PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23895226-6 2013 TGF-beta1-dependent HSC proliferation is mimicked by H2 O2 that is inhibited by catalase, implying that TGF-beta1 action is mediated via reactive oxygen species. Hydrogen Peroxide 53-58 transforming growth factor, beta 1 Mus musculus 0-9 24762191-10 2014 TGF-beta1-induced H2O2 and NOX-4 mRNA expression are also blocked by ATO. Hydrogen Peroxide 18-22 transforming growth factor, beta 1 Mus musculus 0-9 24260309-6 2013 beta3 promoted TGF-beta1/H2O2/HOCl-induced expression of itself via positive feed-back effect on p38 MAPK activation, and also promoted TGF-beta1/H2O2/HOCl-induced expression of alpha3 and SNAI2 by enhancing the activation of ERK pathway, thus resulting in higher invasive capacity of HCC cells. Hydrogen Peroxide 146-150 transforming growth factor, beta 1 Mus musculus 136-145 24260309-7 2013 By enhancing MAPK activation, beta3 enabled TGF-beta1 to augment the promoting effect of H2O2/HOCl on anoikis-resistance of HCC cells. Hydrogen Peroxide 89-93 transforming growth factor, beta 1 Mus musculus 44-53 24260309-8 2013 TGF-beta1/H2O2/HOCl-induced metastatic phenotype was sufficient for HCC cells to extravasate from circulation and form metastatic foci in an experimental metastasis model in nude mice. Hydrogen Peroxide 10-14 transforming growth factor, beta 1 Mus musculus 0-9 24260309-10 2013 These results suggest that beta3 could function as a modulator to promote TGF-beta1/H2O2/HOCl-mediated induction of metastatic phenotype of non-metastatic tumor cells, and that targeting beta3 might be a potential approach in preventing the induction of metastatic phenotype of non-metastatic tumor cells. Hydrogen Peroxide 84-88 transforming growth factor, beta 1 Mus musculus 74-83 24260309-0 2013 beta3 integrin promotes TGF-beta1/H2O2/HOCl-mediated induction of metastatic phenotype of hepatocellular carcinoma cells by enhancing TGF-beta1 signaling. Hydrogen Peroxide 34-38 transforming growth factor, beta 1 Mus musculus 134-143 24260309-3 2013 Here we report that H2O2 and HOCl, the reactive oxygen species produced by neutrophils, could cooperate with TGF-beta1 to induce metastatic phenotype of non-metastatic hepatocellular carcinoma (HCC) cells. Hydrogen Peroxide 20-24 transforming growth factor, beta 1 Mus musculus 109-118 24260309-4 2013 TGF-beta1/H2O2/HOCl, but not TGF-beta1 or H2O2/HOCl, induced beta3 expression by triggering the enhanced activation of p38 MAPK. Hydrogen Peroxide 10-14 transforming growth factor, beta 1 Mus musculus 0-9 24260309-5 2013 Intriguingly, beta3 in turn promoted TGF-beta1/H2O2/HOCl-mediated induction of metastatic phenotype of HCC cells by enhancing TGF-beta1 signaling. Hydrogen Peroxide 47-51 transforming growth factor, beta 1 Mus musculus 126-135 24260309-6 2013 beta3 promoted TGF-beta1/H2O2/HOCl-induced expression of itself via positive feed-back effect on p38 MAPK activation, and also promoted TGF-beta1/H2O2/HOCl-induced expression of alpha3 and SNAI2 by enhancing the activation of ERK pathway, thus resulting in higher invasive capacity of HCC cells. Hydrogen Peroxide 25-29 transforming growth factor, beta 1 Mus musculus 15-24 23895226-6 2013 TGF-beta1-dependent HSC proliferation is mimicked by H2 O2 that is inhibited by catalase, implying that TGF-beta1 action is mediated via reactive oxygen species. Hydrogen Peroxide 53-58 transforming growth factor, beta 1 Mus musculus 104-113 23734265-0 2013 TLR4 