PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23624914-3 2014 Our recent study showed that both ERK and AKT signaling are required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-dependent translation via convergent regulation of the translational repressor 4E-binding protein 1 (4E-BP1) for maintaining CRC transformation. cap 143-146 eukaryotic translation initiation factor 4E Homo sapiens 81-124 23624914-3 2014 Our recent study showed that both ERK and AKT signaling are required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-dependent translation via convergent regulation of the translational repressor 4E-binding protein 1 (4E-BP1) for maintaining CRC transformation. cap 143-146 eukaryotic translation initiation factor 4E Homo sapiens 126-131 23547259-5 2013 Here, we report a novel role of the mTORC1-eukaryotic translation initiation factor 4E (eIF4E) pathway, a key regulator of cap-dependent translation initiation of oncogenic factors, in SG formation. cap 123-126 eukaryotic translation initiation factor 4E Homo sapiens 88-93 23901100-8 2013 Finally, we have successfully separated the two functions of eIF4E to show that its helicase promoting activity increases the rate of translation by a mechanism that is distinct from its cap-binding function. cap 187-190 eukaryotic translation initiation factor 4E Homo sapiens 61-66 23667251-0 2013 Hypoxia-inducible factor-1alpha (HIF-1alpha) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions. cap 54-57 eukaryotic translation initiation factor 4E Homo sapiens 139-145 22392810-5 2012 Targeting the cap-binding pocket of eIF4E should represent a way to inhibit all the eIF4E cellular functions. cap 14-17 eukaryotic translation initiation factor 4E Homo sapiens 36-41 22495651-0 2012 Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target. cap 0-3 eukaryotic translation initiation factor 4E Homo sapiens 44-49 22392810-5 2012 Targeting the cap-binding pocket of eIF4E should represent a way to inhibit all the eIF4E cellular functions. cap 14-17 eukaryotic translation initiation factor 4E Homo sapiens 84-89 20227039-2 2010 While phosphorylation of rpS6 is dispensable for cancer formation, 4EBP-eIF4E exerts significant control over cap-dependent translation, cell growth, cancer initiation, and progression. cap 110-113 eukaryotic translation initiation factor 4E Homo sapiens 72-77 17440067-7 2007 These results indicate that PEITC modulates availability of eIF4E for translation initiation leading to inhibition of cap-dependent translation. cap 118-121 eukaryotic translation initiation factor 4E Homo sapiens 60-65 19159466-3 2009 1 describes an MC sequence region identified in Ago2 that displays similarity to the cap-binding motif in translation initiation factor 4E (eIF4E). cap 85-88 eukaryotic translation initiation factor 4E Homo sapiens 140-145 18343217-4 2008 Here, we show that overexpression of eIF4E-T preferentially inhibits cap-dependent steady-state translation, but not the pioneer round of translation. cap 69-72 eukaryotic translation initiation factor 4E Homo sapiens 37-42 17638893-1 2007 Pathologic redirection of translational control by constitutive activation of eukaryotic translation initiation factor 4F (eIF4F), the cap-dependent translation initiation apparatus, is an obligatory step in oncogenesis; however, its mechanism remains undefined. cap 135-138 eukaryotic translation initiation factor 4E Homo sapiens 78-121 17638893-1 2007 Pathologic redirection of translational control by constitutive activation of eukaryotic translation initiation factor 4F (eIF4F), the cap-dependent translation initiation apparatus, is an obligatory step in oncogenesis; however, its mechanism remains undefined. cap 135-138 eukaryotic translation initiation factor 4E Homo sapiens 123-128 17584618-1 2007 Central to cap-dependent eukaryotic translation initiation is the eIF4F complex, which is composed of the three eukaryotic initiation factors eIF4E, eIF4G, and eIF4A. cap 11-14 eukaryotic translation initiation factor 4E Homo sapiens 142-147 17369309-5 2007 We show that 4EHP binds cap analogs m(7)GpppG and m(7)GTP with 30 and 100 lower affinity than eIF4E. cap 24-27 eukaryotic translation initiation factor 4E Homo sapiens 94-99 16626853-4 2006 VPg/eIF4E interaction results in the inhibition of cell-free protein synthesis, and we show that it