PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32962139-4 2020 We show that DBT protects Neuro2a cells against paraquat (PQ) toxicity by counteracting oxidative stress at low concentrations and increases the synthesis of reduced glutathione and NADPH in a Nrf2-independent manner. Paraquat 58-60 nuclear factor, erythroid derived 2, like 2 Mus musculus 193-197 30734183-0 2019 High-Dose Paraquat Induces Human Bronchial 16HBE Cell Death and Aggravates Acute Lung Intoxication in Mice by Regulating Keap1/p65/Nrf2 Signal Pathway. Paraquat 10-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 131-135 31182998-0 2019 The Alexipharmic Mechanisms of Five Licorice Ingredients Involved in CYP450 and Nrf2 Pathways in Paraquat-Induced Mice Acute Lung Injury. Paraquat 97-105 nuclear factor, erythroid derived 2, like 2 Mus musculus 80-84 32242774-6 2020 RESULTS: MB and PQ reduced the dopamine content (mouse) and Cyp2d22/CYP2D6 activity (mouse/neuroblastoma cells) and increased the nuclear translocation of Nrf2 and expression of NQO1 and Trx1 (both). Paraquat 16-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 155-159 31368498-0 2019 Nrf2-regulated miR-380-3p blocks the translation of Sp3 protein and its mediation of paraquat-induced toxicity in mouse neuroblastoma N2a cells. Paraquat 85-93 nuclear factor, erythroid derived 2, like 2 Mus musculus 0-4 31368498-9 2019 In conclusion, Nrf2-regulated miR-380-3p inhibited cell proliferation and enhanced the PQ-induced toxicity in N2a cells potentially by blocking the translation Sp3 mRNA. Paraquat 87-89 nuclear factor, erythroid derived 2, like 2 Mus musculus 15-19 30734183-7 2019 In vivo experiments also showed that high-dose PQ promotes inflammatory cytokines secretion, lung fibrosis and cell apoptosis, inhibits cell proliferation in mice models by regulating Keap1/p65/Nrf2 signal pathway. Paraquat 47-49 nuclear factor, erythroid derived 2, like 2 Mus musculus 194-198 30734183-8 2019 Therefore, we concluded that high-dose PQ (500 muM) inhibits 16HBE cell proliferation and autophagy, promotes cell death and mice lung fibrosis by regulating Keap1/p65/Nrf2 signal pathway. Paraquat 39-41 nuclear factor, erythroid derived 2, like 2 Mus musculus 168-172 29864937-11 2018 FGF21 also suppressed oxidative stress in PQ-treated A549 cells, as evidenced by a decrease of the MDA level, a reversed activity of antioxidant enzymes and an increased expression of Nrf-2. Paraquat 42-44 nuclear factor, erythroid derived 2, like 2 Mus musculus 184-189 30679998-0 2019 Nrf2 overexpression protects against paraquat-induced A549 cell injury primarily by upregulating P-glycoprotein and reducing intracellular paraquat accumulation. Paraquat 37-45 nuclear factor, erythroid derived 2, like 2 Mus musculus 0-4 30679998-0 2019 Nrf2 overexpression protects against paraquat-induced A549 cell injury primarily by upregulating P-glycoprotein and reducing intracellular paraquat accumulation. Paraquat 139-147 nuclear factor, erythroid derived 2, like 2 Mus musculus 0-4 30679998-3 2019 A previous study has demonstrated that the upregulation of nuclear factor erythroid-2 related factor 2 (Nrf2) prevents PQ toxicity in cell line and murine models. Paraquat 119-121 nuclear factor, erythroid derived 2, like 2 Mus musculus 59-102 30679998-3 2019 A previous study has demonstrated that the upregulation of nuclear factor erythroid-2 related factor 2 (Nrf2) prevents PQ toxicity in cell line and murine models. Paraquat 119-121 nuclear factor, erythroid derived 2, like 2 Mus musculus 104-108 30679998-4 2019 As Nrf2 target genes include a group of membrane transporters, the current study assessed the protective mechanism exerted by Nrf2 against PQ toxicity and intracellular PQ accumulation via its effects on P-glycoprotein (P-gp), a downstream transporter of Nrf2. Paraquat 139-141 nuclear factor, erythroid derived 2, like 2 Mus musculus 3-7 30679998-4 2019 As Nrf2 target genes include a group of membrane transporters, the current study assessed the protective mechanism exerted by