PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2160522-6 1990 In addition, OM-89 treatment induced marked PMA-dependent superoxide and hydrogen peroxide release by macrophages from the LPS low responder mouse strain C3H/HeJ. Hydrogen Peroxide 73-90 toll-like receptor 4 Mus musculus 123-126 8774698-6 1996 Upon treatment with LPS, H2O2 was produced, the nuclear proto-oncogenes fos and jun were activated, then the HO gene was activated. Hydrogen Peroxide 25-29 toll-like receptor 4 Mus musculus 20-23 8774698-11 1996 Super-shift assays with DNA that contained the TRE motif revealed that the Fos and Jun proteins from nuclei of M1 cells treated with LPS and H2O2 bound weakly to the TRE motif, and, in assays with DNA that contained the NF-kappa B motif, nuclear protein from M1 cells treated with H2O2 or LPS bound strongly to the NF-kappa B motif. Hydrogen Peroxide 141-145 toll-like receptor 4 Mus musculus 289-292 8774698-11 1996 Super-shift assays with DNA that contained the TRE motif revealed that the Fos and Jun proteins from nuclei of M1 cells treated with LPS and H2O2 bound weakly to the TRE motif, and, in assays with DNA that contained the NF-kappa B motif, nuclear protein from M1 cells treated with H2O2 or LPS bound strongly to the NF-kappa B motif. Hydrogen Peroxide 281-285 toll-like receptor 4 Mus musculus 133-136 8774698-12 1996 These results strongly suggest that the HO gene in M1 cells is mainly activated by LPS through oxidative activation of NF-kappa B due to production of H2O2. Hydrogen Peroxide 151-155 toll-like receptor 4 Mus musculus 83-86 22895517-5 2012 Stimulation by hydrogen peroxide, or the TLR4 ligands recombinant human high-mobility group protein B1 or lipopolysaccharide, induced PTX3 expression in the Mile Sven 1 endothelial cell line and in primary renal endothelial cells, suggesting that endothelial PTX3 was induced by pathways involving TLR4 and reactive oxygen species. Hydrogen Peroxide 15-32 toll-like receptor 4 Mus musculus 298-302 33940104-5 2021 Typically, PSF with UV/H2O2 treatment for 2 h (PSF-T2) could effectively inhibit pro-inflammatory molecules production (including NO, IL-1beta, IL-6 and TNF-alpha), and down-regulate related genes expression (including Tlr4, Irak, Il-1beta, Il-6, Il-12 and Tnf-alpha). Hydrogen Peroxide 23-27 toll-like receptor 4 Mus musculus 219-223 30208782-6 2018 In addition to inhibition of LPS-induced TLR4 signalling, FP7 negatively regulated TLR4 activation in response to ligands of sterile inflammation (hydroperoxide-rich oxidised LDL, in vitro and Angiotensin II infusion, in vivo). Hydrogen Peroxide 147-160 toll-like receptor 4 Mus musculus 83-87 33127391-9 2021 DUOX2 was exquisitely dependent on TLR4 signaling and mediated the production of epithelial H2O2. Hydrogen Peroxide 92-96 toll-like receptor 4 Mus musculus 35-39 33127391-10 2021 Epithelial H2O2 was significantly increased in villin-TLR4 mice; TLR4-dependent tumorigenesis required the presence of DUOX2 and a microbiota. Hydrogen Peroxide 11-15 toll-like receptor 4 Mus musculus 54-58 33127391-11 2021 Mucosa-associated microbiota transferred from villin-TLR4 mice to wild-type germ-free mice caused increased H2O2 production and tumorigenesis. Hydrogen Peroxide 108-112 toll-like receptor 4 Mus musculus 53-57 33127391-12 2021 CONCLUSIONS: Increased TLR4 signaling in colitis drives expression of DUOX2 and epithelial production of H2O2. Hydrogen Peroxide 105-109 toll-like receptor 4 Mus musculus 23-27 33086058-2 2020 Here we show that Src homology 3 (SH3) domain-containing YSC84-like 1 (SH3YL1), as a Nox4 cytosolic regulator, mediates lipopolysaccharide (LPS)-induced H2O2 generation, leading to acute kidney injury. Hydrogen Peroxide 153-157 toll-like receptor 4 Mus musculus 140-143 33086058-7 2020 We demonstrate that formation of a ternary complex of p22phox-SH3YL1-Nox4, leading to H2O2 generation, induces severe renal failure in the LPS-induced AKI model. Hydrogen Peroxide 86-90 toll-like receptor 4 Mus musculus 139-142 31299629-5 2019 Intracellular hydrogen peroxide was then measured in response to the interaction of the lipopolysaccharides, present on the outer wall of Gram-negative bacteria, with the Toll-like Receptor 4. Hydrogen Peroxide 14-31 toll-like receptor 4 