PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25919042-4	2015	The amount of enalaprilat excreted into the urine was 35% smaller in subjects with the CES1 c.428G/A genotype than in those with the c.428G/G genotype (P = 0.044).	Enalaprilat	14-25	carboxylesterase 1	Homo sapiens	87-91	
25919042-7	2015	CONCLUSIONS: The CES1 c.428G > A SNV decreased enalaprilat concentrations, probably by reducing the hydrolysis of enalapril, but had no observable effect on the pharmacokinetics of quinapril.	Enalaprilat	50-61	carboxylesterase 1	Homo sapiens	17-21	
25832562-3	2015	Enalapril, a carboxyl ester prodrug, is reported to be metabolized by human carboxylesterase-1 (CES1) but not by carboxylesterase-2 (CES2) to its active metabolite enalaprilat.	Enalaprilat	164-175	carboxylesterase 1	Homo sapiens	96-100	
35455696-1	2022	The angiotensin-converting enzyme inhibitor enalapril is hydrolysed to an active metabolite, enalaprilat, in the liver via carboxylesterase 1 (CES1).	Enalaprilat	93-104	carboxylesterase 1	Homo sapiens	123-141	
35455696-1	2022	The angiotensin-converting enzyme inhibitor enalapril is hydrolysed to an active metabolite, enalaprilat, in the liver via carboxylesterase 1 (CES1).	Enalaprilat	93-104	carboxylesterase 1	Homo sapiens	143-147	
35455696-6	2022	Mean peak and trough enalaprilat concentrations, adjusted by clinical variables, were significantly lower in CES1 rs2244613 heterozygotes (by 16.6% and 19.6%) and in CC homozygotes (by 32.7% and 41.4%) vs. the AA genotype.	Enalaprilat	21-32	carboxylesterase 1	Homo sapiens	109-113