PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34663173-0 2021 Genistein alleviates H2O2-induced senescence of human umbilical vein endothelial cells via regulating the TXNIP/NLRP3 axis. Hydrogen Peroxide 21-25 NLR family pyrin domain containing 3 Homo sapiens 112-117 34696918-7 2022 Treatment with H2O2 + VD decreased gene/protein expression of NLRP1, NLRP3, caspase-1, HMGB1, IL-1beta, TNF-alpha and IL-18 in PE and NT explants with H2O2. Hydrogen Peroxide 15-19 NLR family pyrin domain containing 3 Homo sapiens 69-74 34696918-7 2022 Treatment with H2O2 + VD decreased gene/protein expression of NLRP1, NLRP3, caspase-1, HMGB1, IL-1beta, TNF-alpha and IL-18 in PE and NT explants with H2O2. Hydrogen Peroxide 151-155 NLR family pyrin domain containing 3 Homo sapiens 69-74 34965405-9 2022 NLRP3, caspase-1 and IL1-beta expression significantly increased in human lens cells exposed to H2O2 or irradiated with white LED light. Hydrogen Peroxide 96-100 NLR family pyrin domain containing 3 Homo sapiens 0-5 34663173-9 2021 Expressions of TXNIP and NLRP3 in HUVECs were up-regulated by H2O2 but down-regulated by Gen. Overexpressed TXNIP partially reversed the suppressive effect of Gen on H2O2-induced senescence and apoptosis of HUVECs. Hydrogen Peroxide 62-66 NLR family pyrin domain containing 3 Homo sapiens 25-30 34663173-9 2021 Expressions of TXNIP and NLRP3 in HUVECs were up-regulated by H2O2 but down-regulated by Gen. Overexpressed TXNIP partially reversed the suppressive effect of Gen on H2O2-induced senescence and apoptosis of HUVECs. Hydrogen Peroxide 166-170 NLR family pyrin domain containing 3 Homo sapiens 25-30 34663173-11 2021 DISCUSSION AND CONCLUSIONS: H2O2-induced HUVEC senescence was alleviated by Gen via suppressing the TXNIP/NLRP3 axis, which may offer a potential therapeutic approach for improving HUVEC senescence and provide a new direction for the treatment of cardiovascular disease. Hydrogen Peroxide 28-32 NLR family pyrin domain containing 3 Homo sapiens 106-111 34696918-0 2022 Vitamin D decreases expression of NLRP1 and NLRP3 ninflammasomes in placental explants from women with preeclampsia cultured with hydrogen peroxide. Hydrogen Peroxide 130-147 NLR family pyrin domain containing 3 Homo sapiens 44-49 34696918-6 2022 Placental explants from NT cultured with H2O2 showed increased gene and protein expression of NLRP1, NLRP3, caspase-1, IL-1beta, TNF-alpha and HMGB1, while H2O2 was also able to increase TNF-alpha and caspase-1 gene expression in PE. Hydrogen Peroxide 41-45 NLR family pyrin domain containing 3 Homo sapiens 101-106 34663173-8 2021 H2O2-induced HUVEC senescence and the expression of TXNIP and NLRP3 in HUVECs were down-regulated by Gen (40 and 80 microg/mL). Hydrogen Peroxide 0-4 NLR family pyrin domain containing 3 Homo sapiens 62-67 34745125-3 2021 Furthermore, the NLRP3 agonists H2O2 and MSU elicited IL-1beta maturation without inducing specks. Hydrogen Peroxide 32-36 NLR family pyrin domain containing 3 Homo sapiens 17-22 32546974-0 2020 Epigallocatechin-3-Gallate Protects H2O2-Induced Nucleus Pulposus Cell Apoptosis and Inflammation by Inhibiting cGAS/Sting/NLRP3 Activation. Hydrogen Peroxide 36-40 NLR family pyrin domain containing 3 Homo sapiens 123-128 34614009-8 2021 Additionally, treatment with C3G resulted in a significant reduction in the protein expression of inflammatory markers IL-1beta and NLRP3 (p<0.01) as well as an increase in LC3 autophagic marker (p<0.05) in human islets treated with amylin, Abeta1-42, rapamycin, or H2O2. Hydrogen Peroxide 266-270 NLR family pyrin domain containing 3 Homo sapiens 132-137 34515145-0 2022 Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1beta Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells. Hydrogen Peroxide 0-17 NLR family pyrin domain containing 3 Homo sapiens 33-38 34515145-6 2022 We demonstrate that H2O2 primes as well as activates the NLRP3 inflammasome and thereby mediates IL-1beta production and release. Hydrogen Peroxide 20-24 NLR family pyrin domain containing 3 Homo sapiens 57-62 35506157-7 2022 Furthermore, we also demonstrated that GAA suppressed the activation of TLR4/NLRP3 in H2O2-stimulated NP cells. Hydrogen Peroxide 86-90 NLR family pyrin domain containing 3 Homo sapiens 77-82 35506157-8 2022 Thus, our results demonstrate that GAA inhibited the H2O2 induced apoptosis, oxidative stress, and inflammatory responses through the depression of TLR4/NLRP3 signaling axis. Hydrogen Peroxide 53-57 NLR family pyrin domain containing 3 Homo