PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18941904-5 2009 Our findings demonstrate that H(2)O(2)-enhanced osteoblastic differentiation and apoptosis are responsible for the increased calcification in rat CVCs, and LaCl(3) can counteract these effects by suppressing the activation of JNK (JNK2, but not JNK1) and p38 MAPK signaling pathway. Hydrogen Peroxide 30-38 mitogen activated protein kinase 3 Rattus norvegicus 259-263 19885844-5 2010 Hydrogen peroxide (5-25 microM) increased RAGE protein level while activating both EGFR and ERK1/2. Hydrogen Peroxide 0-17 mitogen activated protein kinase 3 Rattus norvegicus 92-98 19362115-0 2009 Rutin from Lonicera japonica inhibits myocardial ischemia/reperfusion-induced apoptosis in vivo and protects H9c2 cells against hydrogen peroxide-mediated injury via ERK1/2 and PI3K/Akt signals in vitro. Hydrogen Peroxide 128-145 mitogen activated protein kinase 3 Rattus norvegicus 166-172 19787459-0 2010 Involvement of ERK1/2 pathway in neuroprotection by salidroside against hydrogen peroxide-induced apoptotic cell death. Hydrogen Peroxide 72-89 mitogen activated protein kinase 3 Rattus norvegicus 15-21 19787459-2 2010 The aim of this study was to investigate the effects of salidroside on hydrogen peroxide (H(2)O(2))-induced cell apoptosis in nerve growth factor (NGF)-differentiated PC12 cells and the possible involvement of the extracellular signal-related protein kinase 1/2 (ERK1/2) signaling pathway. Hydrogen Peroxide 71-88 mitogen activated protein kinase 3 Rattus norvegicus 263-269 19787459-4 2010 According to Western blot analysis, pretreatment with salidroside transiently caused the activation of ERK1/2 pathway; a selective inhibitor of the mitogen-activated protein kinase kinase (MAPKK, MEK) blocked salidroside-activated ERK pathway and thus attenuated the influences of salidroside on H(2)O(2)-induced increase in the level of cleaved caspase-3, a chief executant of apoptosis cascades. Hydrogen Peroxide 296-304 mitogen activated protein kinase 3 Rattus norvegicus 103-109 19720069-4 2009 The extracellular-signal-regulated protein kinase 1/2 (ERK1/2)-connexin 43 (Cx43) signaling pathway is crucial for the regulation of GJIC in rat liver epithelial cells, and resveratrol, but not BHA, blocked the H2O2-induced phosphorylation of Cx43, a critical regulator of GJIC, and ERK1/2 in WB-F344 cells. Hydrogen Peroxide 211-215 mitogen activated protein kinase 3 Rattus norvegicus 55-61 19720069-5 2009 Resveratrol appears to attenuate the H2O2-mediated ERK1/2-Cx43 signaling pathway and consequently reverses H2O2-mediated inhibition of GJIC. Hydrogen Peroxide 37-41 mitogen activated protein kinase 3 Rattus norvegicus 51-57 19720069-5 2009 Resveratrol appears to attenuate the H2O2-mediated ERK1/2-Cx43 signaling pathway and consequently reverses H2O2-mediated inhibition of GJIC. Hydrogen Peroxide 107-111 mitogen activated protein kinase 3 Rattus norvegicus 51-57 18410586-4 2008 In the present study, the effect of melatonin treatment on the hydrogen peroxide (H(2)O(2))-induced activation of the mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways was assessed in H4IIE hepatoma cells. Hydrogen Peroxide 63-80 mitogen activated protein kinase 3 Rattus norvegicus 152-156 19059215-5 2009 We also found that overexpression of wild type PKD1 attenuated H(2)O(2)-induced phosphorylation of p38 MAPK and its upstream activator, MAPK kinase (MKK) 3/6, whereas the phosphorylation was increased by PKD1 siRNA or kinase-dead PKD1. Hydrogen Peroxide 63-71 mitogen activated protein kinase 3 Rattus norvegicus 103-107 18668153-0 2008 Involvement of ERK1/2 and p38 MAPK in up-regulation of 14-3-3 protein induced by hydrogen peroxide preconditioning in PC12 cells. Hydrogen Peroxide 81-98 mitogen activated protein kinase 3 Rattus norvegicus 15-21 18822160-5 2008 Nicotine and H2O2 at these dose and time intervals produced similar levels of malondialdyde (MDA) production and p-ERK1/2 activation. Hydrogen Peroxide 13-17 mitogen activated protein kinase 3 Rattus norvegicus 115-121 18410586-4 2008 In the present study, the effect of melatonin treatment on the hydrogen peroxide (H(2)O(2))-induced activation of the mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways was assessed in H4IIE hepatoma cells. Hydrogen Peroxide 82-90 mitogen activated protein kinase 3 Rattus norvegicus 152-156 18410586-5 2008 It was found that melatonin strongly attenuated H(2)O(2)-induced activation of the ERK1/2 and p38 MAP kinases, as well as several of their downstream targets. Hydrogen Peroxide 48-56 mitogen activated protein kinase 3 Rattus norvegicus 83-89 17965278-10 2008 The antioxidant N-2-mercaptopropionyl glycine (300 microM) reduced H(2)O(2)-mediated MAPK activation but failed to attenuate CCPA-induced MAPK activation. Hydrogen Peroxide 67-75 mitogen activated protein kinase 3 Rattus norvegicus 85-89 18272143-10 2008 Even though H2O2 (2 mM) did not alter p38 MAPK and JNK1/2 phosphorylation in hippocampal slices, it stimulated ERK1/2 