PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22493042-7 2012 PQ at 10 muM stimulated production of inflammatory and profibrogenic factors (tumor necrosis factor alpha, interleukin 6, and transforming growth factor beta1) and induced the transformation of normal human lung fibroblasts (WI38-VA13) to myofibroblasts; both effects were inhibited by Res. Paraquat 0-2 interleukin 6 Homo sapiens 107-120 34877356-14 2021 IL-6 and TNF-alpha were expected to be potential prediction indexes of paraquat-induced ALI. Paraquat 71-79 interleukin 6 Homo sapiens 0-4 29896267-0 2018 Lung injury caused by paraquat poisoning results in increased interleukin-6 and decreased microRNA-146a levels. Paraquat 22-30 interleukin 6 Homo sapiens 62-75 29896267-11 2018 Therefore, the present study demonstrated that increased expression of IL-6 in patients with lung injury caused by paraquat poisoning is associated with decreased expression of miR-146a. Paraquat 115-123 interleukin 6 Homo sapiens 71-75 28194150-0 2016 Epigenetic Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis. Paraquat 93-101 interleukin 6 Homo sapiens 25-38 28194150-6 2016 In PQ-treated lungs and macrophages, we found that the mRNA and protein expression of IL-6 was robustly increased in a time-dependent and a dose-dependent manner. Paraquat 3-5 interleukin 6 Homo sapiens 86-90 28194150-7 2016 Our data demonstrated that PQ-induced IL-6 expression in macrophages plays a central role in pulmonary fibrosis through enhanced epithelial-to-mesenchymal transition (EMT). Paraquat 27-29 interleukin 6 Homo sapiens 38-42 28194150-8 2016 IL-6 expression and its role to enhance PQ-induced pulmonary fibrosis were increased by histone deacetylase (HDAC) inhibition and prevented by histone acetyltransferase (HAT) inhibition. Paraquat 40-42 interleukin 6 Homo sapiens 0-4 28194150-11 2016 In conclusion, IL-6 functioning through EMT in PQ-induced pulmonary fibrosis was regulated dynamically by HDAC and HAT both in vitro and in vivo via epigenetically regulating chromatin accessibility. Paraquat 47-49 interleukin 6 Homo sapiens 15-19 26653645-14 2015 Compared with the blank control group, the PQ group had significantly increased IL-6 and TNF-alpha level (P < 0.05); Compared with the PQ group, the UTI+PQ group had significantly decreased IL-6 and TNF-alpha level (P < 0.05). Paraquat 43-45 interleukin 6 Homo sapiens 80-84 26653645-14 2015 Compared with the blank control group, the PQ group had significantly increased IL-6 and TNF-alpha level (P < 0.05); Compared with the PQ group, the UTI+PQ group had significantly decreased IL-6 and TNF-alpha level (P < 0.05). Paraquat 43-45 interleukin 6 Homo sapiens 193-197 24714343-0 2014 Paraquat-induced reactive oxygen species inhibit neutrophil apoptosis via a p38 MAPK/NF-kappaB-IL-6/TNF-alpha positive-feedback circuit. Paraquat 0-8 interleukin 6 Homo sapiens 95-99 30088170-9 2018 In vitro experiments showed that the levels of TNF-alpha, IL-1beta, and IL-6 secreted by human pulmonary microvascular endothelial cells treated with PQ were attenuated by fasudil. Paraquat 150-152 interleukin 6 Homo sapiens 72-76 29454966-9 2018 The involvement of the IL-6 and GS suggests that the SCG2 may potentially regulate inflammatory factors and excitatory neurotransmitter to the cytotoxicity of PQ on astroglia. Paraquat 159-161 interleukin 6 Homo sapiens 23-27 22804935-5 2012 The relative gene expression and protein expression of IL-6 and TNF-alpha enhanced with the reduced concentrations of RU486, which were the lowest when RU486 concentration was 10(-7) mol/L, as compared with control and PQ exposure groups (P < 0.01 or P < 0.05), while the change of IL-10 content was the opposite. Paraquat 219-221 interleukin 6 Homo sapiens 55-59 20506652-8 2010 The RT-PCR verified the mRNA expression of IL-6 and IL-8 was up-regulated until 48 h after treatment with paraquat. Paraquat 106-114 interleukin 6 Homo sapiens 43-47