PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9169521-6	1997	Synaptic potentiation induced by FK-506 was significantly attenuated by co-injecting BAPTA, heparin/dantrolene (inhibitors of intracellular Ca2+ release), a CaM-binding peptide, or CaM-KII/PKC pseudosubstrate peptides.	Tacrolimus	33-39	carbonic anhydrase 2	Rattus norvegicus	140-143	
9147322-8	1997	Inhibition of FKBP by the immunosuppressants FK506 or rapamycin increased the duration of spontaneous or depolarization-evoked Ca2+ sparks 6- to 7-fold.	Tacrolimus	45-50	carbonic anhydrase 2	Rattus norvegicus	127-130	
9147322-11	1997	FK506 potentiated and prolonged electrically stimulated [Ca2+]i transients and contractions, but did not affect the amplitude and kinetics of the L-type Ca2+ channel current.	Tacrolimus	0-5	carbonic anhydrase 2	Rattus norvegicus	57-60	
9147322-13	1997	In planar lipid bilayers, FK506 (15 microM) prolonged approximately 7-fold the mean open lifetime of reconstituted single RyRs, induced the appearance of long-lasting subconductance states, and markedly slowed the spontaneous decay of RyR activity elicited by fast and sustained Ca2+ stimuli.	Tacrolimus	26-31	carbonic anhydrase 2	Rattus norvegicus	279-282	
8874888-1	1996	The effects of FK506, a Ca2+/calmodulin-dependent phosphatase 2B (calcineurin) inhibitor, on the NMDA receptor-mediated potentials and synaptic plasticity were investigated in the CA1 region of the rat hippocampus.	Tacrolimus	15-20	carbonic anhydrase 2	Rattus norvegicus	24-27	
8874888-6	1996	The differential effects of FK506 on LTP and depotentiation may attribute to the partial inhibition on the activity of NMDA receptors and the subsequent attenuation of intracellular Ca2+ increase.	Tacrolimus	28-33	carbonic anhydrase 2	Rattus norvegicus	182-185	
31467711-3	2019	In this study, we investigated the effective dose and injection time of FK506 as an immunophilin ligand for providing a suitable effect on cells of CA2, CA3, and dentate gyrus of the hippocampus.	Tacrolimus	72-77	carbonic anhydrase 2	Rattus norvegicus	148-151