PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17390614-0 2007 Progress in the methodological strategies for the detection in real samples of desmosine and isodesmosine, two biological markers of elastin degradation. Isodesmosine 93-105 elastin Homo sapiens 133-140 14563926-1 2003 Desmosine (D) and isodesmosine (I), the intramolecular crosslinking amino acids that occur in chains of elastin, have now been found in free form in human urine. Isodesmosine 18-30 elastin Homo sapiens 104-111 14642817-0 2003 LC/ESI-MS analysis of two elastin cross-links, desmosine and isodesmosine, and their radiation-induced degradation products. Isodesmosine 61-73 elastin Homo sapiens 26-33 11723825-1 2001 Elastin is the main protein of elastic fibers and confers the property of elastic recoil to the tissues such as arteries, lung, elastic cartilage,... Elastin synthesis goes through several steps: gene transcription, alternative splicing of pre-mRNA, mRNA translation, hydroxylation of some proline residues of the newly synthesized protein-tropoelastin-, association of with a 67 kDa chaperone protein, secretion of tropoelastin molecules in the extracellular space, and their deposition on the microfibrillar scaffold which contains fibrillin 1, fibrillin 2, MAGP 1 and MAGP 2,.... After the synthesis of cross-links-lysinonorleucine, desmosine, isodesmosine-, elastin becomes insoluble and elastic. Isodesmosine 647-659 elastin Homo sapiens 0-7 12782039-4 2003 Desmosine (Des) and its isomer isodesmosine (Isodes) are crosslinks specifically found in elastin. Isodesmosine 31-43 elastin Homo sapiens 90-97 12782039-4 2003 Desmosine (Des) and its isomer isodesmosine (Isodes) are crosslinks specifically found in elastin. Isodesmosine 45-51 elastin Homo sapiens 90-97 12093072-5 2002 RESULTS: significantly fewer elastin cross-links were found in aneurysm samples compared to controls (desmosines and isodesmosines: 90% reduction; p<0.01). Isodesmosine 117-130 elastin Homo sapiens 29-36 11723825-1 2001 Elastin is the main protein of elastic fibers and confers the property of elastic recoil to the tissues such as arteries, lung, elastic cartilage,... Elastin synthesis goes through several steps: gene transcription, alternative splicing of pre-mRNA, mRNA translation, hydroxylation of some proline residues of the newly synthesized protein-tropoelastin-, association of with a 67 kDa chaperone protein, secretion of tropoelastin molecules in the extracellular space, and their deposition on the microfibrillar scaffold which contains fibrillin 1, fibrillin 2, MAGP 1 and MAGP 2,.... After the synthesis of cross-links-lysinonorleucine, desmosine, isodesmosine-, elastin becomes insoluble and elastic. Isodesmosine 647-659 elastin Homo sapiens 150-157 10885422-2 2000 Desmosine and isodesmosine are elastin-derived cross-linked amino acids whose urine levels are considered representative of elastin breakdown. Isodesmosine 14-26 elastin Homo sapiens 31-38 10885422-2 2000 Desmosine and isodesmosine are elastin-derived cross-linked amino acids whose urine levels are considered representative of elastin breakdown. Isodesmosine 14-26 elastin Homo sapiens 124-131 7581855-1 1995 A method has been developed for the enrichment and analysis of the elastin crosslinks, desmosine and isodesmosine, in biological fluids and tissues. Isodesmosine 101-113 elastin Homo sapiens 67-74 9179924-4 1997 These are covalently cross-linked to form insoluble elastin by formation of desmosine and isodesmosine, catalysed by the enzyme lysyl oxidase. Isodesmosine 90-102 elastin Homo sapiens 52-59 9111761-11 1996 These findings suggest that the relative increase of NEO, OXO or ISOXO to DES and ISDES is associated with age-related weakening and/or damage of elastin, and that the gradual shift from elastin- to collagen-dominant state is a possible cause of the loss of elasticity and the gain of stiffness in the aging aorta. Isodesmosine 82-87 elastin Homo sapiens 146-153 10838739-3 2000 Analogical quadruple-functional crosslinks are formed in the elastin, i.e. desmosine and isodesmosine, which have essential physiological functions in the body. Isodesmosine 89-101 elastin Homo sapiens 61-68 10660450-4 2000 Desmosine (Des) and isodesmosine (Isodes) represent the major crosslinking components of elastin. Isodesmosine 20-32 elastin Homo sapiens 