PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25908444-7 2015 The lysine 68 (K68) site is the most important acetylation site contributing to SOD2 activation and plays a role in cell survival after paraquat treatment. Paraquat 136-144 superoxide dismutase 2 Homo sapiens 80-84 31106605-7 2019 CA alleviated ROS production and prevented the reduction of antioxidant capacity in cells exposed to PQ by increasing NF-E2-related factor 2 (Nrf2), superoxide dismutase 2 (SOD2) and glutathione levels. Paraquat 101-103 superoxide dismutase 2 Homo sapiens 149-171 31106605-7 2019 CA alleviated ROS production and prevented the reduction of antioxidant capacity in cells exposed to PQ by increasing NF-E2-related factor 2 (Nrf2), superoxide dismutase 2 (SOD2) and glutathione levels. Paraquat 101-103 superoxide dismutase 2 Homo sapiens 173-177 27389776-6 2017 We found that T-I pretreatment significantly protected mitochondria against PQ-induced redox impairment through an Nrf2-dependent mechanism involving upregulation of antioxidant enzymes, such as Mn-superoxide dismutase (Mn-SOD), glutathione peroxidase (GPx), and both catalytic and modifier subunits of gamma-glutamate-cysteine ligase (gamma-GCL). Paraquat 76-78 superoxide dismutase 2 Homo sapiens 195-218 27389776-6 2017 We found that T-I pretreatment significantly protected mitochondria against PQ-induced redox impairment through an Nrf2-dependent mechanism involving upregulation of antioxidant enzymes, such as Mn-superoxide dismutase (Mn-SOD), glutathione peroxidase (GPx), and both catalytic and modifier subunits of gamma-glutamate-cysteine ligase (gamma-GCL). Paraquat 76-78 superoxide dismutase 2 Homo sapiens 220-226 19093460-8 2007 More interestingly, E. coli expressing hMnSOD provides resistance against oxidative stress induced by the herbicide paraquat up to 1.2 mM. Paraquat 116-124 superoxide dismutase 2 Homo sapiens 39-45 23602909-9 2013 In contrast, paraquat-induced oxidative stress and cell death were selectively reduced by MnSOD overexpression, but not by CuZnSOD or manganese-porphyrins. Paraquat 13-21 superoxide dismutase 2 Homo sapiens 90-95 21899432-5 2011 A six- to eightfold increase in SOD activity was observed after transduction, rendering MnSOD-overexpressing TK6 cells significantly more resistant to paraquat-induced superoxide radical production than controls. Paraquat 151-159 superoxide dismutase 2 Homo sapiens 32-35 21899432-5 2011 A six- to eightfold increase in SOD activity was observed after transduction, rendering MnSOD-overexpressing TK6 cells significantly more resistant to paraquat-induced superoxide radical production than controls. Paraquat 151-159 superoxide dismutase 2 Homo sapiens 88-93 24736663-3 2014 This effect can be reversed by the specific TrkA tyrosine kinase inhibitor GW441756, by the multi-kinase TrkA inhibitors K252a, CEP-701 and Go6976, which inhibit SOD2 expression, and by siRNA knockdown of SOD2 expression, which restores the sensitivity of TrkAIII expressing SH-SY5Y cells to Rotenone, Paraquat and LY83583-induced mitochondrial free radical ROS production and ROS-mediated death. Paraquat 302-310 superoxide dismutase 2 Homo sapiens 162-166 14503839-3 2003 We hypothesized that the inducibility of Mn-SOD and MT mRNA by paraquat, an intracellular superoxide generator, might be altered in lymphocytes of gastric cancer patients. Paraquat 63-71 superoxide dismutase 2 Homo sapiens 41-47 14499631-5 2003 MnSOD activity was strongly induced in virally transformed WI-38 cells by treatment with the herbicide paraquat or inhibition of GSH synthesis with BSO. Paraquat 103-111 superoxide dismutase 2 Homo sapiens 0-5 10644010-5 1999 Our results show a 20-50% increase in both SOD activities when cells were exposed to TNF or to an oxidative stress produced by Paraquat (a generator of superoxide anion radicals), both in terms of enzymes activity (zymogram) and protein levels (Western blotting and ELISA). Paraquat 127-135 superoxide dismutase 2 Homo sapiens 43-46 10774745-8 2000 Taken together, these results strongly suggest that increases in levels of metallothionein, glutathione S-transferase, Cu,Zn-SOD and Mn-SOD play important roles in protective mechanisms against toxicity of PQ or ROS in AML cells. Paraquat 206-208 superoxide dismutase 2 Homo sapiens 133-139 11306437-6 2001 In addition, 54 to 72% of cells overexpressing both MnSOD and CAT survived in 1 mM paraquat compared with 58 to 73% with MnSOD alone and 27% with control cells. Paraquat 83-91 superoxide dismutase 2 Homo sapiens 52-57 10644010-8 1999 In contrast, the addition of a SOD mimetic (MnTMPyP) completely inhibited Paraquat-stimulated ICAM-1 expression in melanoma cells and significantly decreased it in HUVEC (50%). Paraquat 74-82 superoxide dismutase 2 Homo sapiens 31-34 9925760-3 1999 It was found that superoxide produced by hyperoxic culture conditions (95% O2 atm) or the redox cycling agent paraquat caused a lesion of the import/processing of precursor hMn-SOD in the baculovirus model. Paraquat 110-118 superoxide dismutase 2 Homo sapiens 173-180 8333551-4 1993 Acute survival during paraquat exposure (0-500 microM) was significantly improved in CHO cells expressing human Mn SOD, with 71% of recombinant CHO cells surviving at the 50% lethal dose (LD50) for wild-type CHO controls. Paraquat 22-30 superoxide dismutase 2 Homo sapiens 112-118 1959661-0 1991 Overproduction of human Mn-superoxide dismutase modulates paraquat-mediated toxicity in mammalian cells. Paraquat 58-66 superoxide dismutase 2 Homo sapiens 24-47 9223372-4 1997 This expression system was used to study the effects of paraquat and menadione, two intracellular superoxide generators, on processing of precursor hMn-SOD by insect mitochondria. Paraquat 56-64 superoxide dismutase 2 Homo sapiens 148-155 9223372-5 1997 Paraquat was found to potently inhibit mitochondrial processing of hMn-SOD, leading to the accumulation of precursor hMn-SOD and a decrease in measurable Mn-SOD activity. Paraquat 0-8 superoxide dismutase 2 Homo sapiens 67-74 9223372-5 1997 Paraquat was found to potently inhibit mitochondrial processing of hMn-SOD, leading to the accumulation of precursor hMn-SOD and a decrease in measurable Mn-SOD activity. Paraquat 0-8 superoxide dismutase 2 Homo sapiens 117-124 9223372-5 1997 Paraquat was found to potently inhibit mitochondrial processing of hMn-SOD, leading to the accumulation of precursor hMn-SOD and a decrease in measurable Mn-SOD activity. Paraquat 0-8 superoxide dismutase 2 Homo sapiens 68-74