PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28424666-2 2017 Previously, Aspergillus nidulans mutants lacking the Yap1 ortholog NapA have been characterized as sensitive to H2O2 and menadione. Hydrogen Peroxide 112-116 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 53-57 33995399-7 2021 Most bacteria sense the H2O2 via OxyR or PerR transcription factors, whereas yeast uses the Grx3/Yap1 system. Hydrogen Peroxide 24-28 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 97-101 33145450-6 2020 High, but not low cyanidin was shown to induce Yap1 translocation from cytosol to nucleus, probably by generating reactive oxygen species such as H2O2. Hydrogen Peroxide 146-150 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 47-51 28628095-1 2017 In Saccharomyces cerevisiae, Yap1 regulates an H2O2-inducible transcriptional response that controls cellular H2O2 homeostasis. Hydrogen Peroxide 47-51 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 29-33 28628095-1 2017 In Saccharomyces cerevisiae, Yap1 regulates an H2O2-inducible transcriptional response that controls cellular H2O2 homeostasis. Hydrogen Peroxide 110-114 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 29-33 28628095-2 2017 H2O2 activates Yap1 by oxidation through the intermediary of the thiol peroxidase Orp1. Hydrogen Peroxide 0-4 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 15-19 28628095-3 2017 Upon reacting with H2O2, Orp1 catalytic cysteine oxidizes to a sulfenic acid, which then engages into either an intermolecular disulfide with Yap1, leading to Yap1 activation, or an intramolecular disulfide that commits the enzyme into its peroxidatic cycle. Hydrogen Peroxide 19-23 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 142-146 28628095-3 2017 Upon reacting with H2O2, Orp1 catalytic cysteine oxidizes to a sulfenic acid, which then engages into either an intermolecular disulfide with Yap1, leading to Yap1 activation, or an intramolecular disulfide that commits the enzyme into its peroxidatic cycle. Hydrogen Peroxide 19-23 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 159-163 27864171-13 2017 We found that mitochondrial superoxide dismutase Sod2p and cytoplasmic hydrogen peroxide sensor Yap1p act together as a module of the mitochondrion-to-nucleus signaling pathway. Hydrogen Peroxide 71-88 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 96-101 27706212-9 2016 Moreover, the mutant was sensitive to oxidative stressors such as H2O2 and menadione, similar to S. cerevisiae yap1 mutant, as well as the nitrosative stressor NaNO2. Hydrogen Peroxide 66-70 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 111-115 27864171-5 2017 First, we found that repression of SOD2 prevents ethanol-induced relocalization of yeast hydrogen peroxide-sensing transcription factor Yap1p, one of the key stress resistance proteins. Hydrogen Peroxide 89-106 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 136-141 27864171-8 2017 Moreover, preconditioning with hydrogen peroxide restored the ethanol resistance of yeast cells with repressed SOD2 Interestingly, we found that mitochondrion-to-nucleus signaling by Rtg proteins antagonizes Yap1p activation. Hydrogen Peroxide 31-48 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 208-213 27864171-9 2017 Together, our data suggest that hydrogen peroxide produced by Sod2p activates Yap1p and thus plays a signaling role in ethanol tolerance. Hydrogen Peroxide 32-49 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 78-83 25049418-4 2014 By means of a genetic construct consisting of a fusion between the C-terminal domain of the yeast (Saccharomyces cerevisiae) AP-1-like (YAP1) transcription factor and a tandem affinity purification tag, we detected ~ 100 sulfenylated proteins in Arabidopsis cell suspensions exposed to H2O2 stress. Hydrogen Peroxide 286-290 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 136-140 21476607-7 2011 Here we demonstrate the successful use of the Yap1-cCRD probe in the identification of proteins that form sulfenic acid in response to hydrogen peroxide in Saccharomyces cerevisiae. Hydrogen Peroxide 135-152 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 46-50 24669223-7 2014 The regulatory protein Yap1 plays an important role in the hormetic effects by low concentrations of either hydrogen peroxide or ethanol, and it is involved in the yeast cross-adaptation by low sublethal doses of hydrogen peroxide. Hydrogen Peroxide 108-125 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 23-27 24669223-7 2014 The regulatory protein Yap1 plays an important role in