phosphorylation and the co-incubation with (PhSe)2 (10 microM) blocked this effect. Hydrogen Peroxide 12-16 mitogen activated protein kinase 3 Rattus norvegicus 111-117 18272143-11 2008 Taken together, the present results indicate that (PhSe)2 exerts protective effects against H2O2-induced oxidative damage in hippocampal slices and avoided the increase in ERK1/2 phosphorylation promoted by H2O2. Hydrogen Peroxide 207-211 mitogen activated protein kinase 3 Rattus norvegicus 172-178 18410586-7 2008 Upregulation of ERK1/2, p38, and Akt signaling by H(2)O(2) was accompanied by activation of Ras, an effect that was blocked by melatonin. Hydrogen Peroxide 50-58 mitogen activated protein kinase 3 Rattus norvegicus 16-22 17965278-5 2008 CCPA and H(2)O(2) activated p38 MAPK and p44/p42 ERKs in cytosolic fractions. Hydrogen Peroxide 9-17 mitogen activated protein kinase 3 Rattus norvegicus 32-36 17965278-5 2008 CCPA and H(2)O(2) activated p38 MAPK and p44/p42 ERKs in cytosolic fractions. Hydrogen Peroxide 9-17 mitogen activated protein kinase 3 Rattus norvegicus 41-44 17965278-5 2008 CCPA and H(2)O(2) activated p38 MAPK and p44/p42 ERKs in cytosolic fractions. Hydrogen Peroxide 9-17 mitogen activated protein kinase 3 Rattus norvegicus 49-53 16883639-0 2006 Samul extract protects against the H2O2-induced apoptosis of H9c2 cardiomyoblasts via activation of extracellular regulated kinases (Erk) 1/2. Hydrogen Peroxide 35-39 mitogen activated protein kinase 3 Rattus norvegicus 100-141 17965278-7 2008 The greatest difference between H(2)O(2) and CCPA was in the Triton-insoluble membrane fraction, where H(2)O(2) increased p38 and p42 activation and CCPA reduced MAPK activation. Hydrogen Peroxide 32-40 mitogen activated protein kinase 3 Rattus norvegicus 162-166 17496232-4 2007 Depending on NO levels and antioxidant defenses, more or less H(2)O(2) accumulates in cytosol and nucleus, and the resulting redox grading contributes to dual activation of proliferating and proapoptotic cascades, like ERK1/2 or p38 MAPK. Hydrogen Peroxide 62-70 mitogen activated protein kinase 3 Rattus norvegicus 219-225 16208142-13 2005 Our findings identify an important role for tyrosine kinases, but not PKC, in H(2)O(2)-induced phosphorylation of ERK1/2 and p38MAP kinase in VSMC. Hydrogen Peroxide 78-86 mitogen activated protein kinase 3 Rattus norvegicus 114-120 16362428-7 2006 It was also observed in PC12 cells that H2O2 stimulated phosphorylation of mitogen-activated protein (MAP) kinases, i.e., extracellular signal-regulated kinase1/2 (ERK1/2), c-Jun NH2-terminal kinase (JNK) and p38 MAP kinase. Hydrogen Peroxide 40-44 mitogen activated protein kinase 3 Rattus norvegicus 122-162 16362428-7 2006 It was also observed in PC12 cells that H2O2 stimulated phosphorylation of mitogen-activated protein (MAP) kinases, i.e., extracellular signal-regulated kinase1/2 (ERK1/2), c-Jun NH2-terminal kinase (JNK) and p38 MAP kinase. Hydrogen Peroxide 40-44 mitogen activated protein kinase 3 Rattus norvegicus 164-170 16208142-7 2005 RESULTS: H(2)O(2) stimulated phosphorylation of ERK1/2 and p38MAP kinase in a time-dependent manner. Hydrogen Peroxide 9-17 mitogen activated protein kinase 3 Rattus norvegicus 48-54 16208142-10 2005 The inhibition of NRTK attenuated H(2)O(2)-mediated phosphorylation of ERK1/2 (P < 0.001) but not of p38MAP kinase, whereas Src and JAK2 inhibition significantly decreased phosphorylation of both MAP kinases (P < 0.01). Hydrogen Peroxide 34-42 mitogen activated protein kinase 3 Rattus norvegicus 71-77 16208142-11 2005 CONCLUSION: These data indicate that H(2)O(2) increases ERK1/2 and p38MAP kinase activation through tyrosine kinase-dependent, PKC-independent mechanisms. Hydrogen Peroxide 37-45 mitogen activated protein kinase 3 Rattus norvegicus 56-62 15784961-5 2005 A selective MAPK kinase inhibitor, U0126, blocked the H2O2-induced phosphorylation of Erk1/2 (extracellular signal-regulated kinase) in PC12 cells and increased the levels of active caspase-3 in M-M17-26 under serum withdrawal or H2O2 treatment. Hydrogen Peroxide 54-58 mitogen activated protein kinase 3 Rattus norvegicus 12-16 15942712-14 2005 CONCLUSIONS: ES prevents the delay of wound repair in IEC-6 cells induced by H2O2, probably through the activation of ERK1/2 MAPK and the induction of COX-2. Hydrogen Peroxide 77-81 mitogen activated protein kinase 3 Rattus norvegicus 118-124 15942712-14 2005 CONCLUSIONS: ES prevents the delay of wound repair in IEC-6 cells induced by H2O2, probably through the activation of ERK1/2 MAPK and the induction of COX-2. Hydrogen Peroxide 77-81 mitogen activated protein kinase 3 Rattus norvegicus 125-129 15703274-9 2005 These data suggest that part of cardiac hypertrophic effect of serotonin requires hydrogen peroxide production by MAO A and ERK1/2 activation. Hydrogen Peroxide 82-99 mitogen activated protein kinase 3 Rattus norvegicus 124-130 16179908-11 2005 Furthermore, JNK and ERK were activated by H2O2 and their specific inhibitors SP600125 (for JNK) and U0126 (for