PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32817992-4	2020	Results Tacrolimus significantly increased the expression of LIF, IL-10, and IL-17 and decreased the expression of IL-4, IFN-gamma, and the IFN-gamma/IL-10 ratio in RIF patients.	Tacrolimus	8-18	interleukin 4	Homo sapiens	115-119	
33512727-4	2021	Additionally, we also performed ELISA and Western blot analyses to show that tacrolimus treatment also reduces the levels of eosinophil-specific cytokines IL-4, IL-5, IL-13, TGF-beta, eosinophil-specific chemokines Eotaxin-1, Eotaxin-2, and progenitors target RCAN1 mRNA levels.	Tacrolimus	77-87	interleukin 4	Homo sapiens	155-159	
32067305-6	2020	Two patients with severe food allergy responded favorably to conversion from tacrolimus-based immunosuppression to MMF and corticosteroids with reduction in clinical symptoms, total IgE, specific IgE, IL-1ra, IL-4, RANTES, PDGF, MIP-1a, and TNFalpha.	Tacrolimus	77-87	interleukin 4	Homo sapiens	209-213	
28060893-8	2017	Molecular features involved in inflammation and immune response contributing to DN progression were significantly downregulated by tacrolimus (e.g. the tumor necrosis factor alpha (TNF), interleukin 4, or interleukin 10).	Tacrolimus	131-141	interleukin 4	Homo sapiens	187-200	
32932253-7	2020	The immunological impact of tacrolimus was revealed by reduced percentages of Tfh, Breg, CD19+BAFF-R+ B cells, and increased percentages of Treg cells as well as down-regulated expression of IL-2, IL-4, IL-10, and IL-13 mRNA levels in PBMCs during the treatment.	Tacrolimus	28-38	interleukin 4	Homo sapiens	197-201	
14767008-5	2004	Although interleukin (IL)-12 production of DC was impaired, they did not promote Th2 development as T cells activated by tacrolimus-treated DC produced less interferon (IFN)-gamma, IL-4 and IL-10.	Tacrolimus	121-131	interleukin 4	Homo sapiens	181-185	
24836681-3	2014	STUDY DESIGN AND METHODS: DCs derived from human monocytes were induced in vitro by GM-CSF/IL-4 with tacrolimus.	Tacrolimus	101-111	interleukin 4	Homo sapiens	91-95	
16368244-10	2005	Quantification of intratumor transcription levels using reverse transcription-real-time polymerase chain reaction showed recovery from tacrolimus-induced downregulation of interleukin-4 but not interferon-gamma levels.	Tacrolimus	135-145	interleukin 4	Homo sapiens	172-185	
9667420-4	1998	FK506-induced apoptosis was efficiently attenuated by co-addition of ILs including IL-1beta (2 ng/ml), IL-2 (5 ng/ml) and IL-4 (40 ng/ml) into culture.	Tacrolimus	0-5	interleukin 4	Homo sapiens	122-126	
10887335-5	2000	RESULTS: Dexamethasone, FK506, and cyclosporin A suppressed the production of IL-2, IL-4, and IL-5 by human helper T cells, which shows a similar concentration-response relationship in each case.	Tacrolimus	24-29	interleukin 4	Homo sapiens	84-88	
9510155-8	1998	FK506 also reduced CD3/CD28-induced production of IL-3, IL-4, IL-10, TNF-alpha, and IL-6 but augmented that of GM-CSF, IL-5, IFN-gamma, and IL-13.	Tacrolimus	0-5	interleukin 4	Homo sapiens	56-60	
11407316-6	2001	In a comparative study with steroids (alclometasone dipropionate and betamethason valerate) in anti-CD3/CD2 system, tacrolimus and both steroids inhibited Th1 cytokines (IL-2, IFN-gamma), Th2 cytokines (IL-4, IL-5) and IL-3, GM-CSF (produced by both Th1 and Th2).	Tacrolimus	116-126	interleukin 4	Homo sapiens	203-207	
10623799-2	2000	IL-4 mRNA, constitutively present in basophils, was increased after stimulation by gp120 and was inhibited cyclosporin A and tacrolimus.	Tacrolimus	125-135	interleukin 4	Homo sapiens	0-4	
10515221-11	1999	In conclusion, our study clearly demonstrated that studied ex vivo, FK506 and CsA decrease the frequencies of cells expressing IL-2, IL-4 and IL-2/IFN-gamma in vivo but do not affect those expressing IFN-gamma.	Tacrolimus	68-73	interleukin 4	Homo sapiens	133-137	
