9c2 cells, which further illustrate the mechanism. Hydrogen Peroxide 41-45 NFE2 like bZIP transcription factor 2 Rattus norvegicus 112-116 35158330-3 2021 Nrf2 is activated by H2O2-producing Nox4 and nitric oxide (NO), but also induces NADPH oxidase 4 (Nox4) and endothelial nitric oxide synthase (eNOS). Hydrogen Peroxide 21-25 NFE2 like bZIP transcription factor 2 Rattus norvegicus 0-4 35322376-5 2022 The activation of Nrf2-ARE pathway effectively inhibited H2O2-induced oxidative stress. Hydrogen Peroxide 57-61 NFE2 like bZIP transcription factor 2 Rattus norvegicus 18-22 35178155-7 2022 Furthermore, EUG-BMSC-EVs activated the Nrf2/HO-1 pathway to counteract H2O2-induced damage in TSCs. Hydrogen Peroxide 72-76 NFE2 like bZIP transcription factor 2 Rattus norvegicus 40-44 34997457-0 2022 Involvement of FoxO1, Sp1, and Nrf2 in Upregulation of Negative Regulator of ROS by 15d-PGJ2 Attenuates H2O2-Induced IL-6 Expression in Rat Brain Astrocytes. Hydrogen Peroxide 104-108 NFE2 like bZIP transcription factor 2 Rattus norvegicus 31-35 33838603-5 2021 Furthermore, pretreatment with AHP-2 could protect the H2O2-injured IEC-6 cells by effectively scavenging the overproduced reactive oxygen species (ROS) and regulating of Kelch-like ECH-associated protein 1(Keap1)/ nuclear factor erythroid 2-related factor 2 (Nrf2) signal pathway. Hydrogen Peroxide 55-59 NFE2 like bZIP transcription factor 2 Rattus norvegicus 215-258 33838603-5 2021 Furthermore, pretreatment with AHP-2 could protect the H2O2-injured IEC-6 cells by effectively scavenging the overproduced reactive oxygen species (ROS) and regulating of Kelch-like ECH-associated protein 1(Keap1)/ nuclear factor erythroid 2-related factor 2 (Nrf2) signal pathway. Hydrogen Peroxide 55-59 NFE2 like bZIP transcription factor 2 Rattus norvegicus 260-264 33624427-0 2021 Protective effects of ginsenosides 20(R)-Rg3 on H2O2-induced myocardial cell injury by activating Keap-1/Nrf2/HO-1 signaling pathway. Hydrogen Peroxide 48-52 NFE2 like bZIP transcription factor 2 Rattus norvegicus 105-109 33288327-9 2021 Correspondingly, compared to H2O2 group, the expressions of Mn-SOD and nuclear Nrf2 (N-Nrf2) was up-regulated in Resveratrol + H2O2 group (p < 0.05). Hydrogen Peroxide 127-131 NFE2 like bZIP transcription factor 2 Rattus norvegicus 79-83 32773107-7 2021 Increasing miR-144 with a miR-144 mimic inhibited the expression of Nrf2 and its downstream effectors in WT rat macrophages and consequently impaired their bacterial phagocytic capacity and H2O2 scavenging ability. Hydrogen Peroxide 190-194 NFE2 like bZIP transcription factor 2 Rattus norvegicus 68-72 33505586-11 2021 Further mechanistic studies showed that TP delayed H2O2-mediated NPC degeneration by activating the Keap1/Nrf2/ARE pathway. Hydrogen Peroxide 51-55 NFE2 like bZIP transcription factor 2 Rattus norvegicus 106-110 33312223-0 2020 Ling-Gui-Zhu-Gan Decoction Protects H9c2 Cells against H2O2-Induced Oxidative Injury via Regulation of the Nrf2/Keap1/HO-1 Signaling Pathway. Hydrogen Peroxide 55-59 NFE2 like bZIP transcription factor 2 Rattus norvegicus 107-111 33312223-18 2020 Conclusion: Our results demonstrated that LGZGD attenuated the H2O2-induced injury to H9c2 cells by inhibiting oxidative stress and apoptosis via the Nrf2/Keap1/HO-1 pathway. Hydrogen Peroxide 63-67 NFE2 like bZIP transcription factor 2 Rattus norvegicus 150-154 32203078-6 2020 Moreover, we revealed that GAS pretreatment enhanced the nuclear translocation of Nrf2 under H2O2 treatment. Hydrogen Peroxide 93-97 NFE2 like bZIP transcription factor 