Nrf2 against PQ toxicity and intracellular PQ accumulation via its effects on P-glycoprotein (P-gp), a downstream transporter of Nrf2. Paraquat 139-141 nuclear factor, erythroid derived 2, like 2 Mus musculus 126-130 30679998-4 2019 As Nrf2 target genes include a group of membrane transporters, the current study assessed the protective mechanism exerted by Nrf2 against PQ toxicity and intracellular PQ accumulation via its effects on P-glycoprotein (P-gp), a downstream transporter of Nrf2. Paraquat 139-141 nuclear factor, erythroid derived 2, like 2 Mus musculus 126-130 30679998-4 2019 As Nrf2 target genes include a group of membrane transporters, the current study assessed the protective mechanism exerted by Nrf2 against PQ toxicity and intracellular PQ accumulation via its effects on P-glycoprotein (P-gp), a downstream transporter of Nrf2. Paraquat 169-171 nuclear factor, erythroid derived 2, like 2 Mus musculus 3-7 30679998-10 2019 The results revealed that overexpressed Nrf2 significantly increased P-gp protein levels, decreased the intracellular accumulation of PQ and attenuated PQ-induced toxicity. Paraquat 134-136 nuclear factor, erythroid derived 2, like 2 Mus musculus 40-44 30679998-10 2019 The results revealed that overexpressed Nrf2 significantly increased P-gp protein levels, decreased the intracellular accumulation of PQ and attenuated PQ-induced toxicity. Paraquat 152-154 nuclear factor, erythroid derived 2, like 2 Mus musculus 40-44 30679998-11 2019 However, the protective effects of Nrf2 overexpression on PQ-challenged A549 cells were abrogated following cyclosporine A treatment, a competitive inhibitor of P-gp, which also increased intracellular PQ levels. Paraquat 58-60 nuclear factor, erythroid derived 2, like 2 Mus musculus 35-39 30679998-11 2019 However, the protective effects of Nrf2 overexpression on PQ-challenged A549 cells were abrogated following cyclosporine A treatment, a competitive inhibitor of P-gp, which also increased intracellular PQ levels. Paraquat 202-204 nuclear factor, erythroid derived 2, like 2 Mus musculus 35-39 30679998-12 2019 These data indicated that Nrf2 gene overexpression prevented PQ toxicity in A549 cells, potentially via the upregulation of P-gp activity and the inhibition of intracellular PQ accumulation. Paraquat 61-63 nuclear factor, erythroid derived 2, like 2 Mus musculus 26-30 30679998-12 2019 These data indicated that Nrf2 gene overexpression prevented PQ toxicity in A549 cells, potentially via the upregulation of P-gp activity and the inhibition of intracellular PQ accumulation. Paraquat 174-176 nuclear factor, erythroid derived 2, like 2 Mus musculus 26-30 30679998-13 2019 Thus, Nrf2 and P-gp may serve as potential therapeutic targets for the treatment of PQ-induced injury. Paraquat 84-86 nuclear factor, erythroid derived 2, like 2 Mus musculus 6-10 29627306-0 2018 Paraquat and MPTP induce alteration in the expression profile of long noncoding RNAs in the substantia nigra of mice: Role of the transcription factor Nrf2. Paraquat 0-8 nuclear factor, erythroid derived 2, like 2 Mus musculus 151-155 29627306-5 2018 We aimed to discover novel PQ or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Nrf2-related lncRNAs and explore their association with PD. Paraquat 27-29 nuclear factor, erythroid derived 2, like 2 Mus musculus 85-89 29627306-11 2018 PQ caused lncRNA expression profiling alteration in the substantia nigra (SN) through an interaction with Nrf2, thus changing the NR_027648/Zc3h14/Cybb and NR_030777/Zfp326/Cpne5 mRNA pathways. Paraquat 0-2 nuclear factor, erythroid derived 2, like 2 Mus musculus 106-110 29627306-13 2018 Nrf2 may be involved in the development of neurodegeneration induced by PQ and MPTP via interaction with lncRNAs as the molecular mechanism. Paraquat 72-74 nuclear factor, erythroid derived 2, like 2 Mus musculus 0-4 28115273-10 2017 The redox signaling molecule nuclear factor erythroid related factor 2 (Nrf2) was upregulated in response to paraquat challenge. Paraquat 109-117 nuclear