the hormetic effects by low concentrations of either hydrogen peroxide or ethanol, and it is involved in the yeast cross-adaptation by low sublethal doses of hydrogen peroxide. Hydrogen Peroxide 213-230 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 23-27 23793623-3 2013 In this study, we show that both furfural and HMF act as thiol-reactive electrophiles, thus directly activating the Yap1 transcription factor via the H2O2-independent pathway, depleting cellular glutathione (GSH) levels, and accumulating reactive oxygen species in Saccharomyces cerevisiae. Hydrogen Peroxide 150-154 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 116-120 21844193-3 2011 Although both diamide and H(2)O(2) have been used to impose oxidative stress on cells, these different oxidants trigger Yap1 nuclear localization in distinctly different ways. Hydrogen Peroxide 26-34 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 120-124 20971184-0 2011 Yap1 activation by H2O2 or thiol-reactive chemicals elicits distinct adaptive gene responses. Hydrogen Peroxide 19-23 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 0-4 21383978-4 2011 The Moap1 mutant was sensitive to H2O2, similar to S. cerevisiae yap1 mutants, and MoAP1 complemented Yap1 function in resistance to H2O2, albeit partially. Hydrogen Peroxide 133-137 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 102-106 20971184-6 2011 To determine whether Yap1 activated by H(2)O(2) or thiol-reactive chemicals elicits distinct adaptive gene responses, microarray analysis was performed on the wild-type strain or its isogenic single-deletion strain Deltayap1 treated with control buffer, H(2)O(2), NEM, or acrolein. Hydrogen Peroxide 39-47 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 21-25 20971184-9 2011 These findings demonstrate that the distinct mechanisms of Yap1 activation by H(2)O(2) or thiol-reactive chemicals result in selective expression of protective genes. Hydrogen Peroxide 78-86 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 59-63 20538604-8 2010 Interestingly, the pathway differed from the one triggered by hydrogen peroxide and its activation (measured as Yap1 translocation to the nucleus) was abolished by co-treatment of the cells with alpha-tocopherol. Hydrogen Peroxide 62-79 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 112-116 19230722-1 2009 Saccharomyces cerevisiae responds to elevated levels of hydrogen peroxide in its environment via a redox relay system comprising the thiol peroxidase Gpx3 and transcription factor Yap1. Hydrogen Peroxide 56-73 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 180-184 20073031-5 2010 Higher frequencies of retrotransposition were found in rho(+) and rho(-) cells treated with exogenously added hydrogen peroxide or in cells with disrupted YAP1 gene characterized by increased intracellular levels of hydrogen peroxide. Hydrogen Peroxide 216-233 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 155-159 19807692-12 2009 IXR1 expression is moderately activated by H2O2 and this induction is Yap1p-dependent. Hydrogen Peroxide 43-47 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 70-75 18309271-4 2008 S. cerevisiae Yap1 is a well-known transcription factor that is required for H2O2-dependent stress responses. Hydrogen Peroxide 77-81 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 14-18 18795957-0 2008 The adaptive response of anaerobically grown Saccharomyces cerevisiae to hydrogen peroxide is mediated by the Yap1 and Skn7 transcription factors. Hydrogen Peroxide 73-90 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 110-114 18795957-5 2008 Adaptation to H(2)O(2) treatment was demonstrated to occur when anaerobically grown wild-type cells were aerated for a short time that was reliant on the Yap1p and Skn7p transcription factors. Hydrogen Peroxide 14-22 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 154-159 18206664-2 2008 YAP1, SKN7, GAL11, RPE1, TKL1, IDP1, SLA1, and PET8 were important for adaptation to H2O2. Hydrogen Peroxide 85-89 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 0-4 18206664-4 2008 Transcription factors Yap1p, Skn7p, and Gal11p were important for both acute and chronic responses to H2O2. Hydrogen Peroxide 102-106 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 22-27 18309271-7 2008 It plays the role of a transducer that transfers the hydroperoxide signal to Yap1. Hydrogen Peroxide 53-66 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 77-81 17187783-3 2007 We conclude that specificity determinants of the Cd response are encoded within both Yap1 and