PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8092321-2 1994 In the present study we hypothesized that N-acetyl-L-cysteine (NAC), by increasing the availability of reduced sulfhydryl groups, would enhance the antihypertensive response to the ACEIs captopril and enalaprilat by a mechanism dependent on nitric oxide. Enalaprilat 201-212 X-linked Kx blood group Homo sapiens 63-66 8092321-7 1994 However, when the SHRs were pretreated with NAC, the same dose of enalaprilat significantly reduced blood pressure from 176 +/- 5 to 151 +/- 5 mmHg (n = 6). Enalaprilat 66-77 X-linked Kx blood group Homo sapiens 44-47 8092321-9 1994 The results of this study suggest that NAC, a donor of sulfhydryl groups, potentiates the antihypertensive response to captopril and enalaprilat in SHR by a nitric oxide-dependent mechanism. Enalaprilat 133-144 X-linked Kx blood group Homo sapiens 39-42