factor, erythroid derived 2, like 2 Mus musculus 29-70 29568483-0 2018 Transplantation of endothelial progenitor cells attenuated paraquat-induced acute lung injury via miR-141-3p-Notch-Nrf2 axis. Paraquat 59-67 nuclear factor, erythroid derived 2, like 2 Mus musculus 115-119 29568483-13 2018 Conclusions: Endothelial progenitor cells could provide therapeutic effect on PQ-induced ALI via miR-141-3p-Notch-Nrf2 Axis. Paraquat 78-80 nuclear factor, erythroid derived 2, like 2 Mus musculus 114-118 29316751-12 2017 In addition, compared with the control group, the expressions of HO-1 and Nrf2 were increased in lung tissues in OPC group, and these were decreased in lung tissues in PQ groups. Paraquat 168-170 nuclear factor, erythroid derived 2, like 2 Mus musculus 74-78 29316751-13 2017 Furthermore, the expressions of HO-1 and Nrf2 were also increased in lung tissues in PQ+OPC as com-pared with the PQ group. Paraquat 85-87 nuclear factor, erythroid derived 2, like 2 Mus musculus 41-45 29316751-14 2017 Conclusion: OPC could alleviate PQ-induced systemic toxicity in mice by regulating oxidative stress via NF-kappaB and Nrf2 pathway. Paraquat 32-34 nuclear factor, erythroid derived 2, like 2 Mus musculus 118-122 28428137-0 2017 JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2. Paraquat 16-24 nuclear factor, erythroid derived 2, like 2 Mus musculus 65-69 28115273-0 2017 Ablation of Akt2 prevents paraquat-induced myocardial mitochondrial injury and contractile dysfunction: Role of Nrf2. Paraquat 26-34 nuclear factor, erythroid derived 2, like 2 Mus musculus 112-116 29071302-0 2017 Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2. Paraquat 0-8 nuclear factor, erythroid derived 2, like 2 Mus musculus 131-135 29071302-3 2017 Exposure to 10 mg/kg PQ or 30 mg/kg MPTP caused damage to nerve cells in the substantia nigra (SN) in both Nrf2 (+/+) and Nrf2 (-/-) ICR mice, which included cell morphological changes, detectable apoptosis and a significant reduction in the number of dopaminergic (DA) neurons. Paraquat 21-23 nuclear factor, erythroid derived 2, like 2 Mus musculus 107-111 29071302-3 2017 Exposure to 10 mg/kg PQ or 30 mg/kg MPTP caused damage to nerve cells in the substantia nigra (SN) in both Nrf2 (+/+) and Nrf2 (-/-) ICR mice, which included cell morphological changes, detectable apoptosis and a significant reduction in the number of dopaminergic (DA) neurons. Paraquat 21-23 nuclear factor, erythroid derived 2, like 2 Mus musculus 122-126 29071302-4 2017 When mice were exposed to the same PQ dose of 10 mg/kg, significant fewer tyrosine hydroxylase (TH)-positive DA neurons were observed in the Nrf2 (-/-) mice than that in the Nrf2 (+/+) mice. Paraquat 35-37 nuclear factor, erythroid derived 2, like 2 Mus musculus 141-145 29071302-4 2017 When mice were exposed to the same PQ dose of 10 mg/kg, significant fewer tyrosine hydroxylase (TH)-positive DA neurons were observed in the Nrf2 (-/-) mice than that in the Nrf2 (+/+) mice. Paraquat 35-37 nuclear factor, erythroid derived 2, like 2 Mus musculus 174-178 29071302-5 2017 Both Nrf2 deficiency and PQ or MPTP exposure could alter miRNA expression profile in the SN, suggesting the potential involvement of Nrf2 in the PQ-induced or MPTP-induced miRNA expression alteration. Paraquat 25-27 nuclear factor, erythroid derived 2, like 2 Mus musculus 133-137 29071302-5 2017 Both Nrf2 deficiency and PQ or MPTP exposure could alter miRNA expression profile in the SN, suggesting the potential involvement of Nrf2 in the PQ-induced or MPTP-induced miRNA expression alteration. Paraquat 145-147 nuclear factor, erythroid derived 2, like 2 Mus musculus 5-9 29071302-5 2017 Both Nrf2 deficiency and PQ or MPTP exposure could alter miRNA expression profile in the SN, suggesting the potential involvement of Nrf2 in the PQ-induced or MPTP-induced miRNA expression alteration. Paraquat 145-147 nuclear factor, erythroid derived 2, like 2 Mus musculus 133-137 28115273-10 2017 The redox signaling molecule nuclear factor erythroid related factor 2 (Nrf2) was