stems from the liberation of the cap moiety from the complex with eIF4E. cap 133-136 eukaryotic translation initiation factor 4E Homo sapiens 4-9 17220299-7 2007 Trx1 facilitated synthesis of HIF-1alpha by activating Akt, p70S6K, and eIF-4E, known to control cap-dependent translation. cap 97-100 eukaryotic translation initiation factor 4E Homo sapiens 72-78 17036047-3 2006 Further, cap binding substantially modulates eIF4E"s affinity for eIF4G and the 4E-BPs. cap 9-12 eukaryotic translation initiation factor 4E Homo sapiens 45-50 16531451-7 2006 Looking for an upstream determinant of translational deregulation, we found an increase in the hyperphosphorylated form of the 4E-BP1 protein in the metastatic cell line, possibly resulting in an increased activation of cap-dependent translation due to increased activity of the eIF4E protein. cap 220-223 eukaryotic translation initiation factor 4E Homo sapiens 279-284 16626853-4 2006 VPg/eIF4E interaction results in the inhibition of cell-free protein synthesis, and we show that it stems from the liberation of the cap moiety from the complex with eIF4E. cap 133-136 eukaryotic translation initiation factor 4E Homo sapiens 166-171 15766285-4 2005 The temperature-dependent K(d) values for cap analogues were markedly lower, indicating tighter binding, with the eIF4E(K119A) mutant compared with wild-type eIF4E. cap 42-45 eukaryotic translation initiation factor 4E Homo sapiens 114-119 16405910-5 2006 Binding of eIF4G to apo-eIF4E likewise induces folding of the protein into a state that is similar to, but not identical with, that of cap-bound eIF4E. cap 135-138 eukaryotic translation initiation factor 4E Homo sapiens 24-29 16405910-5 2006 Binding of eIF4G to apo-eIF4E likewise induces folding of the protein into a state that is similar to, but not identical with, that of cap-bound eIF4E. cap 135-138 eukaryotic translation initiation factor 4E Homo sapiens 145-150 16515558-8 2006 We propose that changes in eIF4E phosphorylation in Aplysia neurons are a consequence of changes in cap-dependent translation that are independent of regulation of Aplysia Mnk. cap 100-103 eukaryotic translation initiation factor 4E Homo sapiens 27-32 15901615-4 2005 In the present study, we hypothesized that phosphorylation of eukaryotic initiation factor-4E (eIF4E)-binding protein (4E-BP), which subsequently releases eIF4E and initiates cap-dependent mRNA translation, was required for airway smooth muscle hypertrophy. cap 175-178 eukaryotic translation initiation factor 4E Homo sapiens 62-93 15901615-4 2005 In the present study, we hypothesized that phosphorylation of eukaryotic initiation factor-4E (eIF4E)-binding protein (4E-BP), which subsequently releases eIF4E and initiates cap-dependent mRNA translation, was required for airway smooth muscle hypertrophy. cap 175-178 eukaryotic translation initiation factor 4E Homo sapiens 95-100 15901615-4 2005 In the present study, we hypothesized that phosphorylation of eukaryotic initiation factor-4E (eIF4E)-binding protein (4E-BP), which subsequently releases eIF4E and initiates cap-dependent mRNA translation, was required for airway smooth muscle hypertrophy. cap 175-178 eukaryotic translation initiation factor 4E Homo sapiens 155-160 15766285-4 2005 The temperature-dependent K(d) values for cap analogues were markedly lower, indicating tighter binding, with the eIF4E(K119A) mutant compared with wild-type eIF4E. cap 42-45 eukaryotic translation initiation factor 4E Homo sapiens 158-163 11483729-5 2001 Thus, initiation on the HAV IRES requires that eIF4E be associated with eIF4G and that the cap-binding pocket of eIF4E be empty and unoccupied. cap 91-94 eukaryotic translation initiation factor 4E Homo sapiens 113-118 15491137-4 2004 A nontrivial, statistically important isothermal enthalpy-entropy compensation has been detected (T(c) = 399 +/- 24 K), which points to significant fluctuations of apo-eIF4E and indicates that the cap-binding microstate lies 9.66 +/- 1.7 kJ mol(-1) below the mean energy of all available conformational states. cap 197-200 eukaryotic translation initiation factor 4E Homo sapiens 168-173 11513750-1 2001 The eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP1) interacts directly with eIF4E and prevents it from forming initiation factor (eIF4F) complexes required for the initiation of cap-dependent mRNA