ligand/H2O2 enhances TGF-beta1 signaling to induce metastatic potential of non-invasive breast cancer cells by activating non-Smad pathways. Hydrogen Peroxide 12-16 transforming growth factor, beta 1 Mus musculus 26-35 23734265-8 2013 Therefore, the sustained activation levels of both Smad and non-Smad pathways were gradually increased after prolonged stimulation with TGF-beta1/H2O2/LPS. Hydrogen Peroxide 146-150 transforming growth factor, beta 1 Mus musculus 136-145 23734265-9 2013 Consistent with the activation pattern of signaling pathways, the invasive capacity and anoikis-resistance of non-invasive breast cancer cells were gradually increased after prolonged stimulation with TGF-beta1/H2O2/LPS. Hydrogen Peroxide 211-215 transforming growth factor, beta 1 Mus musculus 201-210 23734265-5 2013 TLR4 ligand (LPS) and H2O2 cooperated with TGF-beta1 to enhance the sustained activation of non-Smad pathways, including p38MAPK, ERK, JNK, PI3K, and NF-kappaB. Hydrogen Peroxide 22-26 transforming growth factor, beta 1 Mus musculus 43-52 23517551-0 2013 Secreted protein acidic and rich in cysteine (SPARC) is upregulated by transforming growth factor (TGF)-beta and is required for TGF-beta-induced hydrogen peroxide production in fibroblasts. Hydrogen Peroxide 146-163 transforming growth factor, beta 1 Mus musculus 99-108 23524570-0 2013 Salvianolate inhibits reactive oxygen species production in H(2)O(2)-treated mouse cardiomyocytes in vitro via the TGFbeta pathway. Hydrogen Peroxide 60-68 transforming growth factor, beta 1 Mus musculus 115-122 23524570-7 2013 Treatment of the cells with H2O2 (1.25 mmol/L) markedly increased ROS and iNOS production, and decreased the levels of NO, TAOC and TGFbeta1 in the culture medium. Hydrogen Peroxide 28-32 transforming growth factor, beta 1 Mus musculus 132-140 23524570-8 2013 Furthermore, the H2O2 treatment significantly increased TGFbeta1 and Smad2/3 expression in the cells. Hydrogen Peroxide 17-21 transforming growth factor, beta 1 Mus musculus 56-64 23524570-9 2013 Addition of salvianolate (0.05, 0.1, and 0.5 g/L) concentration-dependently reversed the H2O2-induced alterations in the culture medium; addition of salvianolate (0.05 g/L) reversed the H2O2-induced increases of TGFbeta1 and Smad2/3 expression in the cells. Hydrogen Peroxide 89-93 transforming growth factor, beta 1 Mus musculus 212-220 23524570-11 2013 CONCLUSION: Salvianolate inhibits ROS and iNOS production and increases TAOC and NO levels in H2O2-treated cardiomyocytes in vitro via downregulation of Smad2/3 and TGFbeta1 expression. Hydrogen Peroxide 94-98 transforming growth factor, beta 1 Mus musculus 165-173 23517551-0 2013 Secreted protein acidic and rich in cysteine (SPARC) is upregulated by transforming growth factor (TGF)-beta and is required for TGF-beta-induced hydrogen peroxide production in fibroblasts. Hydrogen Peroxide 146-163 transforming growth factor, beta 1 Mus musculus 129-137 23517551-6 2013 We also demonstrated that SPARC was required for hydrogen peroxide (H2O2) production in fibroblasts treated with TGF-beta. Hydrogen Peroxide 49-66 transforming growth factor, beta 1 Mus musculus 113-121 23517551-6 2013 We also demonstrated that SPARC was required for hydrogen peroxide (H2O2) production in fibroblasts treated with TGF-beta. Hydrogen Peroxide 68-72 transforming growth factor, beta 1 Mus musculus 113-121 23517551-8 2013 Knockdown of ILK attenuated extracellular H2O2 generation in