PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16824337-0 2006 [Effect of baicalin on expression of heme oxygenase-1 in lung injury of rats associated with paraquat poisoning]. Paraquat 93-101 heme oxygenase 1 Rattus norvegicus 37-53 16824337-1 2006 OBJECTIVE: To investigate the effect of baicalin (Bai) on lung injury, the level of TNF-alpha in cultured liquid of pulmonary interstitial macrophage and the expression of heme oxygenase-1 (HO-1) in lung injury associated with paraquat poisoning. Paraquat 227-235 heme oxygenase 1 Rattus norvegicus 190-194 16824337-16 2006 CONCLUSION: The lung injury associated with paraquat poisoning was alleviated by baicalin, which was possibly related to the decrease of level of TNF-alpha in cultured PIM and the increase of the expression of HO-1 mRNA and protein. Paraquat 44-52 heme oxygenase 1 Rattus norvegicus 210-214 16328009-9 2006 Five genes related to oxidative stress, TRX, HO-1, GST-Yc, NQO-1, and RL/IF-1, and one gene, CLK3, whose function is unknown, showed a significant increase in their expression due to PQ injection. Paraquat 183-185 heme oxygenase 1 Rattus norvegicus 45-57 16328009-11 2006 HO-1 was expressed in the bronchial epithelial cells, some type II cells and macrophages of control lungs, and the cells, especially the bronchial epithelial cells, were strongly stained 3 h following PQ treatment. Paraquat 201-203 heme oxygenase 1 Rattus norvegicus 0-4 33544450-7 2021 PQ significantly increased malondialdehyde, alanine transaminase, aspartate aminotransferase, alkaline phosphatase levels, and Kelch-like ECH-associated protein 1 gene expression and also decreased total antioxidant capacity, total thiol group levels, Glutathione S-transferases, heme oxygenase 1, Nrf2, and NAD(P)H:quinone oxidoreductase 1 genes expression, causing histological damages to liver tissue. Paraquat 0-2 heme oxygenase 1 Rattus norvegicus 280-296 12180188-0 2002 Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and aminolevulinic acid synthase. Paraquat 0-8 heme oxygenase 1 Rattus norvegicus 57-73 12180188-6 2002 This study shows that oxidative stress produced by paraquat leads to an increase in delta-aminolevulinic acid synthase and heme oxygenase-1 activities, indicating that the herbicide affects both heme biosynthesis and degradation. Paraquat 51-59 heme oxygenase 1 Rattus norvegicus 123-139 35236239-2 2022 This research aims to explore whether Res inhibits miR-136-5p expression, increases heme oxygenase 1 (HMOX1) expression, and mitigates oxidative stress and PC12 cell apoptosis triggered by paraquat (PQ). Paraquat 189-197 heme oxygenase 1 Rattus norvegicus 84-100 35236239-2 2022 This research aims to explore whether Res inhibits miR-136-5p expression, increases heme oxygenase 1 (HMOX1) expression, and mitigates oxidative stress and PC12 cell apoptosis triggered by paraquat (PQ). Paraquat 189-197 heme oxygenase 1 Rattus norvegicus 102-107 35236239-2 2022 This research aims to explore whether Res inhibits miR-136-5p expression, increases heme oxygenase 1 (HMOX1) expression, and mitigates oxidative stress and PC12 cell apoptosis triggered by paraquat (PQ). Paraquat 199-201 heme oxygenase 1 Rattus norvegicus 84-100 35236239-2 2022 This research aims to explore whether Res inhibits miR-136-5p expression, increases heme oxygenase 1 (HMOX1) expression, and mitigates oxidative stress and PC12 cell apoptosis triggered by paraquat (PQ). Paraquat 199-201 heme oxygenase 1 Rattus norvegicus 102-107 35236239-4 2022 In addition, PQ reduced the expression of anti-apoptotic protein Bcl-2, HMOX1 mRNA and protein, and nuclear factor-erythroid factor 2-related factor 2 (Nrf2) protein and the activity of superoxide dismutase 1 (SOD1) and PC12 cells. Paraquat 13-15 heme oxygenase 1 Rattus norvegicus 72-77 27866548-0 2016 [Effect of heme oxygenase-1 transduced by cell penetrating peptide PEP-1 on renal injury in rats with acute paraquat poisoning]. Paraquat 108-116 heme oxygenase 1 Rattus norvegicus 11-27 30112919-12 2019 The expression of phosphorylated Nrf2 and heme oxygenase 1 in PQ + STS group was significantly increased compared with PQ and control groups ( p < 0.05 or 0.01). Paraquat 62-64 heme oxygenase 1 Rattus norvegicus 42-58 27866548-1 2016 Objective: To study the effects of heme oxygenase-1 transduced by cell penetrating peptide PEP-1 on renal injury in acute paraquat-induced rats. Paraquat 122-130 heme oxygenase 1 Rattus norvegicus 35-51 27866548-18 2016 Conclusion: The HO-1 protein Can be successfully transduced into renal tissue by cell penetrating peptide PEP-1 and the transduced HO-1 protein reduces renal injury of the acute paraquat-induced rats by inhibiting lipid peroxidation response. Paraquat 178-186 heme oxygenase 1 Rattus norvegicus 16-20 27866548-18 2016 Conclusion: The HO-1 protein Can be successfully transduced into renal tissue by cell penetrating peptide PEP-1 and the transduced HO-1 protein reduces renal injury of the acute paraquat-induced rats by inhibiting lipid peroxidation response. Paraquat 178-186 heme oxygenase 1 Rattus norvegicus 131-135 24812154-7 2015 However, pretreatment with Ad-RUNRF2 and RU486 strongly enhanced the expression levels of NRF2, HO-1, NQO-1, CAT and GSH-Px in the lungs