PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32704568-1 2020 Aims: C-peptide, produced by pancreatic beta cells and co-secreted in the bloodstream with insulin, has antioxidant properties in glucose- and hydrogen peroxide (H2O2)-exposed INS1 beta cells. Hydrogen Peroxide 143-160 insulin 2 Rattus norvegicus 6-15 32704568-1 2020 Aims: C-peptide, produced by pancreatic beta cells and co-secreted in the bloodstream with insulin, has antioxidant properties in glucose- and hydrogen peroxide (H2O2)-exposed INS1 beta cells. Hydrogen Peroxide 162-166 insulin 2 Rattus norvegicus 6-15 32704568-5 2020 To study the ability of C-peptide to lower peroxisomal H2O2, we engineered an INS1 beta cell line stably expressing the peroxisomal-targeted H2O2 sensor HyPer, whose fluorescence increases with cellular H2O2. Hydrogen Peroxide 55-59 insulin 2 Rattus norvegicus 24-33 32704568-5 2020 To study the ability of C-peptide to lower peroxisomal H2O2, we engineered an INS1 beta cell line stably expressing the peroxisomal-targeted H2O2 sensor HyPer, whose fluorescence increases with cellular H2O2. Hydrogen Peroxide 141-145 insulin 2 Rattus norvegicus 24-33 32704568-5 2020 To study the ability of C-peptide to lower peroxisomal H2O2, we engineered an INS1 beta cell line stably expressing the peroxisomal-targeted H2O2 sensor HyPer, whose fluorescence increases with cellular H2O2. Hydrogen Peroxide 141-145 insulin 2 Rattus norvegicus 24-33 32704568-7 2020 Results: C-peptide protects INS1 beta cells from the combined effect of palmitic acid and glucose by reducing peroxisomal H2O2 to baseline levels and increasing expression of catalase. Hydrogen Peroxide 122-126 insulin 2 Rattus norvegicus 9-18