ERK1/2) prevented p21Cip1 expression and blocked cell cycle arrest. Hydrogen Peroxide 43-47 mitogen activated protein kinase 3 Rattus norvegicus 112-118 15784961-5 2005 A selective MAPK kinase inhibitor, U0126, blocked the H2O2-induced phosphorylation of Erk1/2 (extracellular signal-regulated kinase) in PC12 cells and increased the levels of active caspase-3 in M-M17-26 under serum withdrawal or H2O2 treatment. Hydrogen Peroxide 54-58 mitogen activated protein kinase 3 Rattus norvegicus 86-92 15784961-5 2005 A selective MAPK kinase inhibitor, U0126, blocked the H2O2-induced phosphorylation of Erk1/2 (extracellular signal-regulated kinase) in PC12 cells and increased the levels of active caspase-3 in M-M17-26 under serum withdrawal or H2O2 treatment. Hydrogen Peroxide 230-234 mitogen activated protein kinase 3 Rattus norvegicus 12-16 15784961-5 2005 A selective MAPK kinase inhibitor, U0126, blocked the H2O2-induced phosphorylation of Erk1/2 (extracellular signal-regulated kinase) in PC12 cells and increased the levels of active caspase-3 in M-M17-26 under serum withdrawal or H2O2 treatment. Hydrogen Peroxide 230-234 mitogen activated protein kinase 3 Rattus norvegicus 86-92 14975937-5 2004 A Grb2-SOS inhibitor (SH3 binding peptide), an Ras inhibitor (farnesyl transferase inhibitor 277), and an Raf-1 inhibitor (forskolin) each prevented FGF-10- and H2O2-induced A549 cell ERK1/2 phosphorylation. Hydrogen Peroxide 161-165 mitogen activated protein kinase 3 Rattus norvegicus 184-190 15659805-2 2004 Several reports suggest that activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) plays a key role in the disrupted GJIC by hydrogen peroxide, 12-O-tetradecanoylphorbol-13-acetate, and quinones in rat liver epithelial cells. Hydrogen Peroxide 149-166 mitogen activated protein kinase 3 Rattus norvegicus 99-105 15659805-3 2004 Recently, we reported that p38 mitogen-activated protein kinase (MAPK) is also involved in the inhibition of GJIC by hydrogen peroxide in WB-F344 rat liver epithelial cells (WB cells). Hydrogen Peroxide 117-134 mitogen activated protein kinase 3 Rattus norvegicus 65-69 14975937-9 2004 We conclude that FGF-10 attenuates H2O2-induced AEC DNA damage by mechanisms that involve activation of Grb2-SOS/Ras/RAF-1/ERK1/2 pathway and DNA repair. Hydrogen Peroxide 35-39 mitogen activated protein kinase 3 Rattus norvegicus 123-129 14622133-9 2003 By depressing NF-kappaB signalling, H2O2 may still augment P-gp expression when ERK1/2, PKC or SAPK are inhibited. Hydrogen Peroxide 36-40 mitogen activated protein kinase 3 Rattus norvegicus 80-86 15030409-7 2004 Mitochondrial phospho-ERK1/2 increased at 1 microm hydrogen peroxide (H(2)O(2)) concentration, but it decreased at higher 50-100 microm H(2)O(2), almost disappearing after the organelles were maximally stimulated to produce H(2)O(2) with antimycin. Hydrogen Peroxide 51-68 mitogen activated protein kinase 3 Rattus norvegicus 22-28 15228596-4 2004 As free radicals have been considered to serve as second messengers, we examined the effect of H(2)O(2) on activation of the mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinases (ERK) 1/2 and p38. Hydrogen Peroxide 95-103 mitogen activated protein kinase 3 Rattus norvegicus 160-164 15228596-4 2004 As free radicals have been considered to serve as second messengers, we examined the effect of H(2)O(2) on activation of the mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinases (ERK) 1/2 and p38. Hydrogen Peroxide 95-103 mitogen activated protein kinase 3 Rattus norvegicus 167-215 15228596-5 2004 H(2)O(2) caused a time- and concentration-dependent increase in MAPK phosphorylation, an effect that was totally blocked by N-acetyl-L-cysteine. Hydrogen Peroxide 0-8 mitogen activated protein kinase 3 Rattus norvegicus 64-68 12472888-8 2002 Pre-treatment with arsenite increased protein kinase B (Akt) and extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation after H2O2. Hydrogen Peroxide 138-142 mitogen activated protein kinase 3 Rattus norvegicus 108-114 12788379-7 2003 A hypertrophic concentration of H(2)O(2) (10 microM) increased the activity of ERK1/2, but not that of JNK, p38 kinase or Akt. Hydrogen Peroxide 32-40 mitogen activated protein kinase 3 Rattus norvegicus 79-85 12788379-8 2003 An apoptotic concentration of H(2)O(2) (100 microM) activated JNK, p38 kinase and Akt, and further activated ERK1/2. Hydrogen Peroxide 30-38 mitogen activated protein kinase 3 Rattus norvegicus 109-115 12124207-0 2002 H(2)O(2)-induced Ca(2+) overload in NRVM involves ERK1/2 MAP kinases: role for an NHE-1-dependent pathway. Hydrogen Peroxide 0-8 mitogen activated protein kinase 3 Rattus norvegicus 50-56 12145102-4 2002 2: Our findings showed that hydrogen peroxide (H(2)O(2)) stimulated rapid and significant activation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK) and p38 in PC12 cells, which is a model of catecholamine-containing neurons. Hydrogen Peroxide 28-45 mitogen activated protein kinase 3 Rattus norvegicus 104-150 12145102-4 2002 2: