PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35545591-15	2022	Conclusion: PQ induces progressive damage in the LC area of PD-like mice, which may be caused by the abnormal accumulation of pathological alpha-syn in the LC area.	Paraquat	12-14	synuclein, alpha	Mus musculus	139-148	
20200163-6	2010	Immunofluorescence microscopy revealed an increase in punctate (lysosomal) LAMP-2A staining that co-localized with alpha-synuclein within nigral dopaminergic neurons of paraquat-treated and alpha-synuclein-overexpressing animals.	Paraquat	169-177	synuclein, alpha	Mus musculus	115-130	
20200163-6	2010	Immunofluorescence microscopy revealed an increase in punctate (lysosomal) LAMP-2A staining that co-localized with alpha-synuclein within nigral dopaminergic neurons of paraquat-treated and alpha-synuclein-overexpressing animals.	Paraquat	169-177	synuclein, alpha	Mus musculus	190-205	
18056701-2	2008	Oxidative stress, c-Jun N-terminal kinase activation, and alpha-synuclein aggregation are each induced by PQ, but details of the cell death mechanisms involved remain unclear.	Paraquat	106-108	synuclein, alpha	Mus musculus	58-73	
12716914-0	2003	Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration.	Paraquat	48-56	synuclein, alpha	Mus musculus	0-15	
12716914-3	2003	Here, the relationship between alpha-synuclein expression and neuronal injury was studied in mice exposed to the herbicide paraquat.	Paraquat	123-131	synuclein, alpha	Mus musculus	31-46	
12716914-5	2003	In control mice, paraquat caused both the formation of alpha-synuclein-containing intraneuronal deposits and the degeneration of nigrostriatal neurons, as demonstrated by silver staining and a reduction of the counts of TH-positive and Nissl-stained cells.	Paraquat	17-25	synuclein, alpha	Mus musculus	55-70	
22292029-5	2012	By contrast, paraquat treatment of mice resulted in robust accumulation of alpha-Syn and hyperphosphorylation of Tau in striata, through activation of p-GSK-3beta, a major Tau kinase.	Paraquat	13-21	synuclein, alpha	Mus musculus	75-84	
12716914-6	2003	Mice overexpressing alpha-synuclein, either the human wild-type or the Ala53Thr mutant form of the protein, displayed paraquat-induced protein aggregates but were completely protected against neurodegeneration.	Paraquat	118-126	synuclein, alpha	Mus musculus	20-35	
11707429-4	2002	Paraquat markedly accelerated the in vitro rate of alpha-synuclein fibril formation in a dose-dependent fashion.	Paraquat	0-8	synuclein, alpha	Mus musculus	51-66	
11707429-6	2002	This up-regulation followed a consistent pattern, with higher alpha-synuclein at 2 days after each of three weekly paraquat injections and with protein levels returning to control values by day 7 post-treatment.	Paraquat	115-123	synuclein, alpha	Mus musculus	62-77	
26884967-5	2015	By contrast, paraquat and chlorpyrifos together resulted in robust accumulation of alpha-Syn in striata in mice.	Paraquat	13-21	synuclein, alpha	Mus musculus	83-92	
33287470-13	2020	Compared with the control group, the PQ group showed a decrease in the number of Nissl body in the hippocampus and substantia nigra (P<0.05) , a decrease in the number of NeuN and TH positive cells in the substantia nigra (P<0.05) , with a large number of alpha-syn deposition, Iba-1 activation of microglia cells, and an increase in the expression of inflammatory factors (IL-1beta, iNOS) in the hippocampus and substantia nigra (P<0.05) .	Paraquat	37-39	synuclein, alpha	Mus musculus	256-265	
30798073-4	2019	Results showed that mice injected with paraquat and maneb displayed impairments of spatial learning and memory, which was associated with reduced tyrosine hydroxylase expression as well as increased neurodegeneration, synaptic loss, alpha-synuclein expression and Ser129-phosphorylation in the hippocampus.	Paraquat	39-47	synuclein, alpha	Mus musculus	233-248	
29040593-4	2017	Here, we used this model to study the impact of paraquat (PQ) a neurotoxic herbicide incriminated in PD in agricultural workers) on the enteric pSer129 alpha-syn expression in young mice.	Paraquat	48-56	synuclein, alpha	Mus musculus	152-161	
29040593-4	2017	Here, we used this model to study the impact of paraquat (PQ) a neurotoxic herbicide incriminated in PD in agricultural workers) on the enteric pSer129 alpha-syn expression in young mice.	Paraquat	58-60	synuclein, alpha	Mus musculus	152-161	
25952542-0	2016	Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson"s Disease.	Paraquat	68-76	synuclein, alpha	Mus musculus	30-45