TGF-beta-stimulated fibroblasts. Hydrogen Peroxide 42-46 transforming growth factor, beta 1 Mus musculus 61-69 23517551-9 2013 Our results indicated that SPARC is upregulated by TGF-beta and is required for TGF-beta-induced H2O2 production via activation of ILK, and this H2O2 production from fibroblasts is capable of causing epithelial cell injury. Hydrogen Peroxide 97-101 transforming growth factor, beta 1 Mus musculus 51-59 23517551-9 2013 Our results indicated that SPARC is upregulated by TGF-beta and is required for TGF-beta-induced H2O2 production via activation of ILK, and this H2O2 production from fibroblasts is capable of causing epithelial cell injury. Hydrogen Peroxide 97-101 transforming growth factor, beta 1 Mus musculus 80-88 23517551-9 2013 Our results indicated that SPARC is upregulated by TGF-beta and is required for TGF-beta-induced H2O2 production via activation of ILK, and this H2O2 production from fibroblasts is capable of causing epithelial cell injury. Hydrogen Peroxide 145-149 transforming growth factor, beta 1 Mus musculus 51-59 23517551-9 2013 Our results indicated that SPARC is upregulated by TGF-beta and is required for TGF-beta-induced H2O2 production via activation of ILK, and this H2O2 production from fibroblasts is capable of causing epithelial cell injury. Hydrogen Peroxide 145-149 transforming growth factor, beta 1 Mus musculus 80-88 23517551-10 2013 CONCLUSIONS: The results presented in this study suggest that SPARC plays a role in epithelial damage in the IPF lung via enhanced H2O2 production from fibroblasts activated by TGF-beta. Hydrogen Peroxide 131-135 transforming growth factor, beta 1 Mus musculus 177-185 23261430-3 2013 TGFbeta(1) stimulated collagen synthesis and hydrogen peroxide generation in mouse cardiac fibroblasts, and both responses were attenuated by a scavenger of superoxide and hydrogen peroxide (EUK-134). Hydrogen Peroxide 45-62 transforming growth factor, beta 1 Mus musculus 0-10 23261430-3 2013 TGFbeta(1) stimulated collagen synthesis and hydrogen peroxide generation in mouse cardiac fibroblasts, and both responses were attenuated by a scavenger of superoxide and hydrogen peroxide (EUK-134). Hydrogen Peroxide 172-189 transforming growth factor, beta 1 Mus musculus 0-10 23261430-4 2013 Furthermore, by expressing a dominant negative form of Nox4 (Adv-Nox4(DeltaNADPH)) in fibroblasts, TGFbeta(1)-induced hydrogen peroxide production and collagen production were abrogated, suggesting that Nox4-dependent ROS are important for TGFbeta(1) signaling in collagen production. Hydrogen Peroxide 118-135 transforming growth factor, beta 1 Mus musculus 99-109 18434384-8 2008 Finally, sevoflurane protected against necrosis induced with hydrogen peroxide in primary cultures of proximal tubules from TGF-beta1+/+ mice or SMAD3+/+ mice but not in proximal tubules from TGF-beta1+/- or SMAD3-/- mice. Hydrogen Peroxide 61-78 transforming growth factor, beta 1 Mus musculus 124-133 21532881-6 2011 The ability of TGF-beta1 to activate Smad2/3 was unaffected by LOX inactivation in normal MECs, whereas the stimulation of p38 MAPK by TGF-beta1 was blunted by inhibiting LOX activity in malignant MECs or by inducing the degradation of hydrogen peroxide in both cell types. Hydrogen Peroxide 236-253 transforming growth factor, beta 1 Mus musculus 15-24 21532881-6 2011 The ability of TGF-beta1 to activate Smad2/3 was unaffected by LOX inactivation in normal MECs, whereas the