PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26792730-4	2016	Utilizing human Jurkat T cells, we demonstrate that CrkII-SH3N binding of C3G is inhibited by cyclosporin A (CsA) plus FK506 that inhibit the cyclophilin A (CypA) and FK506 binding protein (FKBP) peptidyl-prolyl cis-trans isomerases (PPIases; also termed immunophilins), respectively.	Tacrolimus	119-124	peptidylprolyl isomerase A	Homo sapiens	142-155	
26792730-4	2016	Utilizing human Jurkat T cells, we demonstrate that CrkII-SH3N binding of C3G is inhibited by cyclosporin A (CsA) plus FK506 that inhibit the cyclophilin A (CypA) and FK506 binding protein (FKBP) peptidyl-prolyl cis-trans isomerases (PPIases; also termed immunophilins), respectively.	Tacrolimus	119-124	peptidylprolyl isomerase A	Homo sapiens	157-161	
23224887-4	2013	This suggests that CypA has a role in acquisition of function competence of NCX1 protein.Unlike CsA treatment, which affects the functional expression of all three mammalian NCX proteins similarly, FK506 and rapamycin treatment modulates only the functional expression of NCX2 and NCX3 proteins.	Tacrolimus	198-203	peptidylprolyl isomerase A	Homo sapiens	19-23	
12218175-1	2002	Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the common target for two immunophilin-immunosuppressant complexes, cyclophilin A-cyclosporin A (CyPA-CsA) and FKBP-FK506.	Tacrolimus	181-186	peptidylprolyl isomerase A	Homo sapiens	162-166	
12218175-4	2002	The CyPA-CsA complex binds to a composite surface formed by the catalytic and regulatory subunits of CN, where the complex of FK506 and its binding protein FKBP also binds.	Tacrolimus	126-131	peptidylprolyl isomerase A	Homo sapiens	4-8	
9675023-1	1998	The calcium- and calmodulin-activated protein phosphatase calcineurin (CN) is the target for the immunosuppressive drugs FK506 and cyclosporin A (CsA) when bound to their intracellular receptor proteins, the immunophilins known as FK506-binding protein (FKBP) and cyclophilin A (CypA), respectively.	Tacrolimus	121-126	peptidylprolyl isomerase A	Homo sapiens	264-277	
9675023-1	1998	The calcium- and calmodulin-activated protein phosphatase calcineurin (CN) is the target for the immunosuppressive drugs FK506 and cyclosporin A (CsA) when bound to their intracellular receptor proteins, the immunophilins known as FK506-binding protein (FKBP) and cyclophilin A (CypA), respectively.	Tacrolimus	121-126	peptidylprolyl isomerase A	Homo sapiens	279-283	
9675023-10	1998	Inhibition of CN by the CsA x CypA complex was not time-dependent, but the data did conform to a competitive inhibition model like FK506 x FKBP.	Tacrolimus	131-136	peptidylprolyl isomerase A	Homo sapiens	30-34	
7541038-4	1995	Cyclosporin A and FK506 efficiently disrupt the YY1-CyPA and YY1-FKBP12 interactions.	Tacrolimus	18-23	peptidylprolyl isomerase A	Homo sapiens	52-56