PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17034537-8	2006	The increase of pigmentation was due to the result of the stimulatory action of FK506 on tyrosinase activity and its expression, which eventually led to melanin biosynthesis.	Tacrolimus	80-85	tyrosinase	Homo sapiens	89-99	
26581186-3	2016	This treatment did not affect the transcription levels of tyrosinase, suggesting that FK506 increases melanin synthesis by regulating cellular levels of tyrosinase.	Tacrolimus	86-91	tyrosinase	Homo sapiens	153-163	
26581186-4	2016	Interestingly, FK506 promoted melanosome maturation by increasing melanosomal pH (a marker of melanosome maturation), thereby enhancing the stability of melanosome-localized tyrosinase.	Tacrolimus	15-20	tyrosinase	Homo sapiens	174-184