PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26517911-5	2015	Both physically interact with orthologues of the FK506-binding proteins that chaperon both transporters to the plasma membrane in an action that seems to involve heat shock protein (Hsp)90.	Tacrolimus	49-54	heat shock protein 90 alpha family class A member 1	Homo sapiens	182-188	
30483129-11	2018	Moreover, the present study reveals that combination of radicicol, VER-155008, cyclosporine A, and FK506, which are specific pharmacological inhibitors of Hsp90, Hsp70, Cyps, and FKBPs, respectively, resulted in a stronger inhibition of intoxication of cells with C2 toxin compared to application of the single inhibitors.	Tacrolimus	99-104	heat shock protein 90 alpha family class A member 1	Homo sapiens	155-160	
29079741-1	2017	FK506 binding protein of 51 kDa (FKBP51) is a heat shock protein 90 (Hsp90) co-chaperone involved in the regulation of steroid hormone receptors activity.	Tacrolimus	0-5	heat shock protein 90 alpha family class A member 1	Homo sapiens	46-67	
29079741-1	2017	FK506 binding protein of 51 kDa (FKBP51) is a heat shock protein 90 (Hsp90) co-chaperone involved in the regulation of steroid hormone receptors activity.	Tacrolimus	0-5	heat shock protein 90 alpha family class A member 1	Homo sapiens	69-74	
21523562-1	2011	The Hsp90-associated cis-trans peptidyl-prolyl isomerase--FK506 binding protein 51 (FKBP51)--was recently found to co-localize with the microtubule (MT)-associated protein tau in neurons and physically interact with tau in brain tissues from humans who died from Alzheimer"s disease (AD).	Tacrolimus	58-63	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9	
10574997-1	1999	It has been reported that immunosuppressant cyclosporin A or FK506 binds to immunophilins in the cell and that these immunophilins make a complex with molecular chaperones HSP70 or HSP90.	Tacrolimus	61-66	heat shock protein 90 alpha family class A member 1	Homo sapiens	181-186	
11969419-3	2002	From the study of glucocorticoid receptor (GR).hsp90.immunophilin complexes in mammalian cells, there is considerable evidence that both hsp90 and the FK506-binding immunophilin FKBP52 play a role in receptor movement from the cytoplasm to the nucleus.	Tacrolimus	151-156	heat shock protein 90 alpha family class A member 1	Homo sapiens	47-52	
16554484-0	2006	An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway.	Tacrolimus	43-48	heat shock protein 90 alpha family class A member 1	Homo sapiens	173-194	
1376003-3	1992	A 59-kilodalton member of the FK506- and rapamycin-binding class was found to associate in the absence of these drugs with two heat shock proteins (hsp90 and hsp70) and the glucocorticoid receptor (GR).	Tacrolimus	30-35	heat shock protein 90 alpha family class A member 1	Homo sapiens	148-153	
9195923-0	1997	Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin.	Tacrolimus	108-113	heat shock protein 90 alpha family class A member 1	Homo sapiens	70-75	
9195923-2	1997	The immunophilin, which can be of the FK506- or cyclosporin A-binding class, binds to hsp90 via its tetratricopeptide repeat (TPR) domain, and different receptor heterocomplexes exist depending upon which immunophilin occupies the TPR-binding region of hsp90.	Tacrolimus	38-43	heat shock protein 90 alpha family class A member 1	Homo sapiens	86-91	
9195923-7	1997	Approximately one-half of the GR.hsp90 heterocomplexes in L cell cytosol contains an immunophilin with high affinity FK506 binding activity, such as FKBP51 or FKBP52, and approximately 35% contains PP5.	Tacrolimus	117-122	heat shock protein 90 alpha family class A member 1	Homo sapiens	33-38	
7510997-9	1994	Purification of cytosol PR on immobilized FK506 yields a 9S form still containing hsp90, hsp70 and p59/HBI associated to PR units.	Tacrolimus	42-47	heat shock protein 90 alpha family class A member 1	Homo sapiens	82-87	
9658403-12	1998	The nuclear 9S-[3H]Org2058-PR resulting from cells exposed to Rap, contained, in addition to the heat shock proteins of 90 kDa and 70 kDa (hsp90 and hsp70), the FK506-binding immunophilin FKBP52 but not FKBP51, although the latter was part of unliganded PR heterocomplex associated with hsp90.	Tacrolimus	161-166	heat shock protein 90 alpha family class A member 1	Homo sapiens	287-292