89-96 10660450-4 2000 Desmosine (Des) and isodesmosine (Isodes) represent the major crosslinking components of elastin. Isodesmosine 34-40 elastin Homo sapiens 89-96 10757115-1 1999 Tropoelastin, which is secreted from the cell in a soluble form, contains specific alanine rich repeat domains that are destined to form covalent desmosine and isodesmosine crosslinks in mature insoluble elastin. Isodesmosine 160-172 elastin Homo sapiens 0-12 10757115-1 1999 Tropoelastin, which is secreted from the cell in a soluble form, contains specific alanine rich repeat domains that are destined to form covalent desmosine and isodesmosine crosslinks in mature insoluble elastin. Isodesmosine 160-172 elastin Homo sapiens 5-12 2393394-1 1990 A collagen-like insoluble protein containing the elastin cross-links (desmosine and isodesmosine) has been isolated from Descemet"s membrane. Isodesmosine 84-96 elastin Homo sapiens 49-56 8531009-0 1995 Comparison of ELISA and HPLC for the determination of desmosine or isodesmosine in aortic tissue elastin. Isodesmosine 67-79 elastin Homo sapiens 97-104 3102660-2 1987 Elastin synthesis, as measured by 14C-lysine incorporation into desmosine and isodesmosine, was significantly elevated (P less than 0.05) above control values for a 3-week interval after induction of lung injury. Isodesmosine 78-90 elastin Homo sapiens 0-7 34077773-1 2021 The proposed biosynthetic pathway is similar to that of desmosine and isodesmosine, which are elastin-crosslinking amino acids. Isodesmosine 70-82 elastin Homo sapiens 94-101 3248767-13 1988 Elastin concentration in stomach cancer was determined through the assay of desmosine and isodesmosine which are specific cross-link amino acids in elastin. Isodesmosine 90-102 elastin Homo sapiens 0-7 3248767-13 1988 Elastin concentration in stomach cancer was determined through the assay of desmosine and isodesmosine which are specific cross-link amino acids in elastin. Isodesmosine 90-102 elastin Homo sapiens 148-155 3379243-3 1988 Elastin was quantitated on the basis of labeled desmosine/isodesmosine in the matrices as determined by a cation-exchange HPLC program utilizing a Beckman 6300 amino acid analyzer. Isodesmosine 58-70 elastin Homo sapiens 0-7 2380309-3 1990 The simple sample pretreatment, the optimized chromatographic conditions and the short HPLC analysis time (less than 15 min) allow the accurate and rapid determination of desmosine and isodesmosine, thus permitting the determination of elastin in several kinds of tissues with a minimum of sample manipulation. Isodesmosine 185-197 elastin Homo sapiens 236-243 34839160-1 2021 Desmosine and isodesmosine are crosslinking amino acids of elastin, which is an essential component of the dermal extracellular matrix protein. Isodesmosine 14-26 elastin Homo sapiens 59-66 4037006-5 1985 Uterine elastin contains 2.4 residues of desmosine plus isodesmosine in 1000 residues of amino acids. Isodesmosine 56-68 elastin Homo sapiens 8-15 2869571-2 1986 In addition, biosynthesis of isodesmosine and desmosine, the cross-linking amino acids of elastin, was studied by metabolic labelling with [14C]lysine and subsequent amino acid chromatography of protein hydrolysates. Isodesmosine 29-41 elastin Homo sapiens 90-97 6199445-0 1984 Measurement of cross-linked elastin synthesis in bleomycin-induced pulmonary fibrosis using a highly sensitive assay for desmosine and isodesmosine. Isodesmosine 135-147 elastin Homo sapiens 28-35 2857757-5 1985 Formation of new elastin as monitored by 14C-lysine incorporation into the elastin specific cross-links desmosine and isodesmosine was reduced approximately 40%, although there was no significant difference in the levels of lysyl oxidase activity. Isodesmosine 118-130 elastin Homo sapiens 17-24 2857757-5 1985 Formation of new elastin as monitored by 14C-lysine incorporation into the elastin specific cross-links desmosine and isodesmosine was reduced approximately 40%, although there was no significant difference in the levels of lysyl oxidase activity. Isodesmosine 118-130 elastin Homo sapiens 75-82 3159542-1 1985 Photolysis and partial ozonolysis of guanidinated kappa-elastin led to the destruction of isodesmosine and desmosine up to 96.0 and 91.5% respectively. Isodesmosine 90-102 elastin Homo sapiens 56-63 6199445-1 1984 Cross-linked elastin