PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31560695-8 2019 Compared with that in the control group, the content of LDH, TNF-alpha and MDA in the lung tissue of the PQ group was significantly higher, and the activity of SOD in the lung tissue was significantly lower (all p<0.05). Paraquat 105-107 tumor necrosis factor Homo sapiens 61-70 8317554-7 1993 Enzyme induction with paraquat, adriamycin, or bleomycin was inhibitable by neutralizing antibody to interleukin-1 and tumor necrosis factor, suggesting that the inductions observed with these three drugs are due to the distal mediators, interleukin-1 or tumor necrosis factor released from the cells. Paraquat 22-30 tumor necrosis factor Homo sapiens 119-140 34877356-14 2021 IL-6 and TNF-alpha were expected to be potential prediction indexes of paraquat-induced ALI. Paraquat 71-79 tumor necrosis factor Homo sapiens 9-18 1414690-2 1992 We have studied the effect of paraquat (PQ), a well-known pneumotoxicant, on IL-1 and TNF production by human peripheral blood mononuclear cells from different healthy donors stimulated with endotoxin. Paraquat 30-38 tumor necrosis factor Homo sapiens 86-89 1414690-2 1992 We have studied the effect of paraquat (PQ), a well-known pneumotoxicant, on IL-1 and TNF production by human peripheral blood mononuclear cells from different healthy donors stimulated with endotoxin. Paraquat 40-42 tumor necrosis factor Homo sapiens 86-89 1414690-3 1992 PQ (100 microM) potentiated IL-1 production (2-40 fold) and TNF production (2-18 fold). Paraquat 0-2 tumor necrosis factor Homo sapiens 60-63 1414690-4 1992 It is, therefore, possible that IL-1 and TNF are also involved in the pneumotoxic action of PQ. Paraquat 92-94 tumor necrosis factor Homo sapiens 41-44 31560695-11 2019 There were significant differences in MDA and TNF-alpha content between the PQ group and MH group (all p<0.05). Paraquat 76-78 tumor necrosis factor Homo sapiens 46-55 28474156-13 2017 JNK inhibitor SP600125 reduced JNK phosphorylation, downregulated cleaved caspase-3 protein level, decreased AP-1 transcriptional activity and ROS level, and reduced the transcription and expression of TNF-alpha and IL-6, which improved ALI and cell apoptosis after paraquat poisoning. Paraquat 266-274 tumor necrosis factor Homo sapiens 202-211 31028577-0 2019 Curcumin Modulates Paraquat-Induced Epithelial to Mesenchymal Transition by Regulating Transforming Growth Factor-beta (TGF-beta) in A549 Cells. Paraquat 19-27 tumor necrosis factor Homo sapiens 87-118 31028577-6 2019 Transforming growth factor-beta (TGF-beta) that seems to be involved in PQ-induced EMT was enhanced after PQ intoxication, but curcumin pretreatment has effectively inhibited its expression. Paraquat 72-74 tumor necrosis factor Homo sapiens 0-31 31028577-6 2019 Transforming growth factor-beta (TGF-beta) that seems to be involved in PQ-induced EMT was enhanced after PQ intoxication, but curcumin pretreatment has effectively inhibited its expression. Paraquat 106-108 tumor necrosis factor Homo sapiens 0-31 30088170-9 2018 In vitro experiments showed that the levels of TNF-alpha, IL-1beta, and IL-6 secreted by human pulmonary microvascular endothelial cells treated with PQ were attenuated by fasudil. Paraquat 150-152 tumor necrosis factor Homo sapiens 47-56 29411263-6 2018 We found that a pretreatment with NGN at 80 microM for 2 h decreased the levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in PQ-treated SH-SY5Y cells. Paraquat 186-188 tumor necrosis factor Homo sapiens 143-170 29411263-6 2018 We found that a pretreatment with NGN at 80 microM for 2 h decreased the levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in PQ-treated SH-SY5Y cells. Paraquat 186-188 tumor necrosis factor Homo sapiens 172-181 28083817-6 2018 SH-SY5Y cells were pretreated for 12 h with CA at 1 muM before exposure to PQ for further 24 h. CA suppressed the PQ-induced alterations on the levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2 (COX-2) through a mechanism involving the activation of the Nrf2/HO-1 axis. Paraquat 114-116 tumor necrosis factor Homo sapiens 184-211 28083817-6 2018 SH-SY5Y cells were pretreated for 12 h with CA at 1 muM before exposure to PQ for further 24 h. CA suppressed the PQ-induced alterations on the levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2 (COX-2) through a mechanism involving the activation of the Nrf2/HO-1 axis. Paraquat 114-116 tumor necrosis factor Homo sapiens 213-222 30090494-5 2017 Exposure to 50 or 200 muM paraquat for 24 h elevated the release of interleukin 8 and gene expression of tumor necrosis factor-alpha. Paraquat 26-34 tumor necrosis factor Homo sapiens 105-132 26653645-14 2015 Compared with the blank control group, the PQ group had significantly increased IL-6 and TNF-alpha level (P < 0.05); Compared with the PQ group, the UTI+PQ group had significantly decreased IL-6 and TNF-alpha level (P < 0.05). Paraquat 43-45 tumor necrosis factor Homo sapiens 89-98 26653645-14 2015 Compared with the blank control group, the PQ group had significantly increased IL-6 and TNF-alpha level (P < 0.05); Compared with the PQ group, the UTI+PQ group had significantly decreased IL-6 and TNF-alpha level (P < 0.05). Paraquat 43-45 tumor necrosis factor Homo sapiens 202-211 24714343-0 2014 Paraquat-induced reactive oxygen species inhibit neutrophil apoptosis via a p38 MAPK/NF-kappaB-IL-6/TNF-alpha positive-feedback circuit. Paraquat 0-8 tumor necrosis factor Homo sapiens 100-109 22493042-7 2012 PQ at 10 muM stimulated production of inflammatory and profibrogenic factors (tumor necrosis factor alpha, interleukin 6, and transforming growth factor beta1) and induced the transformation of normal human lung fibroblasts (WI38-VA13) to myofibroblasts; both effects were inhibited by Res. Paraquat 0-2 tumor necrosis factor Homo sapiens 78-105 22804935-5 2012 The relative gene expression and protein expression of IL-6 and TNF-alpha enhanced with the reduced concentrations of RU486, which were the lowest when RU486 concentration was 10(-7) mol/L, as compared with control and PQ exposure groups (P < 0.01 or P < 0.05), while the change of IL-10 content was the opposite. Paraquat 219-221 tumor necrosis factor Homo sapiens 64-73 22230393-7 2011 Finally, in comparison to previous experiments carried out with TNF-alpha and IL-1beta, we have shown that paraquat produced a similar pattern of activation of set of genes involved both in inflammation and apoptosis. Paraquat 107-115 tumor necrosis factor Homo sapiens 64-73