Yap2 C-terminus, whereas those required for H2O2 response are only present in the Yap1 C-terminus. Hydrogen Peroxide 138-142 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 176-180 17707237-0 2007 Multistep disulfide bond formation in Yap1 is required for sensing and transduction of H2O2 stress signal. Hydrogen Peroxide 87-91 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 38-42 18020457-4 2007 In response to H2O2, the Yap1 probe forms mixed disulfide bonds with a variety of proteins. Hydrogen Peroxide 15-19 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 25-29 16219769-9 2005 In this work, we demonstrate that the proper folding of Yap1p in the presence of H(2)O(2) is required for recruitment of the mediator component Rox3p to the TRX2 promoter in addition to the nuclear accumulation of Yap1p during stress by this oxidant. Hydrogen Peroxide 81-89 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 56-61 17122395-6 2007 The formation of intramolecular disulfide bonds has been proposed to be crucial for the H(2)O(2)-induced nuclear localization of Yap1, and we verified the importance of cysteine residues of Yap1 in response to EGCG and GTE. Hydrogen Peroxide 88-96 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 129-133 17122395-6 2007 The formation of intramolecular disulfide bonds has been proposed to be crucial for the H(2)O(2)-induced nuclear localization of Yap1, and we verified the importance of cysteine residues of Yap1 in response to EGCG and GTE. Hydrogen Peroxide 88-96 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 190-194 16219769-9 2005 In this work, we demonstrate that the proper folding of Yap1p in the presence of H(2)O(2) is required for recruitment of the mediator component Rox3p to the TRX2 promoter in addition to the nuclear accumulation of Yap1p during stress by this oxidant. Hydrogen Peroxide 81-89 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 214-219 12743123-6 2003 Our data suggest that Ybp1 is required for the H2O2-induced oxidation of Yap1 and acts in the same pathway as Gpx3. Hydrogen Peroxide 47-51 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 73-77 14556853-0 2003 Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling. Hydrogen Peroxide 34-38 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 25-29 14556853-1 2003 The Yap1 transcription factor regulates yeast responses to H2O2 and to several unrelated chemicals and metals. Hydrogen Peroxide 59-63 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 4-8 14556853-2 2003 Activation by H2O2 involves Yap1 Cys303-Cys598 intra-molecular disulfide bond formation directed by the H2O2 sensor Orp1/Gpx3. Hydrogen Peroxide 14-18 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 28-32 14556853-2 2003 Activation by H2O2 involves Yap1 Cys303-Cys598 intra-molecular disulfide bond formation directed by the H2O2 sensor Orp1/Gpx3. Hydrogen Peroxide 104-108 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 28-32 12743123-0 2003 Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor. Hydrogen Peroxide 25-42 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 68-72 12743123-4 2003 Indeed, Ybp1 forms a stress-induced complex with Yap1 in vivo and stimulates the nuclear accumulation of Yap1 in response to H2O2 but not in response to the thiol-oxidizing agent diamide. Hydrogen Peroxide 125-129 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 105-109 15337745-2 2004 The Gpx3 (Orp1/PHGpx3) protein transduces the hydroperoxide signal to the transcription factor Yap1, a function that could account for most GPX-dependent phenotypes. Hydrogen Peroxide 46-59 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 95-99 15037622-5 2004 The prooxidant protective effect of all six proteins was suppressed in the absence of YAP1, a transcription factor that regulates hydroperoxide homeostasis in Saccharomyces cerevisiae, suggesting a role for the LeGSTUs in the context of the YAP1-dependent stress-responsive machinery. Hydrogen Peroxide 130-143 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 86-90 15075262-2 2004 Previous work has demonstrated that Yap1p is recruited from the cytoplasm to the nucleus upon exposure to the oxidants diamide and H2O2 in a process that requires the transient covalent linkage of the glutathione peroxidase Gpx3p to Yap1p. Hydrogen Peroxide 131-135 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 36-41 15075262-2 2004 Previous work has demonstrated that Yap1p is recruited from the cytoplasm to the nucleus upon exposure to the oxidants diamide and H2O2 in a process that requires the