PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18845086-9	2008	FK506 can not only inhibit the expression of positive co-stimulatory molecules CD28 and ICOS but also promote the expression of negative co-stimulatory molecule CD152, while CsA can exert its immunosuppressive effect mainly through promoting the expression of CD152.	Tacrolimus	0-5	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	161-166	
28112181-0	2017	IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients.	Tacrolimus	52-62	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	9-14	
30633591-7	2019	The expressions of co-inhibitory receptors (CTLA-4, PD-1, Tim-3, LAG-3 and TIGIT) on Tregs in FK506 + MMF group were significant higher than those in the FK506 group and control group.	Tacrolimus	94-99	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	44-50	
18845086-9	2008	FK506 can not only inhibit the expression of positive co-stimulatory molecules CD28 and ICOS but also promote the expression of negative co-stimulatory molecule CD152, while CsA can exert its immunosuppressive effect mainly through promoting the expression of CD152.	Tacrolimus	0-5	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	260-265	
18589137-0	2008	Regulatory effect of FK506 on CD152 and PD-1 in the liver allorecipients.	Tacrolimus	21-26	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	30-35	
18589137-7	2008	CONCLUSION: FK506 up-regulated the expression of CD152 and PD-1 on the T-cell surface inhibiting proliferation and activation of effector T cells, favoring the survival of allorecipients.	Tacrolimus	12-17	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	49-54	
34841735-6	2021	Meanwhile, percentages of regulatory T cells (Tregs) and expression of CTLA-4 were both up to two-fold higher in the RAPA group, suggesting the inconsistent reactivation potential of the FK506 and RAPA groups when an anti-tumour or anti-infection immune response is concerned.	Tacrolimus	187-192	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	71-77