PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23624914-3 2014 Our recent study showed that both ERK and AKT signaling are required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-dependent translation via convergent regulation of the translational repressor 4E-binding protein 1 (4E-BP1) for maintaining CRC transformation. cap 143-146 AKT serine/threonine kinase 1 Homo sapiens 42-45 23624914-4 2014 Here, we identified that the activation of cap-dependent translation by cooperative ERK and AKT signaling is critical for promotion of CRC motility and metastasis. cap 43-46 AKT serine/threonine kinase 1 Homo sapiens 92-95 31114251-10 2019 Finally, it was demonstrated that increased AKT and serum and glucocorticoid-inducible kinase 1 activity contributed to the activation of cap-dependent translation induced by INPP4B. cap 138-141 AKT serine/threonine kinase 1 Homo sapiens 44-47 24970817-6 2014 Treatment with LY294002, a PI3K inhibitor, resulted in cell cycle arrest without apoptosis and a concomitant down-regulation of cap-dependent translation by the suppression of the PI3K/AKT/mTOR pathway. cap 128-131 AKT serine/threonine kinase 1 Homo sapiens 185-188 21859846-0 2011 Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. cap 10-13 AKT serine/threonine kinase 1 Homo sapiens 74-77 21606676-2 2011 One important strategy for stimulating protein synthesis involves the ser/thr kinase Akt, which subsequently triggers inactivation of the cap-dependent translational repressor 4E-BP1 by an mTOR-containing protein complex (mTORC1). cap 138-141 AKT serine/threonine kinase 1 Homo sapiens 85-88 17220299-7 2007 Trx1 facilitated synthesis of HIF-1alpha by activating Akt, p70S6K, and eIF-4E, known to control cap-dependent translation. cap 97-100 AKT serine/threonine kinase 1 Homo sapiens 55-58