PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9681677-1	1998	FcepsilonRI-mediated exocytosis of preformed mediators from mast cells and basophils (e.g. histamine, serotonin, beta-hexosaminidase) is sensitive to the immunosuppressants cyclosporin A and FK506 (IC50 200 and 4 nM, respectively) but not rapamycin.	Tacrolimus	191-196	O-GlcNAcase	Rattus norvegicus	113-132	
16546704-5	2006	CsA and FK506 each dose-dependently inhibited antigen-induced histamine and beta-hexosaminidase secretion and the membrane repolarization phase, with similar IC50s for both actions, approximately 20 nM for CsA and approximately 2 nM for FK506.	Tacrolimus	8-13	O-GlcNAcase	Rattus norvegicus	76-95	
8762016-6	1996	Tacrolimus significantly increased NAG (N-acetyl-beta-glucosaminidase) excretion and associated histological damage, finally decreasing creatinine clearance.	Tacrolimus	0-10	O-GlcNAcase	Rattus norvegicus	35-38	
8762016-6	1996	Tacrolimus significantly increased NAG (N-acetyl-beta-glucosaminidase) excretion and associated histological damage, finally decreasing creatinine clearance.	Tacrolimus	0-10	O-GlcNAcase	Rattus norvegicus	40-69	
1281562-6	1992	The damage induced by FK506 and CsA was characterized by a direct cytotoxic effect on tubular cells, as expressed by release of 3H thymidine from prelabeled cells, N-acetyl-beta-D-glucosaminidase release, and cell detachment.	Tacrolimus	22-27	O-GlcNAcase	Rattus norvegicus	164-195