PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30088170-9	2018	In vitro experiments showed that the levels of TNF-alpha, IL-1beta, and IL-6 secreted by human pulmonary microvascular endothelial cells treated with PQ were attenuated by fasudil.	Paraquat	150-152	interleukin 6	Homo sapiens	72-76	
20506652-8	2010	The RT-PCR verified the mRNA expression of IL-6 and IL-8 was up-regulated until 48 h after treatment with paraquat.	Paraquat	106-114	interleukin 6	Homo sapiens	43-47	
34877356-14	2021	IL-6 and TNF-alpha were expected to be potential prediction indexes of paraquat-induced ALI.	Paraquat	71-79	interleukin 6	Homo sapiens	0-4	
29896267-0	2018	Lung injury caused by paraquat poisoning results in increased interleukin-6 and decreased microRNA-146a levels.	Paraquat	22-30	interleukin 6	Homo sapiens	62-75	
29896267-11	2018	Therefore, the present study demonstrated that increased expression of IL-6 in patients with lung injury caused by paraquat poisoning is associated with decreased expression of miR-146a.	Paraquat	115-123	interleukin 6	Homo sapiens	71-75	
29454966-9	2018	The involvement of the IL-6 and GS suggests that the SCG2 may potentially regulate inflammatory factors and excitatory neurotransmitter to the cytotoxicity of PQ on astroglia.	Paraquat	159-161	interleukin 6	Homo sapiens	23-27	
28194150-0	2016	Epigenetic Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis.	Paraquat	93-101	interleukin 6	Homo sapiens	25-38	
28194150-6	2016	In PQ-treated lungs and macrophages, we found that the mRNA and protein expression of IL-6 was robustly increased in a time-dependent and a dose-dependent manner.	Paraquat	3-5	interleukin 6	Homo sapiens	86-90	
28194150-7	2016	Our data demonstrated that PQ-induced IL-6 expression in macrophages plays a central role in pulmonary fibrosis through enhanced epithelial-to-mesenchymal transition (EMT).	Paraquat	27-29	interleukin 6	Homo sapiens	38-42	
28194150-8	2016	IL-6 expression and its role to enhance PQ-induced pulmonary fibrosis were increased by histone deacetylase (HDAC) inhibition and prevented by histone acetyltransferase (HAT) inhibition.	Paraquat	40-42	interleukin 6	Homo sapiens	0-4	
28194150-11	2016	In conclusion, IL-6 functioning through EMT in PQ-induced pulmonary fibrosis was regulated dynamically by HDAC and HAT both in vitro and in vivo via epigenetically regulating chromatin accessibility.	Paraquat	47-49	interleukin 6	Homo sapiens	15-19	
26653645-14	2015	Compared with the blank control group, the PQ group had significantly increased IL-6 and TNF-alpha level (P < 0.05); Compared with the PQ group, the UTI+PQ group had significantly decreased IL-6 and TNF-alpha level (P < 0.05).	Paraquat	43-45	interleukin 6	Homo sapiens	80-84	
26653645-14	2015	Compared with the blank control group, the PQ group had significantly increased IL-6 and TNF-alpha level (P < 0.05); Compared with the PQ group, the UTI+PQ group had significantly decreased IL-6 and TNF-alpha level (P < 0.05).	Paraquat	43-45	interleukin 6	Homo sapiens	193-197	
22493042-7	2012	PQ at 10 muM stimulated production of inflammatory and profibrogenic factors (tumor necrosis factor alpha, interleukin 6, and transforming growth factor beta1) and induced the transformation of normal human lung fibroblasts (WI38-VA13) to myofibroblasts; both effects were inhibited by Res.	Paraquat	0-2	interleukin 6	Homo sapiens	107-120	
24714343-0	2014	Paraquat-induced reactive oxygen species inhibit neutrophil apoptosis via a p38 MAPK/NF-kappaB-IL-6/TNF-alpha positive-feedback circuit.	Paraquat	0-8	interleukin 6	Homo sapiens	95-99	
22804935-5	2012	The relative gene expression and protein expression of IL-6 and TNF-alpha enhanced with the reduced concentrations of RU486, which were the lowest when RU486 concentration was 10(-7) mol/L, as compared with control and PQ exposure groups (P < 0.01 or P < 0.05), while the change of IL-10 content was the opposite.	Paraquat	219-221	interleukin 6	Homo sapiens	55-59