PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26225676-10	2015	RUNX3 methylation in hydrogen peroxide (H2O2)-treated HepG2 cells was significantly higher than in untreated control cells.	Hydrogen Peroxide	21-38	RUNX family transcription factor 3	Homo sapiens	0-5	
11178967-3	2001	The AML-2/DX100 also showed various levels of resistance to daunorubicin and vincristine but was paradoxically sensitive to hydrogen peroxide (5-fold), t-butyl hydroperoxide (3-fold), and paraquat (2-fold) when compared to the drug-sensitive parental AML-2 cells (AML-2/WT).	Hydrogen Peroxide	124-141	RUNX family transcription factor 3	Homo sapiens	4-9	
26225676-10	2015	RUNX3 methylation in hydrogen peroxide (H2O2)-treated HepG2 cells was significantly higher than in untreated control cells.	Hydrogen Peroxide	40-44	RUNX family transcription factor 3	Homo sapiens	0-5	
26225676-14	2015	In vitro, RUNX3 hypermethylation was experimentally induced by H2O2.	Hydrogen Peroxide	63-67	RUNX family transcription factor 3	Homo sapiens	10-15	
24042352-5	2013	The levels of RUNX3 mRNA and protein were downregulated in response to treatment of the human colorectal cancer cell line SNU-407 with H2O2.	Hydrogen Peroxide	135-139	RUNX family transcription factor 3	Homo sapiens	14-19	
24042352-6	2013	Treatment of the cells with H2O2 also upregulated Akt mRNA and protein expression, and inhibited the binding of RUNX3 to the Akt promoter.	Hydrogen Peroxide	28-32	RUNX family transcription factor 3	Homo sapiens	112-117	
24042352-7	2013	The inverse correlation between the expression levels of RUNX3 and Akt in H2O2-treated cells was also associated with nuclear translocation of beta-catenin and upregulation of cyclin D1 expression, which induced cell proliferation.	Hydrogen Peroxide	74-78	RUNX family transcription factor 3	Homo sapiens	57-62	
23886181-7	2013	Methylation of RUNX3 promoter was significantly increased in cells exposed to H2O2.	Hydrogen Peroxide	78-82	RUNX family transcription factor 3	Homo sapiens	15-20	
22274925-3	2012	RUNX3 mRNA and protein expressions were down-regulated in response to hydrogen peroxide (H(2)O(2)) in the human colorectal cancer cell line SNU-407.	Hydrogen Peroxide	70-87	RUNX family transcription factor 3	Homo sapiens	0-5	
22274925-5	2012	Moreover, methylation-specific PCR data revealed that H(2)O(2) treatment increased RUNX3 promoter methylation; however, NAC and the cytosine methylation inhibitor, 5-aza-2-deoxycytidine (5-Aza-dC), decreased it, suggesting that an epigenetic regulatory mechanism by ROS-induced methylation may be involved in RUNX3 silencing.	Hydrogen Peroxide	54-62	RUNX family transcription factor 3	Homo sapiens	83-88	
22274925-5	2012	Moreover, methylation-specific PCR data revealed that H(2)O(2) treatment increased RUNX3 promoter methylation; however, NAC and the cytosine methylation inhibitor, 5-aza-2-deoxycytidine (5-Aza-dC), decreased it, suggesting that an epigenetic regulatory mechanism by ROS-induced methylation may be involved in RUNX3 silencing.	Hydrogen Peroxide	54-62	RUNX family transcription factor 3	Homo sapiens	309-314	
22274925-8	2012	Additionally, H(2)O(2) treatment inhibited the nuclear localization and expression of RUNX3, which was abolished by NAC treatment.	Hydrogen Peroxide	14-22	RUNX family transcription factor 3	Homo sapiens	86-91	
21968610-2	2012	Down-regulated CAT expression in AML-2/DX100 cells was completely recovered after treatment of hydrogen peroxide (H(2)O(2)) and histone deacetylase inhibitor, trichostatin A (TSA) but was increased slightly by the treatment of DNA methylation inhibitor, 5-aza-2"-deoxycytidine (5-AdC).	Hydrogen Peroxide	95-112	RUNX family transcription factor 3	Homo sapiens	33-38	
21968610-2	2012	Down-regulated CAT expression in AML-2/DX100 cells was completely recovered after treatment of hydrogen peroxide (H(2)O(2)) and histone deacetylase inhibitor, trichostatin A (TSA) but was increased slightly by the treatment of DNA methylation inhibitor, 5-aza-2"-deoxycytidine (5-AdC).	Hydrogen Peroxide	114-122	RUNX family transcription factor 3	Homo sapiens	33-38	
21968610-5	2012	Meanwhile, overexpression of other up-regulated peroxidase genes appears to make compensation for decreased H(2)O(2)-scavenging activity for the down-regulated CAT expression in AML-2/DX100 cells.	Hydrogen Peroxide	108-116	RUNX family transcription factor 3	Homo sapiens	178-183	
17218010-3	2007	AML-2/DX100 characterized by down-regulated catalase expression was supersensitive to exogenous hydrogen peroxide whereas they increased defense mechanisms against endogenous reactive oxygen species (ROS) as compared with AML-2/WT.	Hydrogen Peroxide	96-113	RUNX family transcription factor 3	Homo sapiens	0-5