PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28686070-0 2018 Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. Caffeine 101-109 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 78-93 31164617-3 2019 The metabolic rates of caffeine, dextromethorphan, midazolam, omeprazole, and Losartan to the CYP-specific metabolites are validated measures of in vivo CYP 1A2, 2D6, 3A4, 2C19, and 2C9 activities, respectively. Caffeine 23-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 94-97 32219694-4 2020 Activities of CYP enzymes were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6), and testosterone 6beta-hydroxylation (CYP3A4). Caffeine 76-84 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-17 32219694-4 2020 Activities of CYP enzymes were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6), and testosterone 6beta-hydroxylation (CYP3A4). Caffeine 76-84 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 52-55 31744669-0 2020 Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research. Caffeine 82-90 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 49-64 28686070-2 2018 The pharmacokinetics were investigated for human cytochrome P450 probes after single intravenous and oral administrations of 0.20 and 1.0 mg/kg, respectively, of caffeine, warfarin, omeprazole, metoprolol and midazolam to aged (10-14 years old, n = 4) or rifampicin-treated/young (3 years old, n = 3) male common marmosets all genotyped as heterozygous for a cytochrome P450 2C19 variant. Caffeine 162-170 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 49-64 27273149-0 2017 Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects. Caffeine 125-133 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-82 27712037-4 2017 The pharmacokinetics of CYP selective substrates: caffeine, losartan, and omeprazole changed significantly in a diabetic NASH mouse model, indicating attenuation of the activity of Cyp1a2 and Cyp2c29, respectively. Caffeine 50-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-27 26481538-4 2015 CYP isoenzyme activities were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6) and testosterone 6beta-hydroxylation (CYP3A4). Caffeine 75-83 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 26481538-4 2015 CYP isoenzyme activities were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6) and testosterone 6beta-hydroxylation (CYP3A4). Caffeine 75-83 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 51-54 20002088-4 2009 * This cocktail can be used to test the effects of a new chemical entity on multiple CYP isoforms in a single clinical study: CYP1A2 (caffeine), CYP2C9 (warfarin), CYP2C19 (omeprazole), CYP2D6 (metoprolol), and CYP3A (midazolam) and was designed to overcome potential liabilities of other reported cocktails. Caffeine 134-142 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 85-88 22483397-2 2012 CYP isoform specific substrates and their metabolites of CYP1A2 (caffeine), CYP2C9 (losartan), CYP2C19 (omeprazole), CYP2D6 (dextromethorphan) and CYP3A (midazolam) were all simultaneously analyzed using LC-MS/MS after administration of a mixture of five drugs (i.e., a "cocktail approach") to healthy volunteers. Caffeine 65-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 20532872-7 2010 Polymorphism in the metabolic enzyme cytochrome P-450 is associated with risk of myocardial infarction in caffeine users. Caffeine 106-114 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-53 2220168-1 1990 Caffeine is mainly metabolized by 3-methyl-cholanthrene-inducible cytochrome P-450, whereas metamizol (Analgin) is probably mainly metabolized by phenobarbital inducible cytochromes P-450. Caffeine 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 66-82 20081260-4 2009 A comparative in vitro study provides clear evidence that ticlopidine and DDC, applied at concentrations that inhibit the above-mentioned CYP isoforms, potently (as compared to furafylline) inhibit human CYP1A2 and caffeine metabolism, in particular 1-N- and 3-N-demethylation. Caffeine 215-223 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 138-141 19422358-4 2009 Probe drugs used to measure CYP activities were caffeine (CYP1A2), losartan (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1) and midazolam (CYP3A4). Caffeine 48-56 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-31 1808966-1 1991 Caffeine is mainly metabolized by 3-methylcholanthreneinducible cytochrome P-450, whereas metamizol (Analgin) is probably mainly metabolized by the phenobarbital inducible cytochrome P-450 family. Caffeine 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-80 1808966-2 1991 Therefore the elimination of caffeine from serum and the elimination of the main metabolites of metamizol in urine reflect the activity of these two cytochrome P-450 families. Caffeine 29-37 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 149-165 11956503-4 2002 CYP enzyme activities were measured by means of the metabolic ratios of sparteine (CYP2D6), endogenous cortisol metabolism (CYP3A4), and caffeine (CYP1A2), as well as by the S/R ratio of mephenytoin (CYP2C19) and antipyrine clearance. Caffeine 137-145 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 8857078-1 1996 OBJECTIVES: The biotransformation of caffeine has been studied in vitro using human cytochrome P-450 isoenzymes (CYPs) expressed in human B-lymphoblastoid cell lines, namely CYP1A1, 1A2, 2A6, 2B6, 2D6-Val, 2E1 and 3A4, and microsomal epoxide hydroxylase (EH). Caffeine 37-45 