PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22493070-7 2012 Ang II effects were blunted by an Ang II type 1 receptor antagonist (candesartan) and inhibitors of calcineurin (cyclosporine A and FK506) and nuclear factor of activated T-cells (VIVIT). Tacrolimus 132-137 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 0-6 20580688-4 2010 Mechanical stresses for 2weeks in vivo and for 24h in vitro significantly induced upregulation of calcineurin expression and hypertrophic responses, such as the increases in cardiomyocytes size and specific gene expressions, in cardiomyocytes of angiotensinogen gene knockout (ATG(-/-)) mice, both of which were significantly suppressed by a specific calcineurin inhibitor FK506, suggesting a critical role of calcineurin in mechanical stress-induced cardiac hypertrophy in the ATG(-/-) mice. Tacrolimus 373-378 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 246-261