2 Rattus norvegicus 82-86 32203078-7 2020 Knockdown of Nrf2 expression abolished the protective effects of GAS on H2O2-treated H9c2 cells. Hydrogen Peroxide 72-76 NFE2 like bZIP transcription factor 2 Rattus norvegicus 13-17 32623664-0 2020 beta-Asarone Exerts Antioxidative Effects on H2O2-Stimulated PC12 Cells by Activating Nrf2/HO-1 Pathway. Hydrogen Peroxide 45-49 NFE2 like bZIP transcription factor 2 Rattus norvegicus 86-90 32253686-8 2020 Nrf2 nuclear translocation was up-regulated and NF-kappaB nuclear translocation was down-regulated in Gnaq-PC12 cells after H2O2 treatment. Hydrogen Peroxide 124-128 NFE2 like bZIP transcription factor 2 Rattus norvegicus 0-4 32623664-6 2020 Furthermore, when silenced by Nrf2 siRNA, the protective effect of beta-asarone was reduced and the oxidative stress induced by H2O2 was enhanced. Hydrogen Peroxide 128-132 NFE2 like bZIP transcription factor 2 Rattus norvegicus 30-34 32693824-16 2020 H2O2 reduced Nrf2 expression, which was reversed by probucol"s intervention. Hydrogen Peroxide 0-4 NFE2 like bZIP transcription factor 2 Rattus norvegicus 13-17 31891721-8 2020 In addition, mitochondrial dynamics, Parkin-mediated elimination of dysfunctional mitochondria, and Nrf2-mediated antioxidant system were promoted by H2O2. Hydrogen Peroxide 150-154 NFE2 like bZIP transcription factor 2 Rattus norvegicus 100-104 32633393-6 2020 CONCLUSIONS: Knockdown of p66ShcA can activate Keap1/Nrf2 pathway, which inhibits H2O2-induced oxidative stress and inflammation in H9c2 cells. Hydrogen Peroxide 82-86 NFE2 like bZIP transcription factor 2 Rattus norvegicus 53-57 32320792-9 2020 Using H2O2- and LPS-induced PC12 cells, we found that RA ameliorated the H2O2-induced decrease in viability and increase in apoptosis and oxidative injury by activating the Nrf2/HO-1 pathway. Hydrogen Peroxide 73-77 NFE2 like bZIP transcription factor 2 Rattus norvegicus 173-177 32676950-3 2020 TBI rat models were constructed with or without DHA treatment, and H2O2-induced hippocampal neurons were pretreated with DHA alone or in combination with Nrf2 inhibitor brusatol. Hydrogen Peroxide 67-71 NFE2 like bZIP transcription factor 2 Rattus norvegicus 154-158 32633393-0 2020 Knockdown of p66ShcA activates Nrf2 pathway to protect cardiomyocytes from oxidative stress and inflammation induced by H2O2. Hydrogen Peroxide 120-124 NFE2 like bZIP transcription factor 2 Rattus norvegicus 31-35 32100629-0 2020 Protective effect of tanshinone IIA on H2O2-induced oxidative stress injury in rat cardiomyocytes by activating Nrf2 pathway. Hydrogen Peroxide 39-43 NFE2 like bZIP transcription factor 2 Rattus norvegicus 112-116 32100629-12 2020 All those results suggested that tanshinone IIA could protect H2O2-induced oxidative stress injury in rat cardiomyocytes by activating Nrf2 pathway. Hydrogen Peroxide 62-66 NFE2 like bZIP transcription factor 2 Rattus norvegicus 135-139 31891721-9 2020 Knockdown of Parkin or Nrf2 increased H2O2-induced detrimental effects. Hydrogen Peroxide 38-42 NFE2 like bZIP transcription factor 2 Rattus norvegicus 23-27 31891721-10 2020 Moreover, upregulation of Parkin and Nrf2 by polydatin protected endplate chondrocytes against H2O2-induced mitochondrial dysfunction, oxidative stress, and apoptosis. Hydrogen Peroxide 95-99 NFE2 like bZIP transcription factor 2 Rattus norvegicus 37-41 32115506-9 2020 Moreover, gastrodin increased the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), GPX4, ferroportin-1 (FPN1), and heme oxygenase-1 (HO-1) in C6 cells treated with H2O2. Hydrogen Peroxide 189-193 