Mus musculus 171-191 25944793-6 2015 Using hydrogen peroxide in vitro and hemorrhagic shock/resuscitation in vivo, oxidant-induced TLR4 translocation in macrophages occurred in an Src-dependent manner. Hydrogen Peroxide 6-23 toll-like receptor 4 Mus musculus 94-98 29156799-11 2017 In vitro, AA concentration-dependently inhibited LPS/H2O2-induced NLRP3 inflammaosome activation in KCs and RAW264.7 cells. Hydrogen Peroxide 53-57 toll-like receptor 4 Mus musculus 49-52 29156799-13 2017 Mechanistically, AA attenuated I/R or LPS/H2O2-induced ROS production and phosphorylation level of JNK, p38 MAPK and IkappaBalpha but not ERK, a mechanism dependent on PPARgamma. Hydrogen Peroxide 42-46 toll-like receptor 4 Mus musculus 38-41 28115850-9 2017 TLR4/NF-kappaB and Nrf2 pathways were upregulated with high-fat diet intake in mice, resulting in reduction of superoxide dismutase activity and increase in superoxide radical, H2O2, malondialdehyde, XO, XDH, and XO/XDH ratio. Hydrogen Peroxide 177-181 toll-like receptor 4 Mus musculus 0-4 23734265-0 2013 TLR4 ligand/H2O2 enhances TGF-beta1 signaling to induce metastatic potential of non-invasive breast cancer cells by activating non-Smad pathways. Hydrogen Peroxide 12-16 toll-like receptor 4 Mus musculus 0-4 24070585-7 2013 LPS increased production of TNF-alpha, ROS, and H2O2 and expression of gp91(phox), an active subunit of NADPH oxidase, in a dose- and time-dependent manner, which was significantly reduced by TTX or TTX+cariporide. Hydrogen Peroxide 48-52 toll-like receptor 4 Mus musculus 0-3 23328933-5 2013 The generation of superoxide which is dismutated to hydrogen peroxide upregulates the intracellular toll like receptors (TLR) 7 and 8, and leads to robust production of inflammatory cytokines. Hydrogen Peroxide 52-69 toll-like receptor 4 Mus musculus 121-124 22145029-5 2011 Increasing endogenous H(2)O(2) attenuates p38-MAPK activity in IFNgamma/LPS stimulated WT and p47(phox-/-) DC, which suggests that endogenous Nox 2-derived ROS functions as a secondary messenger in the activated p38-MAPK signaling pathway during IL-12 expression. Hydrogen Peroxide 22-30 toll-like receptor 4 Mus musculus 72-75 20927041-3 2011 This increase was probably due to reactive oxygen species, known to be generated early during ischemic AKI, because the addition of hydrogen peroxide increased TLR4 expression in MS1 microvascular endothelial cells in vitro. Hydrogen Peroxide 132-149 toll-like receptor 4 Mus musculus 160-164 18620044-5 2008 This compound inhibited LPS- and H(2)O(2)-induced increases in phosphatidylinositol 3-kinase (PI3K) activity, PTEN inactivation, NF-kappaB-inducing kinase (NIK), and Akt phosphorylation, which are all upstream of IKK activation, but did not affect the interaction between Toll-like receptor 4 and MyD88 and the activation of mitogen-activated protein kinases. Hydrogen Peroxide 33-41 toll-like receptor 4 Mus musculus 272-292 18059323-12 2008 However, the effects of cigarette smoke extract on LPS-induced nitrite formation were mimicked by hydrogen peroxide and reversed by the anti-oxidants N-acetyl cysteine and glutathione. Hydrogen Peroxide 98-115 toll-like receptor 4 Mus musculus 51-54 16973969-6 2006 LPS treatment enhanced protein levels of p22(phox), a catalytic subunit of NADPH oxidase, and increased NADPH oxidase activity and levels of superoxide radicals and hydrogen peroxide. Hydrogen Peroxide 165-182 toll-like receptor 4 Mus musculus 0-3 15758255-8 2004 Similar to the effects of LPS, treatment of Leydig cells with hydrogen peroxide acutely inhibited steroidogenesis, reduced StAR and 3beta-HSD protein levels, and disrupted DeltaPsim. Hydrogen Peroxide 62-79 toll-like receptor 4 Mus musculus 26-29 10936514-1 2000 H(2)O(2) produced a marked and dose-related inhibition of both lipopolysaccharide (LPS)-induced B-cell proliferation and concanavalin A (Con A)-induced T-cell proliferation. Hydrogen Peroxide 0-8 toll-like receptor 4 Mus musculus 83-86 10936514-5 2000 In addition, H(2)O(2) pretreatment blocked the phosphorylation of two stress-activated mitogen-activated protein kinases (MAPKs), c-Jun N-terminal kinase (JNK) and p38 by LPS in a concentration-dependent fashion. Hydrogen Peroxide 13-21 toll-like receptor 4 Mus musculus 171-174