PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11093160-9	2000	In untransformed human peripheral blood T lymphocytes, these phosphatases function through a cyclosporin A/FK506-resistant co-stimulatory signaling pathway which is common for the accessory receptors CD2 and CD28.	Tacrolimus	107-112	CD2 molecule	Homo sapiens	200-203	
7511258-0	1994	Anti-CD2 monoclonal antibodies synergize with FK506 but not with cyclosporine or rapamycin to induce tolerance.	Tacrolimus	46-51	CD2 molecule	Homo sapiens	5-8	
7511258-15	1994	This suggests that FK506 acts at a different locus in allograft immunity compared with the other immunosuppressants and this may be related to the alternative CD2 T cell activation pathway.	Tacrolimus	19-24	CD2 molecule	Homo sapiens	159-162	
7691614-6	1993	Induction of apoptosis by anti-CD2 mAb was prevented by cyclosporine A and FK 506.	Tacrolimus	75-81	CD2 molecule	Homo sapiens	31-34	
1705513-4	1991	We have shown that FK-506, like CsA, is able to inhibit T cell activation mediated not only by the T cell receptor-CD3 complex, but also via another surface molecule, CD2.	Tacrolimus	19-25	CD2 molecule	Homo sapiens	167-170	
33512727-2	2021	Herein, we present evidence that pre-and post- intraperitoneal administration of tacrolimus (FK506) is very effective in reducing CCR3/SigleF+ eosinophils in Aspergillus-challenged asthma and EoE, CD2-IL-5 induced global eosinophilia and DOX regulated IL-13 induced asthma.	Tacrolimus	81-91	CD2 molecule	Homo sapiens	197-200	
33512727-2	2021	Herein, we present evidence that pre-and post- intraperitoneal administration of tacrolimus (FK506) is very effective in reducing CCR3/SigleF+ eosinophils in Aspergillus-challenged asthma and EoE, CD2-IL-5 induced global eosinophilia and DOX regulated IL-13 induced asthma.	Tacrolimus	93-98	CD2 molecule	Homo sapiens	197-200	
2483716-1	1989	Nanomolar concentrations of the novel immunosuppressive drug FK-506 inhibit the proliferation of human T lymphocytes in vitro induced by mitogenic lectins or by monoclonal antibodies directed against the CD3 or CD2 surface antigens.	Tacrolimus	61-67	CD2 molecule	Homo sapiens	211-214	
15598440-3	2005	Culture supernatant from peripheral blood mononuclear cells (PBMC) stimulated with anti-CD3 plus anti-CD2 antibodies effectively induced the expression of E-selectin, ICAM-1 and VCAM-1 on HMVEC, and treatment with FK506 down-regulated their expression.	Tacrolimus	214-219	CD2 molecule	Homo sapiens	102-105