transient covalent linkage of the glutathione peroxidase Gpx3p to Yap1p. Hydrogen Peroxide 131-135 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 233-238 15075262-4 2004 Ybp1p (Yap1p-binding protein) has recently been demonstrated to be required for Yap1p-mediated H2O2 resistance but not diamide resistance. Hydrogen Peroxide 95-99 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 7-12 15075262-4 2004 Ybp1p (Yap1p-binding protein) has recently been demonstrated to be required for Yap1p-mediated H2O2 resistance but not diamide resistance. Hydrogen Peroxide 95-99 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 80-85 14556853-6 2003 We propose that Yap1 has two distinct molecular redox centers, one triggered by ROS (hydroperoxides and the superoxide anion) and the other by chemicals with thiol reactivity (electrophiles and divalent heavy metals cations). Hydrogen Peroxide 85-99 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 16-20 12743123-5 2003 The H2O2-induced nuclear accumulation of Yap1 is regulated by the oxidation of specific cysteine residues and is dependent on the thiol peroxidase Gpx3. Hydrogen Peroxide 4-8 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 41-45 12446208-0 2002 Hydrogen peroxide-induced carbonylation of key metabolic enzymes in Saccharomyces cerevisiae: the involvement of the oxidative stress response regulators Yap1 and Skn7. Hydrogen Peroxide 0-17 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 154-158 12446208-6 2002 The correlation between H(2)O(2) sensitivity and the accumulation of oxidized proteins was evaluated by assaying protein carbonyls in mutants deficient in the stress response regulators Yap1p and Skn7p. Hydrogen Peroxide 24-32 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 186-191 11509657-2 2001 The nuclear export step is specifically inhibited by H(2)O(2) or the thiol oxidant diamide, resulting in Yap1p nuclear accumulation and induction of transcription of its target genes. Hydrogen Peroxide 53-61 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 105-110 12437921-1 2002 The Yap1 transcription factor regulates hydroperoxide homeostasis in S. cerevisiae. Hydrogen Peroxide 40-53 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 4-8 12437921-2 2002 Yap1 is activated by oxidation when hydroperoxide levels increase. Hydrogen Peroxide 36-49 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 0-4 12437921-4 2002 We identified the glutathione peroxidase (GPx)-like enzyme Gpx3 as a second component of the pathway, serving the role of sensor and transducer of the hydroperoxide signal to Yap1. Hydrogen Peroxide 151-164 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 175-179 12437921-5 2002 When oxidized by H2O2, Gpx3 Cys36 bridges Yap1 Cys598 by a disulfide bond. Hydrogen Peroxide 17-21 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 42-46 12100562-4 2002 This peculiar H2O2 tolerance defect, the nature of the proteins of the Msn2/4 regulon, and the partial overlap of this regulon with the Yap1 H2O2-response regulon, suggest an independent and distinctive role of these two H2O2 stress response pathways. Hydrogen Peroxide 141-145 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 136-140 12100562-4 2002 This peculiar H2O2 tolerance defect, the nature of the proteins of the Msn2/4 regulon, and the partial overlap of this regulon with the Yap1 H2O2-response regulon, suggest an independent and distinctive role of these two H2O2 stress response pathways. Hydrogen Peroxide 141-145 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 136-140 12100562-7 2002 This, and the normal H2O2 induction of a gene reporter under control of the Yap1 regulator when intracellular cAMP level are high, demonstrate that the Ras-cAMP pathway negatively affects the H2O2 stress response through Msn2/4. Hydrogen Peroxide 21-25 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 76-80 12100562-7 2002 This, and the normal H2O2 induction of a gene reporter under control of the Yap1 regulator when intracellular cAMP level are high, demonstrate that the Ras-cAMP pathway negatively affects the H2O2 stress response through Msn2/4. Hydrogen Peroxide 192-196 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 76-80 12100562-8 2002 However, the high H2O2 sensitivity of a strain lacking the PKA-negative regulatory subunit Bcy1, is not only the consequence of the inhibition of Msn2/4 but also of Yap1 through a yet undefined mechanism. Hydrogen Peroxide 18-22 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 165-169 11056165-8 2001 We show that the transcription of FLR1 is