NFE2 like bZIP transcription factor 2 Rattus norvegicus 56-99 31585542-11 2019 Nrf-2 activation inhibited the proliferation, migratory ability, and apoptosis rate enhanced by H2O2. Hydrogen Peroxide 96-100 NFE2 like bZIP transcription factor 2 Rattus norvegicus 0-5 31017264-8 2019 These findings provide evidence suggesting that DHA is able to prevent H2O2-induced oxidative damage to PC12 cells, which is attributed to its antioxidant and anti-apoptotic effects via the regulation NFE2L2/HO-1 signaling. Hydrogen Peroxide 71-75 NFE2 like bZIP transcription factor 2 Rattus norvegicus 201-207 31302408-9 2019 Pharmacological activation of Nrf2 with sulforaphane (SFN) improved NO- and endothelium-derived hyperpolarizing factor-mediated endothelium-dependent vasodilation and H2O2-induced relaxation in vascular beds from aging rats. Hydrogen Peroxide 167-171 NFE2 like bZIP transcription factor 2 Rattus norvegicus 30-34 30746596-7 2019 Silencing of Nrf2 signaling by siRNA abrogated the protective effects offered by EG on H2O2-induced PC12 cells injury, which suggested the important role of Nrf2 pathway in the protection of EG against oxidative stress induced PC12 cell apoptosis. Hydrogen Peroxide 87-91 NFE2 like bZIP transcription factor 2 Rattus norvegicus 13-17 30746596-7 2019 Silencing of Nrf2 signaling by siRNA abrogated the protective effects offered by EG on H2O2-induced PC12 cells injury, which suggested the important role of Nrf2 pathway in the protection of EG against oxidative stress induced PC12 cell apoptosis. Hydrogen Peroxide 87-91 NFE2 like bZIP transcription factor 2 Rattus norvegicus 157-161 30746596-8 2019 These results taken together indicated that EG protects PC12 cells against H2O2-induced cell mitochondrial dysfunction possibly through activation of Nrf2 pathway. Hydrogen Peroxide 75-79 NFE2 like bZIP transcription factor 2 Rattus norvegicus 150-154 30603983-8 2019 Knocking down Nrf2 by siRNA could counteract sinomenine-mediated anti-oxidant stress and anti-inflammation following H2O2-stimulated and LPS-stimulated PC12 cells. Hydrogen Peroxide 117-121 NFE2 like bZIP transcription factor 2 Rattus norvegicus 14-18 30800665-11 2019 The results indicated that the four compounds isolated from G. acuta inhibited the oxidative injury induced by H2O2 by activating the Nrf2/ARE pathway in H9c2 cells and provide evidence that G. acuta may be a potential therapeutic agent for the treatment of cardiovascular diseases. Hydrogen Peroxide 111-115 NFE2 like bZIP transcription factor 2 Rattus norvegicus 134-138 31011401-8 2019 Furthermore, SAA significantly increased the expression of intranuclear Nrf2 and HO-1 proteins compared to HK-2 cells stimulated by LPS on the one hand, which can be enhanced by QNZ to some extent; on the other hand, SAA significantly lowered the expression of p-NF-kappaB p65 and ICAM-1 proteins compared to HK-2 cells stimulated by H2O2, which can be abrogated by ML385 to some extent. Hydrogen Peroxide 334-338 NFE2 like bZIP transcription factor 2 Rattus norvegicus 72-76 30779558-0 2019 Rhein from Rheum rhabarbarum Inhibits Hydrogen-Peroxide-Induced Oxidative Stress in Intestinal Epithelial Cells Partly through PI3K/Akt-Mediated Nrf2/HO-1 Pathways. Hydrogen Peroxide 38-55 NFE2 like bZIP transcription factor 2 Rattus norvegicus 145-149 30972281-4 2019 Among these compounds, the most active 33 not only conferred cytoprotection of H2O2-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. Hydrogen Peroxide 79-83 NFE2 like bZIP transcription factor 2 Rattus norvegicus 180-184 30539753-9 