PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9441903-2 1997 A 6-h preincubation with linsidomine (SIN-1, 0.5 mM) protected endothelial cells from hydrogen peroxide-dependent cytotoxicity and increased the surviving endothelial cell fraction by 85%. Hydrogen Peroxide 86-103 MAPK associated protein 1 Homo sapiens 38-43 9582295-4 1998 Whereas in mere phosphate buffer H2O2 formation from 1.5 mM SIN-1 was low ( approximately 15 microM), incubation of SIN-1 with Good"s buffer compounds resulted in continuous H2O2 formation. Hydrogen Peroxide 174-178 MAPK associated protein 1 Homo sapiens 116-121 9582295-5 1998 After 2 h of incubation of 1.5 mM SIN-1 with 20 mM HEPES about 190 microM H2O2 were formed. Hydrogen Peroxide 74-78 MAPK associated protein 1 Homo sapiens 34-39 9582295-6 1998 The same amount of H2O2 could be achieved from 1.5 mM SIN-1 by action of superoxide dismutase in the absence of HEPES. Hydrogen Peroxide 19-23 MAPK associated protein 1 Homo sapiens 54-59 9582295-9 1998 Furthermore, the peroxynitrite scavenger tryptophan significantly reduced H2O2 formation from SIN-1-HEPES interactions. Hydrogen Peroxide 74-78 MAPK associated protein 1 Homo sapiens 94-99 9202724-3 1997 In the present study, we have compared SIN-1, which generates nitric oxide, superoxide anion and hydrogen peroxide, with two other nitric oxide donors, S-nitrosoglutathione (GSNO) and the tetra-iron-sulphur cluster nitrosyl, Roussin"s black salt (RBS). Hydrogen Peroxide 97-114 MAPK associated protein 1 Homo sapiens 39-44 9202724-12 1997 In addition, H2O2 may be formed in the presence of SIN-1 and may form hydroxyl radical in the presence of a transition metal, such as Fe2+. Hydrogen Peroxide 13-17 MAPK associated protein 1 Homo sapiens 51-56 21497204-8 2011 SIN-1 decomposition products, NO and superoxide anion or peroxynitrite, induced greater cytotoxicity in lymphocyte cultures (separately and in whole blood) supplemented with HEPES - the organic buffer that is widely used to maintain stable physiological pH in cell cultures -, due to H(2)O(2) production, than in cultures without HEPES. Hydrogen Peroxide 284-292 MAPK associated protein 1 Homo sapiens 0-5 8660704-7 1996 3-Morpholinosynodiomine.HCl (SIN-1) and sodium nitroprusside (SNP) enhanced hydrogen peroxide-mediated cytotoxicity, while S-nitrosoglutathione (GSNO), and S-nitroso-N-acetylpenicillamine (SNAP) afforded protection. Hydrogen Peroxide 76-93 MAPK associated protein 1 Homo sapiens 29-34 8769740-7 1996 Cells previously exposed to SNAP and SIN-1 exhibited a significant protection against the cytotoxicity mediated by hydrogen peroxide (250 microM) (P < 0.05). Hydrogen Peroxide 115-132 MAPK associated protein 1 Homo sapiens 37-42 7673115-11 1995 In the presence of SIN-1, Mn-SOD increased accumulation of H2O2 in a concentration-dependent manner. Hydrogen Peroxide 59-63 MAPK associated protein 1 Homo sapiens 19-24 7673115-12 1995 In contrast, Cu,Zn-SOD increased H2O2 accumulation from SIN-1 at low but not high concentrations of the enzyme, suggesting that high concentrations of the Cu,Zn-SOD interacted with the H2O2. Hydrogen Peroxide 33-37 MAPK associated protein 1 Homo sapiens 56-61 7673115-12 1995 In contrast, Cu,Zn-SOD increased H2O2 accumulation from SIN-1 at low but not high concentrations of the enzyme, suggesting that high concentrations of the Cu,Zn-SOD interacted with the H2O2. Hydrogen Peroxide 185-189 MAPK associated protein 1 Homo sapiens 56-61 24639107-8 2014 We found