PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23238171-3 2013 Upon action of acid (p-toluenesulfonic acid in toluene), tacrolimus is dehydrated by loss of water from the beta-hydroxyketone moiety with partial inversion of configuration at C-8, resulting in formation of 5-deoxy-Delta(5,6)-tacrolimus and 5-deoxy-Delta(5,6)-8-epitacrolimus. Tacrolimus 57-67 homeobox C8 Homo sapiens 177-180