Our findings showed that hydrogen peroxide (H(2)O(2)) stimulated rapid and significant activation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK) and p38 in PC12 cells, which is a model of catecholamine-containing neurons. Hydrogen Peroxide 47-55 mitogen activated protein kinase 3 Rattus norvegicus 104-150 11978785-5 2002 Conditioned medium (CM) obtained from cells stimulated with H(2)O(2) induced rapid and monophasic ERK1/2 activation, which was not inhibited by calphostin C. Hydrogen Peroxide 60-68 mitogen activated protein kinase 3 Rattus norvegicus 98-104 12117774-0 2002 The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide. Hydrogen Peroxide 171-188 mitogen activated protein kinase 3 Rattus norvegicus 13-19 12124207-6 2002 H(2)O(2) induced a time- and concentration-dependent increase in diastolic intracellular Ca(2+) concentration that was blocked by inhibition of ERK1/2 activation with 5 microM U-0126 (88%) or inhibition of NHE-1 with 5 microM HOE-642 (50%). Hydrogen Peroxide 0-8 mitogen activated protein kinase 3 Rattus norvegicus 144-150 12124207-8 2002 These results suggest that H(2)O(2) induced Ca(2+) overload is partially mediated by NHE-1 activation secondary to phosphorylation of NHE-1 by the ERK1/2 MAP kinase pathway. Hydrogen Peroxide 27-35 mitogen activated protein kinase 3 Rattus norvegicus 147-153 12117774-4 2002 Moreover, H(2)O(2) activated p38 kinase, extracellular signal-regulated protein kinases (ERK)1/2 and c-Jun N-terminal kinase (JNK) in WB cells. Hydrogen Peroxide 10-18 mitogen activated protein kinase 3 Rattus norvegicus 41-96 11600417-4 2001 H(2)O(2) caused a concentration- and time-dependent activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), p38, and c-Jun NH(2)-terminal kinase (JNK) mitogen-activated protein (MAP) kinases in adult rat ventricular myocytes. Hydrogen Peroxide 0-8 mitogen activated protein kinase 3 Rattus norvegicus 66-112 11880281-4 2002 Direct addition of H(2)O(2) or the superoxide generator menadione activated ERK1/2, which is also prevented by MnTMPyP pretreatment. Hydrogen Peroxide 19-27 mitogen activated protein kinase 3 Rattus norvegicus 76-82 11600417-4 2001 H(2)O(2) caused a concentration- and time-dependent activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), p38, and c-Jun NH(2)-terminal kinase (JNK) mitogen-activated protein (MAP) kinases in adult rat ventricular myocytes. Hydrogen Peroxide 0-8 mitogen activated protein kinase 3 Rattus norvegicus 114-120 11600417-5 2001 H(2)O(2) (50 microM) caused transient activation of ERK1/2 and p38 MAP kinase that was detected as early as 5 min, was maximal at 20 min (9.6 +/- 1.2- and 9.0 +/- 1.6-fold, respectively, vs. control), and returned to baseline at 60 min. Hydrogen Peroxide 0-8 mitogen activated protein kinase 3 Rattus norvegicus 52-58 11447348-6 2001 To our knowledge, this study is the first demonstration that both ERK1/2 and p38 MAP kinase are involved in the PLD2 activation in PC12 cells exposed to H2O2. Hydrogen Peroxide 153-157 mitogen activated protein kinase 3 Rattus norvegicus 66-72 10588574-2 1999 Phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK 1/2) and of p38 kinase was rapidly increased after treatment with NGF, EGF, or H2O2, with NGF causing more prolonged increases than the other agents. Hydrogen Peroxide 150-154 mitogen activated protein kinase 3 Rattus norvegicus 19-65 10588574-2 1999 Phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK 1/2) and of p38 kinase was rapidly increased after treatment with NGF, EGF, or H2O2, with NGF causing more prolonged increases than the other agents. Hydrogen Peroxide 150-154 mitogen activated protein kinase 3 Rattus norvegicus 67-74 33658932-7 2020 The results showed that in the HUVECs, 200 muM H2O2 treatment significantly increased the phosphorylation of SAPK/JNK and the level of ASK1 but decreased the phosphorylation of ERK1/2, while in the HUVECs pretreated with AEE, the H2O2-induced changes were significantly ameliorated. Hydrogen Peroxide 47-51 mitogen activated protein kinase 3 Rattus norvegicus 177-183 8616849-6 1996 Stimulation of ERK1 and ERK2 was associated with the ability of Cr(VI) to increase cellular peroxide levels as determined using the H2O2-sensitive fluorescent probe 2",7"-dichlorofluorescein diacetate and flow cytometry. Hydrogen Peroxide 132-136 mitogen activated protein kinase 3 Rattus norvegicus 15-19 34428890-0 2021 The Protective Effect of Docosahexaenoic Acid on PC12 Cells in Oxidative Stress Induced by H2O2 through the TrkB-Erk1/2-CREB Pathway. Hydrogen Peroxide 91-95 mitogen activated protein kinase 3 Rattus norvegicus 113-119 34428890-10 2021 These results revealed that DHA could protect PC12 cells from damage induced by H2O2 through the TrkB-ERK1/2-CREB pathway. Hydrogen Peroxide 80-84 mitogen activated protein kinase 3 Rattus norvegicus 102-108 9988750-5 1999 Here, we examined the effects of two oxidative stresses, hydrogen peroxide (H2O2) and the anthracycline doxorubicin on the activity of ERK1/2 and the expression