PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11493672-5	2001	The activity of the rate-limiting melanogenic enzyme, tyrosinase, decreased in H(2)O(2)-treated mouse and human melanoma cells.	Hydrogen Peroxide	79-87	tyrosinase	Mus musculus	54-64	
6776205-5	1980	In addition this inactivation of tyrosinase by dopa was not inhibited by any of: 1.4-diazabicyclo[2.2.2]octane, scavenger for singlet oxygen; D-mannitol, that for hydroxyl radical; superoxide dismutase, that for superoxide anion; and catalase, cleavaging enzyme for hydrogen peroxide.	Hydrogen Peroxide	266-283	tyrosinase	Mus musculus	33-43	
33205668-5	2022	Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence.	Hydrogen Peroxide	192-196	tyrosinase	Mus musculus	94-97	
30208515-6	2018	After 50 days, IGF-1 obviously ameliorated depigmentation of mice skin and reduced hair follicle length, skin thickness and Tyrosinase induced by H2O2.	Hydrogen Peroxide	146-150	tyrosinase	Mus musculus	124-134	
1693779-6	1990	Because peroxides may be by-products of melanogenic activity and hydrogen peroxide in particular is known to destroy melanin precursors and melanin, we conclude that pigmentation is controlled not only by tyrosinase but also by a hydroperoxidase.	Hydrogen Peroxide	65-82	tyrosinase	Mus musculus	205-215	
34958200-0	2022	Dual-Locked Near-Infrared Fluorescent Probes for Precise Detection of Melanoma via Hydrogen Peroxide-Tyrosinase Cascade Activation.	Hydrogen Peroxide	83-100	tyrosinase	Mus musculus	101-111	
34958200-4	2022	Here, we report a dual-locked NIR probe, MB-m-borate, which releases fluorophore methylene blue (MB) after hydrogen peroxide-tyrosinase (H2O2-TYR) cascade activation.	Hydrogen Peroxide	137-141	tyrosinase	Mus musculus	125-135	
30458279-5	2019	This molecule is capable of constructing an efficient catalytic redox cycle with tyrosinase and NQO1 in melanoma B16F1 cells to induce selectively the ROS (mainly including hydrogen peroxide, H2O2) accumulation in the cells, resulting in highly selective suppression of melanoma B16F1 cells over tyrosinase-deficient HeLa and normal L-02 cells.	Hydrogen Peroxide	173-190	tyrosinase	Mus musculus	81-91	
30458279-5	2019	This molecule is capable of constructing an efficient catalytic redox cycle with tyrosinase and NQO1 in melanoma B16F1 cells to induce selectively the ROS (mainly including hydrogen peroxide, H2O2) accumulation in the cells, resulting in highly selective suppression of melanoma B16F1 cells over tyrosinase-deficient HeLa and normal L-02 cells.	Hydrogen Peroxide	173-190	tyrosinase	Mus musculus	296-306	
30458279-5	2019	This molecule is capable of constructing an efficient catalytic redox cycle with tyrosinase and NQO1 in melanoma B16F1 cells to induce selectively the ROS (mainly including hydrogen peroxide, H2O2) accumulation in the cells, resulting in highly selective suppression of melanoma B16F1 cells over tyrosinase-deficient HeLa and normal L-02 cells.	Hydrogen Peroxide	192-196	tyrosinase	Mus musculus	81-91	
30458279-5	2019	This molecule is capable of constructing an efficient catalytic redox cycle with tyrosinase and NQO1 in melanoma B16F1 cells to induce selectively the ROS (mainly including hydrogen peroxide, H2O2) accumulation in the cells, resulting in highly selective suppression of melanoma B16F1 cells over tyrosinase-deficient HeLa and normal L-02 cells.	Hydrogen Peroxide	192-196	tyrosinase	Mus musculus	296-306	
29456788-5	2017	H2O2 treatment induced depigmentation and reduced hair follicle length, skin thickness, and tyrosinase expression in vivo.	Hydrogen Peroxide	0-4	tyrosinase	Mus musculus	92-102	
29456788-6	2017	Whereas, antroquinonol obviously ameliorated depigmentation of mice skin and resisted the reduction of hair follicle length, skin thickness, and tyrosinase expression induced by H2O2.	Hydrogen Peroxide	178-182	tyrosinase	Mus musculus	145-155