that exposure to exogenous H2O2 or incubation of dispersed gastric muscle cells with SIN-1 significantly increased the expression of calponin, caldesmon, and smoothelin proteins. Hydrogen Peroxide 36-40 MAPK associated protein 1 Homo sapiens 94-99 23567270-6 2013 Purified, recombinant PGIS showed a half-maximal nitration by 10 muM 3-morpholino sydnonimine (Sin-1) which increased in the presence of bicarbonate, and was only marginally induced by freely diffusing NO2-radicals generated by a peroxidase/nitrite/hydrogen peroxide system. Hydrogen Peroxide 249-266 MAPK associated protein 1 Homo sapiens 95-100 15686499-6 2005 It is concluded that L-type Ca2+ channels are a primary target of SIN-1-induced extracellular nitrosative/oxidative stress, being inactivated by chronic exposure to fluxes of peroxynitrite of 0.5-1 microm/min, while higher concentrations of peroxynitrite and hydrogen peroxide are required for the inhibition of the plasma membrane Ca2+ ATPase and induction of necrotic cell death, respectively. Hydrogen Peroxide 259-276 MAPK associated protein 1 Homo sapiens 66-71 18841468-3 2009 We demonstrated in vitro that the amount of ONOO(-) generated and H(2)O(2) formation directly correlated with SIN-1 concentration. Hydrogen Peroxide 66-74 MAPK associated protein 1 Homo sapiens 110-115 15622856-5 2004 NADH was found to be less sensitive than dihydrorhodamine 123 and 2",7"-dichlorodihydrofluorescein diacetate to oxidation by H2O2, which is produced during SIN-1 decomposition in common buffers. Hydrogen Peroxide 125-129 MAPK associated protein 1 Homo sapiens 156-161 12466224-7 2002 Hydroxycobalamin, a NO scavenger, but not superoxide dismutase and catalase, enzymes that metabolize superoxide and hydrogen peroxide, respectively, abolished the inhibitory effect of DEA/NO and SIN-1, indicating that they inhibit DA uptake through a mechanism related to the production of NO but unrelated to the formation of peroxynitrite. Hydrogen Peroxide 116-133 MAPK associated protein 1 Homo sapiens 195-200 12417336-4 2002 In addition, we show that, in contrast to the reversible inhibition of NSM1 by H2O2 or GSSG which involves the formation of disulfide bonds, irreversible inactivation of this enzyme by peroxynitrite generated from SIN1 is likely due to definitive oxidative thiol modification. Hydrogen Peroxide 79-83 MAPK associated protein 1 Homo sapiens 214-218 11677273-9 2001 and the subsequently formed H(2)O(2) by superoxide dismutase (SOD) plus catalase likewise prevented the nitration of protein-bound tyrosine but actually enhanced the cytotoxicity of SIN-1, indicating that cortical cells can cope with the oxidative but not the nitrosative stress generated. Hydrogen Peroxide 28-36 MAPK associated protein 1 Homo sapiens 182-187 10471084-2 1999 In this context, we have previously shown that cyclic GMP elevations confer cytoprotection against the neurotoxicity induced by SIN-1 in the presence of superoxide dismutase, conditions in which cell death seems to be a consequence of hydrogen peroxide (H2O2) formation. Hydrogen Peroxide 235-252 MAPK associated protein 1 Homo sapiens 128-133 10471084-2 1999 In this context, we have previously shown that cyclic GMP elevations confer cytoprotection against the neurotoxicity induced by SIN-1 in the presence of superoxide dismutase, conditions in which cell death seems to be a consequence of hydrogen peroxide (H2O2) formation. Hydrogen Peroxide 254-258 MAPK associated protein 1 Homo sapiens 128-133