PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12606707-0	2003	Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.	Tacrolimus	15-20	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	45-104	
12606707-6	2003	Binding of BIG1, BIG2, and ARF to cell membranes in vitro was increased by guanosine 5"-[gamma-thio]triphosphate, and further increases were induced by FK506.	Tacrolimus	152-157	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	11-15	
12606707-7	2003	Incubation of Jurkat T cells with FK506 increased binding of BIG1, BIG2, and ARF to Golgi and other membranes in a time- and concentration-dependent manner, without effects on clathrin or gamma-adaptin binding.	Tacrolimus	34-39	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	61-65	
12606707-8	2003	Binding of BIG1, BIG2, and ARF to membranes was also increased by L-732,531, an agonist structurally related to FK506, but was not increased by a related antagonist, L-685,818, nor by cyclosporin A or rapamycin.	Tacrolimus	112-117	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	11-15	
12606707-0	2003	Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.	Tacrolimus	15-20	ADP ribosylation factor guanine nucleotide exchange factor 1	Homo sapiens	106-110