PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8762016-6 1996 Tacrolimus significantly increased NAG (N-acetyl-beta-glucosaminidase) excretion and associated histological damage, finally decreasing creatinine clearance. Tacrolimus 0-10 O-GlcNAcase Rattus norvegicus 35-38 16546704-5 2006 CsA and FK506 each dose-dependently inhibited antigen-induced histamine and beta-hexosaminidase secretion and the membrane repolarization phase, with similar IC50s for both actions, approximately 20 nM for CsA and approximately 2 nM for FK506. Tacrolimus 8-13 O-GlcNAcase Rattus norvegicus 76-95 9681677-1 1998 FcepsilonRI-mediated exocytosis of preformed mediators from mast cells and basophils (e.g. histamine, serotonin, beta-hexosaminidase) is sensitive to the immunosuppressants cyclosporin A and FK506 (IC50 200 and 4 nM, respectively) but not rapamycin. Tacrolimus 191-196 O-GlcNAcase Rattus norvegicus 113-132 8762016-6 1996 Tacrolimus significantly increased NAG (N-acetyl-beta-glucosaminidase) excretion and associated histological damage, finally decreasing creatinine clearance. Tacrolimus 0-10 O-GlcNAcase Rattus norvegicus 40-69 1281562-6 1992 The damage induced by FK506 and CsA was characterized by a direct cytotoxic effect on tubular cells, as expressed by release of 3H thymidine from prelabeled cells, N-acetyl-beta-D-glucosaminidase release, and cell detachment. Tacrolimus 22-27 O-GlcNAcase Rattus norvegicus 164-195