PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 49-52 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 21-27 27002144-2 2016 Under conditions of extreme oxygen depletion (hypoxia), human cells repress eIF4E and switch to an alternative cap-dependent translation mediated by a homolog of eIF4E, eIF4E2. cap 111-114 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 169-175 28487484-3 2017 Here we show that the cap-binding eIF4E-homologous protein 4EHP is an integral component of the miRNA-mediated silencing machinery. cap 22-25 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 59-63 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 49-52 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 144-150 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 120-123 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 21-27 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 120-123 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 144-150 17368478-12 2007 Overall the data, combined with sequence analyses of 4EHP from evolutionary diverse species, strongly support the hypothesis that 4EHP plays a physiological role utilizing both cap-binding and protein-binding functions but which is distinct from eIF4E. cap 177-180 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 130-134 17369309-5 2007 We show that 4EHP binds cap analogs m(7)GpppG and m(7)GTP with 30 and 100 lower affinity than eIF4E. cap 24-27 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 13-17 9582349-6 1998 The three-dimensional structure of 4EHP, as predicted by homology modeling, closely resembles that of eIF4E and site-directed mutagenesis analysis of 4EHP strongly suggests that it shares with eIF4E a common mechanism for cap binding. cap 222-225 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 35-39 9582349-6 1998 The three-dimensional structure of 4EHP, as predicted by homology modeling, closely resembles that of eIF4E and site-directed mutagenesis analysis of 4EHP strongly suggests that it shares with eIF4E a common mechanism for cap binding. cap 222-225 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 150-154