sapiens 153-158 33383234-9 2021 H2O2 supplementation elevated the expression of NLRP3 inflammasome and increased IL-1beta secretion in ITP platelets. Hydrogen Peroxide 0-4 NLR family pyrin domain containing 3 Homo sapiens 48-53 33383234-11 2021 Pretreating ITP platelets with NLRP3 inhibitor MCC950 or caspase-1 inhibitor Z-YVAD-FMK significantly reduced the proportion of pyroptotic cells in H2O2-treated ITP platelets and suppressed IL-1beta secretion in supernatants. Hydrogen Peroxide 148-152 NLR family pyrin domain containing 3 Homo sapiens 31-36 32983576-8 2020 Nod-like receptors pyrins-3 (NLRP3), caspase-1, Pro-IL-1beta, and IL-1beta levels were pronouncedly elevated in cells exposed to H2O2. Hydrogen Peroxide 129-133 NLR family pyrin domain containing 3 Homo sapiens 0-27 32983576-8 2020 Nod-like receptors pyrins-3 (NLRP3), caspase-1, Pro-IL-1beta, and IL-1beta levels were pronouncedly elevated in cells exposed to H2O2. Hydrogen Peroxide 129-133 NLR family pyrin domain containing 3 Homo sapiens 29-34 32347316-6 2020 RESULTS: In hydrogen peroxide (H2O2)-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1beta, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis). Hydrogen Peroxide 12-29 NLR family pyrin domain containing 3 Homo sapiens 263-268 32347316-6 2020 RESULTS: In hydrogen peroxide (H2O2)-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1beta, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis). Hydrogen Peroxide 31-35 NLR family pyrin domain containing 3 Homo sapiens 263-268 32347316-10 2020 CONCLUSIONS: The NLRP3 inflammasome was activated by elevated mitoROS levels and mediated HBx-induced liver inflammation and hepatocellular pyroptosis under H2O2-stress conditions. Hydrogen Peroxide 157-161 NLR family pyrin domain containing 3 Homo sapiens 17-22 32546974-10 2020 Advanced in-vitro study showed that H2O2 significantly increased the expression of cGAS, Sting and NLRP3 protein levels. Hydrogen Peroxide 36-40 NLR family pyrin domain containing 3 Homo sapiens 99-104 32546974-13 2020 Our findings also suggest that EGCG treatment would provide anti-apoptosis, anti-inflammation and promote cell viability in H2O2 treatment-incubated NPCs through inhibiting cGAS/Sting/NLRP3 pathway. Hydrogen Peroxide 124-128 NLR family pyrin domain containing 3 Homo sapiens 184-189 31805556-1 2020 BACKGROUNDS/AIMS: To explore whether NLRP3 is involved in the development of cataract and to study the effect of NLRP3 on hydrogen peroxide (H2O2)-induced injury in human lens epithelial cells. Hydrogen Peroxide 122-139 NLR family pyrin domain containing 3 Homo sapiens 113-118 30323145-8 2018 We found that H2O2 treatment activated NLRP3 inflammasomes and decreased phosphorylation of signal transduction and STAT3 serine 727. Hydrogen Peroxide 14-18 NLR family pyrin domain containing 3 Homo sapiens 39-44 31383789-8 2019 Mechanistically, Dex attenuated H2O2-mediated activation of NF-kappaB and NACHT, LRR, and PYD domains-containing protein 3 (NLRP3), both of which play key roles in inflammation and inflammatory damage. Hydrogen Peroxide 32-36 NLR family pyrin domain containing 3 Homo sapiens 74-122 31383789-8 2019 Mechanistically, Dex attenuated H2O2-mediated activation of NF-kappaB and NACHT, LRR, and PYD domains-containing protein 3 (NLRP3), both of which play key roles in inflammation and inflammatory damage. Hydrogen Peroxide 32-36 NLR family pyrin domain containing 3 Homo sapiens 124-129 30323145-9 2018 BAPTA-AM pretreatment abolished the H2O2-induced activation of NLRP3 inflammasomes, caspase-1 expression, interleukin-1beta expression and apoptosis in SHSY5Y cells, and had no effect in cells with downregulated STAT3 expression by RNAi. Hydrogen Peroxide 36-40 NLR family pyrin domain containing 3 Homo sapiens 63-68 28598074-5 2016 RESULTS: Compared with the control group,H2O2 not only increased the mRNA and protein expression levels of caspase-1 and NALP3 and the protein expression levels of p-ERK/ERK, but also enhanced the secretion of IL-1beta in human lung epithelial cells A549 (P<0.05),while SF group showed no statistic significance of those indicators above (P>0.05). Hydrogen Peroxide 41-45 NLR family pyrin domain containing 3 Homo sapiens 121-126 29196167-3 2018 Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion. Hydrogen Peroxide 98-102 NLR family pyrin domain containing 3 Homo sapiens 76-81 29196167-3 2018 Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion. Hydrogen Peroxide 98-102 NLR family pyrin domain containing 3 Homo sapiens 