upregulated in response to paraquat challenge. Paraquat 109-117 nuclear factor, erythroid derived 2, like 2 Mus musculus 72-76 28115273-11 2017 Findings from in vitro study revealed that stimulation of Nrf2 using sulforaphane (10muM) negated Akt2 ablation-offered beneficial effect against paraquat whereas inhibition of Nrf2 using luteolin (20muM) mimicked Akt2 ablation-induced beneficial effect against paraquat challenge. Paraquat 146-154 nuclear factor, erythroid derived 2, like 2 Mus musculus 58-62 28115273-11 2017 Findings from in vitro study revealed that stimulation of Nrf2 using sulforaphane (10muM) negated Akt2 ablation-offered beneficial effect against paraquat whereas inhibition of Nrf2 using luteolin (20muM) mimicked Akt2 ablation-induced beneficial effect against paraquat challenge. Paraquat 262-270 nuclear factor, erythroid derived 2, like 2 Mus musculus 58-62 28115273-12 2017 Taken together, our data indicate that Akt2 ablation may protect against paraquat toxicity-induced cardiac contractile defect and apoptosis possibly via regulation of Nrf2 activation and mitochondrial homeostasis. Paraquat 73-81 nuclear factor, erythroid derived 2, like 2 Mus musculus 167-171 27507327-0 2016 Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-beta1/Smad3 signaling. Paraquat 36-44 nuclear factor, erythroid derived 2, like 2 Mus musculus 83-87 26708779-2 2016 Previous studies have indicated that nuclear factor, erythroid 2-like 2 (NRF2) is an effective target of antioxidant therapy for paraquat (PQ) poisoning. Paraquat 129-137 nuclear factor, erythroid derived 2, like 2 Mus musculus 73-77 26935021-0 2016 SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro. Paraquat 40-48 nuclear factor, erythroid derived 2, like 2 Mus musculus 124-128 26935021-2 2016 The nuclear factor E2-related factor 2 (NRF2)-antioxidant response element (ARE) antioxidant pathway plays important regulatory roles in the antioxidant therapy of paraquat (PQ) poisoning. Paraquat 164-172 nuclear factor, erythroid derived 2, like 2 Mus musculus 40-44 26935021-2 2016 The nuclear factor E2-related factor 2 (NRF2)-antioxidant response element (ARE) antioxidant pathway plays important regulatory roles in the antioxidant therapy of paraquat (PQ) poisoning. Paraquat 174-176 nuclear factor, erythroid derived 2, like 2 Mus musculus 40-44 26935021-3 2016 In the present study, we investigated whether the SIRT1/NRF2/ARE signaling pathway plays an important role in lung injury induced by PQ. Paraquat 133-135 nuclear factor, erythroid derived 2, like 2 Mus musculus 56-60 26935021-12 2016 The findings of this study demonstrate that the protective effects of SIRT1 are associated with the activation of the NRF2/ARE antioxidant pathway in lung injury induced by PQ poisoning. Paraquat 173-175 nuclear factor, erythroid derived 2, like 2 Mus musculus 118-122 26708779-2 2016 Previous studies have indicated that nuclear factor, erythroid 2-like 2 (NRF2) is an effective target of antioxidant therapy for paraquat (PQ) poisoning. Paraquat 129-137 nuclear factor, erythroid derived 2, like 2 Mus musculus 37-71 26708779-2 2016 Previous studies have indicated that nuclear factor, erythroid 2-like 2 (NRF2) is an effective target of antioxidant therapy for paraquat (PQ) poisoning. Paraquat 139-141 nuclear factor, erythroid derived 2, like 2 Mus musculus 37-71 26708779-2 2016 Previous studies have indicated that nuclear factor, erythroid 2-like 2 (NRF2) is an effective target of antioxidant therapy for paraquat (PQ) poisoning. Paraquat 139-141 nuclear factor, erythroid derived 2, like 2 Mus musculus 73-77 26708779-3 2016 However, the association between SIRT1 and NRF2 and their effects in PQ-induced oxidative stress remains to be elucidated. Paraquat 69-71 nuclear factor, erythroid derived 2, like 2 Mus musculus 43-47 26708779-4 2016 The current study demonstrated that PQ exposure upregulated the expression of SIRT1 and NRF2 following 6- and 24-h exposure in the lungs of mice. Paraquat 36-38 nuclear factor, erythroid derived 2, like 2 