PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26369531-7	2016	Osteoblastic differentiation of hPLFs was also inhibited by combined treatment with 100 muM H2O2, as evidenced by the decreases in alkaline phosphatase (ALP) activity and mineralization.	Hydrogen Peroxide	92-96	alkaline phosphatase, placental	Homo sapiens	131-151	
33988258-6	2021	Under oxidative stress conditions, COL I and ALP expression levels, suppressed by 100 muM H2 O2 , were elevated by PHD2-gene-silencing in hPDLCs.	Hydrogen Peroxide	90-95	alkaline phosphatase, placental	Homo sapiens	45-48	
31345368-11	2019	H2O2-induced oxidative stress suppressed osteogenic differentiation of BMSCs, which was verified by the decrease in ALP activity, calcium deposition, Runx2 and beta-catenin expression.	Hydrogen Peroxide	0-4	alkaline phosphatase, placental	Homo sapiens	116-119	
28624869-5	2018	An increase in CeO2 content in HA coatings better alleviated H2O2-induced inhibition of osteogenic differentiation by increasing alkaline phosphatase (ALP) activity, calcium deposition activity, and mRNA expression levels of osteogenesis markers runt-related transcription factor 2 (Runx2), ALP, and osteocalcin (OCN) in BMSCs.	Hydrogen Peroxide	61-65	alkaline phosphatase, placental	Homo sapiens	129-149	
28624869-5	2018	An increase in CeO2 content in HA coatings better alleviated H2O2-induced inhibition of osteogenic differentiation by increasing alkaline phosphatase (ALP) activity, calcium deposition activity, and mRNA expression levels of osteogenesis markers runt-related transcription factor 2 (Runx2), ALP, and osteocalcin (OCN) in BMSCs.	Hydrogen Peroxide	61-65	alkaline phosphatase, placental	Homo sapiens	151-154	
28624869-5	2018	An increase in CeO2 content in HA coatings better alleviated H2O2-induced inhibition of osteogenic differentiation by increasing alkaline phosphatase (ALP) activity, calcium deposition activity, and mRNA expression levels of osteogenesis markers runt-related transcription factor 2 (Runx2), ALP, and osteocalcin (OCN) in BMSCs.	Hydrogen Peroxide	61-65	alkaline phosphatase, placental	Homo sapiens	291-294	
26923794-5	2016	Triggering the enzyme reaction in the silica colloidosomes gives a hydrogen peroxide signal that induces polymer wall formation in a coexistent population of the FeM-clay colloidosomes, which in turn generates self-regulated membrane-gated ALP-activity within the clay microcompartments.	Hydrogen Peroxide	67-84	alkaline phosphatase, placental	Homo sapiens	240-243	
26369531-7	2016	Osteoblastic differentiation of hPLFs was also inhibited by combined treatment with 100 muM H2O2, as evidenced by the decreases in alkaline phosphatase (ALP) activity and mineralization.	Hydrogen Peroxide	92-96	alkaline phosphatase, placental	Homo sapiens	153-156	
26369531-10	2016	Furthermore, siRNA-mediated silencing of Nrf2 blocked H2O2-induced decreases in ALP activity and mineralization of hPLFs with the concomitant restoration of runt-related transcription factor 2 and osteocalcin mRNA expression and ALP activity.	Hydrogen Peroxide	54-58	alkaline phosphatase, placental	Homo sapiens	80-83	
26369531-10	2016	Furthermore, siRNA-mediated silencing of Nrf2 blocked H2O2-induced decreases in ALP activity and mineralization of hPLFs with the concomitant restoration of runt-related transcription factor 2 and osteocalcin mRNA expression and ALP activity.	Hydrogen Peroxide	54-58	alkaline phosphatase, placental	Homo sapiens	229-232	
26482937-5	2015	Oxidative stress induced by H2O2 inhibits osteogenic differentiation by decreasing alkaline phosphatase (ALP) activity, calcium content and mRNA expression levels of osteogenesis marker genes RUNX2 and OSX in hADMSCs.	Hydrogen Peroxide	28-32	alkaline phosphatase, placental	Homo sapiens	83-103	
25907268-7	2015	The amplified signal was carried out in two steps: (i) an ALP-catalyzed inactive substrate, 1-naphthyl phosphate (NPP), in situ produces NP on the surface of the electrode; (ii) on the one hand, NP as a new reactant could be directly electrooxidized and generated an electrochemical signal, but, on the other hand, NP could be oxidized by hemin/G-quadruplex in the presence of H2O2, resulting in amplification of the electrochemical signal.	Hydrogen Peroxide	377-381	alkaline phosphatase, placental	Homo sapiens	58-61	
25527247-6	2015	Seven days after H2O2 treatment, the cells showed significant reduction in ALP activity compared with negative control and no mineralized nodule deposition.	Hydrogen Peroxide	17-21	alkaline phosphatase, placental	Homo sapiens	75-78	
25057515-4	2014	Thus, ALP causes generation of uncomplexed Cu(2+) ions, which promote multiple oxidation reactions of Amplex UltraRed in the presence of hydrogen peroxide in conjunction with the production of intense fluorescence and colorimetric signals.	Hydrogen Peroxide	137-154	alkaline phosphatase, placental	Homo sapiens	6-9	
32938124-3	2011	The relative CL intensity of fluorescein measured with the addition of 80 mM H2O2 and ODI formed from the reaction of 2.0 muM bis(2,4,6-trichlorophenyl) oxalate and 10.0 muM 4-methyl imidazole in ethyl acetate was proportional to the concentration of ALP in milk.	Hydrogen Peroxide	77-81	alkaline phosphatase, placental	Homo sapiens	251-254