PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32719413-5	2020	Logistic regression analysis showed the male sex and higher C-reactive protein to be independent factors for response to anti-TNF agents and TAC, respectively.	Tacrolimus	141-144	C-reactive protein	Homo sapiens	60-78	
22260742-10	2012	Even after predonisolone and tacrolimus were tapered gradually and discontinued because of her good response, CRP and DAS-CRP became 0.0 mg/dL and 1.5, respectively.	Tacrolimus	29-39	C-reactive protein	Homo sapiens	110-113	
27604685-0	2016	Previous exposure to biologics and C-reactive protein are associated with the response to tacrolimus in inflammatory bowel disease.	Tacrolimus	90-100	C-reactive protein	Homo sapiens	35-53	
24447269-8	2014	The high-sensitivity C-reactive protein was decreased (tacrolimus group, 1 mo) and increased (cyclosporine group, 6 and 12 mo) after the kidney transplant.	Tacrolimus	55-65	C-reactive protein	Homo sapiens	21-39	
23271170-4	2013	RESULTS: Univariate analysis showed that a baseline C-reactive protein (CRP) level of <1.5 mg/dL was the major determinant of  TSS <0.5 at week 52 in the tacrolimus group.	Tacrolimus	160-170	C-reactive protein	Homo sapiens	52-70	
23271170-4	2013	RESULTS: Univariate analysis showed that a baseline C-reactive protein (CRP) level of <1.5 mg/dL was the major determinant of  TSS <0.5 at week 52 in the tacrolimus group.	Tacrolimus	160-170	C-reactive protein	Homo sapiens	72-75	
23271170-8	2013	CONCLUSIONS: Adding tacrolimus to DMARDs significantly suppressed disease activity and joint destruction in patients with early rheumatoid arthritis, a disease duration <=3 years, a CRP <1.5 mg/dL, and a poor response to oral DMARDs.	Tacrolimus	20-30	C-reactive protein	Homo sapiens	185-188	
22260742-10	2012	Even after predonisolone and tacrolimus were tapered gradually and discontinued because of her good response, CRP and DAS-CRP became 0.0 mg/dL and 1.5, respectively.	Tacrolimus	29-39	C-reactive protein	Homo sapiens	122-125	
22353651-2	2011	METHODS: Tacrolimus was administered if the effect of biologics was unsatisfactory for 24 weeks at least in terms of laboratory data or DAS28 level: ESR, CRP level and DAS28 level were not below 15 mm/h, 0.2 mg/dl or 2.6, respectively.	Tacrolimus	9-19	C-reactive protein	Homo sapiens	154-157	
34834375-7	2021	In multivariate analysis, the log Cmin/dose of tacrolimus was significantly and positively associated with the hematocrit, ALAT, and CRP concentrations.	Tacrolimus	47-57	C-reactive protein	Homo sapiens	133-136	
34834375-8	2021	CRP concentrations were higher (p = 0.003) for patients with tacrolimus overexposure (i.e., tacrolimus Cmin > 15 microg/L) (median CRP (10th-90th percentiles): 27 mg/L (3-149 mg/L), n = 91) than they were for patients with a tacrolimus Cmin <= 15 microg/L (13 mg/mL (3-95 mg/L), n = 1482)).	Tacrolimus	61-71	C-reactive protein	Homo sapiens	0-3	
34834375-8	2021	CRP concentrations were higher (p = 0.003) for patients with tacrolimus overexposure (i.e., tacrolimus Cmin > 15 microg/L) (median CRP (10th-90th percentiles): 27 mg/L (3-149 mg/L), n = 91) than they were for patients with a tacrolimus Cmin <= 15 microg/L (13 mg/mL (3-95 mg/L), n = 1482)).	Tacrolimus	92-102	C-reactive protein	Homo sapiens	0-3	
34834375-9	2021	CRP in the fourth quartile (49 to 334 mg/L) was associated with a 2.6-fold increased risk of tacrolimus Cmin overexposure.	Tacrolimus	93-103	C-reactive protein	Homo sapiens	0-3