PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22100870-8 2012 Our data suggest that CsA and FK506, via ROS-dependent and ADAM17-catalyzed HB-EGF shedding induce the mitogenic ERK1/2 signaling cascade in renal MC. Tacrolimus 30-35 ADAM metallopeptidase domain 17 Rattus norvegicus 59-65