translation. cap 195-198 eukaryotic translation initiation factor 4E Homo sapiens 4-35 11513750-1 2001 The eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP1) interacts directly with eIF4E and prevents it from forming initiation factor (eIF4F) complexes required for the initiation of cap-dependent mRNA translation. cap 195-198 eukaryotic translation initiation factor 4E Homo sapiens 37-42 11513750-1 2001 The eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP1) interacts directly with eIF4E and prevents it from forming initiation factor (eIF4F) complexes required for the initiation of cap-dependent mRNA translation. cap 195-198 eukaryotic translation initiation factor 4E Homo sapiens 147-152 15220445-3 2004 Cap-dependent mRNA translation generally correlates with Mnk1 phosphorylation of eIF4E when both are bound to eIF4G. cap 0-3 eukaryotic translation initiation factor 4E Homo sapiens 81-86 15220445-6 2004 The eIF4G-binding site is located in an N-terminal 66-amino-acid peptide of 100K which is sufficient to bind eIF4G, displace Mnk1, block eIF4E phosphorylation, and inhibit eIF4F (cap)-dependent cellular mRNA translation. cap 179-182 eukaryotic translation initiation factor 4E Homo sapiens 137-142 15220445-6 2004 The eIF4G-binding site is located in an N-terminal 66-amino-acid peptide of 100K which is sufficient to bind eIF4G, displace Mnk1, block eIF4E phosphorylation, and inhibit eIF4F (cap)-dependent cellular mRNA translation. cap 179-182 eukaryotic translation initiation factor 4E Homo sapiens 172-177 14507920-1 2003 Insulin stimulates phosphorylation of multiple sites in the eIF4E-binding protein, PHAS-I, leading to dissociation of the PHAS-I.eIF4E complex and to an increase in cap-dependent translation. cap 165-168 eukaryotic translation initiation factor 4E Homo sapiens 60-65 14690557-1 2003 OBJECTIVE: To determine whether the eukaryotic initiation factor-4E (eIF-4E) is involved in the cap-dependent translational regulation of heparanase and study the correlation between heparanase expression and metastatic potential of LS-174T cells. cap 96-99 eukaryotic translation initiation factor 4E Homo sapiens 36-67 14690557-1 2003 OBJECTIVE: To determine whether the eukaryotic initiation factor-4E (eIF-4E) is involved in the cap-dependent translational regulation of heparanase and study the correlation between heparanase expression and metastatic potential of LS-174T cells. cap 96-99 eukaryotic translation initiation factor 4E Homo sapiens 69-75 12691746-9 2003 SDS-PAGE analyses showed that this structural instability is highly related to the fast degradation of cap-free eIF4E, compared with cap-bound or 4E-BP/cap-bound eIF4E, indicating the conferment of structural stability of eIF4E by the binary or ternary complex formation. cap 103-106 eukaryotic translation initiation factor 4E Homo sapiens 112-117 10882133-6 2000 Third, the addition of cap binding protein eIF4E inhibits deadenylation in vitro. cap 23-26 eukaryotic translation initiation factor 4E Homo sapiens 43-48 11463832-9 2001 Instead, we propose that the kinase activity of MNKs, eventually through phosphorylation of eIF4E, may serve to limit cap-dependent translation under physiological conditions. cap 118-121 eukaryotic translation initiation factor 4E Homo sapiens 92-97 8971030-3 1996 This inhibition is causally related to reduced phosphorylation and consequent activation of 4E-BP1, a repressor of the function of the cap-binding protein, eIF4E. cap 135-138 eukaryotic translation initiation factor 4E Homo sapiens 156-161 9582349-6 1998 The three-dimensional structure of 4EHP, as predicted by homology modeling, closely resembles that of eIF4E and site-directed mutagenesis analysis of 4EHP strongly suggests that it shares with eIF4E a common mechanism for cap binding. cap 222-225 eukaryotic translation initiation factor 4E Homo sapiens 102-107 9582349-6 1998 The three-dimensional structure of 4EHP, as predicted by homology modeling, closely resembles that of eIF4E and site-directed mutagenesis analysis of 4EHP strongly suggests that it shares with eIF4E a common mechanism for cap binding. cap 222-225 eukaryotic translation initiation factor 4E Homo sapiens 193-198 10611225-0 2000 Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. cap 131-134 eukaryotic translation initiation factor 4E Homo sapiens 0-43 10611225-0 2000 Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. cap 131-134 eukaryotic translation initiation factor 4E Homo sapiens 45-50 8610440-9 1996 We conclude that eIF4E is dephosphorylated by entry of EMCV, and the effect is strengthened by the decrease in cap-dependent translation. cap 111-114 eukaryotic translation initiation factor 4E Homo sapiens 17-22 8505316-1 1993 Eukaryotic translation initiation factor 4E (eIF-4E) is one component of the m7G-cap-binding protein complex eIF-4F and is required for cap-dependent translation initiation. cap 81-84 eukaryotic translation initiation factor 4E Homo sapiens 0-43 8505316-1 1993 Eukaryotic translation initiation factor 4E (eIF-4E) is one component of the m7G-cap-binding protein complex eIF-4F and is required for cap-dependent translation initiation. cap 81-84 eukaryotic translation initiation factor 4E Homo sapiens 45-51 8505316-1 1993 Eukaryotic translation initiation factor 4E (eIF-4E) is one component of the m7G-cap-binding protein complex eIF-4F and is required for cap-dependent translation initiation. cap 81-84 eukaryotic translation initiation factor 4E Homo sapiens 109-115 28468879-9 2017 The low dependence on eIF4E suggests that viral mRNAs may engage yet-unknown noncanonical host factors for a cap-dependent initiation mechanism.IMPORTANCE Several members of the Arenaviridae family cause serious hemorrhagic fevers in humans. cap 109-112 eukaryotic translation initiation factor 4E Homo sapiens 22-27 2386781-11 1990 Tryptic and CNBr cleavage suggested that eIF-4E* consists of a protease-resistant core of eIF-4E that retains the cap-binding site and consists of approximately residues 47-182. cap 114-117 eukaryotic translation initiation factor 4E Homo sapiens 41-47 2386781-11 1990 Tryptic and CNBr cleavage suggested that eIF-4E* consists of a protease-resistant core of eIF-4E that retains the cap-binding site and consists of approximately residues 47-182. cap 114-117 eukaryotic translation initiation factor 4E Homo sapiens 90-96 28322282-9 2018 The cap-dependent translation initiation gene, EIF4E, is one of the most MIA-dysregulated of all ASD-associated genes and targeted network analyses demonstrate prominent MIA-induced transcriptional dysregulation of mTOR and EIF4E-dependent signaling. cap 4-7 eukaryotic translation initiation factor 4E Homo sapiens 47-52 28322282-9 2018 The cap-dependent translation initiation gene, EIF4E, is one of the most MIA-dysregulated of all ASD-associated genes and targeted network analyses demonstrate prominent MIA-induced transcriptional dysregulation of mTOR and EIF4E-dependent signaling. cap 4-7 eukaryotic translation initiation factor 4E Homo sapiens 224-229 27114554-12 2016 Cap-dependent changes to the structure of eIF4E underpin this selectivity. cap 0-3 eukaryotic translation initiation factor 4E Homo sapiens 42-47 28539821-1 2017 Objectives: 4E-BP1 is a family member of eIF4E binding proteins (4E-BPs) which act as the suppressors of cap-dependent translation of RNA via competitively associating with cap-bound eIF4E. cap 105-108 eukaryotic translation initiation factor 4E Homo sapiens 41-46 28539821-1 2017 Objectives: 4E-BP1 is a family member of eIF4E binding proteins (4E-BPs) which act as the suppressors of cap-dependent translation of RNA via competitively associating with cap-bound eIF4E. cap 105-108 eukaryotic translation initiation factor 4E Homo sapiens 183-188 28487484-3 2017 Here we show that the cap-binding eIF4E-homologous protein 4EHP is an integral component of the miRNA-mediated silencing machinery. cap 22-25 eukaryotic translation initiation factor 4E Homo sapiens 34-39 27002144-2 2016 Under conditions of extreme oxygen depletion (hypoxia), human cells repress eIF4E and switch to an alternative cap-dependent translation mediated by a homolog of eIF4E, eIF4E2. cap 111-114 eukaryotic translation initiation factor 4E Homo sapiens 162-167 25839159-2 2015 We demonstrate here that the cap bound fraction from lymphoma cells was enriched with eIF4G and eIF4E indicating that lymphoma cells exist in an activated translational state. cap 29-32 eukaryotic translation initiation factor 4E Homo sapiens 96-101 25356869-1 2014 The eukaryotic initiation factor eIF4E is essential for cap-dependent initiation of translation in eukaryotes. cap 56-59 eukaryotic translation initiation factor 4E Homo sapiens 33-38