2019 Taken together, we demonstrate that miR-34b protects against focal cerebral I/R-induced oxidative stress injury in MCAO rats and H2O2-induced oxidative stress injury in rat neuroblast B35 cells through targeting Keap1 and downstream Keap1/Nrf2 signaling pathway. Hydrogen Peroxide 129-133 NFE2 like bZIP transcription factor 2 Rattus norvegicus 239-243 29793180-12 2018 Further, the Nrf2 knockdown cells suffered more serious H2O2-induced damage than the wild PC12 cells. Hydrogen Peroxide 56-60 NFE2 like bZIP transcription factor 2 Rattus norvegicus 13-17 30202421-2 2018 This study tested the hypothesis that GABA maintains cellular redox status, and modulates glycogen synthase kinase (GSK)-3beta and antioxidant-related nuclear factor erythroid 2-related factor 2 (NRF2) nuclear mass ratio in the H2O2-injured RINm5F cells. Hydrogen Peroxide 228-232 NFE2 like bZIP transcription factor 2 Rattus norvegicus 196-200 29878401-8 2018 Mechanistically, the protective effect of BRD4 inhibition on H2 O2 -stimulated apoptosis and cartilage matrix degeneration was markedly abrogated by Nrf2 depletion. Hydrogen Peroxide 61-66 NFE2 like bZIP transcription factor 2 Rattus norvegicus 149-153 30407007-3 2018 Compound 1 showed potent protection against H2O2-induced oxidative damage in neuron-like PC12 cells by promoting nuclear translocation of Nrf2 and enhancing the expression of HO-1. Hydrogen Peroxide 44-48 NFE2 like bZIP transcription factor 2 Rattus norvegicus 138-142 30060293-7 2018 The results showed that pretreatment of taurine could reverse the inhibition of cell viability and suppress the induced apoptosis in a dose-dependent manner: taurine significantly reduced H2O2-induced oxidative damage and expression of CHOP, while it induced protein expression of Nrf2 and beta-catenin and activated ERK phosphorylation. Hydrogen Peroxide 188-192 NFE2 like bZIP transcription factor 2 Rattus norvegicus 281-285 30367509-10 2018 The expression of Nrf2, CATA, and gamma-GCS in antioxidant system were reduced after H2 O2 processing, which were restored after the application of hydrogen-rich medium. Hydrogen Peroxide 85-90 NFE2 like bZIP transcription factor 2 Rattus norvegicus 18-22 30154895-0 2018 Plumbagin protects against hydrogen peroxide-induced neurotoxicity by modulating NF-kappaB and Nrf-2. Hydrogen Peroxide 27-44 NFE2 like bZIP transcription factor 2 Rattus norvegicus 95-100 30154895-9 2018 Plumbagin effectively ameliorated H2O2-induced oxidative stress through reducing oxidative stress (p < 0.01) and activating p-Nrf-2 levels. Hydrogen Peroxide 34-38 NFE2 like bZIP transcription factor 2 Rattus norvegicus 129-134 29642608-0 2018 Neuroprotective Effects of Four Phenylethanoid Glycosides on H2O2-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway. Hydrogen Peroxide 61-65 NFE2 like bZIP transcription factor 2 Rattus norvegicus 106-110 28605990-11 2018 However, Nrf2 silence abolished the protective functions of miR-25 on H2O2-induced damage. Hydrogen Peroxide 70-74 NFE2 like bZIP transcription factor 2 Rattus norvegicus 9-13 28605990-13 2018 CONCLUSIONS: miR-25 protects PC-12 cells against H2O2-induced oxidative damage though regulation of Nrf2 and activation of Wnt/beta-catenin and PI3 K/AKT/ERK signaling. Hydrogen Peroxide 49-53 NFE2 like bZIP transcription factor 2 Rattus norvegicus 100-104 29564698-7 2018 All the results demonstrated that GLGZG in the management of cerebral ischemia and H2O2 induced oxidative injury may be associated with activation of Nrf2/ARE signaling pathway. Hydrogen Peroxide 83-87 NFE2 like