9820545-6	1998	IL-4 mRNA, constitutively present in basophils, was increased after stimulation by pFv and was inhibited by cyclosporin A and tacrolimus.	Tacrolimus	126-136	interleukin 4	Homo sapiens	0-4	
9667420-6	1998	The data also suggested that cytokine networks including those via IL-1beta and IL-4 in addition to IL-2 prevent FK506-induced apoptosis.	Tacrolimus	113-118	interleukin 4	Homo sapiens	80-84	
1383612-0	1992	FK-506 inhibits proliferation and IL-4 messenger RNA production by a T-helper 2 cell line.	Tacrolimus	0-6	interleukin 4	Homo sapiens	34-38	
9469459-8	1998	The immunosuppressant, FK506, while strikingly inhibiting the accumulation of IL-4 mRNA and the secretion of protein in response to IL-3/anti-IgE, had no effect on the generation of IL-13 in these cultures; the resistance was attributed to the IL-3-dependent signaling.	Tacrolimus	23-28	interleukin 4	Homo sapiens	78-82	
7518925-3	1994	Here, TNF-alpha gene transcription is shown also to be highly and rapidly induced in human B cells after stimulation via the CD40 and interleukin 4 pathways, which similarly is inhibited by CsA and a panel of CsA or FK506 analogues that block calcineurin phosphatase activity.	Tacrolimus	216-221	interleukin 4	Homo sapiens	134-147	
7507316-6	1993	For instance, CsA and FK 506 inhibit the transcription of IL-3, IL-4, IFN gamma, TNF alpha or GM-CSF by activated T cells, and rapamycin has been shown to block the response to various growth factors such as IL-3, IL-4 or IL-6.	Tacrolimus	22-28	interleukin 4	Homo sapiens	64-68	
7507316-6	1993	For instance, CsA and FK 506 inhibit the transcription of IL-3, IL-4, IFN gamma, TNF alpha or GM-CSF by activated T cells, and rapamycin has been shown to block the response to various growth factors such as IL-3, IL-4 or IL-6.	Tacrolimus	22-28	interleukin 4	Homo sapiens	214-218	
1383612-7	1992	FK-506 markedly inhibits Con A-induced proliferation and IL-4 mRNA production by the T-helper 2 cell line Ly1+2-/9.	Tacrolimus	0-6	interleukin 4	Homo sapiens	57-61	
1383612-8	1992	The ability of FK-506 to block the proliferation and IL-4 production by this helper cell subset suggests that this effect may contribute to its observed marked immunosuppressive properties in vitro and in vivo.	Tacrolimus	15-21	interleukin 4	Homo sapiens	53-57	
1721312-0	1991	FK 506, rapamycin, and cyclosporine: effects on IL-4 and IL-10 mRNA levels in a T-helper 2 cell line.	Tacrolimus	0-6	interleukin 4	Homo sapiens	48-52	
1380951-3	1992	While 1 microgram/ml CSA and 0.1 microgram/ml FK 506 completely suppressed PHA-stimulated accumulation of mRNA for IL2, IL4, IL9, GM-CSF, TNF-alpha and IFN-gamma in PBMC, flu, keto and TGF-beta failed to inhibit any (except TNF-alpha blocked by TGF-beta).	Tacrolimus	46-52	interleukin 4	Homo sapiens	120-123	
1371491-8	1992	When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha.	Tacrolimus	123-128	interleukin 4	Homo sapiens	200-204	
1384862-7	1992	It is likely that the two drugs inhibit the expression of lymphokine receptors, by interfering Ca(2+)-related signals and that IL-6 induces T cell proliferation in a different way than IL-2 and IL-4, which are FK-506- and Cs A-sensitive.	Tacrolimus	210-216	interleukin 4	Homo sapiens	194-198	
2472451-1	1989	FK506, a neutral macrolide with immunosuppressive properties, was shown to selectively and rapidly inhibit the accumulation of IL-2 mRNA, as well as the mRNAs of other early (E) phase T cell activation genes such as IL-3, IL-4, GM-CSF, TNF alpha, IFN-gamma, and c-myc in activated human peripheral blood T cells.	Tacrolimus	0-5	interleukin 4	Homo sapiens	222-226	
1702750-5	1990	FK506 caused a dose-dependent inhibition of cell cycle-related induction of locomotor capacity both of anti-CD3-cultured T cells and IL-4-cultured B cells, with an ID50 of less than 1 ng per ml.	Tacrolimus	0-5	interleukin 4	Homo sapiens	133-137