138-143 29196167-3 2018 Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion. Hydrogen Peroxide 98-102 NLR family pyrin domain containing 3 Homo sapiens 138-143 29196167-3 2018 Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion. Hydrogen Peroxide 103-107 NLR family pyrin domain containing 3 Homo sapiens 76-81 29196167-3 2018 Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion. Hydrogen Peroxide 103-107 NLR family pyrin domain containing 3 Homo sapiens 138-143 29196167-3 2018 Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion. Hydrogen Peroxide 103-107 NLR family pyrin domain containing 3 Homo sapiens 138-143 29196167-3 2018 Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion. Hydrogen Peroxide 103-107 NLR family pyrin domain containing 3 Homo sapiens 76-81 29196167-3 2018 Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion. Hydrogen Peroxide 103-107 NLR family pyrin domain containing 3 Homo sapiens 138-143 29196167-3 2018 Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion. Hydrogen Peroxide 103-107 NLR family pyrin domain containing 3 Homo sapiens 138-143 27614934-0 2016 Corrigendum to "Angiotensin(1-7) attenuated angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1beta/Smad circuit": [Free Radic. Hydrogen Peroxide 108-112 NLR family pyrin domain containing 3 Homo sapiens 123-128 28598074-6 2016 The Z-VAD group, the PD98059 group and the SF+H2O2 group resisted the effects of H2O2 on A549 cells by decreasing the mRNA and protein expressions of caspase-1 and NALP3,and the protein expression of p-ERK/ERK, as well as reducing the secretion of IL-1beta(P<0.05),when compared with the H2O2 group. Hydrogen Peroxide 81-85 NLR family pyrin domain containing 3 Homo sapiens 164-169 28598074-6 2016 The Z-VAD group, the PD98059 group and the SF+H2O2 group resisted the effects of H2O2 on A549 cells by decreasing the mRNA and protein expressions of caspase-1 and NALP3,and the protein expression of p-ERK/ERK, as well as reducing the secretion of IL-1beta(P<0.05),when compared with the H2O2 group. Hydrogen Peroxide 81-85 NLR family pyrin domain containing 3 Homo sapiens 164-169 29951874-6 2018 The maturation of IL-1beta, induced by H2O2, depends on the activation of the NLRP3 inflammasome. Hydrogen Peroxide 39-43 NLR family pyrin domain containing 3 Homo sapiens 78-83 29951874-7 2018 Cyclic stretching enhances the maturation of IL-1beta via promoting H2O2-induced NLRP3 inflammasome activation in tenocytes. Hydrogen Peroxide 68-72 NLR family pyrin domain containing 3 Homo sapiens 81-86 29971445-7 2018 Similarly, H2O2 upregulated TRPM2 protein expression by 80%, and induced both NLRP3 inflammasome activation and increased bioactive IL-1beta secretion (P <= 0.036), whereas ACA pretreatment suppressed these effects (P <= 0.029). Hydrogen Peroxide 11-15 NLR family pyrin domain containing 3 Homo sapiens 78-83 27929137-6 2016 We also revealed that inhibition of PKR suppressed H2O2 induced NFkappaB pathway and NLRP3 activation. Hydrogen Peroxide 51-55 NLR family pyrin domain containing 3 Homo sapiens 85-90 28598074-6 2016 The Z-VAD group, the PD98059 group and the SF+H2O2 group resisted the effects of H2O2 on A549 cells by decreasing the mRNA and protein expressions of caspase-1 and NALP3,and the protein expression of p-ERK/ERK, as well as reducing the secretion of IL-1beta(P<0.05),when compared with the H2O2 group. Hydrogen Peroxide 46-50 NLR family pyrin domain containing 3 Homo sapiens 164-169 22869553-3 2012 In this study, we used the isobaric tags for relative and absolute quantification approach to systemically analyze the interactomes of the NLRP3, AIM2, and RIG-I inflammasomes in nasopharyngeal carcinoma cells treated with specific stimuli of these interactomes (H2O2, poly (dA:dT), and EBV noncoding RNA, respectively). Hydrogen Peroxide 263-267 NLR family pyrin domain containing 3 Homo sapiens 139-144 26121854-5 2015 RESULTS: H2O2 not only increased the mRNA and protein expression levels of NALP3, but also enhanced the secretion of ILbeta1p in human lung epithelial cells A549 (P<0. Hydrogen Peroxide 9-13 NLR family pyrin domain containing 3 Homo sapiens 75-80 26121854-7 2015 NF-kappaB blockers PDTC and sodium ferulateresisted the effects of H2O2 on A549 cells, that decreased the mRNA and protein expression of NALP3 and the mRNA expression of NF-kappaB (P65), reduced the degeneration of IkappaBalpha and the secretion of IL-1beta (P<0. Hydrogen Peroxide 67-71 NLR family pyrin domain containing 3 Homo sapiens 137-142