Mus musculus 88-92 26708779-5 2016 However, long-term exposure to PQ significantly decreased the expression of SIRT1 and NRF2. Paraquat 31-33 nuclear factor, erythroid derived 2, like 2 Mus musculus 86-90 26708779-8 2016 The present results demonstrated that resveratrol reduced PQ-induced oxidative stress and lung injury, potentially through the positive feedback signaling loop between SIRT1 and NRF2. Paraquat 58-60 nuclear factor, erythroid derived 2, like 2 Mus musculus 178-182 26758514-13 2016 In addition, PQ-induced activation of NF-kappaB, Nrf2 and alpha-SMA were enhanced by puerarin. Paraquat 13-15 nuclear factor, erythroid derived 2, like 2 Mus musculus 49-53 25579023-7 2014 Compared with paraquat poisioning group, the pulmonary SOD, Nrf2 mRNA and protein were increased and the lung wet dry ratio were all significantly decreased in mice of THD treatment group at 1 d, 3 d, 7 d (P<0.05). Paraquat 14-22 nuclear factor, erythroid derived 2, like 2 Mus musculus 60-64 25579023-10 2014 CONCLUSIONS: Lipid peroxide damage was one of the mechanisms of paraquat poisioning, thalidomide could attenuate paraquat-induced acute lung injury and its mechanism may be activating the Nrf2-ARE signaling pathway to protect mouse from Lipid peroxide damage. Paraquat 64-72 nuclear factor, erythroid derived 2, like 2 Mus musculus 188-192 22983789-1 2012 The present study was aimed at determining the role of paraquat (PQ) in the activation of the NF-E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and the possible neuroprotective effects of tert-butylhydroquinone (tBHQ) pretreatment on PQ-induced neurodegeneration in vivo and in vitro. Paraquat 55-63 nuclear factor, erythroid derived 2, like 2 Mus musculus 94-116 22983789-1 2012 The present study was aimed at determining the role of paraquat (PQ) in the activation of the NF-E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and the possible neuroprotective effects of tert-butylhydroquinone (tBHQ) pretreatment on PQ-induced neurodegeneration in vivo and in vitro. Paraquat 55-63 nuclear factor, erythroid derived 2, like 2 Mus musculus 118-122 22983789-1 2012 The present study was aimed at determining the role of paraquat (PQ) in the activation of the NF-E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and the possible neuroprotective effects of tert-butylhydroquinone (tBHQ) pretreatment on PQ-induced neurodegeneration in vivo and in vitro. Paraquat 65-67 nuclear factor, erythroid derived 2, like 2 Mus musculus 94-116 22983789-1 2012 The present study was aimed at determining the role of paraquat (PQ) in the activation of the NF-E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and the possible neuroprotective effects of tert-butylhydroquinone (tBHQ) pretreatment on PQ-induced neurodegeneration in vivo and in vitro. Paraquat 65-67 nuclear factor, erythroid derived 2, like 2 Mus musculus 118-122 22983789-1 2012 The present study was aimed at determining the role of paraquat (PQ) in the activation of the NF-E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and the possible neuroprotective effects of tert-butylhydroquinone (tBHQ) pretreatment on PQ-induced neurodegeneration in vivo and in vitro. Paraquat 246-248 nuclear factor, erythroid derived 2, like 2 Mus musculus 118-122 22983789-2 2012 7 mg/kg PQ treatment of male C57BL/6 mice caused decreased spontaneous locomotor activity, decreased tyrosine hydroxylase (TH)-positive neurons, increased terminal deoxynucleotidyl transferase-mediated dUTP biotin nick end-labeling (TUNEL)-positive cells in the substantia nigra, as well as increased protein levels of both nuclear Nrf2 and HO-1. Paraquat 8-10 nuclear factor, erythroid derived 2, like 2 Mus musculus 332-336 19933842-4 2010 Treatment of control cells with arsenite, an inducer of Nrf2 activity, increases their resistance to paraquat, hydrogen peroxide, cadmium, and UV light, rendering these cells as stress resistant as untreated cells from dwarf mice. Paraquat 101-109 nuclear factor, erythroid derived 2, like 2 Mus musculus 56-60