PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12935482-0	1999	Changes in mRNAs of inducible nitric oxide synthase and interleukin-1 beta in the liver, kidney and lung tissues of rats acutely exposed to paraquat.	Paraquat	140-148	interleukin 1 beta	Rattus norvegicus	56-74	
12935482-4	1999	In this study, we have investigated whether mRNAs of iNOS and IL-1 beta are affected in rat liver, kidney and lung tissues by exposure to non-lethal and lethal doses of PQ.	Paraquat	169-171	interleukin 1 beta	Rattus norvegicus	62-71	
12935482-9	1999	These data suggest that acute lethal poisoning and non-lethal poisoning by PQ undergo different mechanisms of action of NO and IL-1 beta systems; the former is due, at least in part, to an increase in NO production, while the latter is due to stimulation of IL-1 beta and/or other cytokines.	Paraquat	75-77	interleukin 1 beta	Rattus norvegicus	127-136	
12935482-9	1999	These data suggest that acute lethal poisoning and non-lethal poisoning by PQ undergo different mechanisms of action of NO and IL-1 beta systems; the former is due, at least in part, to an increase in NO production, while the latter is due to stimulation of IL-1 beta and/or other cytokines.	Paraquat	75-77	interleukin 1 beta	Rattus norvegicus	258-267	
28215032-9	2017	Besides, the activation of NLRP3 inflammasome and secretion of IL-1beta and IL-18 in paraquat-treated rat renal tubular epithelial cells were inhibited by siRNA against DAPK.	Paraquat	85-93	interleukin 1 beta	Rattus norvegicus	63-71	
29026307-9	2017	The results showed that the levels of ROS, malondialdehyde, NF-kappaB, p-NF-kappaB, tumor necrosis factor-alpha and interleukin-1beta were markedly increased after PQ treatment.	Paraquat	164-166	interleukin 1 beta	Rattus norvegicus	116-133	
25357233-11	2014	The PQ group had significantly higher pulmonary histology scores, wet-to-dry weight ratios and phosphorylated p-p38 MAPK levels, as well as higher IL-1beta and TNF-alpha levels in BALF and lung tissues, that did the SB + PQ and control groups (p < 0.05, all).	Paraquat	4-6	interleukin 1 beta	Rattus norvegicus	147-155	
25338942-10	2015	In conclusion, paraquat can induce IL-1beta/IL-18 secretion via NLRP3-ASC-caspase-1 pathway, and the NLRP3 inflammasome is essential for paraquat-induced acute lung injury.	Paraquat	15-23	interleukin 1 beta	Rattus norvegicus	35-43	
24812154-8	2015	Pretreatment with Ad-RUNRF2 and RU486 also strongly suppressed the PQ-induced activation of nuclear factor kappaB (NF-kappaB) and decreased the levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Paraquat	67-69	interleukin 1 beta	Rattus norvegicus	196-213	
24812154-8	2015	Pretreatment with Ad-RUNRF2 and RU486 also strongly suppressed the PQ-induced activation of nuclear factor kappaB (NF-kappaB) and decreased the levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Paraquat	67-69	interleukin 1 beta	Rattus norvegicus	215-223	
28123623-8	2017	Moreover, interleukin (IL)-1beta, IL-6 and TNF-alpha mRNA levels were significantly higher in the paraquat group (P<0.01, respectively).	Paraquat	98-106	interleukin 1 beta	Rattus norvegicus	10-32	
23933652-8	2013	The pretreatment significantly reduced the levels of TNF-alpha, IL-1beta and MDA, increased SOD activity in the peripheral blood of PQ-treated rats.	Paraquat	132-134	interleukin 1 beta	Rattus norvegicus	64-72	
25153082-6	2014	The major changes found in paraquat-treated animals were: decreased body weight and hypothermia, nociception behavior, impairment of locomotor and gait capabilities, enhanced TNF-alpha and IL-1beta expression in the striatum, and cell migration to the lungs and blood.	Paraquat	27-35	interleukin 1 beta	Rattus norvegicus	189-197	
20498031-7	2011	Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis demonstrated that the gene expression levels of interleukin-1 beta and interleukin-6 were significantly increased at 21 days after PQ challenge compared with the controls.	Paraquat	215-217	interleukin 1 beta	Rattus norvegicus	132-150	
23159886-7	2013	Similarly, MB and/or PQ-mediated histopathological symptoms and changes in the catalytic activities/expressions of CYP1A2, CYP2E1, iNOS, TNF-alpha, and IL-1beta were alleviated by NAC and SIL.	Paraquat	21-23	interleukin 1 beta	Rattus norvegicus	152-160	
17535659-1	2007	OBJECTIVE: To observe the change of cytokine interleukin IL-1 beta, IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha) occurred in acute paraquat (PQ) poisoning rats and to investigate the mechanism of acute lung injury caused by paraquat (PQ) poisoning.	Paraquat	139-147	interleukin 1 beta	Rattus norvegicus	57-66