synthesis was measured in the intratracheal bleomycin model of interstitial pulmonary fibrosis by incorporation of 14C-lysine into the elastin-specific crosslinks, desmosine and isodesmosine. Isodesmosine 199-211 elastin Homo sapiens 13-20 435516-1 1979 Desmosine and isodesmosine are two isomers representing the main crosslinks of elastin. Isodesmosine 14-26 elastin Homo sapiens 79-86 7174792-6 1982 Amino acid analyses of both elastin preparations indicated that the values for desmosine and isodesmosine were reduced in Marfan cases to approximately one-half of the control values. Isodesmosine 93-105 elastin Homo sapiens 28-35 7086186-2 1982 Aortae and other tissues from several vertebrates and invertebrates were examined for the presence of elastin, which was defined on the basis of a characteristic amino acid composition, the presence of the unique crosslinks desmosine and isodesmosine, and by histologic criteria. Isodesmosine 238-250 elastin Homo sapiens 102-109 6912069-2 1981 Elastin contains a number of cross-linking amino acid residues such as desmosine and isodesmosine which are primarily hydrophobic in character, but have a positively charged pyridinium ring. Isodesmosine 85-97 elastin Homo sapiens 0-7 7226529-2 1981 Desmosine and isodesmosine, the cross-linking amino acids unique to elastin, were measured directly from acid hydrolysates of hamster and human lungs by amino acid analysis. Isodesmosine 14-26 elastin Homo sapiens 68-75 6224636-0 1983 The estimation of elastin in fetal tissues by radioimmunoassay of isodesmosine. Isodesmosine 66-78 elastin Homo sapiens 18-25 869169-0 1977 Determination of the elastin content of tissues by measuring desmosine and isodesmosine. Isodesmosine 75-87 elastin Homo sapiens 21-28 30449-2 1978 The formation of isodesmosine and desmosine in vitro by the action of lysyl oxidase on tropoelastin was studied. Isodesmosine 17-29 elastin Homo sapiens 87-99 620069-1 1978 Dihydrodesmosine and dihydroisodemosine are dihydropyridines which are believed to be the immediate biosynthetic precursors of desmosine and isodesmosine, the stable pyridinium ion crosslinks of elastin. Isodesmosine 141-153 elastin Homo sapiens 195-202 1030702-6 1976 In the absence of beta-aminopropionitrile, long-term cultures of smooth muscle cells incorporated [14C]lysine into desmosine and isodesmosine, the cross-link amino acids unique to elastin. Isodesmosine 129-141 elastin Homo sapiens 180-187 5577443-0 1971 The presence in elastin of possible cyclic precursors of desmosine and isodesmosine. Isodesmosine 71-83 elastin Homo sapiens 16-23 5005495-0 1971 Desmosine and isodesmosine levels of aortic elastin in control and pyridoxine-deficient monkeys. Isodesmosine 14-26 elastin Homo sapiens 44-51 1215339-1 1975 A rapid large scale procedure was devised for the purification of desmosine and isodesmosine from ligamentum nuchae elastin. Isodesmosine 80-92 elastin Homo sapiens 116-123 4858781-0 1974 Isomers of desmosine and isodesmosine and related reduced compounds in elastin. Isodesmosine 25-37 elastin Homo sapiens 71-78 5097573-9 1971 In elastin from plaque intima, the following polar amino acids were increased significantly: aspartic acid, threonine, serine, glutamic acid, lysine, histidine, and arginine; whereas, cross-linking amino acids: desmosine, isodesmosine, and lysinonorleucine were decreased significantly. Isodesmosine 222-234 elastin Homo sapiens 3-10 30218154-1 2018 PURPOSE: While the elastin-specific crosslinks, desmosine and isodesmosine (DID), are increased in blood, urine, and sputum of patients with clinically documented pulmonary emphysema, the usefulness of DID in detecting early lung injury remains untested. Isodesmosine 62-74 elastin Homo sapiens 19-26 5823928-0 1969 An approach to the study of the structure of desmosine and isodesmosine containing peptides isolated from the elastase digest of elastin. Isodesmosine 59-71 elastin Homo sapiens 129-136 5839176-0 1964 Biosynthesis of the desmosine and isodesmosine cross-bridges in elastin. Isodesmosine 34-46 elastin Homo sapiens 64-71 5422774-0 1970 On the mechanism of formation of desmosine and isodesmosine cross-links of elastin. Isodesmosine 47-59 elastin Homo sapiens 75-82 31218219-1 2019 Novel methodological approaches now demonstrate that the unique elastin degradation products desmosine