PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15910387-1 2005 We encountered two cases of pediatric living-related liver transplant recipients who showed increases in blood concentration of cyclosporine or tacrolimus, a dual substrate for cytochrome P450 (CYP) 3A and P-glycoprotein (P-gp), during a diarrheal episode. Tacrolimus 144-154 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 177-201 15910387-8 2005 These findings suggest that the suppression of CYP3A and P-gp activities may be involved in the mechanism of elevated blood concentrations of cyclosporine and tacrolimus during enteritis-induced diarrhea. Tacrolimus 159-169 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 47-52 9630010-0 1998 FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction. Tacrolimus 0-5 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 117-122 9630010-0 1998 FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction. Tacrolimus 7-17 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 117-122 9630010-1 1998 Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. Tacrolimus 0-10 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 107-126 9630010-1 1998 Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. Tacrolimus 0-10 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 128-133 9630010-1 1998 Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. Tacrolimus 12-17 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 107-126 9630010-1 1998 Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. Tacrolimus 12-17 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 128-133 9630010-7 1998 It is hypothesized that the interaction between the two drugs relies on a mechanism involving both competition of FK506 and CsA for CYP3A and of their immunophilin complexes for a common site on the calcineurin-calmodulin complex. Tacrolimus 114-119 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 132-137 7524055-6 1994 Correlation of the 6 beta-testosterone hydroxylase activity with the FK 506 metabolite (M1) initial formation rate is consistent with the belief that CYP 3A isozymes are involved in FK 506 metabolism in male rats. Tacrolimus 69-75 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 150-156 9209689-0 1997 Implication of CYP 3A in the toxicity of cyclosporin G (CsG), cyclosporin A (CsA) and FK506 on rat hepatocytes in primary culture. Tacrolimus 86-91 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 15-21 9209689-1 1997 FK506, cyclosporin A (CsA), and its structural analog cyclosporin G (CsG) are immunosuppressant drugs mainly metabolized by hepatic cytochrome P-450 3A (CYP 3A) oxygenase. Tacrolimus 0-5 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 132-151 9209689-1 1997 FK506, cyclosporin A (CsA), and its structural analog cyclosporin G (CsG) are immunosuppressant drugs mainly metabolized by hepatic cytochrome P-450 3A (CYP 3A) oxygenase. Tacrolimus 0-5 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 153-159 9209689-12 1997 Our results show that the toxicity of the three drugs in rat hepatocytes is dependent on CYP 3A induction: increased for FK506, decreased for CsA and CsG. Tacrolimus 121-126 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 89-95 7524055-6 1994 Correlation of the 6 beta-testosterone hydroxylase activity with the FK 506 metabolite (M1) initial formation rate is consistent with the belief that CYP 3A isozymes are involved in FK 506 metabolism in male rats. Tacrolimus 182-188 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 150-156 7512020-3 1994 CYP3A enzymes are thought to be responsible for metabolizing FK 506 in male rats. Tacrolimus 61-67 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 0-5 26024817-6 2015 The permeability of FK506 was improved dramatically by CD-PVM/MA-NPs compared to its solution, probably due to the synergistic inhibition effect of P-gp and cytochrome P450 3A (CYP3A). Tacrolimus 20-25 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 157-175 26024817-6 2015 The permeability of FK506 was improved dramatically by CD-PVM/MA-NPs compared to its solution, probably due to the synergistic inhibition effect of P-gp and cytochrome P450 3A (CYP3A). Tacrolimus 20-25 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 177-182 26024817-11 2015 The present study suggested that the novel multifunctional CD-PVM/MA is a promising efficient oral delivery carrier for FK506, due to its ability in solubilization, inhibitory effects on both P-gp and CYP 3A, high bioadhesion, and sustained release capability. Tacrolimus 120-125 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 201-207 22996305-1 2013 In our previous reports, Wuzhi tablet (an herbal preparation of ethanol extract of Wuweizi (Schisandra sphenanthera)) can significantly increase the blood concentration of tacrolimus and paclitaxel in rats by inhibiting the CYP3A-mediated metabolism and the P-gp-mediated efflux. Tacrolimus 172-182 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 224-229 18581211-1 2008 PURPOSE: To design a double-coated nanoparticulate delivery system of tacrolimus capable of overcoming the P-glycoprotein pump and CYP3A barriers without affecting their physiological activities. Tacrolimus 70-80 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 131-136