bZIP transcription factor 2 Rattus norvegicus 150-154 29689082-7 2018 Propofol also promoted nuclear localization of Nrf2 in the presence of H2O2. Hydrogen Peroxide 71-75 NFE2 like bZIP transcription factor 2 Rattus norvegicus 47-51 29642608-4 2018 PhGs pretreatment significantly suppressed H2O2-induced cytotoxicity in PC12 cells by triggering the nuclear translocation of Nrf2 and reversing the downregulated protein expression of heme oxygenase 1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), glutamate cysteine ligase-catalytic subunit (GCLC), and glutamate-cysteine ligase modifier subunit (GCLM). Hydrogen Peroxide 43-47 NFE2 like bZIP transcription factor 2 Rattus norvegicus 126-130 29490296-0 2018 Resveratrol Alleviates Inflammatory Responses and Oxidative Stress in Rat Kidney Ischemia-Reperfusion Injury and H2O2-Induced NRK-52E Cells via the Nrf2/TLR4/NF-kappaB Pathway. Hydrogen Peroxide 113-117 NFE2 like bZIP transcription factor 2 Rattus norvegicus 148-152 29288352-2 2018 RESULTS: Sublethal concentrations of H2O2 decreased cell migration and expression of CXCR4 and CCR2 as well as Nrf2 expression in MSCs. Hydrogen Peroxide 37-41 NFE2 like bZIP transcription factor 2 Rattus norvegicus 111-115 29201196-6 2017 Furthermore, LBP inhibited the H2O2-induced decrease in nuclear factor erythroid 2-related factor 2 (Nrf)2 and heme oxygenase (HO)-1 expression and binding of Nrf2 to the promoters of HO-1. Hydrogen Peroxide 31-35 NFE2 like bZIP transcription factor 2 Rattus norvegicus 101-106 29329609-0 2017 Garcinia xanthochymus extract protects PC12 cells from H2O2-induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways. Hydrogen Peroxide 55-59 NFE2 like bZIP transcription factor 2 Rattus norvegicus 113-117 29201196-6 2017 Furthermore, LBP inhibited the H2O2-induced decrease in nuclear factor erythroid 2-related factor 2 (Nrf)2 and heme oxygenase (HO)-1 expression and binding of Nrf2 to the promoters of HO-1. Hydrogen Peroxide 31-35 NFE2 like bZIP transcription factor 2 Rattus norvegicus 159-163 29201913-0 2017 Proanthocyanidins Attenuation of H2O2-Induced Oxidative Damage in Tendon-Derived Stem Cells via Upregulating Nrf-2 Signaling Pathway. Hydrogen Peroxide 33-37 NFE2 like bZIP transcription factor 2 Rattus norvegicus 109-114 29745556-6 2017 H 2O 2 inhibited expression of myocardin in mRNA and protein levels, and increased expression of Nrf2 in mRNA and protein levels. Hydrogen Peroxide 0-6 NFE2 like bZIP transcription factor 2 Rattus norvegicus 97-101 29745556-10 2017 Oxidative damage induced by H 2O 2 in rat myocardial cell might activate Nrf2-related signaling pathway through down-regulation of myocardin. Hydrogen Peroxide 28-34 NFE2 like bZIP transcription factor 2 Rattus norvegicus 73-77 29201913-9 2017 Furthermore, H2O2 upregulated Nrf-2, GCLM, NQO-1, and HO-1 without significant difference, while the proteins expressions were increased with significant difference in PCs group and PCs + H2O2 cotreated group. Hydrogen Peroxide 13-17 NFE2 like bZIP transcription factor 2 Rattus norvegicus 30-35 29201913-9 2017 Furthermore, H2O2 upregulated Nrf-2, GCLM, NQO-1, and HO-1 without significant difference, while the proteins expressions were increased with significant difference in PCs group and PCs + H2O2 cotreated group. Hydrogen Peroxide 188-192 NFE2 like bZIP transcription factor 2 Rattus norvegicus 30-35 26779387-9 2015 To confirm that Nrf2 is an integral component of this improved anti-oxidant response, we transfected IFN-gamma-polarized cells with either silencing RNA to Nrf2 or control