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 84-100 8081318-5 1994 The demethylation of caffeine by the hepatic cytochrome P-450 oxygenases begins within minutes and dimethylxanthines (especially paraxanthine) are generated. Caffeine 21-29 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 45-61 1981505-0 1990 Quinolone inhibition of cytochrome P-450-dependent caffeine metabolism in human liver microsomes. Caffeine 51-59 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-40 1981505-7 1990 The results indicate that the reduction of caffeine clearance by concomitant quinolone application observed in vivo is primarily due to a competitive interaction of the inhibiting quinolones with the cytochrome P-450 isoenzyme(s) mediating caffeine demethylation. Caffeine 43-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 200-216 1981505-7 1990 The results indicate that the reduction of caffeine clearance by concomitant quinolone application observed in vivo is primarily due to a competitive interaction of the inhibiting quinolones with the cytochrome P-450 isoenzyme(s) mediating caffeine demethylation. Caffeine 240-248 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 200-216 2220168-2 1990 Therefore the elimination of caffeine from serum and the amount of the main metabolites of metamizol excreted into urine reflect the activity of these two cytochrome P-450 families. Caffeine 29-37 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 155-171 35280254-2 2021 Caffeine is almost exclusively metabolized in the liver by the cytochrome P-450 enzyme system to the main product paraxanthine and the additional products theobromine and theophylline. Caffeine 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 63-79 4095131-0 1985 [Elimination of caffeine and metamizol in in vivo characterization of cytochrome P-450 dependent biotransformation reactions in aged humans]. Caffeine 16-24 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-86 3593412-2 1987 The nature of the cytochrome P-450-dependent enzyme reactions giving rise to four primary metabolites of caffeine was investigated using microsomes isolated from livers of human kidney donors. Caffeine 105-113 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-34 3593412-8 1987 Taken together, the data support suggestions from in vivo studies that a PAH-inducible isozyme of cytochrome P-450 plays a significant role in the biotransformation of caffeine in man. Caffeine 168-176 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 98-114 4095132-2 1985 That"s why the half life of caffeine and the elimination of the main metabolites of metamizol were used as parameters in vivo characterizing both groups of the cytochrome P-450-complex. Caffeine 28-36 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 160-176 3671445-2 1987 From the elimination velocity of these model substances conclusions concerning the activity of 3-methylcholanthrene (caffeine elimination) and phenobarbital inducible isoenzymes (metamizol elimination) of cytochrome P-450 are drawn. Caffeine 117-125 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 205-221 4095132-1 1985 Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and metamizol (noramidopyrine methanesulfonate sodium) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB). Caffeine 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-81 32941854-7 2020 CYP activities were measured in the incubation medium using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A1/2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19) and testosterone 6beta-hydroxylation (CYP3A4). Caffeine 88-96 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 3991787-1 1985 Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and noramidopyrine-methanesulfonate sodium (metamizol, Analgin) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB). Caffeine 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-81 32725383-4 2021 RESULTS: Seventy-two metabolic drug interaction studies were identified where volume of distribution at steady-state (Vss) values were available for the CYP index substrates caffeine (CYP1A2), metoprolol (CYP2D6), midazolam (CYP3A4), theophylline (CYP1A2), and tolbutamide (CYP2C9). Caffeine 174-182 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 153-156 32279279-3 2020 METHODS: The activity of these enzymes was determined by the following CYP-specific reactions: caffeine 3-N-demethylation/CYP1A2, diclofenac 4"-hydroxylation/CYP2C9, perazine N-demethylation/CYP2C19, bufuralol 1"-hydroxylation/CYP2D6 and testosterone 6beta-hydroxylation/CYP3A4, respectively, using HPLC. Caffeine 95-103 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 71-74 32941854-7 2020 CYP activities were measured in the incubation medium using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A1/2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19) and testosterone 6beta-hydroxylation (CYP3A4). Caffeine 88-96 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-67 31658882-1 2020 As an important member of cytochrome P450 (CYP) enzymes, human CYP1A2 is associated with the metabolism of caffeine and melatonin and the activation of precarcinogens. Caffeine 107-115 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-41 31658882-1 2020 As an important member of cytochrome P450 (CYP) enzymes, human CYP1A2 is associated with the metabolism of caffeine and melatonin and the activation of precarcinogens. Caffeine 107-115 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 43-46