induced upon cell treatment with the oxidizing agents diamide, diethylmaleate, hydrogen peroxide, and tert-butyl hydroperoxide, the antimitotic drug benomyl, and the alkylating agent methylmethane sulfonate and that this induction is mediated by Yap1p through the three YREs. Hydrogen Peroxide 121-138 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 288-293 11169101-1 2001 The Saccharomyces cerevisiae Yap1p transcription factor is required for the H2O2-dependent activation of many antioxidant genes including the TRX2 gene encoding thioredoxin 2. Hydrogen Peroxide 76-80 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 29-34 11169101-5 2001 In Deltatrr1 mutants treated with H2O2, the Yap1p targets, as well as genes comprising a general environmental stress response and genes encoding protein-folding chaperones, are hyperinduced. Hydrogen Peroxide 34-38 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 44-49 10347154-3 1999 The respective roles of Yap1 and Skn7 in the induction of defense genes by H2O2 were analyzed by two-dimensional gel electrophoresis. Hydrogen Peroxide 75-79 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 24-28 10844671-0 2000 A large-scale study of Yap1p-dependent genes in normal aerobic and H2O2-stress conditions: the role of Yap1p in cell proliferation control in yeast. Hydrogen Peroxide 67-71 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 23-28 11013218-0 2000 H2O2 sensing through oxidation of the Yap1 transcription factor. Hydrogen Peroxide 0-4 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 38-42 11013218-3 2000 We provide biochemical and genetic evidence that upon H2O2 treatment, Yap1 is activated by oxidation and deactivated by enzymatic reduction with Yap1-controlled thioredoxins, thus providing a mechanism for autoregulation. Hydrogen Peroxide 54-58 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 70-74 11013218-3 2000 We provide biochemical and genetic evidence that upon H2O2 treatment, Yap1 is activated by oxidation and deactivated by enzymatic reduction with Yap1-controlled thioredoxins, thus providing a mechanism for autoregulation. Hydrogen Peroxide 54-58 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 145-149 11013218-4 2000 Two cysteines essential for Yap1 oxidation are also essential for its activation by H2O2. Hydrogen Peroxide 84-88 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 28-32 11018516-3 2000 Additionally, in Yap1(-) yeast, CEO1 also induced cross-tolerance to oxidative damage caused by hydrogen peroxide and diamide. Hydrogen Peroxide 96-113 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 17-21 10347154-9 1999 Such a specialization may explain, at least in part, the dissociated function of Yap1 and Skn7 in H2O2 and cadmium resistance. Hydrogen Peroxide 98-102 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 81-85 9439570-3 1997 When expressed in S. cerevisiae, this gene efficiently complements some of the phenotypes associated with both yap1 and yap2 mutations and also mediates AP-1 response element-dependent transcriptional activation in response to H2O2. Hydrogen Peroxide 227-231 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 111-115 9372930-6 1997 Yap-dependent transcription is abolished in strains containing high levels of protein kinase A; in contrast, Gcn4 transcriptional activity is stimulated by protein kinase A. Interestingly, Yap1 transcriptional activity is stimulated by hydrogen peroxide, whereas Yap2 activity is stimulated by aminotriazole and cadmium. Hydrogen Peroxide 236-253 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 189-193 7565103-10 1995 Furthermore, while the H2O2-mediated induction of SSA1 expression is shown to by YAP1 dependent, the heat-shock-mediated induction of the SSA1 gene does not require YAP1. Hydrogen Peroxide 23-27 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 81-85 9373181-1 1997 To define the essential amino acid residues of Yap1 in stress response, we generated yap1 mutations by in vitro mutagenesis, which cause defects in mediating resistance to the stress of H2O2, but not of CdCl2. Hydrogen Peroxide 186-190 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 47-51 9373181-1 1997 To define the essential amino acid residues of Yap1 in stress response, we generated yap1 mutations by in vitro mutagenesis, which cause defects in mediating resistance to the stress of H2O2, but not of CdCl2. Hydrogen Peroxide 186-190 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 85-89 9065458-0 1997 The Saccharomyces cerevisiae AP-1 protein discriminates between oxidative