PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9113418-7	1997	PD98059, a specific inhibitor of MEK1, attenuated the hydrogen peroxide-induced ERKs activation and c-fos and c-jun expression.	Hydrogen Peroxide	54-71	mitogen-activated protein kinase kinase 1	Homo sapiens	33-37	
14729104-8	2004	Furthermore, H(2)O(2)-mediated increases in ERK1/2 activation were sensitive to the MAPK kinase 1 (MEK1) inhibitor PD 98059 (2"-amino-3"-methoxyflavone), whereas JNK responses were blocked by the JNK inhibitor SP 600125 (anthra[1-9-cd]pyrazol-6(2H)-one).	Hydrogen Peroxide	13-21	mitogen-activated protein kinase kinase 1	Homo sapiens	99-103	
11495722-2	2001	Submillimolar concentrations of H(2)O(2)-induced phosphorylation of ERK1/2 and MAP/ERK kinase 1 and 2 (MEK1/2) without antigenic stimulation.	Hydrogen Peroxide	32-40	mitogen-activated protein kinase kinase 1	Homo sapiens	103-109	
10629214-10	2000	The specific MEK1/2 inhibitor, PD98059, completely blocked the effects of H(2)O(2) on import.	Hydrogen Peroxide	74-82	mitogen-activated protein kinase kinase 1	Homo sapiens	13-19	
29983082-0	2018	Orexin-A protects SH-SY5Y cells against H2O2-induced oxidative damage via the PI3K/MEK1/2/ERK1/2 signaling pathway.	Hydrogen Peroxide	40-44	mitogen-activated protein kinase kinase 1	Homo sapiens	83-89	
29983082-6	2018	Pre-treatment with Orexin-A also attenuated H2O2-induced increases in phosphorylation of MEK1/2 and ERK1/2.	Hydrogen Peroxide	44-48	mitogen-activated protein kinase kinase 1	Homo sapiens	89-95	
29983082-9	2018	These results show that the PI3K/MEK1/2/ERK1/2 signaling pathway is involved in the neuroprotective effects of Orexin-A against H2O2-induced oxidative damage in SH-SY5Y cells.	Hydrogen Peroxide	128-132	mitogen-activated protein kinase kinase 1	Homo sapiens	33-39	
18982020-7	2008	Similar to the mpk4 and mekk1 mutants, the mkk1 mkk2 double mutant seedlings accumulate high levels of H2O2, display spontaneous cell death, constitutively express Pathogenesis Related (PR) genes and exhibit pathogen resistance.	Hydrogen Peroxide	103-107	mitogen-activated protein kinase kinase 1	Homo sapiens	43-47	
24726849-7	2014	The use of U0126, a specific inhibitor of MEK1/2, proved that H2O2-induced decrease of occludin in EA.hy926 cells was likely associated with activation of ERK1/2, which indicated that the regulation of farrerol on occludin expression in H2O2-induced EA.hy926 cells was likely related to the modulation of ERK1/2 activation.	Hydrogen Peroxide	62-66	mitogen-activated protein kinase kinase 1	Homo sapiens	42-48	
26950103-5	2016	These activities could be attributed to the inhibition of the H2O2-induced phosphorylation of MAP/ERK kinase 1 (MEK1) and p44/42 mitogen-activated protein kinases (MAPK), and to the antioxidant activity of achillolide A, but not to H2O2 scavenging.	Hydrogen Peroxide	62-66	mitogen-activated protein kinase kinase 1	Homo sapiens	112-116	
26950103-5	2016	These activities could be attributed to the inhibition of the H2O2-induced phosphorylation of MAP/ERK kinase 1 (MEK1) and p44/42 mitogen-activated protein kinases (MAPK), and to the antioxidant activity of achillolide A, but not to H2O2 scavenging.	Hydrogen Peroxide	232-236	mitogen-activated protein kinase kinase 1	Homo sapiens	112-116	
24695490-9	2014	However, preventing ERK1/2 activation further increased H2O2-induced cell death with U0126, an inhibitor of ERK upstream kinase MEK1/2.	Hydrogen Peroxide	56-60	mitogen-activated protein kinase kinase 1	Homo sapiens	128-134	
21344509-3	2011	Our study revealed that FK228 combined with exogenous H(2)O(2) cooperatively induced activation of Mek1/2 and Erk1/2 to increase Nox-1 elevation, intracellular ROS production, caspase activation, and cell death.	Hydrogen Peroxide	54-62	mitogen-activated protein kinase kinase 1	Homo sapiens	99-105	
19038233-0	2009	trans-Resveratrol inhibits H2O2-induced adenocarcinoma gastric cells proliferation via inactivation of MEK1/2-ERK1/2-c-Jun signalling axis.	Hydrogen Peroxide	27-31	mitogen-activated protein kinase kinase 1	Homo sapiens	103-109	
19038233-2	2009	We demonstrate that H(2)O(2) accelerates cell growth and induces a prompt MEK1/2-ERK1/2 activation.	Hydrogen Peroxide	20-28	mitogen-activated protein kinase kinase 1	Homo sapiens	74-80	
18339970-4	2008	In contrast, overexpression of active MEK1 enhanced H2O2-induced cell death.	Hydrogen Peroxide	52-56	mitogen-activated protein kinase kinase 1	Homo sapiens	38-42	
17397968-7	2007	Gene expression microarrays were employed to examine the specific transcriptional changes in N27 cells exposed to 100 microM H2O2 for 4 h. Changes in genes encoding pro- or anti-apoptotic proteins included up-regulation of BIK, PAWR, STAT5B, NPAS2, Jun B, MEK4, CCT7, PPP3CC, and PSDM3, while key down-regulated genes included BNIP3, NPTXR, RAGA, STK6, YWHAH, and MAP2K1.	Hydrogen Peroxide	125-129	mitogen-activated protein kinase kinase 1	Homo sapiens	364-370	
15895830-7	2005	The ERK activation and cell death induced by H2O2 was prevented by catalase, the hydrogen peroxide scavenger, and U0126, an inhibitor of ERK upstream kinase MEK1/2.	Hydrogen Peroxide	45-49	mitogen-activated protein kinase kinase 1	Homo sapiens	157-163	
15895830-8	2005	Transient transfection with constitutive active MEK1, an upstream activator of ERK1/2, increased H2O2-induced cell death, whereas transfection with dominant-negative mutants of MEK1 decreased the cell death.	Hydrogen Peroxide	97-101	mitogen-activated protein kinase kinase 1	Homo sapiens	48-52	
15895830-8	2005	Transient transfection with constitutive active MEK1, an upstream activator of ERK1/2, increased H2O2-induced cell death, whereas transfection with dominant-negative mutants of MEK1 decreased the cell death.	Hydrogen Peroxide	97-101	mitogen-activated protein kinase kinase 1	Homo sapiens	177-181	
16125295-8	2005	Cell death induced by H2O2 was prevented by PD98059, an inhibitor of ERK upstream kinase MEK1/2.	Hydrogen Peroxide	22-26	mitogen-activated protein kinase kinase 1	Homo sapiens	89-95	
16050986-5	2005	Cell cultures were exposed to the MEK1/2 inhibitor, UO126, subsequent to H2O2+/-17beta-E2 treatment and the DeltaPsi(m) examined using JC-1, a potentiometric dye which serves as an indicator for the state of mitochondrial membrane potential.	Hydrogen Peroxide	73-77	mitogen-activated protein kinase kinase 1	Homo sapiens	34-40