of COX isoforms and PG formation in neonatal rat primary cardiomyocytes. Hydrogen Peroxide 57-74 mitogen activated protein kinase 3 Rattus norvegicus 135-141 9988750-5 1999 Here, we examined the effects of two oxidative stresses, hydrogen peroxide (H2O2) and the anthracycline doxorubicin on the activity of ERK1/2 and the expression of COX isoforms and PG formation in neonatal rat primary cardiomyocytes. Hydrogen Peroxide 76-80 mitogen activated protein kinase 3 Rattus norvegicus 135-141 9988750-13 1999 In cardiomyocytes cell injury by H2O2 and doxorubicin is limited by an increase in prostacyclin formation that reflects induction of COX-2 mediated by ERK1/2 activation. Hydrogen Peroxide 33-37 mitogen activated protein kinase 3 Rattus norvegicus 151-157 9677316-3 1998 Maximal activation occurred at 15-30 min, but was still detectable after 2 h. Both ERK1 and ERK2 were activated 16-fold by 0.1 mM H2O2 with a similar time course to the SAPKs/JNKs, and this was comparable with their activation by 1 microM PMA, the most powerful activator of ERKs that we have so far identified in these cells. Hydrogen Peroxide 130-134 mitogen activated protein kinase 3 Rattus norvegicus 83-87 9677316-3 1998 Maximal activation occurred at 15-30 min, but was still detectable after 2 h. Both ERK1 and ERK2 were activated 16-fold by 0.1 mM H2O2 with a similar time course to the SAPKs/JNKs, and this was comparable with their activation by 1 microM PMA, the most powerful activator of ERKs that we have so far identified in these cells. Hydrogen Peroxide 130-134 mitogen activated protein kinase 3 Rattus norvegicus 275-279 9677316-4 1998 The activation of ERKs by H2O2 was inhibited by PD98059, which inhibits the activation of MAPK (or ERK) kinases, and by the protein kinase C (PKC) inhibitor, GF109203X. Hydrogen Peroxide 26-30 mitogen activated protein kinase 3 Rattus norvegicus 18-22 33658932-9 2020 Moreover, inhibition of ASK1 and ERK1/2 showed that ASK1 plays a vital role in the protective effect of AEE on H2O2-induced apoptosis. Hydrogen Peroxide 111-115 mitogen activated protein kinase 3 Rattus norvegicus 33-39 31356907-10 2019 Moreover, HRS increased cGMP level, decreased p-ERK1/2 (diminished with KT5823) in the platelets stimulated by H2O2. Hydrogen Peroxide 111-115 mitogen activated protein kinase 3 Rattus norvegicus 48-54 31655619-0 2019 Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90rsk-CREB pathway. Hydrogen Peroxide 115-132 mitogen activated protein kinase 3 Rattus norvegicus 157-163 30876692-8 2019 These results suggest that CaMEK plays an important role in protecting cardiomyocytes against H2O2-induced injury and autophagy in NCMs via ERK1/2 pathway. Hydrogen Peroxide 94-98 mitogen activated protein kinase 3 Rattus norvegicus 140-146 30615921-15 2019 Mechanistically, SMI upregulated intracellular AKT phosphorylation and downregulate ERK1/2 phosphorylation in H2O2-treated cardiomyocytes. Hydrogen Peroxide 110-114 mitogen activated protein kinase 3 Rattus norvegicus 84-90 31030942-8 2019 Furthermore, H2O2 treatment effectively enhanced the phosphorylation of AKT, ERK1/2 and the expression of KLF4, whereas LY294002 (a specific inhibitor of PI3K), U0126 (a specific inhibitor of ERK1/2) significantly attenuated the H2O2-induced up-regulation of KLF4. Hydrogen Peroxide 13-17 mitogen activated protein kinase 3 Rattus norvegicus 77-83 31030942-8 2019 Furthermore, H2O2 treatment effectively enhanced the phosphorylation of AKT, ERK1/2 and the expression of KLF4, whereas LY294002 (a specific inhibitor of PI3K), U0126 (a specific inhibitor of ERK1/2) significantly attenuated the H2O2-induced up-regulation of KLF4. Hydrogen Peroxide 13-17 mitogen activated protein kinase 3 Rattus norvegicus 192-198 31030942-9 2019 In conclusion, these results demonstrated that p22phox promotes Ang-II-induced VSMC phenotypic switch via the H2O2-ERK1/2/AKT-KLF4 signaling pathway. Hydrogen Peroxide 110-114 mitogen activated protein kinase 3 Rattus norvegicus 115-121 29404859-0 2019 Serum Exosomes Attenuate H2O2-Induced Apoptosis in Rat H9C2 Cardiomyocytes via ERK1/2. Hydrogen Peroxide 25-29 mitogen activated protein kinase 3 Rattus norvegicus 79-85 30876692-0 2019 Cardioprotective effects of constitutively active MEK1 against H2O2-induced apoptosis and autophagy in cardiomyocytes via the ERK1/2 signaling pathway. Hydrogen Peroxide 63-67 mitogen activated protein kinase 3 Rattus norvegicus 126-132 30876692-6 2019 Furthermore, we demonstrated that CaMEK phosphorylated the ERK1/2 pathway-related proteins, ERK1/2, p70S6K and GSK3beta, in NCMs with H2O2 stimulation. Hydrogen Peroxide 134-138 mitogen activated protein kinase 3 Rattus norvegicus 59-65 30876692-6 2019 Furthermore, we demonstrated that CaMEK phosphorylated the ERK1/2 pathway-related proteins, ERK1/2, p70S6K and GSK3beta, in NCMs with H2O2 stimulation. Hydrogen Peroxide 134-138 mitogen activated protein kinase 3 Rattus norvegicus 92-98 28447781-4 2017 Western blot analysis showed that artemisinin upregulated the