PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22743729-11	2012	In liver recipients, a possible association between recipient ACE, CYP3A5, ABCB1 and CYP2C8 genetic polymorphisms and tacrolimus-induced nephrotoxicity was suggested.	Tacrolimus	118-128	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	85-91	
28316087-11	2017	Further, CYP2C8*3 and CYP2J2 c.-76G>T SNPs influenced the renal function of these patients and the occurrence of adverse events during treatment with tacrolimus and mycophenolate sodium.	Tacrolimus	153-163	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	9-15	
28316087-1	2017	STUDY OBJECTIVE: To investigate the influence of single nucleotide polymorphisms (SNPs) in genes encoding metabolizing enzymes (CYP2C8, CYP2J2, and UGT2B7) and transporters (ABCC2 and ABCG2) on dose and dose-adjusted trough blood concentrations (C:D ratio), clinical outcomes, and occurrence of adverse events of tacrolimus and mycophenolate sodium in Brazilian kidney transplant recipients.	Tacrolimus	313-323	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	128-134	
28316087-7	2017	The CYP2C8*3 variant was also associated with slightly higher tacrolimus C:D values and higher estimated glomerular filtration rate but only in CYP3A5-nonexpressing patients (CYP3A5*3C/*3C carriers).	Tacrolimus	62-72	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	4-10	
22369694-1	2012	We retrospectively examined the association of polymorphisms in the CYP3A, CYP2J2, CYP2C8, and ABCB1 genes with pharmacokinetic (PKs) and pharmacodynamic (PDs) parameters of tacrolimus in 103 renal transplant recipients for a period of 1 year.	Tacrolimus	174-184	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	83-89	
31244435-0	2019	Association of Genetic Variants in CYP3A4, CYP3A5, CYP2C8, and CYP2C19 with Tacrolimus Pharmacokinetics in Renal Transplant Recipients.	Tacrolimus	76-86	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	51-57	
30577195-11	2018	CONCLUSIONS: CYP2C8*3 and CYP3A5*3 appear to be predictive of risk of tacrolimus-induced early renal impairment.	Tacrolimus	70-80	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	13-19