and isodesmosine are detectable in plasma of cystic fibrosis patients and correlate to lung function, exacerbation frequency and disease progression http://bit.ly/2VwZOcx. Isodesmosine 107-119 elastin Homo sapiens 64-71 29558926-4 2018 The amino acids desmosine and isodesmosine (DES) are unique to elastin. Isodesmosine 30-42 elastin Homo sapiens 63-70 29289686-4 2018 Two cross-linking amino acids, desmosine and isodesmosine (DI), are unique to mature elastin and can serve as biomarkers of the degradation of elastin. Isodesmosine 45-57 elastin Homo sapiens 85-92 29289686-4 2018 Two cross-linking amino acids, desmosine and isodesmosine (DI), are unique to mature elastin and can serve as biomarkers of the degradation of elastin. Isodesmosine 45-57 elastin Homo sapiens 143-150 30062515-1 2018 Desmosine (Des) and isodesmosine (Isodes), cross-linking amino acids in the biomolecule elastin, may be used as biomarkers for various pathological conditions associated with elastin degradation. Isodesmosine 20-32 elastin Homo sapiens 88-95 30062515-1 2018 Desmosine (Des) and isodesmosine (Isodes), cross-linking amino acids in the biomolecule elastin, may be used as biomarkers for various pathological conditions associated with elastin degradation. Isodesmosine 20-32 elastin Homo sapiens 175-182 30062515-1 2018 Desmosine (Des) and isodesmosine (Isodes), cross-linking amino acids in the biomolecule elastin, may be used as biomarkers for various pathological conditions associated with elastin degradation. Isodesmosine 34-40 elastin Homo sapiens 88-95 30062515-1 2018 Desmosine (Des) and isodesmosine (Isodes), cross-linking amino acids in the biomolecule elastin, may be used as biomarkers for various pathological conditions associated with elastin degradation. Isodesmosine 34-40 elastin Homo sapiens 175-182 29461896-5 2018 This discovery gave focus to two amino acids that reside only in body elastin, desmosine and isodesmosine, which can be measured as biomarkers of elastin degradation in body fluids with increased accuracy and sensitivity. Isodesmosine 93-105 elastin Homo sapiens 70-77 29461896-5 2018 This discovery gave focus to two amino acids that reside only in body elastin, desmosine and isodesmosine, which can be measured as biomarkers of elastin degradation in body fluids with increased accuracy and sensitivity. Isodesmosine 93-105 elastin Homo sapiens 146-153 29055397-10 2017 Since the amino acids desmosine and isodesmosine (DES) are unique to crosslinked elastin fibers, systemic elastin degradation can be assessed with the plasma DES assay. Isodesmosine 36-48 elastin Homo sapiens 81-88 28848909-2 2016 Desmosine and isodesmosine (DES/IDES) are unique crosslinkers of mature elastin fibers and are utilized as measures of elastin degradation. Isodesmosine 14-26 elastin Homo sapiens 72-79 25762453-1 2015 BACKGROUND: The unique elastin crosslinks, desmosine and isodesmosine (DID) are significantly elevated in blood, urine, and sputum from patients with COPD, and may decline following treatment of the disease. Isodesmosine 57-69 elastin Homo sapiens 23-30 27564670-3 2016 Amino acids desmosine and isodesmosine are unique cross-links in mature elastin fibers and can serve as biomarkers of elastin degradation when measured in body fluids. Isodesmosine 26-38 elastin Homo sapiens 72-79 27564670-3 2016 Amino acids desmosine and isodesmosine are unique cross-links in mature elastin fibers and can serve as biomarkers of elastin degradation when measured in body fluids. Isodesmosine 26-38 elastin Homo sapiens 118-125 23547990-2 2013 A huge amount of data, accumulated over the years, have provided solid evidence that two pyridinium-ring-containing amino acid isoforms, desmosine and isodesmosine (usually referred to as desmosines), unique to mature elastin in humans, are representative of the elastin breakdown occurring in chronic destructive disorders, such as COPD. Isodesmosine 151-163 elastin Homo sapiens 218-225 25890800-0 2015 [(13)C3,(15)N1]-labeled isodesmosine: A potential internal standard for LC-MS/MS analysis of desmosines in elastin degradation. Isodesmosine 24-36 elastin Homo sapiens 107-114 25890800-1 2015 Isodesmosine and desmosine are crosslinking amino acids that are present only in elastin. Isodesmosine 0-12 elastin Homo sapiens 81-88 25890800-4 2015 The labeled isodesmosine