PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8474022-6 1993 Other putative human CYP1A xenobiotic substrates and inhibitors, including caffeine, 5- and 8-methoxypsoralen, nifedipine, paraxanthine, propranolol and theophylline similarly inhibited CYP1A1- and 1A2-catalyzed phenacetin O-deethylation and the high-affinity human liver phenacetin O-deethylase. Caffeine 75-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 186-192 8095225-0 1993 Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Caffeine 0-8 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 58-64 8095225-6 1993 Caffeine was shown to be metabolized by CYP1A2 and CYP1A1. Caffeine 0-8 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-57 8095225-9 1993 Inhibition studies with caffeine, phenacetin, 17 beta-estradiol, and progesterone as inhibitors of the CYP1A1 and CYP1A2 catalyzed O-deethylation of 7-ethoxyresorufin suggest all compounds as possible substrates of CYP1A enzymes. Caffeine 24-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 103-109 8095225-12 1993 These data clearly demonstrate the capacity of human CYP1A1 and CYP1A2 to metabolize caffeine. Caffeine 85-93 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 33995046-4 2021 As both caffeine and furanocoumarin bioactive are metabolized by the same hepatic CYP1A1/2 isozyme in humans, caffeine/ARFP product interactions may occur after co-administration. Caffeine 8-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-90 33995046-4 2021 As both caffeine and furanocoumarin bioactive are metabolized by the same hepatic CYP1A1/2 isozyme in humans, caffeine/ARFP product interactions may occur after co-administration. Caffeine 110-118 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-90 31190057-6 2019 RESULTS: In the UK Biobank, we identified 6 independent GWAS variants, including those implicated for caffeine (ARID3B/CYP1A1), carbohydrate metabolism (FGF21), schizophrenia (ZNF804A), and encoding enzymes important for N6-methyladenosine RNA transmethylation (METTL4, YWHAB, and YTHDF3), which regulates the pace of the circadian clock. Caffeine 102-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 119-125 27509179-5 2016 However, when excluding smokers and users of hormonal contraceptives, 89% of caffeine AUC variation was due to genetic effects and, even in the entire group, 8% of caffeine AUC variation could be explained by a CYP1A1/1A2 promotor polymorphism (rs2470893). Caffeine 164-172 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 211-217 25075865-0 2014 Phenotype refinement strengthens the association of AHR and CYP1A1 genotype with caffeine consumption. Caffeine 81-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 60-66 21876539-6 2012 CYP1A1 was found to be downregulated in lymphoblastoid cell lines treated with caffeine. Caffeine 79-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 21876539-7 2012 CYP1A1 is known to metabolize polycyclic aromatic hydrocarbons, which are important constituents of coffee, whereas CYP1A2 is involved in the primary metabolism of caffeine. Caffeine 164-172 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 22854411-0 2012 Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption. Caffeine 90-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 50-56 22854411-1 2012 BACKGROUND: Recent genome-wide association studies (GWASs) from populations of European descent identified single nucleotide polymorphisms (SNPs) in aryl-hydrocarbon receptor (AHR) and cytochrome P450 1A1 and 1A2 (CYP1A1-CYP1A2) genes that are associated with habitual caffeine and coffee consumption. Caffeine 269-277 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 185-212 22854411-1 2012 BACKGROUND: Recent genome-wide association studies (GWASs) from populations of European descent identified single nucleotide polymorphisms (SNPs) in aryl-hydrocarbon receptor (AHR) and cytochrome P450 1A1 and 1A2 (CYP1A1-CYP1A2) genes that are associated with habitual caffeine and coffee consumption. Caffeine 269-277 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 214-220 22854411-10 2012 CONCLUSION: Our findings show that previous associations between SNPs in AHR and CYP1A1-CYP1A2 and caffeine and coffee consumption from GWASs in European populations are also observed in an ethnically distinct Costa Rican population, but age and smoking are important effect modifiers. Caffeine 99-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 81-87 12646505-8 2003 Significant interaction may exist between polymorphic variants of CYP1A1 and caffeine that could explain weak or inconsistent associations between caffeine and ovarian cancer when genotype has not been considered. Caffeine 77-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-72 12646505-8 2003 Significant interaction may exist between polymorphic variants of CYP1A1 and caffeine that could explain weak or inconsistent associations between caffeine and ovarian cancer when genotype has not been considered. Caffeine 147-155 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-72 8857078-1 1996 OBJECTIVES: The biotransformation of caffeine has been studied in vitro using human cytochrome P-450 isoenzymes (CYPs) expressed in human B-lymphoblastoid cell lines, namely CYP1A1, 1A2, 2A6, 2B6, 2D6-Val, 2E1 and 3A4, and microsomal epoxide hydroxylase (EH). Caffeine 37-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 174-180 8857078-6 1996 The affinity of caffeine for CYP1A1 was comparable to that of its homologue 1A2. Caffeine 16-24 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 29-35