PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25573966-1	2015	In this issue of Blood, Liu et al report on OSU-T315, a new agent that specifically disrupts the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway and shows high proapoptotic activity against chronic lymphocytic leukemia (CLL) cells, which may indicate a potential therapeutic application in this disease	osu	44-47	AKT serine/threonine kinase 1	Homo sapiens	152-155	
17848913-0	2007	PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound.	osu	80-83	AKT serine/threonine kinase 1	Homo sapiens	6-9	
24994714-8	2014	OSU-53 activated Foxo3a through two Akt-dependent pathways, one at the level of nuclear localization by blocking Akt- and IKKbeta-mediated phosphorylation, and a second at the level of protein stabilization via cytoplasmic sequestration of MDM2, an E3 ligase responsible for Foxo3a degradation.	osu	0-3	AKT serine/threonine kinase 1	Homo sapiens	36-39	
24994714-8	2014	OSU-53 activated Foxo3a through two Akt-dependent pathways, one at the level of nuclear localization by blocking Akt- and IKKbeta-mediated phosphorylation, and a second at the level of protein stabilization via cytoplasmic sequestration of MDM2, an E3 ligase responsible for Foxo3a degradation.	osu	0-3	AKT serine/threonine kinase 1	Homo sapiens	113-116	
17848913-11	2007	PDK-1/AKT pathway may be an attractive therapeutic target for cancer intervention in RMS using OSU-03012.	osu	95-98	AKT serine/threonine kinase 1	Homo sapiens	6-9	
16168126-10	2005	RESULTS: OSU-03012 and OSU-O3013 inhibited P-Akt and its downstream signalling through 4EBP-1 and GSK at concentrations well below that of celecoxib.	osu	9-12	AKT serine/threonine kinase 1	Homo sapiens	45-48	
16168126-10	2005	RESULTS: OSU-03012 and OSU-O3013 inhibited P-Akt and its downstream signalling through 4EBP-1 and GSK at concentrations well below that of celecoxib.	osu	23-26	AKT serine/threonine kinase 1	Homo sapiens	45-48