PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25891728-6	2015	Immunohistochemistry and Western blot analysis data revealed that the FK506 treatment increased expression of heme oxygenase-1 (HO-1) in Jurkat cells in a dose-dependent manner.	Tacrolimus	70-75	heme oxygenase 1	Homo sapiens	110-126	
25891728-6	2015	Immunohistochemistry and Western blot analysis data revealed that the FK506 treatment increased expression of heme oxygenase-1 (HO-1) in Jurkat cells in a dose-dependent manner.	Tacrolimus	70-75	heme oxygenase 1	Homo sapiens	128-132	
25891728-7	2015	HO-1 expression was induced after 6 hours of treatment of FK506 to Jurkat cells, peaked at 24 hours, and then decreased after 48 hours.	Tacrolimus	58-63	heme oxygenase 1	Homo sapiens	0-4	
25891728-8	2015	CONCLUSIONS: These results suggest that FK506 induces Nrf 2-driven transcriptional activation of the antioxidant response element by activating HO-1 and free radicals such as reactive oxygen species and nitric oxide.	Tacrolimus	40-45	heme oxygenase 1	Homo sapiens	144-148	
12352326-9	2002	Endothelial NOS mRNA was increased in cyclosporine-and tacrolimus-treated patients in comparison with controls (0.92 +/- 0.09, 0.96 +/- 0.04, and 0.37 +/- 0.05 respectively; p < 0.001), whereas no difference was found between patients and controls in HO-1 mRNA.	Tacrolimus	55-65	heme oxygenase 1	Homo sapiens	254-258