phosphorylation of p38 and extracellular signal-regulated kinases1/2 (ERK1/2) and reversed the inhibitory effect of H2O2 on the phosphorylation of these two kinases. Hydrogen Peroxide 178-182 mitogen activated protein kinase 3 Rattus norvegicus 132-138 29066484-8 2017 Effect of ERK1/2 on cell proliferation in response to AG and H2O2 was evaluated by MTT assay while the functional status of AR42J cells was determined by release of amylase following CCK-8 stimulation. Hydrogen Peroxide 61-65 mitogen activated protein kinase 3 Rattus norvegicus 10-16 29052798-7 2018 Taken together, our investigations demonstrated that curcumin pretreatment conferred BMSCs the ability to survive from H2O2-induced oxidative stress, which might attribute to its prevention of mitochondrial dysfunction and deactivation of Akt and Erk1/2 signaling pathways. Hydrogen Peroxide 119-123 mitogen activated protein kinase 3 Rattus norvegicus 247-253 25203460-8 2015 Quercetin attenuated H2 O2 -induced activation of ERK1/2, PKB, p38 MAPK and JNK, but inhibitors of these kinases did not modulate quercetin-induced protection or H2 O2 -induced cell death. Hydrogen Peroxide 21-26 mitogen activated protein kinase 3 Rattus norvegicus 50-56 27168176-11 2016 The altered BCRP expression and function by ammonia and H2 O2 were restored by ROS scavenger N-acetylcysteine and ERK1/2 inhibitor U0126. Hydrogen Peroxide 56-61 mitogen activated protein kinase 3 Rattus norvegicus 114-120 28378219-7 2017 Furthermore, KR-33889 reversed H2O2-induced decrease in phosphorylation of Akt, GSK-3beta, ERK1/2, p38 MAPK, and SAPK/JNK during most H2O2 exposure time. Hydrogen Peroxide 31-35 mitogen activated protein kinase 3 Rattus norvegicus 91-97 27444820-9 2016 Moreover, application of KXS2012 in cultured astrocytes, or in H2O2-stressed astrocytes, induced the expressions of neurotrophic factors: the increase might be associated with the modification of Erk1/2 and CREB phosphorylation. Hydrogen Peroxide 63-67 mitogen activated protein kinase 3 Rattus norvegicus 196-202 25203460-8 2015 Quercetin attenuated H2 O2 -induced activation of ERK1/2, PKB, p38 MAPK and JNK, but inhibitors of these kinases did not modulate quercetin-induced protection or H2 O2 -induced cell death. Hydrogen Peroxide 21-26 mitogen activated protein kinase 3 Rattus norvegicus 67-71 25380156-0 2015 c-Src, ERK1/2 and Rho kinase mediate hydrogen peroxide-induced vascular contraction in hypertension: role of TXA2, NAD(P)H oxidase and mitochondria. Hydrogen Peroxide 37-54 mitogen activated protein kinase 3 Rattus norvegicus 7-13 25450615-6 2015 We investigated the molecular mechanisms which underlie this more proliferative phenotype in isolated neonatal rat cardiomyocytes (NRCs) in vitro, and demonstrate that Nox4 overexpression mediates an H2O2-dependent activation of the ERK1/2 signalling pathway, which in turn phosphorylates and activates the transcription factor c-myc. Hydrogen Peroxide 200-204 mitogen activated protein kinase 3 Rattus norvegicus 233-239 25380156-6 2015 The ERK1/2 inhibitor PD98059 reduced H2O2 but not U46619-induced contraction only in SHR arteries. Hydrogen Peroxide 37-41 mitogen activated protein kinase 3 Rattus norvegicus 4-10 25380156-11 2015 The effects induced by H2O2 were abolished by inhibitors of TXA2 synthase, ERK1/2 and c-Src. Hydrogen Peroxide 23-27 mitogen activated protein kinase 3 Rattus norvegicus 75-81 25380156-15 2015 Moreover, ERK1/2 activation contributes to H2O2 contraction in SHR through effects on mitochondria/NAD(P)H Oxidase. Hydrogen Peroxide 43-47 mitogen activated protein kinase 3 Rattus norvegicus 10-16 24607510-10 2014 Furthermore, rhamnetin recovered the H2O2-induced decrease in phosphorylation of Akt/GSK-3beta and MAPKs (ERK1/2, p38 MAPK, and JNK) and pretreatment with their inhibitors, attenuating the rhamnetin-induced cytoprotective effect. Hydrogen Peroxide 37-41 mitogen activated protein kinase 3 Rattus norvegicus 106-112 25216715-3 2014 Hydrogen peroxide activates Trk tyrosine kinase; Akt and ERK1/2 are activated downstream of this protein kinase. Hydrogen Peroxide 0-17 mitogen activated protein kinase 3 Rattus norvegicus 57-63 25216715-7 2014 Activation of ERK1/2 by hydrogen peroxide was enhanced by GM1 at a concentration of 10 microM and to a lesser extent at a concentration of 100 nM. Hydrogen Peroxide 24-41 mitogen activated protein kinase 3 Rattus norvegicus 14-20 25216715-8 2014 Thus, the protective and metabolic effects of GM1 ganglioside on PC12 cells exposed to hydrogen peroxide appear to depend on the activation of Trk receptor tyrosine kinase and downstream activation of Akt and ERK1/2. Hydrogen Peroxide 87-104 mitogen activated protein kinase 3 Rattus norvegicus 209-215 26550832-7 2015 Taken together, these results demonstrate that INH2BP prevents H2O2-induced apoptosis in H9c2 cells by reducing the production of intracellular ROS, regulating apoptotic-related proteins, and the activation of the ERK1/2 and p38 MAPK. Hydrogen Peroxide 63-67 mitogen activated protein kinase 3 