of PQ intoxicated rats, with increased GSH and decreased MDA (p < 0.05). Paraquat 140-142 heme oxygenase 1 Rattus norvegicus 96-100 26598004-6 2015 Consequently, paraquat induced expression of Nrf2-dependent ARE-driven genes, such as gamma-glutamylcysteine synthetase, catalase, and hemeoxygenase-1. Paraquat 14-22 heme oxygenase 1 Rattus norvegicus 135-150 24771067-8 2014 CYP2E1 inhibitor, DAS noticeably alleviated maneb- and paraquat-induced ROS, LPO, 4-HNE, SOD, Nrf2 and HO-1, GST, GSH, and GST-pi while iNOS, nitrite content and GSTA4-4 levels were unchanged. Paraquat 55-63 heme oxygenase 1 Rattus norvegicus 103-107 24771067-0 2014 CYP2E1-mediated oxidative stress regulates HO-1 and GST expression in maneb- and paraquat-treated rat polymorphonuclear leukocytes. Paraquat 81-89 heme oxygenase 1 Rattus norvegicus 43-47 24771067-2 2014 The study aimed to investigate the role of CYP2E1 in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes (PMNs) and its crosstalk with iNOS-mediated nitrosative stress and GSTA4-4-linked protective effect, if any and their consequent links with the nuclear factor erythoid 2-related factor 2 (Nrf2) activation and heme oxygenase-1 (HO-1) expression. Paraquat 64-72 heme oxygenase 1 Rattus norvegicus 343-359 24771067-2 2014 The study aimed to investigate the role of CYP2E1 in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes (PMNs) and its crosstalk with iNOS-mediated nitrosative stress and GSTA4-4-linked protective effect, if any and their consequent links with the nuclear factor erythoid 2-related factor 2 (Nrf2) activation and heme oxygenase-1 (HO-1) expression. Paraquat 64-72 heme oxygenase 1 Rattus norvegicus 361-365 24771067-10 2014 The results demonstrate that CYP2E1 induces iNOS-independent free radical generation and subsequently modulates the Nrf2-dependent HO-1 and 4-HNE-mediated GST expression in maneb- and paraquat-treated PMNs. Paraquat 184-192 heme oxygenase 1 Rattus norvegicus 131-135 22983789-5 2012 The dual-luciferase reporter gene also revealed that the transcriptional activation of HO-1 gene expression of the antioxidant responsive element via Nrf2 occurred as a consequence of 100 and 300 muM PQ exposure. Paraquat 200-202 heme oxygenase 1 Rattus norvegicus 87-91 25169090-9 2014 Both paraquat group and curcumin intervention group showed increase in MDA content, decreases in SOD and CAT activities, increases in HO-1 and NQO-1 activities, and increases in the protein and mRNA levels of Nrf2, in comparison with the control group (P < 0.05 for all except HO-1 activity in paraquat group on day 7). Paraquat 5-13 heme oxygenase 1 Rattus norvegicus 134-138 25169090-9 2014 Both paraquat group and curcumin intervention group showed increase in MDA content, decreases in SOD and CAT activities, increases in HO-1 and NQO-1 activities, and increases in the protein and mRNA levels of Nrf2, in comparison with the control group (P < 0.05 for all except HO-1 activity in paraquat group on day 7). Paraquat 5-13 heme oxygenase 1 Rattus norvegicus 280-284 22983789-6 2012 Collectively, these results clearly indicated for the first time that the Nrf2/HO-1 pathway in the substantia nigra was activated by PQ, and pretreatment with tBHQ conferred neuroprotection against PQ-induced Parkinsonism presumably by increasing Nrf2 and HO-1 expression. Paraquat 198-200 heme oxygenase 1 Rattus norvegicus 79-83 22983789-6 2012 Collectively, these results clearly indicated for the first time that the Nrf2/HO-1 pathway in the substantia nigra was activated by PQ, and pretreatment with tBHQ conferred neuroprotection against PQ-induced Parkinsonism presumably by increasing Nrf2 and HO-1 expression. Paraquat 198-200 heme oxygenase 1 Rattus norvegicus 256-260 22983789-6 2012 Collectively, these results clearly indicated for the first time that the Nrf2/HO-1 pathway in the substantia nigra was activated by PQ, and pretreatment with tBHQ conferred neuroprotection against PQ-induced Parkinsonism presumably by increasing Nrf2 and HO-1 expression. Paraquat 133-135 heme oxygenase 1 Rattus norvegicus 79-83 22185821-3 2012 By knocking down the Nrf2 gene, we confirmed that cyclo(His-Pro) inhibits NF-kappaB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway. Paraquat 116-124 heme oxygenase 1 Rattus norvegicus 173-189 22185821-4 2012 The protection required functional heme oxygenase-1 activity, since zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, prevented NF-kappaB inhibition, and the presence of exogenous carbon monoxide and bilirubin afforded cytoprotection against paraquat-induced toxicity by preventing NF-kappaB activation. Paraquat 246-254 heme oxygenase 1 Rattus norvegicus 35-51 20600150-9 2010 KEY FINDINGS: Pulmonary MDA level and HO-1 expression were elevated and the TOSC was reduced rapidly by an intraperitoneal dose of PQ. Paraquat 131-133 heme oxygenase 1 Rattus norvegicus 38-42 20095327-0 2009 [Pathologic changes and expression of Heme oxygenase-1 in paraquat-induced renal injury]. Paraquat 58-66 heme oxygenase 1 Rattus norvegicus 38-54 20095327-14 2009 The higher expression of HO-1 and HO-1 mRNA were involved in the procedures of paraquat-induced renal injury. Paraquat 79-87 heme oxygenase 1 Rattus norvegicus 25-38