stimulation of p38 MAPK by TGF-beta1 was blunted by inhibiting LOX activity in malignant MECs or by inducing the degradation of hydrogen peroxide in both cell types. Hydrogen Peroxide 236-253 transforming growth factor, beta 1 Mus musculus 135-144 19531652-8 2009 The elimination of ROS inhibited EMT, whereas H2O2 treatment rescued TGF-beta1-induced EMT in cells in which the LIP increase was abrogated. Hydrogen Peroxide 46-50 transforming growth factor, beta 1 Mus musculus 69-78 15591224-0 2005 c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells. Hydrogen Peroxide 10-27 transforming growth factor, beta 1 Mus musculus 36-68 18336470-5 2008 Furthermore, TGF-beta1 demonstrated extreme anti-apoptotic behaviour against hydrogen peroxide-mediated apoptotic cell death. Hydrogen Peroxide 77-94 transforming growth factor, beta 1 Mus musculus 13-22 18336470-6 2008 At low dosages, TGF-beta1 enhanced (by approximately 76%) cell survival against hydrogen peroxide treatment via inactivation of caspase-3 and -9. Hydrogen Peroxide 80-97 transforming growth factor, beta 1 Mus musculus 16-25 16176460-7 2005 The present studies, using a murine fetal wound repair model, show that hydrogen peroxide interferes with scarless healing, possibly through the induction of transforming growth factor-beta1. Hydrogen Peroxide 72-89 transforming growth factor, beta 1 Mus musculus 158-190 17145552-8 2006 Treatment of normal hepatocytes with H(2)O(2) resulted in a sustained increase in ROS and resistance to TGFbeta apoptosis that was reversed when these cells were pretreated with an antioxidant. Hydrogen Peroxide 37-45 transforming growth factor, beta 1 Mus musculus 104-111 15591224-6 2005 Confocal immunofluorescence analysis showed that TGF-beta1 stimulates production of hydrogen peroxide. Hydrogen Peroxide 84-101 transforming growth factor, beta 1 Mus musculus 49-58 15591224-9 2005 CONCLUSIONS: Our results suggest that TGF-beta1 activates c-Src and generates hydrogen peroxide through NAD(P)H oxidase, and these signaling pathways lead to the activation of specific sets of genes, including SM22alpha and PAI-1. Hydrogen Peroxide 78-95 transforming growth factor, beta 1 Mus musculus 38-47 15591224-13 2005 These results indicate that c-Src and hydrogen peroxide are required for TGF-beta1 signaling. Hydrogen Peroxide 38-55 transforming growth factor, beta 1 Mus musculus 73-82 11563880-7 2001 TGF-beta1 and IFN-gamma blocked migration by inhibiting the VCAM-1-stimulated production of low levels of ROS (0.1-0.9 microM H2O2). Hydrogen Peroxide 126-130 transforming growth factor, beta 1 Mus musculus 0-9 12959930-6 2004 In addition, we showed that TGF-beta stimulated superoxide production and increased release of H2O2 from the cells, whereas GSH ester decreased basal and TGF-beta + glucose oxidase-stimulated H2O2 release. Hydrogen Peroxide 95-99 transforming growth factor, beta 1 Mus musculus 28-36 12959930-6 2004 In addition, we showed that TGF-beta stimulated superoxide production and increased release of H2O2 from the cells, whereas GSH ester decreased basal and TGF-beta + glucose oxidase-stimulated H2O2 release. Hydrogen Peroxide 192-196 transforming growth factor, beta 1 Mus musculus 28-36 12959930-6 2004 In addition, we showed that TGF-beta stimulated superoxide production and increased release of H2O2 from the cells, whereas GSH ester decreased basal and TGF-beta + glucose oxidase-stimulated H2O2 release. Hydrogen Peroxide 192-196 