silencing RNA and found that hydrogen peroxide scavenging was significantly impaired in the si-Nrf2-treated cells. Hydrogen Peroxide 201-218 NFE2 like bZIP transcription factor 2 Rattus norvegicus 16-20 27300444-8 2016 CONCLUSION: Our study demonstrates that 0.01 mM hydrogen peroxide can effectively protect rat aortic vascular smooth muscle cells against oxidative stress by preventing vascular calcification induced ROS production through Nrf-2 pathway. Hydrogen Peroxide 48-65 NFE2 like bZIP transcription factor 2 Rattus norvegicus 223-228 26212730-6 2015 Treatment with H2O2 was also shown to increase Nrf-2 and ERK phosphorylation. Hydrogen Peroxide 15-19 NFE2 like bZIP transcription factor 2 Rattus norvegicus 47-52 26779387-9 2015 To confirm that Nrf2 is an integral component of this improved anti-oxidant response, we transfected IFN-gamma-polarized cells with either silencing RNA to Nrf2 or control silencing RNA and found that hydrogen peroxide scavenging was significantly impaired in the si-Nrf2-treated cells. Hydrogen Peroxide 201-218 NFE2 like bZIP transcription factor 2 Rattus norvegicus 156-160 26779387-9 2015 To confirm that Nrf2 is an integral component of this improved anti-oxidant response, we transfected IFN-gamma-polarized cells with either silencing RNA to Nrf2 or control silencing RNA and found that hydrogen peroxide scavenging was significantly impaired in the si-Nrf2-treated cells. Hydrogen Peroxide 201-218 NFE2 like bZIP transcription factor 2 Rattus norvegicus 156-160 25996919-11 2015 Lactate increased NRF-2 nuclear expression and SOD activity probably as counter-regulatory responses to increased O2 -/H2O2. Hydrogen Peroxide 119-123 NFE2 like bZIP transcription factor 2 Rattus norvegicus 18-23 26622408-0 2015 Preconditioning with Gua Lou Gui Zhi decoction enhances H2O2-induced Nrf2/HO-1 activation in PC12 cells. Hydrogen Peroxide 56-60 NFE2 like bZIP transcription factor 2 Rattus norvegicus 69-73 26622408-12 2015 Therefore, the results demonstrated that GLGZD protected PC12 cells injured by H2O2, which may be associated with the upregulation of Nrf2 and HO-1 mRNA and protein expression levels in PC12 cells. Hydrogen Peroxide 79-83 NFE2 like bZIP transcription factor 2 Rattus norvegicus 134-138 26204396-8 2015 The results of this study show that Lady Joy can induce the Nrf2 pathway, inhibit NF-kB, and protect ER from stress induced by H2O2. Hydrogen Peroxide 127-131 NFE2 like bZIP transcription factor 2 Rattus norvegicus 60-64 24505606-9 2014 We also found that knocking down Nrf2 with its short hairpin RNA inhibited lithium-increased expression of Nrf2 and suppressed the protective effect of lithium against hydrogen peroxide (H2O2)-reduced cell viability and H2O2-increased DNA fragmentation. Hydrogen Peroxide 187-191 NFE2 like bZIP transcription factor 2 Rattus norvegicus 33-37 25975093-4 2015 Furthermore, the oxidative injury produced by H2O2 was mitigated by torularhodin pretreatment via down-regulation of GSK-3beta and Keap1 genes while up-regulating the expressions of Nrf2, HO-1 and NQO1 genes. Hydrogen Peroxide 46-50 NFE2 like bZIP transcription factor 2 Rattus norvegicus 182-186 25497288-9 2015 Pre-treatment of H9c2 cells with 14p activated Nrf2 signaling pathway, attenuated H2O2-increased MDA and SOD level, followed by the inhibition of TBHP-induced cell death and Bax/Bcl-2-caspase-3 pathway activation. Hydrogen Peroxide 82-86 NFE2 like bZIP transcription factor 2 Rattus norvegicus 47-51 24505606-9 2014 We also found that knocking down Nrf2 with its short hairpin RNA inhibited