stress elicited by the oxidants H2O2 and diamide. Hydrogen Peroxide 106-110 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 29-33 9065458-2 1997 Transcriptional activation by yAP-1 has been shown to be inducible by exposure of cells to H2O2 and diamide, among other oxidative stress eliciting compounds. Hydrogen Peroxide 91-95 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 30-35 9065458-9 1997 While yAP-1 transactivation is enhanced by exposure to either H2O2 or diamide, the protein responds to the oxidative stress produced by these compounds in nonidentical ways. Hydrogen Peroxide 62-66 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 6-11 9044254-5 1997 Moreover, regulation of the GSH1 gene by H2O2, although requiring the Yap1 protein, appears to be mediated by a mechanism distinct from that which regulates the Yap1-dependent induction of genes encoding thioredoxin (TRX2) and a stress-inducible HSP70 (SSA1) by H2O2. Hydrogen Peroxide 41-45 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 70-74 9235926-2 1997 This gene encodes a protein highly homologous to S. cerevisiae yAP-1, a bZip transcription factor known to mediate cellular resistance to toxicants such as cycloheximide (CYH), 4-nitroquinoline N-oxide (4-NQO), cadmium, and hydrogen peroxide. Hydrogen Peroxide 224-241 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 63-68 9235926-4 1997 Cap1 and yAP-1 are functional homologues, since CAP1 expression in a yap1 mutant strain partially restores the ability of the cells to grow on toxic concentrations of cadmium or hydrogen peroxide. Hydrogen Peroxide 178-195 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 9-14 9235926-4 1997 Cap1 and yAP-1 are functional homologues, since CAP1 expression in a yap1 mutant strain partially restores the ability of the cells to grow on toxic concentrations of cadmium or hydrogen peroxide. Hydrogen Peroxide 178-195 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 69-73 7565103-2 1995 We show that yeast mutants deleted for either the YAP1 or the YAP2 genes are hypersensitive to oxidants, particularly H2O2, and that these genes play a role in regulating the induction of the H2O2 adaptive stress response in Saccharomyces cerevisiae. Hydrogen Peroxide 118-122 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 50-54 7565103-2 1995 We show that yeast mutants deleted for either the YAP1 or the YAP2 genes are hypersensitive to oxidants, particularly H2O2, and that these genes play a role in regulating the induction of the H2O2 adaptive stress response in Saccharomyces cerevisiae. Hydrogen Peroxide 192-196 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 50-54 8313910-2 1994 Cells deficient in YAP1 were found to be hypersensitive to hydroperoxides and thioloxidants, whereas overexpression of YAP1 conferred hyper-resistance to the same conditions. Hydrogen Peroxide 59-73 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 19-23 8313910-5 1994 Using a specific genetic screen, the TRX2 gene, one of two genes of S. cerevisiae that encode thioredoxin protein, was identified as being essential for YAP1 dependent resistance to hydroperoxides. Hydrogen Peroxide 182-196 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 153-157 8313910-0 1994 YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides. Hydrogen Peroxide 115-129 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 0-4 8107671-6 1994 The yap1 disruptant has been shown to be sensitive to H2O2. Hydrogen Peroxide 54-58 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 4-8 8107671-9 1994 YAP1 was able to mediate both cadmium- and H2O2-induced transcriptional activation of an ARE-dependent promoter. Hydrogen Peroxide 43-47 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 0-4 1525853-2 1992 The observed H2O2-sensitivity of par1 mutants has been attributed to an increased sensitivity to reduced oxygen intermediates. Hydrogen Peroxide 13-17 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 33-37 1525853-7 1992 The finding that H2O2 promotes DNA-binding of human c-jun is consistent with a similar function for PAR1/YAP1/SNQ3 and c-jun in cellular metabolism. Hydrogen Peroxide 17-21 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 110-114 1889413-10 1991 PAR1 null mutants, constructed by insertion of the LEU2 gene into the open reading frame, showed a remarkable phenotype: they did not grow on slightly alkaline buffered media (pH greater than 7) and became hypersensitive to oxidative stress by hydrogen peroxide. Hydrogen Peroxide 244-261 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 0-4