transforming growth factor, beta 1 Mus musculus 154-162 31469894-10 2019 Compared with normal fibroblasts and TGF-beta-induced myofibroblasts, H2O2-induced senescent fibroblasts showed a nonfibrogenic phenotype, including a reduced response to growth factor basic fibroblast growth factor (bFGF) or platelet-derived growth factor-BB (PDGF-BB), increased matrix metalloproteinase (MMP)1/3/13 expression, and decreased fibronectin and collagen I expression. Hydrogen Peroxide 70-74 transforming growth factor, beta 1 Mus musculus 37-45 7929412-2 1994 Our earlier study suggested that the mouse osteoblastic cell line, MC3T3-E1, was sensitive to growth inhibition by TGF beta 1 and that this effect was partly mediated by H2O2. Hydrogen Peroxide 170-174 transforming growth factor, beta 1 Mus musculus 115-125 8051207-0 1994 Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells. Hydrogen Peroxide 14-31 transforming growth factor, beta 1 Mus musculus 35-68 8051207-11 1994 These findings suggest that H2O2 acts as a mediator for the TGF-beta 1-induced transcription of egr-1 gene. Hydrogen Peroxide 28-32 transforming growth factor, beta 1 Mus musculus 60-70 1667586-2 1991 TGF-beta 1 stimulated cells to release H2O2 in the late G1 phase, but not in the G0 phase, even though TGF-beta 1 receptors were present in both phases. Hydrogen Peroxide 39-43 transforming growth factor, beta 1 Mus musculus 0-10 1667586-4 1991 TGF-beta 1 and H2O2 increased the phosphorylation of the same proteins with a molecular weight of 30,000 in cells in the late G1 phase, and the increase by TGF-beta 1 was abolished at least partly by catalase. Hydrogen Peroxide 15-19 transforming growth factor, beta 1 Mus musculus 156-166 1667586-5 1991 The results suggest that H2O2 is one of the mediators of inhibition of DNA synthesis by TGF-beta 1. Hydrogen Peroxide 25-29 transforming growth factor, beta 1 Mus musculus 88-98 34485393-8 2021 Mechanistically, we found that the expression of transforming growth factor (TGF)-beta1 and smads were significantly decreased in the N1LR overexpression group exposed to H2O2. Hydrogen Peroxide 171-175 transforming growth factor, beta 1 Mus musculus 49-87 32300244-9 2020 In H2O2-treated HK-2 cells, addition of PK (6 pg/mL) significantly decreased ROS production, regulated the expression of oxidant and antioxidant enzymes, suppressed the expression of TGF-beta1 and MCP-1, and inhibited cell apoptosis. Hydrogen Peroxide 3-7 transforming growth factor, beta 1 Mus musculus 183-192 34419603-7 2021 The role of TGFbeta1 in autophagy after hydrogen peroxide (H2O2) treatment was analyzed. Hydrogen Peroxide 59-63 transforming growth factor, beta 1 Mus musculus 12-20 34419603-8 2021 The protective effect of TGFbeta1 against H2O2 treatment was assessed by cell viability assay and TUNEL assay. Hydrogen Peroxide 42-46 transforming growth factor, beta 1 Mus musculus 25-33 34419603-14 2021 TGFbeta1 pretreatment suppressed cell death of chondrocytes following H2O2 treatment, but this protective effect was abolished by FOXO1 knockdown. Hydrogen Peroxide 70-74 transforming growth factor, beta 1 Mus musculus 0-8 32764116-7 2021 By using primary human and mouse lung fibroblasts, we showed that TGF-beta1 upregulates DUOX1 and its maturation factor DUOXA1 and that DUOX1-derived H2O2 promoted the duration of TGF-beta1-activated Smad3 phosphorylation by preventing phospho-Smad3 degradation. Hydrogen Peroxide 150-154 transforming growth