lithium-increased expression of Nrf2 and suppressed the protective effect of lithium against hydrogen peroxide (H2O2)-reduced cell viability and H2O2-increased DNA fragmentation. Hydrogen Peroxide 220-224 NFE2 like bZIP transcription factor 2 Rattus norvegicus 33-37 24505606-9 2014 We also found that knocking down Nrf2 with its short hairpin RNA inhibited lithium-increased expression of Nrf2 and suppressed the protective effect of lithium against hydrogen peroxide (H2O2)-reduced cell viability and H2O2-increased DNA fragmentation. Hydrogen Peroxide 168-185 NFE2 like bZIP transcription factor 2 Rattus norvegicus 33-37 23639191-11 2013 Moreover, calycopterin, in presence of H2O2 inhibited the decrease caused by oxidative stress in stress-sensing transcription factors, CREB and Nrf2, which play an important role in antioxidant capacity of the cell. Hydrogen Peroxide 39-43 NFE2 like bZIP transcription factor 2 Rattus norvegicus 144-148 23051850-7 2012 We found that luteolin pretreatment prevented apoptosis, increased the expression of heme oxygenase-1 (HO-1), and enhanced the binding of Nrf2 to the antioxidant response element, providing an adaptive survival response against H(2)O(2)-derived oxidative cytotoxicity. Hydrogen Peroxide 228-236 NFE2 like bZIP transcription factor 2 Rattus norvegicus 138-142 23235569-7 2013 Further, Nrf2-targeted gene transcription (regulates antioxidant, anti-inflammatory, and cytoprotective responses) in mesangial cells was associated with decreased basal and reduced angiotensin II-stimulated hydrogen peroxide and calcium ion levels. Hydrogen Peroxide 208-225 NFE2 like bZIP transcription factor 2 Rattus norvegicus 9-13 23298159-6 2013 The Compound 3, which is the most effective imine analog of oxyresveratrol, exhibited these cytoprotective effects against hydrogen peroxide-induced oxidative stress through the regulation of heme oxygenase-1 (HO-1) expression and the translocation of nuclear factor E2-related factor 2 (Nrf2). Hydrogen Peroxide 123-140 NFE2 like bZIP transcription factor 2 Rattus norvegicus 288-292 22736614-10 2012 In the H2O2-induced rat corneal epithelium, SA3K alleviated the oxidative stress and downregulated NOX4 and NRF2. Hydrogen Peroxide 7-11 NFE2 like bZIP transcription factor 2 Rattus norvegicus 108-112 21602469-7 2011 In contrast, in cultured aorta segments of aged (24 mo old) rats, the induction of Nrf2-dependent responses by H(2)O(2) and high glucose are blunted. Hydrogen Peroxide 111-119 NFE2 like bZIP transcription factor 2 Rattus norvegicus 83-87 21345685-0 2011 Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds. Hydrogen Peroxide 88-92 NFE2 like bZIP transcription factor 2 Rattus norvegicus 46-50 22609376-0 2012 Eriodictyol protects against H(2)O(2)-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Hydrogen Peroxide 29-37 NFE2 like bZIP transcription factor 2 Rattus norvegicus 96-100 21478407-5 2011 In particular, H(2)O(2) preconditioning counteracted oxidative stress-induced apoptosis by decreasing caspase-3 activity, increasing Bcl2 expression and selectively increasing the expression and activity of antioxidant and phase II enzymes through Nrf1 and Nrf2 translocation to the nucleus. Hydrogen Peroxide 15-23 NFE2 like bZIP transcription factor 2 Rattus norvegicus 257-261 21478407-8 2011 These findings demonstrate, for the first time, a key role for Nrf1, and not only for Nrf2, in the induction of phase II enzymes triggered by H(2)O(2) preconditioning. Hydrogen Peroxide 142-150 NFE2 like bZIP transcription factor 2 Rattus norvegicus 86-90