Rattus norvegicus 214-220 25128810-0 2014 The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3beta and ERK1/2 signaling pathway. Hydrogen Peroxide 42-59 mitogen activated protein kinase 3 Rattus norvegicus 133-139 25128810-9 2014 These findings indicate that hispidin protects against apoptosis in H9c2 cardiomyoblast cells exposed to hydrogen peroxide through reducing intracellular ROS production, regulating apoptosis-related proteins, and the activation of the Akt/GSK-3beta and ERK1/2 signaling pathways. Hydrogen Peroxide 105-122 mitogen activated protein kinase 3 Rattus norvegicus 253-259 24607510-10 2014 Furthermore, rhamnetin recovered the H2O2-induced decrease in phosphorylation of Akt/GSK-3beta and MAPKs (ERK1/2, p38 MAPK, and JNK) and pretreatment with their inhibitors, attenuating the rhamnetin-induced cytoprotective effect. Hydrogen Peroxide 37-41 mitogen activated protein kinase 3 Rattus norvegicus 99-103 22441302-8 2012 ERK1/2 phosphorylation showed the same profile of H2O2 changes. Hydrogen Peroxide 50-54 mitogen activated protein kinase 3 Rattus norvegicus 0-6 23667869-1 2013 Preincubation with 100 nM and 100 muM alpha-tocopherol for 18 h prevented long-term activation of extracellular signal-activated kinase (ERK1/2), induced by H2O2in PC12 cells. Hydrogen Peroxide 157-161 mitogen activated protein kinase 3 Rattus norvegicus 137-143 23667869-3 2013 These data show that prevention of long-term activation of ERK1/2 by alpha-tocopherol contributes to the increase in viability of PC12 cells exposed to H2O2. Hydrogen Peroxide 152-156 mitogen activated protein kinase 3 Rattus norvegicus 59-65 24049114-2 2013 Hydrogen peroxide (H2O2) increases NHE1 activity acutely via ERK1/2 signaling. Hydrogen Peroxide 0-17 mitogen activated protein kinase 3 Rattus norvegicus 61-67 24049114-2 2013 Hydrogen peroxide (H2O2) increases NHE1 activity acutely via ERK1/2 signaling. Hydrogen Peroxide 19-23 mitogen activated protein kinase 3 Rattus norvegicus 61-67 24049114-8 2013 H2O2 stimulation (100 muM) raised NHE1 activity significantly less in E (45%) than S (167%); however, activity remained 185% greater in E. ERK1/2 inhibition abrogated the increases. Hydrogen Peroxide 0-4 mitogen activated protein kinase 3 Rattus norvegicus 139-145 24049114-9 2013 H2O2-stimulated ERK1/2 phosphorylation levels normalized to total ERK1/2 were similar between groups. Hydrogen Peroxide 0-4 mitogen activated protein kinase 3 Rattus norvegicus 16-22 24049114-9 2013 H2O2-stimulated ERK1/2 phosphorylation levels normalized to total ERK1/2 were similar between groups. Hydrogen Peroxide 0-4 mitogen activated protein kinase 3 Rattus norvegicus 66-72 22268112-5 2012 In addition, H(2)O(2) also increased the phosphorylation of EGF-R, PDGF-R, ERK1/2, and AKT, which was attenuated by the respective inhibitors, whereas the inhibitors of EGF-R and PDGE-R also inhibited the enhanced phosphorylation of ERK1/2 and AKT. Hydrogen Peroxide 13-21 mitogen activated protein kinase 3 Rattus norvegicus 75-81 22268112-5 2012 In addition, H(2)O(2) also increased the phosphorylation of EGF-R, PDGF-R, ERK1/2, and AKT, which was attenuated by the respective inhibitors, whereas the inhibitors of EGF-R and PDGE-R also inhibited the enhanced phosphorylation of ERK1/2 and AKT. Hydrogen Peroxide 13-21 mitogen activated protein kinase 3 Rattus norvegicus 233-239 22268112-9 2012 These results suggest that H(2)O(2) increases the expression of G(i)alpha proteins in VSMC through the transactivation of EGF-R/PDGF-R and ERK1/2 and phosphatidylinositol-3 kinase signaling pathways. Hydrogen Peroxide 27-35 mitogen activated protein kinase 3 Rattus norvegicus 139-145 22134701-5 2012 Exposure of H9c2 cells to CoCl(2) or hydrogen peroxide (H(2)O(2)) upregulated expression of phosphorylated (p) ERK1/2, which was reduced by pretreatment with NaHS or N-acetyl-L-cysteine, a ROS scavenger. Hydrogen Peroxide 37-54 mitogen activated protein kinase 3 Rattus norvegicus 111-117 22134701-5 2012 Exposure of H9c2 cells to CoCl(2) or hydrogen peroxide (H(2)O(2)) upregulated expression of phosphorylated (p) ERK1/2, which was reduced by pretreatment with NaHS or N-acetyl-L-cysteine, a ROS scavenger. Hydrogen Peroxide 56-64 mitogen activated protein kinase 3 Rattus norvegicus 111-117 20629637-4 2010 Results indicated that the MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase] inhibitor (PD98059) and 10 muM Sal B remarkably prevented BMSCs from H2O2-induced apoptosis through attenuating caspase-3 activation, which is accompanied by the significant up-regulation of Bcl-2. Hydrogen Peroxide 193-197 mitogen activated protein kinase 3 Rattus norvegicus 32-36 23109870-5 2012 The data obtained suggest that inhibition by alpha-tocopherol in late stage ERK 1/2 and Akt activation induced by H(2)O(2) in PC12 cells makes contribution to its protective effect, while total inhibition of these enzymes is not protective. Hydrogen Peroxide 114-122 mitogen activated protein kinase 3 Rattus norvegicus 76-83 21960664-0 2011 