PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24836681-3	2014	STUDY DESIGN AND METHODS: DCs derived from human monocytes were induced in vitro by GM-CSF/IL-4 with tacrolimus.	Tacrolimus	101-111	colony stimulating factor 2	Homo sapiens	84-90	
11407316-6	2001	In a comparative study with steroids (alclometasone dipropionate and betamethason valerate) in anti-CD3/CD2 system, tacrolimus and both steroids inhibited Th1 cytokines (IL-2, IFN-gamma), Th2 cytokines (IL-4, IL-5) and IL-3, GM-CSF (produced by both Th1 and Th2).	Tacrolimus	116-126	colony stimulating factor 2	Homo sapiens	225-231	
20159692-4	2010	RESULTS: Compared with the control group, high-concentration FK506 (20 ng/ml) significantly inhibited the secretions of IL-2, IL-6, IL-12, IL-17, IFN-gamma, TNF-alpha, GM-CSF and G-CSF.	Tacrolimus	61-66	colony stimulating factor 2	Homo sapiens	168-174	
20159692-5	2010	At a moderate concentration (5 ng/ml), FK506 inhibited the secretion of GM-CSF significantly.	Tacrolimus	39-44	colony stimulating factor 2	Homo sapiens	72-78	
20159692-6	2010	CONCLUSION: FK506 effectively inhibits the secretion of proinflammatory cytokines including IL-6, IFN-gamma and TNF-alpha and also the secretion of IL-2, IL-12, IL-17, GM-CSF and G-CSF.	Tacrolimus	12-17	colony stimulating factor 2	Homo sapiens	168-174	
18262659-3	2008	The culture study showed reduced IL-12, IL-17, IFN-gamma, GM-CSF, TNF-alpha and MIP-1beta, and elevated IL-10 in the PBMC from patients who received tacrolimus, which suggests inhibition of T cells and macrophages, and enhancement of type 1 regulatory T cells.	Tacrolimus	149-159	colony stimulating factor 2	Homo sapiens	58-64	
14579277-4	2003	Only very high doses of cyclosporin A and FK506 inhibited macrophage proliferation induced by growth factors, such as M-CSF, granulocyte-macrophage (GM)-CSF or IL-3.	Tacrolimus	42-47	colony stimulating factor 2	Homo sapiens	125-156	
9510155-8	1998	FK506 also reduced CD3/CD28-induced production of IL-3, IL-4, IL-10, TNF-alpha, and IL-6 but augmented that of GM-CSF, IL-5, IFN-gamma, and IL-13.	Tacrolimus	0-5	colony stimulating factor 2	Homo sapiens	111-117	
10861056-9	2000	In vitro, tacrolimus suppressed GM-CSF-stimulated growth of myeloid DC from normal BM much more effectively than from FL-BM without affecting MHC class II or costimulatory molecule expression.	Tacrolimus	10-20	colony stimulating factor 2	Homo sapiens	32-38	
9749865-7	1998	Tacrolimus also significantly suppressed the production of IL-8 and GM-CSF by the TCCs.	Tacrolimus	0-10	colony stimulating factor 2	Homo sapiens	68-74	
8846199-6	1995	FK506 strongly suppressed the production of IL-2 (IC50 = 0.01 microM) and GM-CSF (IC50 = 0.03 microM), but was inactive (< 30% inhibition at 1 microM) against IL-5 and IFN-gamma.	Tacrolimus	0-5	colony stimulating factor 2	Homo sapiens	74-80	
8575571-0	1995	FK506 and cyclosporin A inhibit granulocyte/macrophage colony-stimulating factor production by mononuclear cells in asthma.	Tacrolimus	0-5	colony stimulating factor 2	Homo sapiens	32-80	
8575571-3	1995	To assess this, we compared the inhibitory effects of FK506 and cyclosporin A on production of granulocyte/macrophage colony-stimulating factor and interleukin-5 by interleukin-2- or Dermatophagoides farinae-stimulated mononuclear cells from patients with asthma, and their contribution to proliferation and survival of eosinophils in vitro.	Tacrolimus	54-59	colony stimulating factor 2	Homo sapiens	95-143	
8575571-4	1995	FK506 inhibited granulocyte/macrophage colony-stimulating factor production by stimulated mononuclear cells from asthma patients at lower concentrations than cyclosporin A.	Tacrolimus	0-5	colony stimulating factor 2	Homo sapiens	16-64	
8186461-2	1994	The expression of GM-CSF and IL-2 is inhibited by immunosuppressive drugs such as cyclosporin A (CsA) and FK506.	Tacrolimus	106-111	colony stimulating factor 2	Homo sapiens	18-24	
7690315-8	1993	FK506 was found to inhibit the synthesis of IL3 and GM-CSF, whereas rapamycin failed to suppress the cytokine production of eosinophils.	Tacrolimus	0-5	colony stimulating factor 2	Homo sapiens	52-58	
7507316-6	1993	For instance, CsA and FK 506 inhibit the transcription of IL-3, IL-4, IFN gamma, TNF alpha or GM-CSF by activated T cells, and rapamycin has been shown to block the response to various growth factors such as IL-3, IL-4 or IL-6.	Tacrolimus	22-28	colony stimulating factor 2	Homo sapiens	94-100	
2472451-1	1989	FK506, a neutral macrolide with immunosuppressive properties, was shown to selectively and rapidly inhibit the accumulation of IL-2 mRNA, as well as the mRNAs of other early (E) phase T cell activation genes such as IL-3, IL-4, GM-CSF, TNF alpha, IFN-gamma, and c-myc in activated human peripheral blood T cells.	Tacrolimus	0-5	colony stimulating factor 2	Homo sapiens	228-234	
1281674-0	1992	FK506 and rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA.	Tacrolimus	0-5	colony stimulating factor 2	Homo sapiens	64-70	
1281674-2	1992	Using Northern analyses and promoter-reporter constructs we analyzed the transcriptional and posttranscriptional effects of FK506 and rapamycin on IL-2, GM-CSF, and IL-2R alpha gene expression.	Tacrolimus	124-129	colony stimulating factor 2	Homo sapiens	153-159	
1380951-3	1992	While 1 microgram/ml CSA and 0.1 microgram/ml FK 506 completely suppressed PHA-stimulated accumulation of mRNA for IL2, IL4, IL9, GM-CSF, TNF-alpha and IFN-gamma in PBMC, flu, keto and TGF-beta failed to inhibit any (except TNF-alpha blocked by TGF-beta).	Tacrolimus	46-52	colony stimulating factor 2	Homo sapiens	130-136