PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9658403-12 1998 The nuclear 9S-[3H]Org2058-PR resulting from cells exposed to Rap, contained, in addition to the heat shock proteins of 90 kDa and 70 kDa (hsp90 and hsp70), the FK506-binding immunophilin FKBP52 but not FKBP51, although the latter was part of unliganded PR heterocomplex associated with hsp90. Tacrolimus 161-166 heat shock protein 90 alpha family class A member 1 Homo sapiens 287-292 11969419-3 2002 From the study of glucocorticoid receptor (GR).hsp90.immunophilin complexes in mammalian cells, there is considerable evidence that both hsp90 and the FK506-binding immunophilin FKBP52 play a role in receptor movement from the cytoplasm to the nucleus. Tacrolimus 151-156 heat shock protein 90 alpha family class A member 1 Homo sapiens 47-52 10574997-1 1999 It has been reported that immunosuppressant cyclosporin A or FK506 binds to immunophilins in the cell and that these immunophilins make a complex with molecular chaperones HSP70 or HSP90. Tacrolimus 61-66 heat shock protein 90 alpha family class A member 1 Homo sapiens 181-186 30483129-11 2018 Moreover, the present study reveals that combination of radicicol, VER-155008, cyclosporine A, and FK506, which are specific pharmacological inhibitors of Hsp90, Hsp70, Cyps, and FKBPs, respectively, resulted in a stronger inhibition of intoxication of cells with C2 toxin compared to application of the single inhibitors. Tacrolimus 99-104 heat shock protein 90 alpha family class A member 1 Homo sapiens 155-160 9195923-0 1997 Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. Tacrolimus 108-113 heat shock protein 90 alpha family class A member 1 Homo sapiens 70-75 9195923-2 1997 The immunophilin, which can be of the FK506- or cyclosporin A-binding class, binds to hsp90 via its tetratricopeptide repeat (TPR) domain, and different receptor heterocomplexes exist depending upon which immunophilin occupies the TPR-binding region of hsp90. Tacrolimus 38-43 heat shock protein 90 alpha family class A member 1 Homo sapiens 86-91 9195923-7 1997 Approximately one-half of the GR.hsp90 heterocomplexes in L cell cytosol contains an immunophilin with high affinity FK506 binding activity, such as FKBP51 or FKBP52, and approximately 35% contains PP5. Tacrolimus 117-122 heat shock protein 90 alpha family class A member 1 Homo sapiens 33-38 1376003-3 1992 A 59-kilodalton member of the FK506- and rapamycin-binding class was found to associate in the absence of these drugs with two heat shock proteins (hsp90 and hsp70) and the glucocorticoid receptor (GR). Tacrolimus 30-35 heat shock protein 90 alpha family class A member 1 Homo sapiens 148-153 7510997-9 1994 Purification of cytosol PR on immobilized FK506 yields a 9S form still containing hsp90, hsp70 and p59/HBI associated to PR units. Tacrolimus 42-47 heat shock protein 90 alpha family class A member 1 Homo sapiens 82-87 21523562-1 2011 The Hsp90-associated cis-trans peptidyl-prolyl isomerase--FK506 binding protein 51 (FKBP51)--was recently found to co-localize with the microtubule (MT)-associated protein tau in neurons and physically interact with tau in brain tissues from humans who died from Alzheimer"s disease (AD). Tacrolimus 58-63 heat shock protein 90 alpha family class A member 1 Homo sapiens 4-9 26517911-5 2015 Both physically interact with orthologues of the FK506-binding proteins that chaperon both transporters to the plasma membrane in an action that seems to involve heat shock protein (Hsp)90. Tacrolimus 49-54 heat shock protein 90 alpha family class A member 1 Homo sapiens 182-188 29079741-1 2017 FK506 binding protein of 51 kDa (FKBP51) is a heat shock protein 90 (Hsp90) co-chaperone involved in the regulation of steroid hormone receptors activity. Tacrolimus 0-5 heat shock protein 90 alpha family class A member 1 Homo sapiens 46-67 29079741-1 2017 FK506 binding protein of 51 kDa (FKBP51) is a heat shock protein 90 (Hsp90) co-chaperone involved in the regulation of steroid hormone receptors activity. Tacrolimus 0-5 heat shock protein 90 alpha family class A member 1 Homo sapiens 69-74 16554484-0 2006 An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway. Tacrolimus 43-48 heat shock protein 90 alpha family class A member 1 Homo sapiens 173-194