is a potential internal standard for the quantitative LC-MS/MS analysis of desmosines in elastin degradation. Isodesmosine 12-24 elastin Homo sapiens 114-121 24395662-1 2014 Desmosine (DES) and isodesmosine are two isomer amino acids unique-to-mature, cross-linked elastin. Isodesmosine 20-32 elastin Homo sapiens 91-98 24597689-0 2014 Biomimetic Chichibabin pyridine synthesis of the COPD biomarkers and elastin cross-linkers isodesmosine and desmosine. Isodesmosine 91-103 elastin Homo sapiens 69-76 24597689-1 2014 The tetrasubstituted pyridinium amino acids isodesmosine and desmosine are cross-linkers of elastin and are attractive biomarkers for the diagnosis of chronic obstructive pulmonary disease (COPD). Isodesmosine 44-56 elastin Homo sapiens 92-99 23560990-4 2013 METHODS: Desmosine and isodesmosine (DI), which occur only in elastin, are amino acid cross-links in mature elastin. Isodesmosine 23-35 elastin Homo sapiens 62-69 23560990-4 2013 METHODS: Desmosine and isodesmosine (DI), which occur only in elastin, are amino acid cross-links in mature elastin. Isodesmosine 23-35 elastin Homo sapiens 108-115 23547990-2 2013 A huge amount of data, accumulated over the years, have provided solid evidence that two pyridinium-ring-containing amino acid isoforms, desmosine and isodesmosine (usually referred to as desmosines), unique to mature elastin in humans, are representative of the elastin breakdown occurring in chronic destructive disorders, such as COPD. Isodesmosine 151-163 elastin Homo sapiens 263-270 21793711-1 2011 Desmosine and isodesmosine are products of elastin breakdown which are candidate biomarkers to measure lung destruction in COPD. Isodesmosine 14-26 elastin Homo sapiens 43-50 21757624-6 2011 The amino acids desmosine and isodesmosine exist only in matrix elastin; can be measured specifically and sensitively in plasma, urine, and sputum; and indicate changes in the systemic balance between elastase activity and elastase inhibition brought on by the systemic inflammatory state. Isodesmosine 30-42 elastin Homo sapiens 64-71 21726534-0 2011 Liberation of desmosine and isodesmosine as amino acids from insoluble elastin by elastolytic proteases. Isodesmosine 28-40 elastin Homo sapiens 71-78 21726534-6 2011 Elastin oxidized by reactive oxygen species (ROS) liberated more unconjugated DES and IDE than did non-oxidized elastin when incubated with MMP-12 or neutrophil elastase. Isodesmosine 86-89 elastin Homo sapiens 0-7 21726534-2 2011 Releases of the elastin cross-links desmosine (DES) and isodesmosine (IDE) may reflect elastin degradation in cardiovascular diseases. Isodesmosine 56-68 elastin Homo sapiens 16-23 21726534-2 2011 Releases of the elastin cross-links desmosine (DES) and isodesmosine (IDE) may reflect elastin degradation in cardiovascular diseases. Isodesmosine 56-68 elastin Homo sapiens 87-94 21726534-2 2011 Releases of the elastin cross-links desmosine (DES) and isodesmosine (IDE) may reflect elastin degradation in cardiovascular diseases. Isodesmosine 70-73 elastin Homo sapiens 16-23 21726534-2 2011 Releases of the elastin cross-links desmosine (DES) and isodesmosine (IDE) may reflect elastin degradation in cardiovascular diseases. Isodesmosine 70-73 elastin Homo sapiens 87-94 21621489-0 2011 Quantitation of desmosine and isodesmosine in urine, plasma, and sputum by LC-MS/MS as biomarkers for elastin degradation. Isodesmosine 30-42 elastin Homo sapiens 102-109 20625235-1 2010 Desmosine (DES) and isodesmosine (IDES) are both pyridinium amino acid isomers that serve as cross-linking molecules binding the polymeric chains of amino acids into elastin. Isodesmosine 20-32 elastin Homo sapiens 166-173 19243601-1 2009 BACKGROUND: Desmosine and Isodesmosine (D/I) are cross-linking amino acids which are present only in mature elastin. Isodesmosine 26-38 elastin Homo sapiens 108-115 19247601-6 2009 We describe the determination of these cross-links in detail.Elastin is also stabilised by cross-linking based on oxidative deamination of most of its lysine residues to yield tetravalent cross-links, desmosine and iso-desmosine, the determination of which is also described.A second cross-linking pathway occurs during ageing (and to a greater extent in diabetes mellitus) involving reaction with tissue glucose. Isodesmosine 215-228 elastin Homo sapiens 61-68