3-(2,6-dimethylphenyl)-2-selenoxo-1,3-thiazolidin-4-one suppresses hydrogen peroxide-induced cytotoxicity on PC12 cells via activation of MAPK. Hydrogen Peroxide 67-84 mitogen activated protein kinase 3 Rattus norvegicus 138-142 21258655-2 2011 Application of hydrogen peroxide to PC12 cells activated multiple tyrosine kinases (c-Src, epidermal growth factor receptor (EGFR), and Pyk2) and the serine-threonine kinase ERK1/2. Hydrogen Peroxide 15-32 mitogen activated protein kinase 3 Rattus norvegicus 174-180 22097737-0 2011 [Effect of ERK1/2 signaling pathway on astragaloside IV protects H9c2 cells against H2O2-induced oxidative injury]. Hydrogen Peroxide 84-88 mitogen activated protein kinase 3 Rattus norvegicus 11-17 22097737-10 2011 Treated with 10 mg/L or 20 mg/L of AST, expression of p-ERK1/2 in H9c2 cells injured from H2O2 was increased significantly (P < 0.01), when PD98059 (inhibitor of ERK1/2) was added, the effects of AST were cancelled. Hydrogen Peroxide 90-94 mitogen activated protein kinase 3 Rattus norvegicus 56-62 22097737-11 2011 CONCLUSION: AST protects H9c2 cells against H2O2-induced oxidative injury partly through ERK1/2 signaling pathway. Hydrogen Peroxide 44-48 mitogen activated protein kinase 3 Rattus norvegicus 89-95 21094128-0 2011 MAPK signaling in H9c2 cardiomyoblasts exposed to cholesterol secoaldehyde--role of hydrogen peroxide. Hydrogen Peroxide 84-101 mitogen activated protein kinase 3 Rattus norvegicus 0-4 21094128-8 2011 Overall, these findings are consistent with MAPK signaling resulting from increased cellular H(2)O(2) in ChSeco-induced cytotoxicity in cardiomyoblasts. Hydrogen Peroxide 93-101 mitogen activated protein kinase 3 Rattus norvegicus 44-48 20629637-6 2010 Furthermore, Sal B inhibited the ERK1/2 phosphorylations stimulated by H2O2. Hydrogen Peroxide 71-75 mitogen activated protein kinase 3 Rattus norvegicus 33-39 20629637-7 2010 Taken together, our results showed that H2O2-induced apoptosis in BMSCs via the ROS/MEK/ERK1/2 pathway and Sal B may exert its cytoprotection through mediating the pathway. Hydrogen Peroxide 40-44 mitogen activated protein kinase 3 Rattus norvegicus 88-94 20495008-8 2010 Long term activation of ERK1/2 by NGF requires SOD activation, low levels of hydrogen peroxide, and the integrity of the microtubular cytoskeleton. Hydrogen Peroxide 77-94 mitogen activated protein kinase 3 Rattus norvegicus 24-30 20868529-5 2010 In response to H2O2, overexpressing SH2B1beta enhanced PI3K (phosphatidylinositol 3-kinas)-AKT (protein kinase B) and MEK (MAPK/ERK kinase)-extracellular-signal regulated kinases 1 and 2 (ERK1/2) signaling pathways. Hydrogen Peroxide 15-19 mitogen activated protein kinase 3 Rattus norvegicus 123-127 20868529-5 2010 In response to H2O2, overexpressing SH2B1beta enhanced PI3K (phosphatidylinositol 3-kinas)-AKT (protein kinase B) and MEK (MAPK/ERK kinase)-extracellular-signal regulated kinases 1 and 2 (ERK1/2) signaling pathways. Hydrogen Peroxide 15-19 mitogen activated protein kinase 3 Rattus norvegicus 188-194 20868529-6 2010 We further demonstrated that SH2B1beta was able to reduce H2O2-induced nuclear localization of FoxO1 and 3a transcription factors, which lie downstream of PI3K-AKT and MEK-ERK1/2 pathways. Hydrogen Peroxide 58-62 mitogen activated protein kinase 3 Rattus norvegicus 172-178 20868529-8 2010 CONCLUSIONS: Overexpressing the adaptor protein SH2B1beta enhanced H2O2-induced PI3K-AKT and MEK-ERK1/2 signaling, reduced nucleus-localized FoxOs and the expression of a pro-apoptotic gene, FasL. Hydrogen Peroxide 67-71 mitogen activated protein kinase 3 Rattus norvegicus 97-103 20495008-11 2010 Local activation of ERK1/2 by Ki-Ras stimulates mitochondrial SOD, which reduces reactive oxygen species and produces H(2)O(2). Hydrogen Peroxide 118-126 mitogen activated protein kinase 3 Rattus norvegicus 20-26 20302682-3 2010 The extracellular signal-regulated protein kinase 1/2 (ERK1/2)-connexin 43 (Cx43) signalling pathway is crucial for the regulation of GJIC, and both GOK and GRK blocked the H2O2-induced phosphorylation of Cx43 and ERK1/2 in WB-F344 cells. Hydrogen Peroxide 173-177 mitogen activated protein kinase 3 Rattus norvegicus 55-61 20302682-3 2010 The extracellular signal-regulated protein kinase 1/2 (ERK1/2)-connexin 43 (Cx43) signalling pathway is crucial for the regulation of GJIC, and both GOK and GRK blocked the H2O2-induced phosphorylation of Cx43 and ERK1/2 in WB-F344 cells. Hydrogen Peroxide 173-177 mitogen activated protein kinase 3 Rattus norvegicus 214-220 20302682-4 2010 Quercetin alone attenuated the H2O2-mediated ERK1/2-Cx43 signalling pathway and consequently reversed H2O2-mediated inhibition of GJIC in WB-F344 cells. Hydrogen Peroxide 31-35 mitogen activated protein kinase 3 Rattus norvegicus 45-51 20302682-4 2010 Quercetin alone attenuated the H2O2-mediated ERK1/2-Cx43 signalling pathway and consequently reversed H2O2-mediated inhibition of GJIC in WB-F344 cells. Hydrogen Peroxide 102-106 mitogen activated protein kinase 3 Rattus norvegicus 45-51