factor, beta 1 Mus musculus 180-189 27986445-6 2017 p5RHH-mediated Nox4 siRNA transfection greatly attenuated TGFbeta1-induced upregulation of Nox4 mRNA (p<0.01) and protein (p<0.0001) levels and decreased hydrogen peroxide production (p<0.0001). Hydrogen Peroxide 160-177 transforming growth factor, beta 1 Mus musculus 58-66 30397232-6 2018 Addition of H2O2 to mesangial cells induced DNA demethylation and upregulated Tgfb1 expression. Hydrogen Peroxide 12-16 transforming growth factor, beta 1 Mus musculus 78-83 29402900-8 2018 Treatment with GSH significantly attenuated the H2O2-induced upregulation of genes related to NADPH oxidase in 3T3-L1 adipocytes, and that of Il6, Tgfb, and Pdgfb in RAW264.7 cells. Hydrogen Peroxide 48-52 transforming growth factor, beta 1 Mus musculus 147-151 27456753-0 2016 Activation of TGF-beta1 by AQP3-Mediated H2O2 Transport into Fibroblasts of a Bleomycin-Induced Mouse Model of Scleroderma. Hydrogen Peroxide 41-45 transforming growth factor, beta 1 Mus musculus 14-23 27212017-5 2016 CA inhibited TGF-beta-induced hydrogen peroxide generation via inhibition of NADPH oxidase 4 (Nox4) expressions. Hydrogen Peroxide 30-47 transforming growth factor, beta 1 Mus musculus 13-21 27830032-5 2016 Since H2O2 treatment activates MAPK, NF-kappaB and TGF-beta1 in cells, our study suggested that H2 could inhibit H2O2 activated MAPK and NF-kappaB activation as well as TGF-beta1 expression in treated cells. Hydrogen Peroxide 6-10 transforming growth factor, beta 1 Mus musculus 51-60 27830032-5 2016 Since H2O2 treatment activates MAPK, NF-kappaB and TGF-beta1 in cells, our study suggested that H2 could inhibit H2O2 activated MAPK and NF-kappaB activation as well as TGF-beta1 expression in treated cells. Hydrogen Peroxide 6-10 transforming growth factor, beta 1 Mus musculus 169-178 27830032-5 2016 Since H2O2 treatment activates MAPK, NF-kappaB and TGF-beta1 in cells, our study suggested that H2 could inhibit H2O2 activated MAPK and NF-kappaB activation as well as TGF-beta1 expression in treated cells. Hydrogen Peroxide 113-117 transforming growth factor, beta 1 Mus musculus 51-60 27456753-8 2016 These results demonstrate that AQP3-mediated transport of H2O2 into bleomycin mice fibroblasts activated transforming growth factor-beta1, and silencing AQP3 is a potential approach for treating scleroderma. Hydrogen Peroxide 58-62 transforming growth factor, beta 1 Mus musculus 105-137 25315297-9 2014 Application of TGFbeta1 increased both VEGFR2 and eNOS expression levels,whereas blocking TGFbeta1 or addition of catalase inhibited the phosphorylation of VEGFR2 and eNOS, indicating H2O2 and TGFbeta1 signaling downstream of Nox4 is critical to maintain EC angiogenic functions. Hydrogen Peroxide 184-188 transforming growth factor, beta 1 Mus musculus 90-98 26334580-1 2016 BACKGROUND & AIM: Hydrogen peroxide-inducible clone-5 (Hic-5), also named as transforming growth factor beta-1-induced transcript 1 protein (Tgfb1i1), was found to be induced by TGF-beta. Hydrogen Peroxide 22-39 transforming growth factor, beta 1 Mus musculus 182-190 25315297-9 2014 Application of TGFbeta1 increased both VEGFR2 and eNOS expression levels,whereas blocking TGFbeta1 or addition of catalase inhibited the phosphorylation of VEGFR2 and eNOS, indicating H2O2 and TGFbeta1 signaling downstream of Nox4 is critical to maintain EC angiogenic functions. Hydrogen Peroxide 184-188 transforming growth factor, beta 1 Mus musculus 90-98